2V0SA

Crystal structure of a hairpin exchange variant (lr1) of the targeting line-1 retrotransposon endonuclease
Total Genus 69
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
69
sequence length
229
structure length
229
Chain Sequence
ITILTLNINGLNSAIKRHRLASWIKSQDPSVCCIQETHLTCRDTHRLKIKGWRKIYQANGKQKKAGVAILVSDKTDFKPTKIKRDKEGHYIMVKGSIQQEELTILNIYAPNTGAPRFIKQVLSDLQRDLDSHTLIMGDFNTPLSTLDRSTRQKVNKDTQELNSALHQADLIDIYRTLHPKSTEYTFSTANGESKIDHIVGSKALLSKCKRTEIITNYLSDHSAIKLELR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Determinants for DNA Target Structure Selectivity of the Human Line-1 Retrotransposon Endonuclease.
pubmed doi rcsb
molecule tags Transcription
source organism Homo sapiens
molecule keywords LR1
total genus 69
structure length 229
sequence length 229
ec nomenclature ec 2.7.7.49: RNA-directed DNA polymerase.
pdb deposition date 2007-05-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03372 Exo_endo_phos Endonuclease/Exonuclease/phosphatase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.10.10 Alpha Beta 4-Layer Sandwich Deoxyribonuclease I; Chain A Endonuclease/exonuclease/phosphatase 2v0sA00
4B5GA 4F1HB 3G00A 4F1RA 2DDTA 4GYZA 5CFGA 1I9YA 5J3ZA 5HT2A 4L1ZA 5J8NA 2F1NA 4AWNA 4F1IA 3K55A 1Y21A 1BIXA 4L20A 5INPA 2UYRX 1ATND 5INKA 2DDSA 3N9VA 2A41B 1E9NA 5J42A 4PUQA 5A7IA 3G0RA 3G6SA 3L1WA 4B5FA 5DFFA 5INOA 1AKOA 4GZ0A 2D1KB 1YJHA 5EWTA 3G4TA 3MPRA 3G8VA 3W2XA 5J3SA 3MTCA 4CMNA 1DE9A 4FPVA 3NGNA 4B5MA 1HD7A 5DFHA 3FZIA 5DFJA 4GZ2A 4C1RA 3GA6A 4L21A 3I5VA 2V0RA 3I41A 1VYBA 3CJCD 5A7JA 4L1YA 5DG0A 3WCXA 2A3ZB 2IMQX 4RUWA 3W3DB 1WDUA 4F1HA 5INNA 2XSWA 5J3PA 3NGOA 5DV2A 1DNKA 3DNIA 4B5HA 1I9ZA 3G38A 1DEWA 1DE8A 4GEWA 5CFEA 5INMA 3NR8A 4QHEA 5INQA 3I48A 2A40B 2ISIA 4LNDA 3G3YA 4CMLA 3G2CA 3U8UA 2EI9A 4K6LF 3W2YA 4JG3A 2F2FB 4QH9A 3TEBA 3G2DA 3G3CA 4B5JA 2DNJA 1NTFA 4GZ1A 4FVAA 5DV4A 4QHDA 2DDRA 1ZWXA 1SR4B 3G0AA 2JC5A 2V0SA 2J63A 5DFIA 3NGQA 4IEMA 3I46A 2O3HA 2A42B 2VOAA 5INLA 2O3CA 4A9CA 3G91A 4B5IA 1SI6X 2JC4A 3G1KA
chains in the Genus database with same CATH superfamily
4B5GA 4F1HB 3G00A 4F1RA 2DDTA 4GYZA 5CFGA 1I9YA 5J3ZA 5HT2A 4L1ZA 5J8NA 2F1NA 4AWNA 4F1IA 3K55A 1Y21A 1BIXA 4L20A 5INPA 2UYRX 1ATND 5INKA 2DDSA 3N9VA 2A41B 1E9NA 5J42A 4PUQA 5A7IA 3G0RA 3G6SA 3L1WA 4B5FA 5DFFA 5INOA 1AKOA 4GZ0A 2D1KB 1YJHA 5EWTA 3G4TA 3MPRA 3G8VA 3W2XA 5J3SA 3MTCA 4CMNA 1DE9A 4FPVA 3NGNA 4B5MA 1HD7A 5DFHA 3FZIA 5DFJA 4GZ2A 4C1RA 3GA6A 4L21A 3I5VA 2V0RA 3I41A 1VYBA 3CJCD 5A7JA 4L1YA 5DG0A 3WCXA 2A3ZB 2IMQX 4RUWA 3W3DB 1WDUA 4F1HA 5INNA 2XSWA 5J3PA 3NGOA 5DV2A 1DNKA 3DNIA 4B5HA 1I9ZA 3G38A 1DEWA 1DE8A 4GEWA 5CFEA 5INMA 3NR8A 4QHEA 5INQA 3I48A 2A40B 2ISIA 4LNDA 3G3YA 4CMLA 3G2CA 3U8UA 2EI9A 4K6LF 3W2YA 4JG3A 2F2FB 4QH9A 3TEBA 3G2DA 3G3CA 4B5JA 2DNJA 1NTFA 4GZ1A 4FVAA 5DV4A 4QHDA 2DDRA 1ZWXA 1SR4B 3G0AA 2JC5A 2V0SA 2J63A 5DFIA 3NGQA 4IEMA 3I46A 2O3HA 2A42B 2VOAA 5INLA 2O3CA 4A9CA 3G91A 4B5IA 1SI6X 2JC4A 3G1KA
chains in the Genus database with same CATH topology
4B5GA 4F1HB 3G00A 4F1RA 2DDTA 4GYZA 5CFGA 1I9YA 5J3ZA 5HT2A 4L1ZA 5J8NA 2F1NA 4AWNA 4F1IA 3K55A 1Y21A 1BIXA 4L20A 5INPA 2UYRX 1ATND 5INKA 2DDSA 3N9VA 2A41B 1E9NA 5J42A 4PUQA 5A7IA 3G0RA 3G6SA 3L1WA 4B5FA 5DFFA 5INOA 1AKOA 4GZ0A 2D1KB 1YJHA 5EWTA 3G4TA 3MPRA 3G8VA 3W2XA 5J3SA 3MTCA 4CMNA 1DE9A 4FPVA 3NGNA 4B5MA 1HD7A 5DFHA 3FZIA 5DFJA 4GZ2A 4C1RA 3GA6A 4L21A 3I5VA 2V0RA 3I41A 1VYBA 3CJCD 5A7JA 4L1YA 5DG0A 3WCXA 2A3ZB 2IMQX 4RUWA 3W3DB 1WDUA 4F1HA 5INNA 2XSWA 5J3PA 3NGOA 5DV2A 1DNKA 3DNIA 4B5HA 1I9ZA 3G38A 1DEWA 1DE8A 4GEWA 5CFEA 5INMA 3NR8A 4QHEA 5INQA 3I48A 2A40B 2ISIA 4LNDA 3G3YA 4CMLA 3G2CA 3U8UA 2EI9A 4K6LF 3W2YA 4JG3A 2F2FB 4QH9A 3TEBA 3G2DA 3G3CA 4B5JA 2DNJA 1NTFA 4GZ1A 4FVAA 5DV4A 4QHDA 2DDRA 1ZWXA 1SR4B 3G0AA 2JC5A 2V0SA 2J63A 5DFIA 3NGQA 4IEMA 3I46A 2O3HA 2A42B 2VOAA 5INLA 2O3CA 4A9CA 3G91A 4B5IA 1SI6X 2JC4A 3G1KA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4B5G A;  4F1H B;  3G00 A;  4F1R A;  2DDT A;  4GYZ A;  5CFG A;  1I9Y A;  5J3Z A;  5HT2 A;  4L1Z A;  5J8N A;  2F1N A;  4AWN A;  4F1I A;  3K55 A;  1Y21 A;  1BIX A;  4L20 A;  5INP A;  2UYR X;  1ATN D;  5INK A;  2DDS A;  3N9V A;  2A41 B;  1E9N A;  5J42 A;  4PUQ A;  5A7I A;  3G0R A;  3G6S A;  3L1W A;  4B5F A;  5DFF A;  5INO A;  1AKO A;  4GZ0 A;  2D1K B;  1YJH A;  5EWT A;  3G4T A;  3MPR A;  3G8V A;  3W2X A;  5J3S A;  3MTC A;  4CMN A;  1DE9 A;  4FPV A;  3NGN A;  4B5M A;  1HD7 A;  5DFH A;  3FZI A;  5DFJ A;  4GZ2 A;  4C1R A;  3GA6 A;  4L21 A;  3I5V A;  2V0R A;  3I41 A;  1VYB A;  3CJC D;  5A7J A;  4L1Y A;  5DG0 A;  3WCX A;  2A3Z B;  2IMQ X;  4RUW A;  3W3D B;  1WDU A;  4F1H A;  5INN A;  2XSW A;  5J3P A;  3NGO A;  5DV2 A;  1DNK A;  3DNI A;  4B5H A;  1I9Z A;  3G38 A;  1DEW A;  1DE8 A;  4GEW A;  5CFE A;  5INM A;  3NR8 A;  4QHE A;  5INQ A;  3I48 A;  2A40 B;  2ISI A;  4LND A;  3G3Y A;  4CML A;  3G2C A;  3U8U A;  2EI9 A;  4K6L F;  3W2Y A;  4JG3 A;  2F2F B;  4QH9 A;  3TEB A;  3G2D A;  3G3C A;  4B5J A;  2DNJ A;  1NTF A;  4GZ1 A;  4FVA A;  5DV4 A;  4QHD A;  2DDR A;  1ZWX A;  1SR4 B;  3G0A A;  2JC5 A;  2V0S A;  2J63 A;  5DFI A;  3NGQ A;  4IEM A;  3I46 A;  2O3H A;  2A42 B;  2VOA A;  5INL A;  2O3C A;  4A9C A;  3G91 A;  4B5I A;  1SI6 X;  2JC4 A;  3G1K A; 
#chains in the Genus database with same CATH topology
 4B5G A;  4F1H B;  3G00 A;  4F1R A;  2DDT A;  4GYZ A;  5CFG A;  1I9Y A;  5J3Z A;  5HT2 A;  4L1Z A;  5J8N A;  2F1N A;  4AWN A;  4F1I A;  3K55 A;  1Y21 A;  1BIX A;  4L20 A;  5INP A;  2UYR X;  1ATN D;  5INK A;  2DDS A;  3N9V A;  2A41 B;  1E9N A;  5J42 A;  4PUQ A;  5A7I A;  3G0R A;  3G6S A;  3L1W A;  4B5F A;  5DFF A;  5INO A;  1AKO A;  4GZ0 A;  2D1K B;  1YJH A;  5EWT A;  3G4T A;  3MPR A;  3G8V A;  3W2X A;  5J3S A;  3MTC A;  4CMN A;  1DE9 A;  4FPV A;  3NGN A;  4B5M A;  1HD7 A;  5DFH A;  3FZI A;  5DFJ A;  4GZ2 A;  4C1R A;  3GA6 A;  4L21 A;  3I5V A;  2V0R A;  3I41 A;  1VYB A;  3CJC D;  5A7J A;  4L1Y A;  5DG0 A;  3WCX A;  2A3Z B;  2IMQ X;  4RUW A;  3W3D B;  1WDU A;  4F1H A;  5INN A;  2XSW A;  5J3P A;  3NGO A;  5DV2 A;  1DNK A;  3DNI A;  4B5H A;  1I9Z A;  3G38 A;  1DEW A;  1DE8 A;  4GEW A;  5CFE A;  5INM A;  3NR8 A;  4QHE A;  5INQ A;  3I48 A;  2A40 B;  2ISI A;  4LND A;  3G3Y A;  4CML A;  3G2C A;  3U8U A;  2EI9 A;  4K6L F;  3W2Y A;  4JG3 A;  2F2F B;  4QH9 A;  3TEB A;  3G2D A;  3G3C A;  4B5J A;  2DNJ A;  1NTF A;  4GZ1 A;  4FVA A;  5DV4 A;  4QHD A;  2DDR A;  1ZWX A;  1SR4 B;  3G0A A;  2JC5 A;  2V0S A;  2J63 A;  5DFI A;  3NGQ A;  4IEM A;  3I46 A;  2O3H A;  2A42 B;  2VOA A;  5INL A;  2O3C A;  4A9C A;  3G91 A;  4B5I A;  1SI6 X;  2JC4 A;  3G1K A; 
#chains in the Genus database with same CATH homology
 4B5G A;  4F1H B;  3G00 A;  4F1R A;  2DDT A;  4GYZ A;  5CFG A;  1I9Y A;  5J3Z A;  5HT2 A;  4L1Z A;  5J8N A;  2F1N A;  4AWN A;  4F1I A;  3K55 A;  1Y21 A;  1BIX A;  4L20 A;  5INP A;  2UYR X;  1ATN D;  5INK A;  2DDS A;  3N9V A;  2A41 B;  1E9N A;  5J42 A;  4PUQ A;  5A7I A;  3G0R A;  3G6S A;  3L1W A;  4B5F A;  5DFF A;  5INO A;  1AKO A;  4GZ0 A;  2D1K B;  1YJH A;  5EWT A;  3G4T A;  3MPR A;  3G8V A;  3W2X A;  5J3S A;  3MTC A;  4CMN A;  1DE9 A;  4FPV A;  3NGN A;  4B5M A;  1HD7 A;  5DFH A;  3FZI A;  5DFJ A;  4GZ2 A;  4C1R A;  3GA6 A;  4L21 A;  3I5V A;  2V0R A;  3I41 A;  1VYB A;  3CJC D;  5A7J A;  4L1Y A;  5DG0 A;  3WCX A;  2A3Z B;  2IMQ X;  4RUW A;  3W3D B;  1WDU A;  4F1H A;  5INN A;  2XSW A;  5J3P A;  3NGO A;  5DV2 A;  1DNK A;  3DNI A;  4B5H A;  1I9Z A;  3G38 A;  1DEW A;  1DE8 A;  4GEW A;  5CFE A;  5INM A;  3NR8 A;  4QHE A;  5INQ A;  3I48 A;  2A40 B;  2ISI A;  4LND A;  3G3Y A;  4CML A;  3G2C A;  3U8U A;  2EI9 A;  4K6L F;  3W2Y A;  4JG3 A;  2F2F B;  4QH9 A;  3TEB A;  3G2D A;  3G3C A;  4B5J A;  2DNJ A;  1NTF A;  4GZ1 A;  4FVA A;  5DV4 A;  4QHD A;  2DDR A;  1ZWX A;  1SR4 B;  3G0A A;  2JC5 A;  2V0S A;  2J63 A;  5DFI A;  3NGQ A;  4IEM A;  3I46 A;  2O3H A;  2A42 B;  2VOA A;  5INL A;  2O3C A;  4A9C A;  3G91 A;  4B5I A;  1SI6 X;  2JC4 A;  3G1K A; 
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similar chains in the pdb database (?% sequence similarity)

 
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