2XHLA

Structure of a functional derivative of clostridium botulinum neurotoxin type b
Total Genus 117
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
117
sequence length
441
structure length
430
Chain Sequence
MPVTINNFNYNDPIDNNNIIMMEPPFARGTGRYYKAFKITDRIWIIPERYTFGYKPEDFNKSSGIFNRDVCEYYDPDYLNTNDKKNIFLQTMIKLFNRIKSKPLGEKLLEMIINGIPYLGDRRVPLEEFNTNIASVTVNKLISNPGEVERKKGIFANLIIFGPGPVLNENETIDIGIQNHFASREGFGGIMQMKFCPEYVSVFNNVQGYFSDPALILMHELIHVLHGLYGIKVDDLPIVPNEKKFFMQSTDAIQAEELYTFGGQDPSIITPSTDKSIYDKVLQNFRGIVDRLNKVLVCISDPNININIYKNKFKDKYKFVEDSEGKYSIDVESFDKLYKSLMFGFTETNIAENYKIKTRASYFSDSLPPVKIKNLLDNEIYTIEEGFNISDKDMEKEYRGQNKAINKQAYEEISKEHLAVYKIQMCVDGI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure and Activity of a Functional Derivative of Clostridium Botulinum Neurotoxin B.
pubmed doi rcsb
molecule tags Hydrolase
source organism Clostridium botulinum
molecule keywords BOTULINUM NEUROTOXIN B LIGHT CHAIN
total genus 117
structure length 430
sequence length 441
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2010-06-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01742 Peptidase_M27 Clostridial neurotoxin zinc protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 2xhlA00
1S0DA 4J1LA 3C89A 3V0BA 3QW7A 1S0GA 2ISEA 3BOKA 1E1HA 3DEBA 1XTGA 2G7PA 3DSEA 4KTXA 1Z7HA 1G9AA 2A8AA 2IMCA 3K3QB 1ZKXA 4KS6A 2G7QA 3BWIA 1S0BA 2IMAA 1F31A 2A97A 3C8AA 2NYYA 3QIYA 3FIIA 2ILPA 3DDAA 4KUFA 1F82A 4HEVA 1ZB7A 3DS9A 2NZ9A 1I1EA 3QJ0A 3V0AA 3D3XA 1XTFA 3C88A 3FFZA 3QIZA 2XHLA 4EJ5A 3BONA 1EPWA 3V0BB 2ISHA 3BTAA 1S0FA 3QW6A 2IMBA 3NF3A 2ETFA 2G7NA 4ZKTB 2ISGA 1ZL5A 3ZUSA 1G9CA 5BQMA 4ELCA 2G7KA 3ZURA 3C8BA 2QN0A 5BQNA 1T3AA 1T3CA 3QIXA 1G9DA 1ZL6A 4ZJXA 3DDBA 3FIEA 1S0EA 3QW8A 3QW5A 2FPQA 1YVGA 3V0AB 1G9BA 3ZUQA 3VUOA 3BOOA 1S0CA 2W2DA 1ZN3A 4EL4A 2NP0A 1ZKWA
chains in the Genus database with same CATH superfamily
1S0DA 4J1LA 3C89A 3V0BA 3QW7A 1S0GA 2ISEA 3BOKA 1E1HA 3DEBA 1XTGA 2G7PA 3DSEA 2YPTA 3CQBA 4KTXA 1Z7HA 1G9AA 2A8AA 2IMCA 3K3QB 1ZKXA 4KS6A 2EJQA 2G7QA 3BWIA 4QHFA 1S0BA 2IMAA 1F31A 2A97A 3C8AA 2NYYA 3QIYA 3FIIA 2ILPA 3DDAA 4KUFA 1F82A 4AW6A 4HEVA 1ZB7A 3DS9A 2NZ9A 1I1EA 3QJ0A 3V0AA 3D3XA 1XTFA 3C88A 4JIXA 3FFZA 3QIZA 2XHLA 3E11A 4EJ5A 3BONA 1EPWA 3V0BB 2ISHA 3BTAA 1S0FA 4IL3A 3QW6A 2IMBA 3NF3A 4JIUA 2ETFA 2G7NA 4ZKTB 2ISGA 1ZL5A 3ZUSA 1G9CA 5BQMA 4ELCA 2G7KA 3ZURA 3C8BA 2QN0A 5BQNA 1T3AA 1T3CA 3QIXA 1G9DA 1ZL6A 4ZJXA 3DDBA 3FIEA 1S0EA 3QW8A 3QW5A 2FPQA 1YVGA 3V0AB 1G9BA 3ZUQA 3VUOA 3BOOA 1S0CA 2W2DA 1ZN3A 4EL4A 2NP0A 1ZKWA
chains in the Genus database with same CATH topology
1S0DA 4J1LA 3C89A 3V0BA 3QW7A 1S0GA 2ISEA 3BOKA 1E1HA 3DEBA 1XTGA 2G7PA 3DSEA 4KTXA 1Z7HA 1G9AA 2A8AA 2IMCA 3K3QB 1ZKXA 4KS6A 2G7QA 3BWIA 1S0BA 2IMAA 1F31A 2A97A 3C8AA 2NYYA 3QIYA 3FIIA 2ILPA 3DDAA 4KUFA 1F82A 4HEVA 1ZB7A 3DS9A 2NZ9A 1I1EA 3QJ0A 3V0AA 3D3XA 1XTFA 3C88A 3FFZA 3QIZA 2XHLA 4EJ5A 3BONA 1EPWA 3V0BB 2ISHA 3BTAA 1S0FA 3QW6A 2IMBA 3NF3A 2ETFA 2G7NA 4ZKTB 2ISGA 1ZL5A 3ZUSA 1G9CA 5BQMA 4ELCA 2G7KA 3ZURA 3C8BA 2QN0A 5BQNA 1T3AA 1T3CA 3QIXA 1G9DA 1ZL6A 4ZJXA 3DDBA 3FIEA 1S0EA 3QW8A 3QW5A 2FPQA 1YVGA 3V0AB 1G9BA 3ZUQA 3VUOA 3BOOA 1S0CA 2W2DA 1ZN3A 4EL4A 2NP0A 1ZKWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1S0D A;  4J1L A;  3C89 A;  3V0B A;  3QW7 A;  1S0G A;  2ISE A;  3BOK A;  1E1H A;  3DEB A;  1XTG A;  2G7P A;  3DSE A;  4KTX A;  1Z7H A;  1G9A A;  2A8A A;  2IMC A;  3K3Q B;  1ZKX A;  4KS6 A;  2G7Q A;  3BWI A;  1S0B A;  2IMA A;  1F31 A;  2A97 A;  3C8A A;  2NYY A;  3QIY A;  3FII A;  2ILP A;  3DDA A;  4KUF A;  1F82 A;  4HEV A;  1ZB7 A;  3DS9 A;  2NZ9 A;  1I1E A;  3QJ0 A;  3V0A A;  3D3X A;  1XTF A;  3C88 A;  3FFZ A;  3QIZ A;  2XHL A;  4EJ5 A;  3BON A;  1EPW A;  3V0B B;  2ISH A;  3BTA A;  1S0F A;  3QW6 A;  2IMB A;  3NF3 A;  2ETF A;  2G7N A;  4ZKT B;  2ISG A;  1ZL5 A;  3ZUS A;  1G9C A;  5BQM A;  4ELC A;  2G7K A;  3ZUR A;  3C8B A;  2QN0 A;  5BQN A;  1T3A A;  1T3C A;  3QIX A;  1G9D A;  1ZL6 A;  4ZJX A;  3DDB A;  3FIE A;  1S0E A;  3QW8 A;  3QW5 A;  2FPQ A;  1YVG A;  3V0A B;  1G9B A;  3ZUQ A;  3VUO A;  3BOO A;  1S0C A;  2W2D A;  1ZN3 A;  4EL4 A;  2NP0 A;  1ZKW A; 
#chains in the Genus database with same CATH topology
 1S0D A;  4J1L A;  3C89 A;  3V0B A;  3QW7 A;  1S0G A;  2ISE A;  3BOK A;  1E1H A;  3DEB A;  1XTG A;  2G7P A;  3DSE A;  2YPT A;  3CQB A;  4KTX A;  1Z7H A;  1G9A A;  2A8A A;  2IMC A;  3K3Q B;  1ZKX A;  4KS6 A;  2EJQ A;  2G7Q A;  3BWI A;  4QHF A;  1S0B A;  2IMA A;  1F31 A;  2A97 A;  3C8A A;  2NYY A;  3QIY A;  3FII A;  2ILP A;  3DDA A;  4KUF A;  1F82 A;  4AW6 A;  4HEV A;  1ZB7 A;  3DS9 A;  2NZ9 A;  1I1E A;  3QJ0 A;  3V0A A;  3D3X A;  1XTF A;  3C88 A;  4JIX A;  3FFZ A;  3QIZ A;  2XHL A;  3E11 A;  4EJ5 A;  3BON A;  1EPW A;  3V0B B;  2ISH A;  3BTA A;  1S0F A;  4IL3 A;  3QW6 A;  2IMB A;  3NF3 A;  4JIU A;  2ETF A;  2G7N A;  4ZKT B;  2ISG A;  1ZL5 A;  3ZUS A;  1G9C A;  5BQM A;  4ELC A;  2G7K A;  3ZUR A;  3C8B A;  2QN0 A;  5BQN A;  1T3A A;  1T3C A;  3QIX A;  1G9D A;  1ZL6 A;  4ZJX A;  3DDB A;  3FIE A;  1S0E A;  3QW8 A;  3QW5 A;  2FPQ A;  1YVG A;  3V0A B;  1G9B A;  3ZUQ A;  3VUO A;  3BOO A;  1S0C A;  2W2D A;  1ZN3 A;  4EL4 A;  2NP0 A;  1ZKW A; 
#chains in the Genus database with same CATH homology
 1S0D A;  4J1L A;  3C89 A;  3V0B A;  3QW7 A;  1S0G A;  2ISE A;  3BOK A;  1E1H A;  3DEB A;  1XTG A;  2G7P A;  3DSE A;  4KTX A;  1Z7H A;  1G9A A;  2A8A A;  2IMC A;  3K3Q B;  1ZKX A;  4KS6 A;  2G7Q A;  3BWI A;  1S0B A;  2IMA A;  1F31 A;  2A97 A;  3C8A A;  2NYY A;  3QIY A;  3FII A;  2ILP A;  3DDA A;  4KUF A;  1F82 A;  4HEV A;  1ZB7 A;  3DS9 A;  2NZ9 A;  1I1E A;  3QJ0 A;  3V0A A;  3D3X A;  1XTF A;  3C88 A;  3FFZ A;  3QIZ A;  2XHL A;  4EJ5 A;  3BON A;  1EPW A;  3V0B B;  2ISH A;  3BTA A;  1S0F A;  3QW6 A;  2IMB A;  3NF3 A;  2ETF A;  2G7N A;  4ZKT B;  2ISG A;  1ZL5 A;  3ZUS A;  1G9C A;  5BQM A;  4ELC A;  2G7K A;  3ZUR A;  3C8B A;  2QN0 A;  5BQN A;  1T3A A;  1T3C A;  3QIX A;  1G9D A;  1ZL6 A;  4ZJX A;  3DDB A;  3FIE A;  1S0E A;  3QW8 A;  3QW5 A;  2FPQ A;  1YVG A;  3V0A B;  1G9B A;  3ZUQ A;  3VUO A;  3BOO A;  1S0C A;  2W2D A;  1ZN3 A;  4EL4 A;  2NP0 A;  1ZKW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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