2QN0A

Structure of botulinum neurotoxin serotype c1 light chain protease
Total Genus 141
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
141
sequence length
429
structure length
429
Chain Sequence
PITINNFNYSDPVDNKNILYLDTHLNTLANEPEKAFRITGNIWVIPDRFSRNSNPNLNKPPRVTSPKSGYYDPNYLSTDSDKDTFLKEIIKLFKRINSREIGEELIYRLSTDIPFPGNNNTPINTFDFDVDFNSVDVKTRQGNNWVKTGSINPSVIITGPRENIIDPETSTFKLTNNTFAAQEGFGALSIISISPRFMLTYSNATNDVGEGRFSKSEFCMDPILILMHELNHAMHNLYGIAIPNDQTISSVTSNIFYSQYNVKLEYAEIYAFGGPTIDLIPKSARKYFEEKALDYYRSIAKRLNSITTANPSSFNKYIGEYKQKLIRKYRFVVESSGEVTVNRNKFVELYNELTQIFTEFNYAKIYNVQNRKIYLSNVYTPVTANILDDNVYDIQNGFNIPKSNLNVLFMGQNLSRNPALRKVNPEPLV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural and biochemical studies of botulinum neurotoxin serotype C1 light chain protease: implications for dual substrate specificity.
pubmed doi rcsb
molecule tags Toxin
source organism Clostridium botulinum
molecule keywords Neurotoxin
total genus 141
structure length 429
sequence length 429
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2007-07-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01742 Peptidase_M27 Clostridial neurotoxin zinc protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 2qn0A00
3BTAA 1S0BA 3QW7A 2NYYA 2G7KA 3DS9A 1T3CA 3C8AA 2A8AA 1S0GA 3C8BA 3K3QB 2G7NA 1ZL5A 5BQMA 2ETFA 3BOKA 1ZL6A 4EJ5A 3QIXA 1G9BA 2IMCA 3ZURA 3DDAA 2IMAA 3D3XA 3V0BB 3QJ0A 1EPWA 2ILPA 1S0FA 4EL4A 3ZUQA 2IMBA 1G9CA 4ZJXA 3C89A 2G7QA 3BONA 2XHLA 2QN0A 3QW6A 2A97A 3C88A 5BQNA 3V0AB 3QIZA 1S0DA 2NP0A 3QIYA 4KS6A 2G7PA 4HEVA 4J1LA 3DSEA 3V0BA 1XTGA 3QW5A 1ZN3A 1S0EA 1G9AA 1XTFA 3DEBA 2ISGA 4ZKTB 3VUOA 3QW8A 1F82A 1G9DA 1Z7HA 1S0CA 4KUFA 1YVGA 3FIEA 1F31A 3BOOA 2ISHA 3FIIA 2NZ9A 1E1HA 1ZKWA 3NF3A 1ZKXA 2W2DA 3DDBA 1I1EA 3V0AA 3BWIA 2ISEA 4KTXA 1ZB7A 1T3AA 2FPQA 4ELCA 3ZUSA 3FFZA
chains in the Genus database with same CATH superfamily
4AW6A 3BTAA 1S0BA 3QW7A 2NYYA 2EJQA 2G7KA 3DS9A 1T3CA 3C8AA 2A8AA 1S0GA 3C8BA 3K3QB 2G7NA 1ZL5A 5BQMA 2ETFA 3BOKA 1ZL6A 4EJ5A 3QIXA 1G9BA 2IMCA 3ZURA 3DDAA 2IMAA 3D3XA 3V0BB 3QJ0A 3E11A 1EPWA 2ILPA 1S0FA 4EL4A 3ZUQA 4JIUA 2IMBA 1G9CA 4ZJXA 3C89A 2G7QA 3BONA 2XHLA 2QN0A 3QW6A 2A97A 3C88A 5BQNA 3V0AB 3QIZA 1S0DA 2NP0A 4IL3A 3QIYA 4KS6A 2G7PA 4HEVA 4J1LA 3DSEA 3V0BA 1XTGA 3QW5A 1ZN3A 1S0EA 1G9AA 1XTFA 3DEBA 2ISGA 4ZKTB 3VUOA 3QW8A 1F82A 1G9DA 1Z7HA 1S0CA 4KUFA 1YVGA 3FIEA 1F31A 4QHFA 3BOOA 2ISHA 3FIIA 2NZ9A 1E1HA 1ZKWA 3NF3A 1ZKXA 2W2DA 3DDBA 1I1EA 3CQBA 3V0AA 3BWIA 2ISEA 4KTXA 1ZB7A 1T3AA 2FPQA 4ELCA 2YPTA 3ZUSA 3FFZA 4JIXA
chains in the Genus database with same CATH topology
3BTAA 1S0BA 3QW7A 2NYYA 2G7KA 3DS9A 1T3CA 3C8AA 2A8AA 1S0GA 3C8BA 3K3QB 2G7NA 1ZL5A 5BQMA 2ETFA 3BOKA 1ZL6A 4EJ5A 3QIXA 1G9BA 2IMCA 3ZURA 3DDAA 2IMAA 3D3XA 3V0BB 3QJ0A 1EPWA 2ILPA 1S0FA 4EL4A 3ZUQA 2IMBA 1G9CA 4ZJXA 3C89A 2G7QA 3BONA 2XHLA 2QN0A 3QW6A 2A97A 3C88A 5BQNA 3V0AB 3QIZA 1S0DA 2NP0A 3QIYA 4KS6A 2G7PA 4HEVA 4J1LA 3DSEA 3V0BA 1XTGA 3QW5A 1ZN3A 1S0EA 1G9AA 1XTFA 3DEBA 2ISGA 4ZKTB 3VUOA 3QW8A 1F82A 1G9DA 1Z7HA 1S0CA 4KUFA 1YVGA 3FIEA 1F31A 3BOOA 2ISHA 3FIIA 2NZ9A 1E1HA 1ZKWA 3NF3A 1ZKXA 2W2DA 3DDBA 1I1EA 3V0AA 3BWIA 2ISEA 4KTXA 1ZB7A 1T3AA 2FPQA 4ELCA 3ZUSA 3FFZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BTA A;  1S0B A;  3QW7 A;  2NYY A;  2G7K A;  3DS9 A;  1T3C A;  3C8A A;  2A8A A;  1S0G A;  3C8B A;  3K3Q B;  2G7N A;  1ZL5 A;  5BQM A;  2ETF A;  3BOK A;  1ZL6 A;  4EJ5 A;  3QIX A;  1G9B A;  2IMC A;  3ZUR A;  3DDA A;  2IMA A;  3D3X A;  3V0B B;  3QJ0 A;  1EPW A;  2ILP A;  1S0F A;  4EL4 A;  3ZUQ A;  2IMB A;  1G9C A;  4ZJX A;  3C89 A;  2G7Q A;  3BON A;  2XHL A;  2QN0 A;  3QW6 A;  2A97 A;  3C88 A;  5BQN A;  3V0A B;  3QIZ A;  1S0D A;  2NP0 A;  3QIY A;  4KS6 A;  2G7P A;  4HEV A;  4J1L A;  3DSE A;  3V0B A;  1XTG A;  3QW5 A;  1ZN3 A;  1S0E A;  1G9A A;  1XTF A;  3DEB A;  2ISG A;  4ZKT B;  3VUO A;  3QW8 A;  1F82 A;  1G9D A;  1Z7H A;  1S0C A;  4KUF A;  1YVG A;  3FIE A;  1F31 A;  3BOO A;  2ISH A;  3FII A;  2NZ9 A;  1E1H A;  1ZKW A;  3NF3 A;  1ZKX A;  2W2D A;  3DDB A;  1I1E A;  3V0A A;  3BWI A;  2ISE A;  4KTX A;  1ZB7 A;  1T3A A;  2FPQ A;  4ELC A;  3ZUS A;  3FFZ A; 
#chains in the Genus database with same CATH topology
 4AW6 A;  3BTA A;  1S0B A;  3QW7 A;  2NYY A;  2EJQ A;  2G7K A;  3DS9 A;  1T3C A;  3C8A A;  2A8A A;  1S0G A;  3C8B A;  3K3Q B;  2G7N A;  1ZL5 A;  5BQM A;  2ETF A;  3BOK A;  1ZL6 A;  4EJ5 A;  3QIX A;  1G9B A;  2IMC A;  3ZUR A;  3DDA A;  2IMA A;  3D3X A;  3V0B B;  3QJ0 A;  3E11 A;  1EPW A;  2ILP A;  1S0F A;  4EL4 A;  3ZUQ A;  4JIU A;  2IMB A;  1G9C A;  4ZJX A;  3C89 A;  2G7Q A;  3BON A;  2XHL A;  2QN0 A;  3QW6 A;  2A97 A;  3C88 A;  5BQN A;  3V0A B;  3QIZ A;  1S0D A;  2NP0 A;  4IL3 A;  3QIY A;  4KS6 A;  2G7P A;  4HEV A;  4J1L A;  3DSE A;  3V0B A;  1XTG A;  3QW5 A;  1ZN3 A;  1S0E A;  1G9A A;  1XTF A;  3DEB A;  2ISG A;  4ZKT B;  3VUO A;  3QW8 A;  1F82 A;  1G9D A;  1Z7H A;  1S0C A;  4KUF A;  1YVG A;  3FIE A;  1F31 A;  4QHF A;  3BOO A;  2ISH A;  3FII A;  2NZ9 A;  1E1H A;  1ZKW A;  3NF3 A;  1ZKX A;  2W2D A;  3DDB A;  1I1E A;  3CQB A;  3V0A A;  3BWI A;  2ISE A;  4KTX A;  1ZB7 A;  1T3A A;  2FPQ A;  4ELC A;  2YPT A;  3ZUS A;  3FFZ A;  4JIX A; 
#chains in the Genus database with same CATH homology
 3BTA A;  1S0B A;  3QW7 A;  2NYY A;  2G7K A;  3DS9 A;  1T3C A;  3C8A A;  2A8A A;  1S0G A;  3C8B A;  3K3Q B;  2G7N A;  1ZL5 A;  5BQM A;  2ETF A;  3BOK A;  1ZL6 A;  4EJ5 A;  3QIX A;  1G9B A;  2IMC A;  3ZUR A;  3DDA A;  2IMA A;  3D3X A;  3V0B B;  3QJ0 A;  1EPW A;  2ILP A;  1S0F A;  4EL4 A;  3ZUQ A;  2IMB A;  1G9C A;  4ZJX A;  3C89 A;  2G7Q A;  3BON A;  2XHL A;  2QN0 A;  3QW6 A;  2A97 A;  3C88 A;  5BQN A;  3V0A B;  3QIZ A;  1S0D A;  2NP0 A;  3QIY A;  4KS6 A;  2G7P A;  4HEV A;  4J1L A;  3DSE A;  3V0B A;  1XTG A;  3QW5 A;  1ZN3 A;  1S0E A;  1G9A A;  1XTF A;  3DEB A;  2ISG A;  4ZKT B;  3VUO A;  3QW8 A;  1F82 A;  1G9D A;  1Z7H A;  1S0C A;  4KUF A;  1YVG A;  3FIE A;  1F31 A;  3BOO A;  2ISH A;  3FII A;  2NZ9 A;  1E1H A;  1ZKW A;  3NF3 A;  1ZKX A;  2W2D A;  3DDB A;  1I1E A;  3V0A A;  3BWI A;  2ISE A;  4KTX A;  1ZB7 A;  1T3A A;  2FPQ A;  4ELC A;  3ZUS A;  3FFZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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