3BOKA

Structure of the c. botulinum neurotoxin serotype a apo-enzyme
Total Genus 148
50100150200250300350400020406080100120140
Genus TraceResidueGenus

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
148
sequence length
423
structure length
416
Chain Sequence
MQFVNKQFNYKDPVNGVDIAYIKIPQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLF

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
S2 (33-39)TVIII1 (2-5)EMPTYTIV1 (15-18)TI1 (9-12)TII2 (76-79)TI3 (74-77)S5 (134-138)3H1 (131-133)S1 (19-23)TII1 (39-42)TI5 (139-142)S6 (144-148)S3 (42-48)TVIII3 (68-71)TIV4 (49-52)TIV7 (156-159)TVIII2 (51-54)S9 (184-187)AH1 (81-100)S17 (372-376)AH2 (102-113)AH4 (217-233)AH9 (335-348)AH8 (310-321)TI7 (170-173)TIV6 (121-124)S4 (126-127)TI8 (174-177)TIV8 (175-178)TVIII4 (157-160)S8 (164-167)S10 (192-196)TI9 (189-192)AH3 (200-204)S18 (413-418)TI19 (405-408)TI18 (396-399)TI10 (205-208)TI17 (395-398)S12 (242-244)TI11 (238-241)AH5 (249-254)S13 (257-259)AH10 (351-358)AH6 (260-266)AH7 (276-299)S15 (323-325)TI12 (326-329)TIV10 (365-368)TIV14 (406-409)3H4 (410-412)TI13 (380-383)TI14 (381-384)TI15 (385-388)TI16 (386-389)TIV12 (392-395)TII'1 (388-391)TIV11 (389-392)3H3 (402-404)TII3 (398-401)S7 (151-155)O2 (117-119)TIV9 (176-179)S11 (213-214)3H2 (268-273)S14 (302-303)S16 (331-333)Updating...
connected with : NaN
publication title Catalytic features of the botulinum neurotoxin A light chain revealed by high resolution structure of an inhibitory peptide complex.
pubmed doi rcsb
molecule tags Toxin
source organism Clostridium botulinum
molecule keywords Neurotoxin A
total genus 148
structure length 416
sequence length 423
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2007-12-17
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 3bokA00
2NP0A 1G9AA 3BWIA 1S0EA 1F31A 3BOOA 1S0GA 3K3QB 4ZJXA 2ILPA 3C89A 3V0BA 1XTGA 1I1EA 3DEBA 1ZKXA 3QW6A 3BOKA 3C88A 3NF3A 2QN0A 3BTAA 2FPQA 2ISEA 1F82A 4ZKTB 4KTXA 3FIEA 2ISHA 3ZUSA 1ZN3A 4HEVA 2IMBA 4ELCA 1YVGA 1ZL5A 2ETFA 2G7PA 3ZUQA 2W2DA 3C8AA 1G9BA 4KUFA 3FFZA 1S0CA 3FIIA 4KS6A 1G9DA 3C8BA 2G7KA 1E1HA 2XHLA 1T3CA 1S0DA 3QJ0A 2G7QA 1XTFA 3QIZA 2A8AA 3DS9A 2ISGA 2A97A 3DDBA 3ZURA 1ZL6A 3QIYA 1T3AA 4EL4A 1S0BA 3V0AB 3QW8A 3QW5A 1ZB7A 3QW7A 4EJ5A 3BONA 1S0FA 3DSEA 1EPWA 1G9CA 3V0BB 1Z7HA 2G7NA 2NYYA 2IMCA 2IMAA 5BQMA 3QIXA 3D3XA 3DDAA 5BQNA 4J1LA 1ZKWA 3VUOA 2NZ9A 3V0AA
chains in the Genus database with same CATH superfamily
2NP0A 1G9AA 3BWIA 1S0EA 1F31A 3BOOA 1S0GA 3K3QB 4ZJXA 2ILPA 3C89A 3V0BA 1XTGA 1I1EA 3DEBA 1ZKXA 3QW6A 3BOKA 3C88A 3NF3A 2QN0A 3BTAA 2FPQA 2ISEA 1F82A 4ZKTB 4KTXA 3FIEA 2ISHA 3ZUSA 1ZN3A 4HEVA 2IMBA 4ELCA 1YVGA 1ZL5A 2ETFA 2G7PA 3ZUQA 2W2DA 3C8AA 1G9BA 4KUFA 3FFZA 1S0CA 4IL3A 4JIXA 3FIIA 3CQBA 4KS6A 1G9DA 3C8BA 2G7KA 1E1HA 2XHLA 1T3CA 1S0DA 3QJ0A 2G7QA 1XTFA 3QIZA 2A8AA 3DS9A 2YPTA 2ISGA 2A97A 3DDBA 3ZURA 1ZL6A 3QIYA 4AW6A 1T3AA 4EL4A 1S0BA 3V0AB 3QW8A 3QW5A 1ZB7A 4JIUA 3QW7A 4EJ5A 3BONA 1S0FA 3DSEA 1EPWA 1G9CA 3V0BB 1Z7HA 2G7NA 2NYYA 2IMCA 2IMAA 5BQMA 3QIXA 3D3XA 3DDAA 4QHFA 3E11A 5BQNA 4J1LA 1ZKWA 3VUOA 2NZ9A 2EJQA 3V0AA
chains in the Genus database with same CATH topology
2NP0A 1G9AA 3BWIA 1S0EA 1F31A 3BOOA 1S0GA 3K3QB 4ZJXA 2ILPA 3C89A 3V0BA 1XTGA 1I1EA 3DEBA 1ZKXA 3QW6A 3BOKA 3C88A 3NF3A 2QN0A 3BTAA 2FPQA 2ISEA 1F82A 4ZKTB 4KTXA 3FIEA 2ISHA 3ZUSA 1ZN3A 4HEVA 2IMBA 4ELCA 1YVGA 1ZL5A 2ETFA 2G7PA 3ZUQA 2W2DA 3C8AA 1G9BA 4KUFA 3FFZA 1S0CA 3FIIA 4KS6A 1G9DA 3C8BA 2G7KA 1E1HA 2XHLA 1T3CA 1S0DA 3QJ0A 2G7QA 1XTFA 3QIZA 2A8AA 3DS9A 2ISGA 2A97A 3DDBA 3ZURA 1ZL6A 3QIYA 1T3AA 4EL4A 1S0BA 3V0AB 3QW8A 3QW5A 1ZB7A 3QW7A 4EJ5A 3BONA 1S0FA 3DSEA 1EPWA 1G9CA 3V0BB 1Z7HA 2G7NA 2NYYA 2IMCA 2IMAA 5BQMA 3QIXA 3D3XA 3DDAA 5BQNA 4J1LA 1ZKWA 3VUOA 2NZ9A 3V0AA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2NP0 A;  1G9A A;  3BWI A;  1S0E A;  1F31 A;  3BOO A;  1S0G A;  3K3Q B;  4ZJX A;  2ILP A;  3C89 A;  3V0B A;  1XTG A;  1I1E A;  3DEB A;  1ZKX A;  3QW6 A;  3BOK A;  3C88 A;  3NF3 A;  2QN0 A;  3BTA A;  2FPQ A;  2ISE A;  1F82 A;  4ZKT B;  4KTX A;  3FIE A;  2ISH A;  3ZUS A;  1ZN3 A;  4HEV A;  2IMB A;  4ELC A;  1YVG A;  1ZL5 A;  2ETF A;  2G7P A;  3ZUQ A;  2W2D A;  3C8A A;  1G9B A;  4KUF A;  3FFZ A;  1S0C A;  3FII A;  4KS6 A;  1G9D A;  3C8B A;  2G7K A;  1E1H A;  2XHL A;  1T3C A;  1S0D A;  3QJ0 A;  2G7Q A;  1XTF A;  3QIZ A;  2A8A A;  3DS9 A;  2ISG A;  2A97 A;  3DDB A;  3ZUR A;  1ZL6 A;  3QIY A;  1T3A A;  4EL4 A;  1S0B A;  3V0A B;  3QW8 A;  3QW5 A;  1ZB7 A;  3QW7 A;  4EJ5 A;  3BON A;  1S0F A;  3DSE A;  1EPW A;  1G9C A;  3V0B B;  1Z7H A;  2G7N A;  2NYY A;  2IMC A;  2IMA A;  5BQM A;  3QIX A;  3D3X A;  3DDA A;  5BQN A;  4J1L A;  1ZKW A;  3VUO A;  2NZ9 A;  3V0A A; 
#chains in the Genus database with same CATH topology
 2NP0 A;  1G9A A;  3BWI A;  1S0E A;  1F31 A;  3BOO A;  1S0G A;  3K3Q B;  4ZJX A;  2ILP A;  3C89 A;  3V0B A;  1XTG A;  1I1E A;  3DEB A;  1ZKX A;  3QW6 A;  3BOK A;  3C88 A;  3NF3 A;  2QN0 A;  3BTA A;  2FPQ A;  2ISE A;  1F82 A;  4ZKT B;  4KTX A;  3FIE A;  2ISH A;  3ZUS A;  1ZN3 A;  4HEV A;  2IMB A;  4ELC A;  1YVG A;  1ZL5 A;  2ETF A;  2G7P A;  3ZUQ A;  2W2D A;  3C8A A;  1G9B A;  4KUF A;  3FFZ A;  1S0C A;  4IL3 A;  4JIX A;  3FII A;  3CQB A;  4KS6 A;  1G9D A;  3C8B A;  2G7K A;  1E1H A;  2XHL A;  1T3C A;  1S0D A;  3QJ0 A;  2G7Q A;  1XTF A;  3QIZ A;  2A8A A;  3DS9 A;  2YPT A;  2ISG A;  2A97 A;  3DDB A;  3ZUR A;  1ZL6 A;  3QIY A;  4AW6 A;  1T3A A;  4EL4 A;  1S0B A;  3V0A B;  3QW8 A;  3QW5 A;  1ZB7 A;  4JIU A;  3QW7 A;  4EJ5 A;  3BON A;  1S0F A;  3DSE A;  1EPW A;  1G9C A;  3V0B B;  1Z7H A;  2G7N A;  2NYY A;  2IMC A;  2IMA A;  5BQM A;  3QIX A;  3D3X A;  3DDA A;  4QHF A;  3E11 A;  5BQN A;  4J1L A;  1ZKW A;  3VUO A;  2NZ9 A;  2EJQ A;  3V0A A; 
#chains in the Genus database with same CATH homology
 2NP0 A;  1G9A A;  3BWI A;  1S0E A;  1F31 A;  3BOO A;  1S0G A;  3K3Q B;  4ZJX A;  2ILP A;  3C89 A;  3V0B A;  1XTG A;  1I1E A;  3DEB A;  1ZKX A;  3QW6 A;  3BOK A;  3C88 A;  3NF3 A;  2QN0 A;  3BTA A;  2FPQ A;  2ISE A;  1F82 A;  4ZKT B;  4KTX A;  3FIE A;  2ISH A;  3ZUS A;  1ZN3 A;  4HEV A;  2IMB A;  4ELC A;  1YVG A;  1ZL5 A;  2ETF A;  2G7P A;  3ZUQ A;  2W2D A;  3C8A A;  1G9B A;  4KUF A;  3FFZ A;  1S0C A;  3FII A;  4KS6 A;  1G9D A;  3C8B A;  2G7K A;  1E1H A;  2XHL A;  1T3C A;  1S0D A;  3QJ0 A;  2G7Q A;  1XTF A;  3QIZ A;  2A8A A;  3DS9 A;  2ISG A;  2A97 A;  3DDB A;  3ZUR A;  1ZL6 A;  3QIY A;  1T3A A;  4EL4 A;  1S0B A;  3V0A B;  3QW8 A;  3QW5 A;  1ZB7 A;  3QW7 A;  4EJ5 A;  3BON A;  1S0F A;  3DSE A;  1EPW A;  1G9C A;  3V0B B;  1Z7H A;  2G7N A;  2NYY A;  2IMC A;  2IMA A;  5BQM A;  3QIX A;  3D3X A;  3DDA A;  5BQN A;  4J1L A;  1ZKW A;  3VUO A;  2NZ9 A;  3V0A A; 
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similar chains in the Genus database (?% sequence similarity)
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