The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
141
|
sequence length |
423
|
structure length |
423
|
Chain Sequence |
MPFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLF
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Substrate binding mode and its implication on drug design for botulinum neurotoxin A
pubmed doi rcsb |
| molecule tags |
Hydrolase
|
| source organism |
Clostridium botulinum
|
| molecule keywords |
Botulinum neurotoxin A light chain
|
| total genus |
141
|
| structure length |
423
|
| sequence length |
423
|
| ec nomenclature |
ec
3.4.24.69: Bontoxilysin. |
| pdb deposition date | 2008-06-05 |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Alpha Beta | Alpha-Beta Complex | Zincin-like | Metalloproteases ("zincins"), catalytic domain like |
#chains in the Genus database with same CATH superfamily 2QN0 A; 3V0A B; 3BOK A; 2W2D A; 1S0D A; 4ZJX A; 1XTF A; 1T3C A; 3V0B B; 4ELC A; 2ISH A; 2ETF A; 1S0E A; 1S0C A; 1ZL6 A; 2XHL A; 3ZUQ A; 5BQN A; 1S0B A; 4EL4 A; 1S0G A; 3C8A A; 1Z7H A; 3BWI A; 2A8A A; 4HEV A; 3QW5 A; 1F82 A; 3DSE A; 4ZKT B; 2IMB A; 3QW6 A; 1ZKX A; 1T3A A; 3FFZ A; 3DS9 A; 3ZUR A; 1YVG A; 3D3X A; 3QW7 A; 5BQM A; 1F31 A; 2NZ9 A; 2NYY A; 1G9B A; 3C8B A; 3QIY A; 3BTA A; 2ILP A; 3K3Q B; 1G9C A; 3QIZ A; 3V0A A; 1S0F A; 3QW8 A; 1ZKW A; 3FII A; 3DDA A; 3QIX A; 1I1E A; 1G9A A; 2A97 A; 1EPW A; 3C88 A; 3BON A; 4KS6 A; 2IMC A; 4EJ5 A; 1XTG A; 3V0B A; 3C89 A; 3QJ0 A; 3FIE A; 2ISG A; 4KTX A; 1ZN3 A; 2IMA A; 3DDB A; 2G7Q A; 2G7K A; 3BOO A; 2NP0 A; 2ISE A; 4J1L A; 1G9D A; 1ZB7 A; 1E1H A; 3VUO A; 1ZL5 A; 3ZUS A; 2G7P A; 2G7N A; 3DEB A; 2FPQ A; 3NF3 A; 4KUF A; #chains in the Genus database with same CATH topology 2QN0 A; 3V0A B; 3BOK A; 2W2D A; 1S0D A; 4ZJX A; 1XTF A; 1T3C A; 3V0B B; 4ELC A; 2ISH A; 2ETF A; 1S0E A; 1S0C A; 1ZL6 A; 2YPT A; 2XHL A; 3ZUQ A; 5BQN A; 1S0B A; 4EL4 A; 1S0G A; 3C8A A; 1Z7H A; 3BWI A; 2A8A A; 4HEV A; 3QW5 A; 1F82 A; 3DSE A; 4ZKT B; 4JIX A; 2IMB A; 3QW6 A; 1ZKX A; 1T3A A; 3FFZ A; 3DS9 A; 3ZUR A; 1YVG A; 3CQB A; 3D3X A; 3QW7 A; 5BQM A; 1F31 A; 2EJQ A; 2NZ9 A; 2NYY A; 1G9B A; 3C8B A; 3QIY A; 3BTA A; 2ILP A; 3K3Q B; 1G9C A; 3QIZ A; 3V0A A; 1S0F A; 3QW8 A; 1ZKW A; 3FII A; 3DDA A; 3QIX A; 1I1E A; 1G9A A; 2A97 A; 1EPW A; 3C88 A; 3BON A; 4KS6 A; 2IMC A; 4EJ5 A; 1XTG A; 3V0B A; 3C89 A; 3QJ0 A; 4IL3 A; 3FIE A; 3E11 A; 2ISG A; 4KTX A; 1ZN3 A; 2IMA A; 3DDB A; 4JIU A; 2G7Q A; 2G7K A; 3BOO A; 2NP0 A; 2ISE A; 4J1L A; 1G9D A; 1ZB7 A; 1E1H A; 3VUO A; 1ZL5 A; 3ZUS A; 4AW6 A; 2G7P A; 2G7N A; 3DEB A; 2FPQ A; 4QHF A; 3NF3 A; 4KUF A; #chains in the Genus database with same CATH homology 2QN0 A; 3V0A B; 3BOK A; 2W2D A; 1S0D A; 4ZJX A; 1XTF A; 1T3C A; 3V0B B; 4ELC A; 2ISH A; 2ETF A; 1S0E A; 1S0C A; 1ZL6 A; 2XHL A; 3ZUQ A; 5BQN A; 1S0B A; 4EL4 A; 1S0G A; 3C8A A; 1Z7H A; 3BWI A; 2A8A A; 4HEV A; 3QW5 A; 1F82 A; 3DSE A; 4ZKT B; 2IMB A; 3QW6 A; 1ZKX A; 1T3A A; 3FFZ A; 3DS9 A; 3ZUR A; 1YVG A; 3D3X A; 3QW7 A; 5BQM A; 1F31 A; 2NZ9 A; 2NYY A; 1G9B A; 3C8B A; 3QIY A; 3BTA A; 2ILP A; 3K3Q B; 1G9C A; 3QIZ A; 3V0A A; 1S0F A; 3QW8 A; 1ZKW A; 3FII A; 3DDA A; 3QIX A; 1I1E A; 1G9A A; 2A97 A; 1EPW A; 3C88 A; 3BON A; 4KS6 A; 2IMC A; 4EJ5 A; 1XTG A; 3V0B A; 3C89 A; 3QJ0 A; 3FIE A; 2ISG A; 4KTX A; 1ZN3 A; 2IMA A; 3DDB A; 2G7Q A; 2G7K A; 3BOO A; 2NP0 A; 2ISE A; 4J1L A; 1G9D A; 1ZB7 A; 1E1H A; 3VUO A; 1ZL5 A; 3ZUS A; 2G7P A; 2G7N A; 3DEB A; 2FPQ A; 3NF3 A; 4KUF A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
