2G7PA

Structure of the light chain of botulinum neurotoxin serotype a bound to small molecule inhibitors
Total Genus 131
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
131
sequence length
417
structure length
411
Chain Sequence
MFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHDVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAEHRLYGIAINPNRVFKVNTNAYYEGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDVASTLNKAKSIIGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVNFFKVINAKTFLNFDKAVFRINIVPDENYTIKDGFNLKGANLSTNFNGQNTEINSRNFTRLKN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Light chain of botulinum neurotoxin serotype A: structural resolution of a catalytic intermediate.
pubmed doi rcsb
molecule tags Hydrolase
source organism Clostridium botulinum
molecule keywords Botulinum neurotoxin type A
total genus 131
structure length 411
sequence length 417
chains with identical sequence B
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2006-02-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01742 Peptidase_M27 Clostridial neurotoxin zinc protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 2g7pA00
2G7QA 2ISEA 2W2DA 4HEVA 3QIYA 1F82A 3QIXA 4ELCA 3D3XA 1G9AA 1ZKXA 1S0CA 3C89A 2XHLA 4KTXA 1I1EA 3FIEA 3C8AA 3FFZA 2NYYA 1ZB7A 2A8AA 2ISGA 2A97A 4EL4A 4J1LA 3V0AB 3DEBA 2IMCA 3BOOA 2ETFA 3V0BB 3BONA 1EPWA 1ZN3A 3VUOA 3DS9A 2G7NA 2QN0A 1G9DA 3BWIA 1E1HA 1S0BA 1F31A 2NZ9A 3BTAA 3QW5A 1G9BA 1YVGA 3QW8A 2IMBA 1T3AA 2IMAA 1XTFA 2ISHA 3DDAA 1ZL5A 4EJ5A 2ILPA 1G9CA 3ZURA 3FIIA 2G7KA 4ZKTB 2NP0A 1Z7HA 4KS6A 3DDBA 2G7PA 3DSEA 3QIZA 2FPQA 3BOKA 1S0GA 3ZUSA 3V0AA 1S0DA 3K3QB 3V0BA 3QW6A 1S0FA 1XTGA 3NF3A 3ZUQA 3C8BA 5BQNA 3C88A 4KUFA 4ZJXA 1T3CA 3QJ0A 1ZKWA 5BQMA 1S0EA 3QW7A 1ZL6A
chains in the Genus database with same CATH superfamily
2G7QA 2ISEA 2W2DA 4HEVA 3QIYA 1F82A 3QIXA 4ELCA 2EJQA 3D3XA 1G9AA 1ZKXA 1S0CA 3C89A 2XHLA 4KTXA 1I1EA 3FIEA 3C8AA 3FFZA 2NYYA 1ZB7A 2A8AA 2ISGA 2A97A 4EL4A 4J1LA 3V0AB 2YPTA 3DEBA 2IMCA 3BOOA 2ETFA 3V0BB 3BONA 1EPWA 1ZN3A 3VUOA 3DS9A 4JIXA 2G7NA 2QN0A 1G9DA 3BWIA 1E1HA 1S0BA 1F31A 3CQBA 2NZ9A 3BTAA 3QW5A 1G9BA 1YVGA 3QW8A 4QHFA 3E11A 4AW6A 2IMBA 1T3AA 2IMAA 1XTFA 2ISHA 3DDAA 1ZL5A 4EJ5A 2ILPA 1G9CA 3ZURA 3FIIA 2G7KA 4ZKTB 2NP0A 1Z7HA 4KS6A 3DDBA 2G7PA 3DSEA 4JIUA 3QIZA 2FPQA 3BOKA 1S0GA 3ZUSA 3V0AA 1S0DA 3K3QB 3V0BA 3QW6A 1S0FA 1XTGA 3NF3A 3ZUQA 3C8BA 5BQNA 3C88A 4KUFA 4ZJXA 1T3CA 3QJ0A 1ZKWA 5BQMA 1S0EA 3QW7A 4IL3A 1ZL6A
chains in the Genus database with same CATH topology
2G7QA 2ISEA 2W2DA 4HEVA 3QIYA 1F82A 3QIXA 4ELCA 3D3XA 1G9AA 1ZKXA 1S0CA 3C89A 2XHLA 4KTXA 1I1EA 3FIEA 3C8AA 3FFZA 2NYYA 1ZB7A 2A8AA 2ISGA 2A97A 4EL4A 4J1LA 3V0AB 3DEBA 2IMCA 3BOOA 2ETFA 3V0BB 3BONA 1EPWA 1ZN3A 3VUOA 3DS9A 2G7NA 2QN0A 1G9DA 3BWIA 1E1HA 1S0BA 1F31A 2NZ9A 3BTAA 3QW5A 1G9BA 1YVGA 3QW8A 2IMBA 1T3AA 2IMAA 1XTFA 2ISHA 3DDAA 1ZL5A 4EJ5A 2ILPA 1G9CA 3ZURA 3FIIA 2G7KA 4ZKTB 2NP0A 1Z7HA 4KS6A 3DDBA 2G7PA 3DSEA 3QIZA 2FPQA 3BOKA 1S0GA 3ZUSA 3V0AA 1S0DA 3K3QB 3V0BA 3QW6A 1S0FA 1XTGA 3NF3A 3ZUQA 3C8BA 5BQNA 3C88A 4KUFA 4ZJXA 1T3CA 3QJ0A 1ZKWA 5BQMA 1S0EA 3QW7A 1ZL6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2G7Q A;  2ISE A;  2W2D A;  4HEV A;  3QIY A;  1F82 A;  3QIX A;  4ELC A;  3D3X A;  1G9A A;  1ZKX A;  1S0C A;  3C89 A;  2XHL A;  4KTX A;  1I1E A;  3FIE A;  3C8A A;  3FFZ A;  2NYY A;  1ZB7 A;  2A8A A;  2ISG A;  2A97 A;  4EL4 A;  4J1L A;  3V0A B;  3DEB A;  2IMC A;  3BOO A;  2ETF A;  3V0B B;  3BON A;  1EPW A;  1ZN3 A;  3VUO A;  3DS9 A;  2G7N A;  2QN0 A;  1G9D A;  3BWI A;  1E1H A;  1S0B A;  1F31 A;  2NZ9 A;  3BTA A;  3QW5 A;  1G9B A;  1YVG A;  3QW8 A;  2IMB A;  1T3A A;  2IMA A;  1XTF A;  2ISH A;  3DDA A;  1ZL5 A;  4EJ5 A;  2ILP A;  1G9C A;  3ZUR A;  3FII A;  2G7K A;  4ZKT B;  2NP0 A;  1Z7H A;  4KS6 A;  3DDB A;  2G7P A;  3DSE A;  3QIZ A;  2FPQ A;  3BOK A;  1S0G A;  3ZUS A;  3V0A A;  1S0D A;  3K3Q B;  3V0B A;  3QW6 A;  1S0F A;  1XTG A;  3NF3 A;  3ZUQ A;  3C8B A;  5BQN A;  3C88 A;  4KUF A;  4ZJX A;  1T3C A;  3QJ0 A;  1ZKW A;  5BQM A;  1S0E A;  3QW7 A;  1ZL6 A; 
#chains in the Genus database with same CATH topology
 2G7Q A;  2ISE A;  2W2D A;  4HEV A;  3QIY A;  1F82 A;  3QIX A;  4ELC A;  2EJQ A;  3D3X A;  1G9A A;  1ZKX A;  1S0C A;  3C89 A;  2XHL A;  4KTX A;  1I1E A;  3FIE A;  3C8A A;  3FFZ A;  2NYY A;  1ZB7 A;  2A8A A;  2ISG A;  2A97 A;  4EL4 A;  4J1L A;  3V0A B;  2YPT A;  3DEB A;  2IMC A;  3BOO A;  2ETF A;  3V0B B;  3BON A;  1EPW A;  1ZN3 A;  3VUO A;  3DS9 A;  4JIX A;  2G7N A;  2QN0 A;  1G9D A;  3BWI A;  1E1H A;  1S0B A;  1F31 A;  3CQB A;  2NZ9 A;  3BTA A;  3QW5 A;  1G9B A;  1YVG A;  3QW8 A;  4QHF A;  3E11 A;  4AW6 A;  2IMB A;  1T3A A;  2IMA A;  1XTF A;  2ISH A;  3DDA A;  1ZL5 A;  4EJ5 A;  2ILP A;  1G9C A;  3ZUR A;  3FII A;  2G7K A;  4ZKT B;  2NP0 A;  1Z7H A;  4KS6 A;  3DDB A;  2G7P A;  3DSE A;  4JIU A;  3QIZ A;  2FPQ A;  3BOK A;  1S0G A;  3ZUS A;  3V0A A;  1S0D A;  3K3Q B;  3V0B A;  3QW6 A;  1S0F A;  1XTG A;  3NF3 A;  3ZUQ A;  3C8B A;  5BQN A;  3C88 A;  4KUF A;  4ZJX A;  1T3C A;  3QJ0 A;  1ZKW A;  5BQM A;  1S0E A;  3QW7 A;  4IL3 A;  1ZL6 A; 
#chains in the Genus database with same CATH homology
 2G7Q A;  2ISE A;  2W2D A;  4HEV A;  3QIY A;  1F82 A;  3QIX A;  4ELC A;  3D3X A;  1G9A A;  1ZKX A;  1S0C A;  3C89 A;  2XHL A;  4KTX A;  1I1E A;  3FIE A;  3C8A A;  3FFZ A;  2NYY A;  1ZB7 A;  2A8A A;  2ISG A;  2A97 A;  4EL4 A;  4J1L A;  3V0A B;  3DEB A;  2IMC A;  3BOO A;  2ETF A;  3V0B B;  3BON A;  1EPW A;  1ZN3 A;  3VUO A;  3DS9 A;  2G7N A;  2QN0 A;  1G9D A;  3BWI A;  1E1H A;  1S0B A;  1F31 A;  2NZ9 A;  3BTA A;  3QW5 A;  1G9B A;  1YVG A;  3QW8 A;  2IMB A;  1T3A A;  2IMA A;  1XTF A;  2ISH A;  3DDA A;  1ZL5 A;  4EJ5 A;  2ILP A;  1G9C A;  3ZUR A;  3FII A;  2G7K A;  4ZKT B;  2NP0 A;  1Z7H A;  4KS6 A;  3DDB A;  2G7P A;  3DSE A;  3QIZ A;  2FPQ A;  3BOK A;  1S0G A;  3ZUS A;  3V0A A;  1S0D A;  3K3Q B;  3V0B A;  3QW6 A;  1S0F A;  1XTG A;  3NF3 A;  3ZUQ A;  3C8B A;  5BQN A;  3C88 A;  4KUF A;  4ZJX A;  1T3C A;  3QJ0 A;  1ZKW A;  5BQM A;  1S0E A;  3QW7 A;  1ZL6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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