2XHLA

Structure of a functional derivative of clostridium botulinum neurotoxin type b
Total Genus 117
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
117
sequence length
441
structure length
430
Chain Sequence
MPVTINNFNYNDPIDNNNIIMMEPPFARGTGRYYKAFKITDRIWIIPERYTFGYKPEDFNKSSGIFNRDVCEYYDPDYLNTNDKKNIFLQTMIKLFNRIKSKPLGEKLLEMIINGIPYLGDRRVPLEEFNTNIASVTVNKLISNPGEVERKKGIFANLIIFGPGPVLNENETIDIGIQNHFASREGFGGIMQMKFCPEYVSVFNNVQGYFSDPALILMHELIHVLHGLYGIKVDDLPIVPNEKKFFMQSTDAIQAEELYTFGGQDPSIITPSTDKSIYDKVLQNFRGIVDRLNKVLVCISDPNININIYKNKFKDKYKFVEDSEGKYSIDVESFDKLYKSLMFGFTETNIAENYKIKTRASYFSDSLPPVKIKNLLDNEIYTIEEGFNISDKDMEKEYRGQNKAINKQAYEEISKEHLAVYKIQMCVDGI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure and Activity of a Functional Derivative of Clostridium Botulinum Neurotoxin B.
pubmed doi rcsb
molecule tags Hydrolase
source organism Clostridium botulinum
molecule keywords BOTULINUM NEUROTOXIN B LIGHT CHAIN
total genus 117
structure length 430
sequence length 441
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2010-06-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01742 Peptidase_M27 Clostridial neurotoxin zinc protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 2xhlA00
2W2DA 1EPWA 5BQMA 2G7PA 2XHLA 2G7KA 1ZL6A 1G9CA 2G7QA 4KTXA 1ZKXA 2IMCA 3BTAA 4HEVA 1S0BA 1S0EA 1S0DA 4ZKTB 3ZURA 3V0BB 3BOOA 3V0AB 1Z7HA 2QN0A 1F82A 1G9AA 2IMAA 4KS6A 2A8AA 3C8AA 3QW5A 1ZKWA 4EJ5A 1ZN3A 3C88A 1I1EA 3QW7A 3QIYA 1F31A 1G9DA 1G9BA 3QW8A 5BQNA 2ISEA 1S0GA 2ISGA 4J1LA 3D3XA 3V0BA 3V0AA 1YVGA 3QW6A 2G7NA 3FIIA 3DDAA 3VUOA 2NP0A 3NF3A 3K3QB 2ETFA 3BOKA 2A97A 3ZUSA 3BONA 3DDBA 1ZB7A 3DS9A 4ZJXA 1ZL5A 1E1HA 2FPQA 2NYYA 1S0FA 4KUFA 3BWIA 2NZ9A 3DSEA 1T3CA 4EL4A 3DEBA 1XTFA 2ISHA 1XTGA 3C89A 2IMBA 3QJ0A 1T3AA 3FFZA 3C8BA 3FIEA 3ZUQA 4ELCA 1S0CA 2ILPA 3QIXA 3QIZA
chains in the Genus database with same CATH superfamily
2W2DA 1EPWA 5BQMA 2YPTA 2G7PA 2XHLA 2G7KA 1ZL6A 1G9CA 2G7QA 4KTXA 1ZKXA 2IMCA 3BTAA 4HEVA 1S0BA 1S0EA 1S0DA 4ZKTB 3ZURA 3V0BB 3BOOA 3V0AB 1Z7HA 2QN0A 1F82A 1G9AA 2IMAA 4KS6A 2A8AA 3C8AA 3QW5A 3CQBA 1ZKWA 4EJ5A 1ZN3A 3C88A 1I1EA 3QW7A 3QIYA 1F31A 1G9DA 1G9BA 3QW8A 5BQNA 2ISEA 1S0GA 2ISGA 4J1LA 3D3XA 3V0BA 4JIUA 3V0AA 1YVGA 3QW6A 2G7NA 2EJQA 3FIIA 3DDAA 3VUOA 4IL3A 2NP0A 3NF3A 3K3QB 2ETFA 3BOKA 2A97A 3ZUSA 4JIXA 3BONA 3DDBA 4QHFA 1ZB7A 3DS9A 4ZJXA 1ZL5A 1E1HA 4AW6A 2FPQA 2NYYA 1S0FA 4KUFA 3BWIA 2NZ9A 3E11A 3DSEA 1T3CA 4EL4A 3DEBA 1XTFA 2ISHA 1XTGA 3C89A 2IMBA 3QJ0A 1T3AA 3FFZA 3C8BA 3FIEA 3ZUQA 4ELCA 1S0CA 2ILPA 3QIXA 3QIZA
chains in the Genus database with same CATH topology
2W2DA 1EPWA 5BQMA 2G7PA 2XHLA 2G7KA 1ZL6A 1G9CA 2G7QA 4KTXA 1ZKXA 2IMCA 3BTAA 4HEVA 1S0BA 1S0EA 1S0DA 4ZKTB 3ZURA 3V0BB 3BOOA 3V0AB 1Z7HA 2QN0A 1F82A 1G9AA 2IMAA 4KS6A 2A8AA 3C8AA 3QW5A 1ZKWA 4EJ5A 1ZN3A 3C88A 1I1EA 3QW7A 3QIYA 1F31A 1G9DA 1G9BA 3QW8A 5BQNA 2ISEA 1S0GA 2ISGA 4J1LA 3D3XA 3V0BA 3V0AA 1YVGA 3QW6A 2G7NA 3FIIA 3DDAA 3VUOA 2NP0A 3NF3A 3K3QB 2ETFA 3BOKA 2A97A 3ZUSA 3BONA 3DDBA 1ZB7A 3DS9A 4ZJXA 1ZL5A 1E1HA 2FPQA 2NYYA 1S0FA 4KUFA 3BWIA 2NZ9A 3DSEA 1T3CA 4EL4A 3DEBA 1XTFA 2ISHA 1XTGA 3C89A 2IMBA 3QJ0A 1T3AA 3FFZA 3C8BA 3FIEA 3ZUQA 4ELCA 1S0CA 2ILPA 3QIXA 3QIZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2W2D A;  1EPW A;  5BQM A;  2G7P A;  2XHL A;  2G7K A;  1ZL6 A;  1G9C A;  2G7Q A;  4KTX A;  1ZKX A;  2IMC A;  3BTA A;  4HEV A;  1S0B A;  1S0E A;  1S0D A;  4ZKT B;  3ZUR A;  3V0B B;  3BOO A;  3V0A B;  1Z7H A;  2QN0 A;  1F82 A;  1G9A A;  2IMA A;  4KS6 A;  2A8A A;  3C8A A;  3QW5 A;  1ZKW A;  4EJ5 A;  1ZN3 A;  3C88 A;  1I1E A;  3QW7 A;  3QIY A;  1F31 A;  1G9D A;  1G9B A;  3QW8 A;  5BQN A;  2ISE A;  1S0G A;  2ISG A;  4J1L A;  3D3X A;  3V0B A;  3V0A A;  1YVG A;  3QW6 A;  2G7N A;  3FII A;  3DDA A;  3VUO A;  2NP0 A;  3NF3 A;  3K3Q B;  2ETF A;  3BOK A;  2A97 A;  3ZUS A;  3BON A;  3DDB A;  1ZB7 A;  3DS9 A;  4ZJX A;  1ZL5 A;  1E1H A;  2FPQ A;  2NYY A;  1S0F A;  4KUF A;  3BWI A;  2NZ9 A;  3DSE A;  1T3C A;  4EL4 A;  3DEB A;  1XTF A;  2ISH A;  1XTG A;  3C89 A;  2IMB A;  3QJ0 A;  1T3A A;  3FFZ A;  3C8B A;  3FIE A;  3ZUQ A;  4ELC A;  1S0C A;  2ILP A;  3QIX A;  3QIZ A; 
#chains in the Genus database with same CATH topology
 2W2D A;  1EPW A;  5BQM A;  2YPT A;  2G7P A;  2XHL A;  2G7K A;  1ZL6 A;  1G9C A;  2G7Q A;  4KTX A;  1ZKX A;  2IMC A;  3BTA A;  4HEV A;  1S0B A;  1S0E A;  1S0D A;  4ZKT B;  3ZUR A;  3V0B B;  3BOO A;  3V0A B;  1Z7H A;  2QN0 A;  1F82 A;  1G9A A;  2IMA A;  4KS6 A;  2A8A A;  3C8A A;  3QW5 A;  3CQB A;  1ZKW A;  4EJ5 A;  1ZN3 A;  3C88 A;  1I1E A;  3QW7 A;  3QIY A;  1F31 A;  1G9D A;  1G9B A;  3QW8 A;  5BQN A;  2ISE A;  1S0G A;  2ISG A;  4J1L A;  3D3X A;  3V0B A;  4JIU A;  3V0A A;  1YVG A;  3QW6 A;  2G7N A;  2EJQ A;  3FII A;  3DDA A;  3VUO A;  4IL3 A;  2NP0 A;  3NF3 A;  3K3Q B;  2ETF A;  3BOK A;  2A97 A;  3ZUS A;  4JIX A;  3BON A;  3DDB A;  4QHF A;  1ZB7 A;  3DS9 A;  4ZJX A;  1ZL5 A;  1E1H A;  4AW6 A;  2FPQ A;  2NYY A;  1S0F A;  4KUF A;  3BWI A;  2NZ9 A;  3E11 A;  3DSE A;  1T3C A;  4EL4 A;  3DEB A;  1XTF A;  2ISH A;  1XTG A;  3C89 A;  2IMB A;  3QJ0 A;  1T3A A;  3FFZ A;  3C8B A;  3FIE A;  3ZUQ A;  4ELC A;  1S0C A;  2ILP A;  3QIX A;  3QIZ A; 
#chains in the Genus database with same CATH homology
 2W2D A;  1EPW A;  5BQM A;  2G7P A;  2XHL A;  2G7K A;  1ZL6 A;  1G9C A;  2G7Q A;  4KTX A;  1ZKX A;  2IMC A;  3BTA A;  4HEV A;  1S0B A;  1S0E A;  1S0D A;  4ZKT B;  3ZUR A;  3V0B B;  3BOO A;  3V0A B;  1Z7H A;  2QN0 A;  1F82 A;  1G9A A;  2IMA A;  4KS6 A;  2A8A A;  3C8A A;  3QW5 A;  1ZKW A;  4EJ5 A;  1ZN3 A;  3C88 A;  1I1E A;  3QW7 A;  3QIY A;  1F31 A;  1G9D A;  1G9B A;  3QW8 A;  5BQN A;  2ISE A;  1S0G A;  2ISG A;  4J1L A;  3D3X A;  3V0B A;  3V0A A;  1YVG A;  3QW6 A;  2G7N A;  3FII A;  3DDA A;  3VUO A;  2NP0 A;  3NF3 A;  3K3Q B;  2ETF A;  3BOK A;  2A97 A;  3ZUS A;  3BON A;  3DDB A;  1ZB7 A;  3DS9 A;  4ZJX A;  1ZL5 A;  1E1H A;  2FPQ A;  2NYY A;  1S0F A;  4KUF A;  3BWI A;  2NZ9 A;  3DSE A;  1T3C A;  4EL4 A;  3DEB A;  1XTF A;  2ISH A;  1XTG A;  3C89 A;  2IMB A;  3QJ0 A;  1T3A A;  3FFZ A;  3C8B A;  3FIE A;  3ZUQ A;  4ELC A;  1S0C A;  2ILP A;  3QIX A;  3QIZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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