2G7NA

Structure of the light chain of botulinum neurotoxin serotype a bound to small molecule inhibitors
Total Genus 136
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
136
sequence length
419
structure length
415
Chain Sequence
MFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHDVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAEHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDVASTLNKAKSIIGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVNFFKVINRKTYLNFDKAVFRINIVPDENYTIKDGFNLKGANLSTNFNGQNTEINSRNFTRLKNFT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the Light Chain of Botulinum Neurotoxin Serotype A bound to Small Molecule Inhibitors
rcsb
molecule tags Hydrolase
source organism Clostridium botulinum
molecule keywords Botulinum neurotoxin type A
total genus 136
structure length 415
sequence length 419
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2006-02-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01742 Peptidase_M27 Clostridial neurotoxin zinc protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 2g7nA00
3VUOA 1G9AA 1YVGA 2ETFA 3QIXA 1ZL5A 2A97A 3ZUSA 1ZL6A 1EPWA 3DDBA 1T3CA 4EL4A 4J1LA 2A8AA 2G7KA 1ZB7A 1S0BA 2IMCA 3BONA 1F31A 1S0FA 1F82A 3FIIA 3C89A 3V0BA 5BQMA 2G7PA 3DDAA 1G9CA 2ISGA 3QIYA 3V0AB 3BOKA 3NF3A 2ILPA 3K3QB 1Z7HA 2ISHA 1XTGA 3DSEA 1XTFA 4ZKTB 1G9DA 3QJ0A 3BTAA 4ELCA 3ZURA 3FFZA 3QW6A 3DEBA 3D3XA 2NYYA 3C8BA 2G7QA 4KS6A 1ZKXA 1T3AA 4HEVA 3ZUQA 2FPQA 3C88A 1S0EA 1S0GA 3DS9A 2IMAA 1ZKWA 3FIEA 2ISEA 3V0BB 3QW7A 4ZJXA 2W2DA 3V0AA 2IMBA 5BQNA 3QW5A 2QN0A 2XHLA 4KUFA 3BWIA 1G9BA 2NZ9A 3QW8A 1E1HA 3QIZA 1S0CA 4EJ5A 1I1EA 4KTXA 3BOOA 1S0DA 2NP0A 1ZN3A 2G7NA 3C8AA
chains in the Genus database with same CATH superfamily
3VUOA 1G9AA 1YVGA 2ETFA 3QIXA 1ZL5A 4JIXA 2A97A 3ZUSA 1ZL6A 1EPWA 3DDBA 1T3CA 4EL4A 4J1LA 2A8AA 2G7KA 1ZB7A 1S0BA 2IMCA 3BONA 1F31A 1S0FA 1F82A 3FIIA 3C89A 3V0BA 5BQMA 2G7PA 3DDAA 4QHFA 1G9CA 2ISGA 3QIYA 3V0AB 3BOKA 3NF3A 2ILPA 3K3QB 1Z7HA 2ISHA 1XTGA 3DSEA 1XTFA 4ZKTB 1G9DA 3QJ0A 3BTAA 4ELCA 3ZURA 3FFZA 3E11A 3QW6A 3DEBA 3D3XA 2NYYA 3C8BA 2G7QA 4KS6A 1ZKXA 4AW6A 4IL3A 1T3AA 4HEVA 3ZUQA 4JIUA 2FPQA 3C88A 1S0EA 1S0GA 3DS9A 2IMAA 1ZKWA 3FIEA 3CQBA 2ISEA 2YPTA 3V0BB 3QW7A 2EJQA 4ZJXA 2W2DA 3V0AA 2IMBA 5BQNA 3QW5A 2QN0A 2XHLA 4KUFA 3BWIA 1G9BA 2NZ9A 3QW8A 1E1HA 3QIZA 1S0CA 4EJ5A 1I1EA 4KTXA 3BOOA 1S0DA 2NP0A 1ZN3A 2G7NA 3C8AA
chains in the Genus database with same CATH topology
3VUOA 1G9AA 1YVGA 2ETFA 3QIXA 1ZL5A 2A97A 3ZUSA 1ZL6A 1EPWA 3DDBA 1T3CA 4EL4A 4J1LA 2A8AA 2G7KA 1ZB7A 1S0BA 2IMCA 3BONA 1F31A 1S0FA 1F82A 3FIIA 3C89A 3V0BA 5BQMA 2G7PA 3DDAA 1G9CA 2ISGA 3QIYA 3V0AB 3BOKA 3NF3A 2ILPA 3K3QB 1Z7HA 2ISHA 1XTGA 3DSEA 1XTFA 4ZKTB 1G9DA 3QJ0A 3BTAA 4ELCA 3ZURA 3FFZA 3QW6A 3DEBA 3D3XA 2NYYA 3C8BA 2G7QA 4KS6A 1ZKXA 1T3AA 4HEVA 3ZUQA 2FPQA 3C88A 1S0EA 1S0GA 3DS9A 2IMAA 1ZKWA 3FIEA 2ISEA 3V0BB 3QW7A 4ZJXA 2W2DA 3V0AA 2IMBA 5BQNA 3QW5A 2QN0A 2XHLA 4KUFA 3BWIA 1G9BA 2NZ9A 3QW8A 1E1HA 3QIZA 1S0CA 4EJ5A 1I1EA 4KTXA 3BOOA 1S0DA 2NP0A 1ZN3A 2G7NA 3C8AA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3VUO A;  1G9A A;  1YVG A;  2ETF A;  3QIX A;  1ZL5 A;  2A97 A;  3ZUS A;  1ZL6 A;  1EPW A;  3DDB A;  1T3C A;  4EL4 A;  4J1L A;  2A8A A;  2G7K A;  1ZB7 A;  1S0B A;  2IMC A;  3BON A;  1F31 A;  1S0F A;  1F82 A;  3FII A;  3C89 A;  3V0B A;  5BQM A;  2G7P A;  3DDA A;  1G9C A;  2ISG A;  3QIY A;  3V0A B;  3BOK A;  3NF3 A;  2ILP A;  3K3Q B;  1Z7H A;  2ISH A;  1XTG A;  3DSE A;  1XTF A;  4ZKT B;  1G9D A;  3QJ0 A;  3BTA A;  4ELC A;  3ZUR A;  3FFZ A;  3QW6 A;  3DEB A;  3D3X A;  2NYY A;  3C8B A;  2G7Q A;  4KS6 A;  1ZKX A;  1T3A A;  4HEV A;  3ZUQ A;  2FPQ A;  3C88 A;  1S0E A;  1S0G A;  3DS9 A;  2IMA A;  1ZKW A;  3FIE A;  2ISE A;  3V0B B;  3QW7 A;  4ZJX A;  2W2D A;  3V0A A;  2IMB A;  5BQN A;  3QW5 A;  2QN0 A;  2XHL A;  4KUF A;  3BWI A;  1G9B A;  2NZ9 A;  3QW8 A;  1E1H A;  3QIZ A;  1S0C A;  4EJ5 A;  1I1E A;  4KTX A;  3BOO A;  1S0D A;  2NP0 A;  1ZN3 A;  2G7N A;  3C8A A; 
#chains in the Genus database with same CATH topology
 3VUO A;  1G9A A;  1YVG A;  2ETF A;  3QIX A;  1ZL5 A;  4JIX A;  2A97 A;  3ZUS A;  1ZL6 A;  1EPW A;  3DDB A;  1T3C A;  4EL4 A;  4J1L A;  2A8A A;  2G7K A;  1ZB7 A;  1S0B A;  2IMC A;  3BON A;  1F31 A;  1S0F A;  1F82 A;  3FII A;  3C89 A;  3V0B A;  5BQM A;  2G7P A;  3DDA A;  4QHF A;  1G9C A;  2ISG A;  3QIY A;  3V0A B;  3BOK A;  3NF3 A;  2ILP A;  3K3Q B;  1Z7H A;  2ISH A;  1XTG A;  3DSE A;  1XTF A;  4ZKT B;  1G9D A;  3QJ0 A;  3BTA A;  4ELC A;  3ZUR A;  3FFZ A;  3E11 A;  3QW6 A;  3DEB A;  3D3X A;  2NYY A;  3C8B A;  2G7Q A;  4KS6 A;  1ZKX A;  4AW6 A;  4IL3 A;  1T3A A;  4HEV A;  3ZUQ A;  4JIU A;  2FPQ A;  3C88 A;  1S0E A;  1S0G A;  3DS9 A;  2IMA A;  1ZKW A;  3FIE A;  3CQB A;  2ISE A;  2YPT A;  3V0B B;  3QW7 A;  2EJQ A;  4ZJX A;  2W2D A;  3V0A A;  2IMB A;  5BQN A;  3QW5 A;  2QN0 A;  2XHL A;  4KUF A;  3BWI A;  1G9B A;  2NZ9 A;  3QW8 A;  1E1H A;  3QIZ A;  1S0C A;  4EJ5 A;  1I1E A;  4KTX A;  3BOO A;  1S0D A;  2NP0 A;  1ZN3 A;  2G7N A;  3C8A A; 
#chains in the Genus database with same CATH homology
 3VUO A;  1G9A A;  1YVG A;  2ETF A;  3QIX A;  1ZL5 A;  2A97 A;  3ZUS A;  1ZL6 A;  1EPW A;  3DDB A;  1T3C A;  4EL4 A;  4J1L A;  2A8A A;  2G7K A;  1ZB7 A;  1S0B A;  2IMC A;  3BON A;  1F31 A;  1S0F A;  1F82 A;  3FII A;  3C89 A;  3V0B A;  5BQM A;  2G7P A;  3DDA A;  1G9C A;  2ISG A;  3QIY A;  3V0A B;  3BOK A;  3NF3 A;  2ILP A;  3K3Q B;  1Z7H A;  2ISH A;  1XTG A;  3DSE A;  1XTF A;  4ZKT B;  1G9D A;  3QJ0 A;  3BTA A;  4ELC A;  3ZUR A;  3FFZ A;  3QW6 A;  3DEB A;  3D3X A;  2NYY A;  3C8B A;  2G7Q A;  4KS6 A;  1ZKX A;  1T3A A;  4HEV A;  3ZUQ A;  2FPQ A;  3C88 A;  1S0E A;  1S0G A;  3DS9 A;  2IMA A;  1ZKW A;  3FIE A;  2ISE A;  3V0B B;  3QW7 A;  4ZJX A;  2W2D A;  3V0A A;  2IMB A;  5BQN A;  3QW5 A;  2QN0 A;  2XHL A;  4KUF A;  3BWI A;  1G9B A;  2NZ9 A;  3QW8 A;  1E1H A;  3QIZ A;  1S0C A;  4EJ5 A;  1I1E A;  4KTX A;  3BOO A;  1S0D A;  2NP0 A;  1ZN3 A;  2G7N A;  3C8A A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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