3C8BA

Crystal structure of the catalytic domain of botulinum neurotoxin serotype a with inhibitory peptide rrgi
Total Genus 136
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
136
sequence length
423
structure length
423
Chain Sequence
MPFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure- and Substrate-based Inhibitor Design for Clostridium botulinum Neurotoxin Serotype A
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Clostridium botulinum
molecule keywords Botulinum neurotoxin A light chain
total genus 136
structure length 423
sequence length 423
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2008-02-11
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 3c8bA00
1YVGA 5BQNA 3VUOA 4ZKTB 2IMCA 1ZKWA 3NF3A 1ZN3A 1S0FA 3QIXA 3C89A 3C8BA 3DDAA 2G7PA 2QN0A 1S0GA 1S0CA 1EPWA 3DS9A 3QIZA 3BWIA 3ZURA 1T3AA 1I1EA 3FIIA 3BTAA 3QW6A 1G9BA 3V0AB 3QIYA 2A97A 2W2DA 4KTXA 1T3CA 1XTFA 2ISEA 3QW7A 3ZUQA 1E1HA 1G9AA 1XTGA 1ZL5A 1G9CA 1ZKXA 3V0BB 3BOOA 3QW5A 2NYYA 2NZ9A 2G7QA 3BONA 2G7KA 3FFZA 2NP0A 4HEVA 1F82A 2IMBA 1S0EA 1S0BA 4J1LA 2ILPA 3V0AA 1ZB7A 2G7NA 3BOKA 3C8AA 2ISGA 3FIEA 3QJ0A 3ZUSA 4ELCA 4KUFA 3V0BA 2FPQA 2IMAA 3C88A 4EJ5A 1G9DA 3DSEA 3QW8A 2XHLA 1ZL6A 2ISHA 2A8AA 4EL4A 3DDBA 4ZJXA 3K3QB 3D3XA 1S0DA 3DEBA 4KS6A 5BQMA 1Z7HA 2ETFA 1F31A
chains in the Genus database with same CATH superfamily
1YVGA 5BQNA 4QHFA 3VUOA 4ZKTB 2IMCA 1ZKWA 3NF3A 3CQBA 1ZN3A 1S0FA 3QIXA 3C89A 3C8BA 3DDAA 2G7PA 2QN0A 4AW6A 1S0GA 1S0CA 1EPWA 3DS9A 3QIZA 3BWIA 3ZURA 1T3AA 1I1EA 3FIIA 3BTAA 3QW6A 1G9BA 3V0AB 3QIYA 2A97A 2W2DA 4IL3A 4KTXA 1T3CA 1XTFA 2ISEA 3QW7A 3ZUQA 1E1HA 1G9AA 1XTGA 1ZL5A 1G9CA 1ZKXA 3V0BB 4JIUA 2EJQA 3BOOA 3QW5A 2NYYA 2NZ9A 2G7QA 3BONA 2G7KA 3FFZA 2NP0A 3E11A 4HEVA 1F82A 2IMBA 1S0EA 1S0BA 4J1LA 2ILPA 3V0AA 1ZB7A 2G7NA 3BOKA 3C8AA 4JIXA 2ISGA 3FIEA 3QJ0A 3ZUSA 4ELCA 4KUFA 3V0BA 2FPQA 2IMAA 2YPTA 3C88A 4EJ5A 1G9DA 3DSEA 3QW8A 2XHLA 1ZL6A 2ISHA 2A8AA 4EL4A 3DDBA 4ZJXA 3K3QB 3D3XA 1S0DA 3DEBA 4KS6A 5BQMA 1Z7HA 2ETFA 1F31A
chains in the Genus database with same CATH topology
1YVGA 5BQNA 3VUOA 4ZKTB 2IMCA 1ZKWA 3NF3A 1ZN3A 1S0FA 3QIXA 3C89A 3C8BA 3DDAA 2G7PA 2QN0A 1S0GA 1S0CA 1EPWA 3DS9A 3QIZA 3BWIA 3ZURA 1T3AA 1I1EA 3FIIA 3BTAA 3QW6A 1G9BA 3V0AB 3QIYA 2A97A 2W2DA 4KTXA 1T3CA 1XTFA 2ISEA 3QW7A 3ZUQA 1E1HA 1G9AA 1XTGA 1ZL5A 1G9CA 1ZKXA 3V0BB 3BOOA 3QW5A 2NYYA 2NZ9A 2G7QA 3BONA 2G7KA 3FFZA 2NP0A 4HEVA 1F82A 2IMBA 1S0EA 1S0BA 4J1LA 2ILPA 3V0AA 1ZB7A 2G7NA 3BOKA 3C8AA 2ISGA 3FIEA 3QJ0A 3ZUSA 4ELCA 4KUFA 3V0BA 2FPQA 2IMAA 3C88A 4EJ5A 1G9DA 3DSEA 3QW8A 2XHLA 1ZL6A 2ISHA 2A8AA 4EL4A 3DDBA 4ZJXA 3K3QB 3D3XA 1S0DA 3DEBA 4KS6A 5BQMA 1Z7HA 2ETFA 1F31A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YVG A;  5BQN A;  3VUO A;  4ZKT B;  2IMC A;  1ZKW A;  3NF3 A;  1ZN3 A;  1S0F A;  3QIX A;  3C89 A;  3C8B A;  3DDA A;  2G7P A;  2QN0 A;  1S0G A;  1S0C A;  1EPW A;  3DS9 A;  3QIZ A;  3BWI A;  3ZUR A;  1T3A A;  1I1E A;  3FII A;  3BTA A;  3QW6 A;  1G9B A;  3V0A B;  3QIY A;  2A97 A;  2W2D A;  4KTX A;  1T3C A;  1XTF A;  2ISE A;  3QW7 A;  3ZUQ A;  1E1H A;  1G9A A;  1XTG A;  1ZL5 A;  1G9C A;  1ZKX A;  3V0B B;  3BOO A;  3QW5 A;  2NYY A;  2NZ9 A;  2G7Q A;  3BON A;  2G7K A;  3FFZ A;  2NP0 A;  4HEV A;  1F82 A;  2IMB A;  1S0E A;  1S0B A;  4J1L A;  2ILP A;  3V0A A;  1ZB7 A;  2G7N A;  3BOK A;  3C8A A;  2ISG A;  3FIE A;  3QJ0 A;  3ZUS A;  4ELC A;  4KUF A;  3V0B A;  2FPQ A;  2IMA A;  3C88 A;  4EJ5 A;  1G9D A;  3DSE A;  3QW8 A;  2XHL A;  1ZL6 A;  2ISH A;  2A8A A;  4EL4 A;  3DDB A;  4ZJX A;  3K3Q B;  3D3X A;  1S0D A;  3DEB A;  4KS6 A;  5BQM A;  1Z7H A;  2ETF A;  1F31 A; 
#chains in the Genus database with same CATH topology
 1YVG A;  5BQN A;  4QHF A;  3VUO A;  4ZKT B;  2IMC A;  1ZKW A;  3NF3 A;  3CQB A;  1ZN3 A;  1S0F A;  3QIX A;  3C89 A;  3C8B A;  3DDA A;  2G7P A;  2QN0 A;  4AW6 A;  1S0G A;  1S0C A;  1EPW A;  3DS9 A;  3QIZ A;  3BWI A;  3ZUR A;  1T3A A;  1I1E A;  3FII A;  3BTA A;  3QW6 A;  1G9B A;  3V0A B;  3QIY A;  2A97 A;  2W2D A;  4IL3 A;  4KTX A;  1T3C A;  1XTF A;  2ISE A;  3QW7 A;  3ZUQ A;  1E1H A;  1G9A A;  1XTG A;  1ZL5 A;  1G9C A;  1ZKX A;  3V0B B;  4JIU A;  2EJQ A;  3BOO A;  3QW5 A;  2NYY A;  2NZ9 A;  2G7Q A;  3BON A;  2G7K A;  3FFZ A;  2NP0 A;  3E11 A;  4HEV A;  1F82 A;  2IMB A;  1S0E A;  1S0B A;  4J1L A;  2ILP A;  3V0A A;  1ZB7 A;  2G7N A;  3BOK A;  3C8A A;  4JIX A;  2ISG A;  3FIE A;  3QJ0 A;  3ZUS A;  4ELC A;  4KUF A;  3V0B A;  2FPQ A;  2IMA A;  2YPT A;  3C88 A;  4EJ5 A;  1G9D A;  3DSE A;  3QW8 A;  2XHL A;  1ZL6 A;  2ISH A;  2A8A A;  4EL4 A;  3DDB A;  4ZJX A;  3K3Q B;  3D3X A;  1S0D A;  3DEB A;  4KS6 A;  5BQM A;  1Z7H A;  2ETF A;  1F31 A; 
#chains in the Genus database with same CATH homology
 1YVG A;  5BQN A;  3VUO A;  4ZKT B;  2IMC A;  1ZKW A;  3NF3 A;  1ZN3 A;  1S0F A;  3QIX A;  3C89 A;  3C8B A;  3DDA A;  2G7P A;  2QN0 A;  1S0G A;  1S0C A;  1EPW A;  3DS9 A;  3QIZ A;  3BWI A;  3ZUR A;  1T3A A;  1I1E A;  3FII A;  3BTA A;  3QW6 A;  1G9B A;  3V0A B;  3QIY A;  2A97 A;  2W2D A;  4KTX A;  1T3C A;  1XTF A;  2ISE A;  3QW7 A;  3ZUQ A;  1E1H A;  1G9A A;  1XTG A;  1ZL5 A;  1G9C A;  1ZKX A;  3V0B B;  3BOO A;  3QW5 A;  2NYY A;  2NZ9 A;  2G7Q A;  3BON A;  2G7K A;  3FFZ A;  2NP0 A;  4HEV A;  1F82 A;  2IMB A;  1S0E A;  1S0B A;  4J1L A;  2ILP A;  3V0A A;  1ZB7 A;  2G7N A;  3BOK A;  3C8A A;  2ISG A;  3FIE A;  3QJ0 A;  3ZUS A;  4ELC A;  4KUF A;  3V0B A;  2FPQ A;  2IMA A;  3C88 A;  4EJ5 A;  1G9D A;  3DSE A;  3QW8 A;  2XHL A;  1ZL6 A;  2ISH A;  2A8A A;  4EL4 A;  3DDB A;  4ZJX A;  3K3Q B;  3D3X A;  1S0D A;  3DEB A;  4KS6 A;  5BQM A;  1Z7H A;  2ETF A;  1F31 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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