2G7QA

Structure of the light chain of botulinum neurotoxin serotype a bound to small molecule inhibitors
Total Genus 131
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
131
sequence length
417
structure length
411
Chain Sequence
MFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHDVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAEHRLYGIAINPNRVFKVNTNAYYEGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDVASTLNKAKSIIGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVNFFKVINAKTFLNFDKAVFRINIVPDENYTIKDGFNLKGANLSTNFNGQNTEINSRNFTRLKN
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Light chain of botulinum neurotoxin serotype A: structural resolution of a catalytic intermediate.
pubmed doi rcsb
molecule tags Hydrolase
source organism Clostridium botulinum
molecule keywords Botulinum neurotoxin type A
total genus 131
structure length 411
sequence length 417
chains with identical sequence B
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2006-02-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01742 Peptidase_M27 Clostridial neurotoxin zinc protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 2g7qA00
3FIIA 4EL4A 3DDAA 2ISHA 4KUFA 2IMAA 3C88A 3V0AB 1ZB7A 4ELCA 1S0BA 2QN0A 4ZJXA 3NF3A 1G9BA 3BOOA 1YVGA 1XTFA 1Z7HA 4ZKTB 1G9AA 3DS9A 3BWIA 2ILPA 4J1LA 2ISGA 3ZURA 2ETFA 3QW8A 1T3AA 3K3QB 3ZUSA 3C8BA 1F82A 3VUOA 1E1HA 3DDBA 3QW6A 3QIXA 1ZL6A 2FPQA 3C8AA 1ZN3A 3BTAA 2G7QA 2G7NA 1I1EA 1S0GA 2G7KA 2NZ9A 3FIEA 3QJ0A 3BOKA 2A8AA 3ZUQA 4HEVA 5BQMA 2W2DA 5BQNA 2NYYA 4KTXA 1XTGA 3QW7A 3C89A 1S0DA 1F31A 1ZKWA 2IMBA 2XHLA 2G7PA 4EJ5A 1EPWA 1G9DA 2ISEA 3V0BB 3V0BA 3QIYA 3QW5A 2NP0A 3DSEA 3DEBA 1T3CA 1S0CA 3V0AA 1ZKXA 2A97A 4KS6A 2IMCA 1ZL5A 1G9CA 1S0FA 3BONA 3D3XA 1S0EA 3FFZA 3QIZA
chains in the Genus database with same CATH superfamily
3FIIA 4EL4A 3DDAA 2ISHA 4KUFA 2IMAA 3C88A 2YPTA 3V0AB 1ZB7A 4ELCA 1S0BA 2QN0A 4ZJXA 3NF3A 1G9BA 3BOOA 1YVGA 1XTFA 1Z7HA 4ZKTB 1G9AA 3DS9A 3BWIA 2ILPA 4J1LA 2ISGA 3ZURA 2ETFA 3CQBA 3QW8A 1T3AA 3K3QB 3ZUSA 4JIUA 3C8BA 1F82A 3VUOA 1E1HA 3DDBA 3QW6A 3QIXA 1ZL6A 2FPQA 3C8AA 1ZN3A 3BTAA 2G7QA 4AW6A 2G7NA 1I1EA 4QHFA 1S0GA 2G7KA 2NZ9A 3FIEA 3QJ0A 3BOKA 2A8AA 3ZUQA 4HEVA 5BQMA 2W2DA 5BQNA 2NYYA 4KTXA 1XTGA 4JIXA 3QW7A 3C89A 1S0DA 1F31A 1ZKWA 2IMBA 2XHLA 2G7PA 4IL3A 4EJ5A 1EPWA 1G9DA 2ISEA 3V0BB 2EJQA 3V0BA 3QIYA 3QW5A 2NP0A 3DSEA 3DEBA 1T3CA 1S0CA 3V0AA 1ZKXA 2A97A 4KS6A 2IMCA 1ZL5A 1G9CA 1S0FA 3BONA 3E11A 3D3XA 1S0EA 3FFZA 3QIZA
chains in the Genus database with same CATH topology
3FIIA 4EL4A 3DDAA 2ISHA 4KUFA 2IMAA 3C88A 3V0AB 1ZB7A 4ELCA 1S0BA 2QN0A 4ZJXA 3NF3A 1G9BA 3BOOA 1YVGA 1XTFA 1Z7HA 4ZKTB 1G9AA 3DS9A 3BWIA 2ILPA 4J1LA 2ISGA 3ZURA 2ETFA 3QW8A 1T3AA 3K3QB 3ZUSA 3C8BA 1F82A 3VUOA 1E1HA 3DDBA 3QW6A 3QIXA 1ZL6A 2FPQA 3C8AA 1ZN3A 3BTAA 2G7QA 2G7NA 1I1EA 1S0GA 2G7KA 2NZ9A 3FIEA 3QJ0A 3BOKA 2A8AA 3ZUQA 4HEVA 5BQMA 2W2DA 5BQNA 2NYYA 4KTXA 1XTGA 3QW7A 3C89A 1S0DA 1F31A 1ZKWA 2IMBA 2XHLA 2G7PA 4EJ5A 1EPWA 1G9DA 2ISEA 3V0BB 3V0BA 3QIYA 3QW5A 2NP0A 3DSEA 3DEBA 1T3CA 1S0CA 3V0AA 1ZKXA 2A97A 4KS6A 2IMCA 1ZL5A 1G9CA 1S0FA 3BONA 3D3XA 1S0EA 3FFZA 3QIZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3FII A;  4EL4 A;  3DDA A;  2ISH A;  4KUF A;  2IMA A;  3C88 A;  3V0A B;  1ZB7 A;  4ELC A;  1S0B A;  2QN0 A;  4ZJX A;  3NF3 A;  1G9B A;  3BOO A;  1YVG A;  1XTF A;  1Z7H A;  4ZKT B;  1G9A A;  3DS9 A;  3BWI A;  2ILP A;  4J1L A;  2ISG A;  3ZUR A;  2ETF A;  3QW8 A;  1T3A A;  3K3Q B;  3ZUS A;  3C8B A;  1F82 A;  3VUO A;  1E1H A;  3DDB A;  3QW6 A;  3QIX A;  1ZL6 A;  2FPQ A;  3C8A A;  1ZN3 A;  3BTA A;  2G7Q A;  2G7N A;  1I1E A;  1S0G A;  2G7K A;  2NZ9 A;  3FIE A;  3QJ0 A;  3BOK A;  2A8A A;  3ZUQ A;  4HEV A;  5BQM A;  2W2D A;  5BQN A;  2NYY A;  4KTX A;  1XTG A;  3QW7 A;  3C89 A;  1S0D A;  1F31 A;  1ZKW A;  2IMB A;  2XHL A;  2G7P A;  4EJ5 A;  1EPW A;  1G9D A;  2ISE A;  3V0B B;  3V0B A;  3QIY A;  3QW5 A;  2NP0 A;  3DSE A;  3DEB A;  1T3C A;  1S0C A;  3V0A A;  1ZKX A;  2A97 A;  4KS6 A;  2IMC A;  1ZL5 A;  1G9C A;  1S0F A;  3BON A;  3D3X A;  1S0E A;  3FFZ A;  3QIZ A; 
#chains in the Genus database with same CATH topology
 3FII A;  4EL4 A;  3DDA A;  2ISH A;  4KUF A;  2IMA A;  3C88 A;  2YPT A;  3V0A B;  1ZB7 A;  4ELC A;  1S0B A;  2QN0 A;  4ZJX A;  3NF3 A;  1G9B A;  3BOO A;  1YVG A;  1XTF A;  1Z7H A;  4ZKT B;  1G9A A;  3DS9 A;  3BWI A;  2ILP A;  4J1L A;  2ISG A;  3ZUR A;  2ETF A;  3CQB A;  3QW8 A;  1T3A A;  3K3Q B;  3ZUS A;  4JIU A;  3C8B A;  1F82 A;  3VUO A;  1E1H A;  3DDB A;  3QW6 A;  3QIX A;  1ZL6 A;  2FPQ A;  3C8A A;  1ZN3 A;  3BTA A;  2G7Q A;  4AW6 A;  2G7N A;  1I1E A;  4QHF A;  1S0G A;  2G7K A;  2NZ9 A;  3FIE A;  3QJ0 A;  3BOK A;  2A8A A;  3ZUQ A;  4HEV A;  5BQM A;  2W2D A;  5BQN A;  2NYY A;  4KTX A;  1XTG A;  4JIX A;  3QW7 A;  3C89 A;  1S0D A;  1F31 A;  1ZKW A;  2IMB A;  2XHL A;  2G7P A;  4IL3 A;  4EJ5 A;  1EPW A;  1G9D A;  2ISE A;  3V0B B;  2EJQ A;  3V0B A;  3QIY A;  3QW5 A;  2NP0 A;  3DSE A;  3DEB A;  1T3C A;  1S0C A;  3V0A A;  1ZKX A;  2A97 A;  4KS6 A;  2IMC A;  1ZL5 A;  1G9C A;  1S0F A;  3BON A;  3E11 A;  3D3X A;  1S0E A;  3FFZ A;  3QIZ A; 
#chains in the Genus database with same CATH homology
 3FII A;  4EL4 A;  3DDA A;  2ISH A;  4KUF A;  2IMA A;  3C88 A;  3V0A B;  1ZB7 A;  4ELC A;  1S0B A;  2QN0 A;  4ZJX A;  3NF3 A;  1G9B A;  3BOO A;  1YVG A;  1XTF A;  1Z7H A;  4ZKT B;  1G9A A;  3DS9 A;  3BWI A;  2ILP A;  4J1L A;  2ISG A;  3ZUR A;  2ETF A;  3QW8 A;  1T3A A;  3K3Q B;  3ZUS A;  3C8B A;  1F82 A;  3VUO A;  1E1H A;  3DDB A;  3QW6 A;  3QIX A;  1ZL6 A;  2FPQ A;  3C8A A;  1ZN3 A;  3BTA A;  2G7Q A;  2G7N A;  1I1E A;  1S0G A;  2G7K A;  2NZ9 A;  3FIE A;  3QJ0 A;  3BOK A;  2A8A A;  3ZUQ A;  4HEV A;  5BQM A;  2W2D A;  5BQN A;  2NYY A;  4KTX A;  1XTG A;  3QW7 A;  3C89 A;  1S0D A;  1F31 A;  1ZKW A;  2IMB A;  2XHL A;  2G7P A;  4EJ5 A;  1EPW A;  1G9D A;  2ISE A;  3V0B B;  3V0B A;  3QIY A;  3QW5 A;  2NP0 A;  3DSE A;  3DEB A;  1T3C A;  1S0C A;  3V0A A;  1ZKX A;  2A97 A;  4KS6 A;  2IMC A;  1ZL5 A;  1G9C A;  1S0F A;  3BON A;  3D3X A;  1S0E A;  3FFZ A;  3QIZ A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...