3BONA

Structure of the c. botulinum neurotoxin serotype a with zn2+ cofactor bound
Total Genus 148
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
148
sequence length
422
structure length
416
Chain Sequence
QFVNKQFNYKDPVNGVDIAYIKIPGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Catalytic features of the botulinum neurotoxin A light chain revealed by high resolution structure of an inhibitory peptide complex.
pubmed doi rcsb
molecule tags Toxin
source organism Clostridium botulinum
molecule keywords Neurotoxin A
total genus 148
structure length 416
sequence length 422
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2007-12-17
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 3bonA00
1ZL6A 3FIIA 1XTGA 2ETFA 3DDAA 1G9BA 4J1LA 2ISEA 3BOKA 2XHLA 1T3AA 3DEBA 3DDBA 3V0AA 3FIEA 3V0AB 1G9CA 3C88A 3QJ0A 3BWIA 1ZKXA 3D3XA 2NZ9A 1E1HA 1G9AA 2A97A 2IMAA 2QN0A 3NF3A 1ZL5A 3V0BA 3FFZA 4ZJXA 1S0EA 3QW6A 3V0BB 3BOOA 2FPQA 1YVGA 3ZUSA 2IMCA 1S0BA 2IMBA 2ISHA 3DS9A 1T3CA 4ZKTB 3QIYA 1S0DA 2G7QA 3ZURA 1S0CA 4KS6A 3QW8A 4KUFA 2NP0A 3VUOA 1G9DA 3DSEA 1ZN3A 1XTFA 2G7KA 2G7PA 1Z7HA 1F82A 3C8BA 3QW7A 3QIXA 3C8AA 2W2DA 4EL4A 3BTAA 4KTXA 1ZB7A 5BQNA 2A8AA 3QW5A 3ZUQA 1S0FA 3C89A 3QIZA 4HEVA 1S0GA 1F31A 1EPWA 5BQMA 2ISGA 4EJ5A 3K3QB 1ZKWA 4ELCA 2NYYA 3BONA 2G7NA 2ILPA 1I1EA
chains in the Genus database with same CATH superfamily
1ZL6A 4IL3A 3FIIA 1XTGA 2ETFA 3DDAA 1G9BA 4J1LA 2EJQA 2ISEA 3BOKA 2XHLA 1T3AA 3DEBA 3DDBA 3V0AA 3FIEA 3V0AB 1G9CA 3C88A 3QJ0A 3BWIA 1ZKXA 3D3XA 2NZ9A 1E1HA 1G9AA 2A97A 2IMAA 2QN0A 3NF3A 1ZL5A 3V0BA 3FFZA 4ZJXA 1S0EA 3QW6A 3V0BB 2YPTA 3BOOA 2FPQA 1YVGA 3ZUSA 4JIUA 2IMCA 1S0BA 2IMBA 2ISHA 3DS9A 1T3CA 4ZKTB 3QIYA 1S0DA 2G7QA 3ZURA 1S0CA 4KS6A 3QW8A 3E11A 4KUFA 2NP0A 3VUOA 1G9DA 3DSEA 3CQBA 1ZN3A 1XTFA 2G7KA 2G7PA 1Z7HA 1F82A 3C8BA 3QW7A 3QIXA 3C8AA 2W2DA 4EL4A 3BTAA 4KTXA 1ZB7A 4AW6A 5BQNA 2A8AA 3QW5A 4JIXA 3ZUQA 1S0FA 3C89A 3QIZA 4HEVA 1S0GA 1F31A 4QHFA 1EPWA 5BQMA 2ISGA 4EJ5A 3K3QB 1ZKWA 4ELCA 2NYYA 3BONA 2G7NA 2ILPA 1I1EA
chains in the Genus database with same CATH topology
1ZL6A 3FIIA 1XTGA 2ETFA 3DDAA 1G9BA 4J1LA 2ISEA 3BOKA 2XHLA 1T3AA 3DEBA 3DDBA 3V0AA 3FIEA 3V0AB 1G9CA 3C88A 3QJ0A 3BWIA 1ZKXA 3D3XA 2NZ9A 1E1HA 1G9AA 2A97A 2IMAA 2QN0A 3NF3A 1ZL5A 3V0BA 3FFZA 4ZJXA 1S0EA 3QW6A 3V0BB 3BOOA 2FPQA 1YVGA 3ZUSA 2IMCA 1S0BA 2IMBA 2ISHA 3DS9A 1T3CA 4ZKTB 3QIYA 1S0DA 2G7QA 3ZURA 1S0CA 4KS6A 3QW8A 4KUFA 2NP0A 3VUOA 1G9DA 3DSEA 1ZN3A 1XTFA 2G7KA 2G7PA 1Z7HA 1F82A 3C8BA 3QW7A 3QIXA 3C8AA 2W2DA 4EL4A 3BTAA 4KTXA 1ZB7A 5BQNA 2A8AA 3QW5A 3ZUQA 1S0FA 3C89A 3QIZA 4HEVA 1S0GA 1F31A 1EPWA 5BQMA 2ISGA 4EJ5A 3K3QB 1ZKWA 4ELCA 2NYYA 3BONA 2G7NA 2ILPA 1I1EA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ZL6 A;  3FII A;  1XTG A;  2ETF A;  3DDA A;  1G9B A;  4J1L A;  2ISE A;  3BOK A;  2XHL A;  1T3A A;  3DEB A;  3DDB A;  3V0A A;  3FIE A;  3V0A B;  1G9C A;  3C88 A;  3QJ0 A;  3BWI A;  1ZKX A;  3D3X A;  2NZ9 A;  1E1H A;  1G9A A;  2A97 A;  2IMA A;  2QN0 A;  3NF3 A;  1ZL5 A;  3V0B A;  3FFZ A;  4ZJX A;  1S0E A;  3QW6 A;  3V0B B;  3BOO A;  2FPQ A;  1YVG A;  3ZUS A;  2IMC A;  1S0B A;  2IMB A;  2ISH A;  3DS9 A;  1T3C A;  4ZKT B;  3QIY A;  1S0D A;  2G7Q A;  3ZUR A;  1S0C A;  4KS6 A;  3QW8 A;  4KUF A;  2NP0 A;  3VUO A;  1G9D A;  3DSE A;  1ZN3 A;  1XTF A;  2G7K A;  2G7P A;  1Z7H A;  1F82 A;  3C8B A;  3QW7 A;  3QIX A;  3C8A A;  2W2D A;  4EL4 A;  3BTA A;  4KTX A;  1ZB7 A;  5BQN A;  2A8A A;  3QW5 A;  3ZUQ A;  1S0F A;  3C89 A;  3QIZ A;  4HEV A;  1S0G A;  1F31 A;  1EPW A;  5BQM A;  2ISG A;  4EJ5 A;  3K3Q B;  1ZKW A;  4ELC A;  2NYY A;  3BON A;  2G7N A;  2ILP A;  1I1E A; 
#chains in the Genus database with same CATH topology
 1ZL6 A;  4IL3 A;  3FII A;  1XTG A;  2ETF A;  3DDA A;  1G9B A;  4J1L A;  2EJQ A;  2ISE A;  3BOK A;  2XHL A;  1T3A A;  3DEB A;  3DDB A;  3V0A A;  3FIE A;  3V0A B;  1G9C A;  3C88 A;  3QJ0 A;  3BWI A;  1ZKX A;  3D3X A;  2NZ9 A;  1E1H A;  1G9A A;  2A97 A;  2IMA A;  2QN0 A;  3NF3 A;  1ZL5 A;  3V0B A;  3FFZ A;  4ZJX A;  1S0E A;  3QW6 A;  3V0B B;  2YPT A;  3BOO A;  2FPQ A;  1YVG A;  3ZUS A;  4JIU A;  2IMC A;  1S0B A;  2IMB A;  2ISH A;  3DS9 A;  1T3C A;  4ZKT B;  3QIY A;  1S0D A;  2G7Q A;  3ZUR A;  1S0C A;  4KS6 A;  3QW8 A;  3E11 A;  4KUF A;  2NP0 A;  3VUO A;  1G9D A;  3DSE A;  3CQB A;  1ZN3 A;  1XTF A;  2G7K A;  2G7P A;  1Z7H A;  1F82 A;  3C8B A;  3QW7 A;  3QIX A;  3C8A A;  2W2D A;  4EL4 A;  3BTA A;  4KTX A;  1ZB7 A;  4AW6 A;  5BQN A;  2A8A A;  3QW5 A;  4JIX A;  3ZUQ A;  1S0F A;  3C89 A;  3QIZ A;  4HEV A;  1S0G A;  1F31 A;  4QHF A;  1EPW A;  5BQM A;  2ISG A;  4EJ5 A;  3K3Q B;  1ZKW A;  4ELC A;  2NYY A;  3BON A;  2G7N A;  2ILP A;  1I1E A; 
#chains in the Genus database with same CATH homology
 1ZL6 A;  3FII A;  1XTG A;  2ETF A;  3DDA A;  1G9B A;  4J1L A;  2ISE A;  3BOK A;  2XHL A;  1T3A A;  3DEB A;  3DDB A;  3V0A A;  3FIE A;  3V0A B;  1G9C A;  3C88 A;  3QJ0 A;  3BWI A;  1ZKX A;  3D3X A;  2NZ9 A;  1E1H A;  1G9A A;  2A97 A;  2IMA A;  2QN0 A;  3NF3 A;  1ZL5 A;  3V0B A;  3FFZ A;  4ZJX A;  1S0E A;  3QW6 A;  3V0B B;  3BOO A;  2FPQ A;  1YVG A;  3ZUS A;  2IMC A;  1S0B A;  2IMB A;  2ISH A;  3DS9 A;  1T3C A;  4ZKT B;  3QIY A;  1S0D A;  2G7Q A;  3ZUR A;  1S0C A;  4KS6 A;  3QW8 A;  4KUF A;  2NP0 A;  3VUO A;  1G9D A;  3DSE A;  1ZN3 A;  1XTF A;  2G7K A;  2G7P A;  1Z7H A;  1F82 A;  3C8B A;  3QW7 A;  3QIX A;  3C8A A;  2W2D A;  4EL4 A;  3BTA A;  4KTX A;  1ZB7 A;  5BQN A;  2A8A A;  3QW5 A;  3ZUQ A;  1S0F A;  3C89 A;  3QIZ A;  4HEV A;  1S0G A;  1F31 A;  1EPW A;  5BQM A;  2ISG A;  4EJ5 A;  3K3Q B;  1ZKW A;  4ELC A;  2NYY A;  3BON A;  2G7N A;  2ILP A;  1I1E A; 
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similar chains in the Genus database (?% sequence similarity)
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#similar chains in the Genus database (?% sequence similarity)
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