2XHLA

Structure of a functional derivative of clostridium botulinum neurotoxin type b
Total Genus 117
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
117
sequence length
441
structure length
430
Chain Sequence
MPVTINNFNYNDPIDNNNIIMMEPPFARGTGRYYKAFKITDRIWIIPERYTFGYKPEDFNKSSGIFNRDVCEYYDPDYLNTNDKKNIFLQTMIKLFNRIKSKPLGEKLLEMIINGIPYLGDRRVPLEEFNTNIASVTVNKLISNPGEVERKKGIFANLIIFGPGPVLNENETIDIGIQNHFASREGFGGIMQMKFCPEYVSVFNNVQGYFSDPALILMHELIHVLHGLYGIKVDDLPIVPNEKKFFMQSTDAIQAEELYTFGGQDPSIITPSTDKSIYDKVLQNFRGIVDRLNKVLVCISDPNININIYKNKFKDKYKFVEDSEGKYSIDVESFDKLYKSLMFGFTETNIAENYKIKTRASYFSDSLPPVKIKNLLDNEIYTIEEGFNISDKDMEKEYRGQNKAINKQAYEEISKEHLAVYKIQMCVDGI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure and Activity of a Functional Derivative of Clostridium Botulinum Neurotoxin B.
pubmed doi rcsb
molecule tags Hydrolase
source organism Clostridium botulinum
molecule keywords BOTULINUM NEUROTOXIN B LIGHT CHAIN
total genus 117
structure length 430
sequence length 441
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2010-06-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01742 Peptidase_M27 Clostridial neurotoxin zinc protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 2xhlA00
3ZUSA 1E1HA 3C88A 3QIZA 2A8AA 2IMBA 3QW8A 2ISGA 2NZ9A 4KUFA 3C8AA 2G7PA 3D3XA 3DS9A 3BWIA 1ZB7A 3V0AA 1S0BA 3FIIA 3BONA 2IMAA 1T3CA 1S0DA 2IMCA 2W2DA 4J1LA 3FFZA 1G9AA 1ZKXA 3ZUQA 1S0GA 3V0AB 2QN0A 1XTFA 1F82A 4ZJXA 3V0BA 2A97A 3K3QB 4KS6A 3DSEA 1ZN3A 3QIXA 1G9CA 1I1EA 1T3AA 3ZURA 2FPQA 1ZL6A 3BOOA 3QIYA 1ZKWA 4ELCA 3C89A 1S0EA 4EL4A 3QJ0A 3QW6A 3V0BB 4HEVA 3BTAA 1EPWA 1S0FA 2G7QA 1ZL5A 5BQNA 3BOKA 2NP0A 4ZKTB 2ISHA 1XTGA 3QW7A 4KTXA 2G7NA 3NF3A 2ILPA 3DDAA 3VUOA 3FIEA 2ETFA 3DDBA 1Z7HA 4EJ5A 1G9DA 1S0CA 2XHLA 5BQMA 2G7KA 2NYYA 3DEBA 1G9BA 2ISEA 3C8BA 1YVGA 1F31A 3QW5A
chains in the Genus database with same CATH superfamily
3ZUSA 1E1HA 3C88A 3QIZA 4JIXA 2A8AA 2IMBA 3QW8A 3E11A 2ISGA 2NZ9A 4KUFA 3C8AA 2G7PA 2EJQA 4QHFA 3D3XA 3CQBA 3DS9A 3BWIA 1ZB7A 3V0AA 1S0BA 3FIIA 3BONA 2IMAA 1T3CA 1S0DA 2IMCA 2W2DA 2YPTA 4J1LA 3FFZA 1G9AA 1ZKXA 3ZUQA 1S0GA 3V0AB 2QN0A 1XTFA 1F82A 4ZJXA 3V0BA 2A97A 3K3QB 4KS6A 3DSEA 1ZN3A 3QIXA 1G9CA 1I1EA 1T3AA 3ZURA 2FPQA 4IL3A 1ZL6A 3BOOA 3QIYA 1ZKWA 4ELCA 4AW6A 3C89A 1S0EA 4EL4A 3QJ0A 3QW6A 3V0BB 4HEVA 3BTAA 1EPWA 1S0FA 2G7QA 1ZL5A 5BQNA 3BOKA 2NP0A 4ZKTB 2ISHA 1XTGA 3QW7A 4KTXA 2G7NA 3NF3A 2ILPA 3DDAA 3VUOA 3FIEA 2ETFA 3DDBA 1Z7HA 4EJ5A 1G9DA 1S0CA 2XHLA 5BQMA 2G7KA 2NYYA 3DEBA 4JIUA 1G9BA 2ISEA 3C8BA 1YVGA 1F31A 3QW5A
chains in the Genus database with same CATH topology
3ZUSA 1E1HA 3C88A 3QIZA 2A8AA 2IMBA 3QW8A 2ISGA 2NZ9A 4KUFA 3C8AA 2G7PA 3D3XA 3DS9A 3BWIA 1ZB7A 3V0AA 1S0BA 3FIIA 3BONA 2IMAA 1T3CA 1S0DA 2IMCA 2W2DA 4J1LA 3FFZA 1G9AA 1ZKXA 3ZUQA 1S0GA 3V0AB 2QN0A 1XTFA 1F82A 4ZJXA 3V0BA 2A97A 3K3QB 4KS6A 3DSEA 1ZN3A 3QIXA 1G9CA 1I1EA 1T3AA 3ZURA 2FPQA 1ZL6A 3BOOA 3QIYA 1ZKWA 4ELCA 3C89A 1S0EA 4EL4A 3QJ0A 3QW6A 3V0BB 4HEVA 3BTAA 1EPWA 1S0FA 2G7QA 1ZL5A 5BQNA 3BOKA 2NP0A 4ZKTB 2ISHA 1XTGA 3QW7A 4KTXA 2G7NA 3NF3A 2ILPA 3DDAA 3VUOA 3FIEA 2ETFA 3DDBA 1Z7HA 4EJ5A 1G9DA 1S0CA 2XHLA 5BQMA 2G7KA 2NYYA 3DEBA 1G9BA 2ISEA 3C8BA 1YVGA 1F31A 3QW5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3ZUS A;  1E1H A;  3C88 A;  3QIZ A;  2A8A A;  2IMB A;  3QW8 A;  2ISG A;  2NZ9 A;  4KUF A;  3C8A A;  2G7P A;  3D3X A;  3DS9 A;  3BWI A;  1ZB7 A;  3V0A A;  1S0B A;  3FII A;  3BON A;  2IMA A;  1T3C A;  1S0D A;  2IMC A;  2W2D A;  4J1L A;  3FFZ A;  1G9A A;  1ZKX A;  3ZUQ A;  1S0G A;  3V0A B;  2QN0 A;  1XTF A;  1F82 A;  4ZJX A;  3V0B A;  2A97 A;  3K3Q B;  4KS6 A;  3DSE A;  1ZN3 A;  3QIX A;  1G9C A;  1I1E A;  1T3A A;  3ZUR A;  2FPQ A;  1ZL6 A;  3BOO A;  3QIY A;  1ZKW A;  4ELC A;  3C89 A;  1S0E A;  4EL4 A;  3QJ0 A;  3QW6 A;  3V0B B;  4HEV A;  3BTA A;  1EPW A;  1S0F A;  2G7Q A;  1ZL5 A;  5BQN A;  3BOK A;  2NP0 A;  4ZKT B;  2ISH A;  1XTG A;  3QW7 A;  4KTX A;  2G7N A;  3NF3 A;  2ILP A;  3DDA A;  3VUO A;  3FIE A;  2ETF A;  3DDB A;  1Z7H A;  4EJ5 A;  1G9D A;  1S0C A;  2XHL A;  5BQM A;  2G7K A;  2NYY A;  3DEB A;  1G9B A;  2ISE A;  3C8B A;  1YVG A;  1F31 A;  3QW5 A; 
#chains in the Genus database with same CATH topology
 3ZUS A;  1E1H A;  3C88 A;  3QIZ A;  4JIX A;  2A8A A;  2IMB A;  3QW8 A;  3E11 A;  2ISG A;  2NZ9 A;  4KUF A;  3C8A A;  2G7P A;  2EJQ A;  4QHF A;  3D3X A;  3CQB A;  3DS9 A;  3BWI A;  1ZB7 A;  3V0A A;  1S0B A;  3FII A;  3BON A;  2IMA A;  1T3C A;  1S0D A;  2IMC A;  2W2D A;  2YPT A;  4J1L A;  3FFZ A;  1G9A A;  1ZKX A;  3ZUQ A;  1S0G A;  3V0A B;  2QN0 A;  1XTF A;  1F82 A;  4ZJX A;  3V0B A;  2A97 A;  3K3Q B;  4KS6 A;  3DSE A;  1ZN3 A;  3QIX A;  1G9C A;  1I1E A;  1T3A A;  3ZUR A;  2FPQ A;  4IL3 A;  1ZL6 A;  3BOO A;  3QIY A;  1ZKW A;  4ELC A;  4AW6 A;  3C89 A;  1S0E A;  4EL4 A;  3QJ0 A;  3QW6 A;  3V0B B;  4HEV A;  3BTA A;  1EPW A;  1S0F A;  2G7Q A;  1ZL5 A;  5BQN A;  3BOK A;  2NP0 A;  4ZKT B;  2ISH A;  1XTG A;  3QW7 A;  4KTX A;  2G7N A;  3NF3 A;  2ILP A;  3DDA A;  3VUO A;  3FIE A;  2ETF A;  3DDB A;  1Z7H A;  4EJ5 A;  1G9D A;  1S0C A;  2XHL A;  5BQM A;  2G7K A;  2NYY A;  3DEB A;  4JIU A;  1G9B A;  2ISE A;  3C8B A;  1YVG A;  1F31 A;  3QW5 A; 
#chains in the Genus database with same CATH homology
 3ZUS A;  1E1H A;  3C88 A;  3QIZ A;  2A8A A;  2IMB A;  3QW8 A;  2ISG A;  2NZ9 A;  4KUF A;  3C8A A;  2G7P A;  3D3X A;  3DS9 A;  3BWI A;  1ZB7 A;  3V0A A;  1S0B A;  3FII A;  3BON A;  2IMA A;  1T3C A;  1S0D A;  2IMC A;  2W2D A;  4J1L A;  3FFZ A;  1G9A A;  1ZKX A;  3ZUQ A;  1S0G A;  3V0A B;  2QN0 A;  1XTF A;  1F82 A;  4ZJX A;  3V0B A;  2A97 A;  3K3Q B;  4KS6 A;  3DSE A;  1ZN3 A;  3QIX A;  1G9C A;  1I1E A;  1T3A A;  3ZUR A;  2FPQ A;  1ZL6 A;  3BOO A;  3QIY A;  1ZKW A;  4ELC A;  3C89 A;  1S0E A;  4EL4 A;  3QJ0 A;  3QW6 A;  3V0B B;  4HEV A;  3BTA A;  1EPW A;  1S0F A;  2G7Q A;  1ZL5 A;  5BQN A;  3BOK A;  2NP0 A;  4ZKT B;  2ISH A;  1XTG A;  3QW7 A;  4KTX A;  2G7N A;  3NF3 A;  2ILP A;  3DDA A;  3VUO A;  3FIE A;  2ETF A;  3DDB A;  1Z7H A;  4EJ5 A;  1G9D A;  1S0C A;  2XHL A;  5BQM A;  2G7K A;  2NYY A;  3DEB A;  1G9B A;  2ISE A;  3C8B A;  1YVG A;  1F31 A;  3QW5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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