3DS9A

A potent peptidomimetic inhibitor of botulinum neurotoxin serotype a has a very different conformation than snap-25 substrate
Total Genus 133
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
133
sequence length
415
structure length
398
Chain Sequence
FVNKQFNYKDPVNGVDIAYIKIPNAMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEEAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNASGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase, toxin
source organism Clostridium botulinum
publication title A Potent Peptidomimetic Inhibitor of Botulinum Neurotoxin Serotype A Has a Very Different Conformation than SNAP-25 Substrate
pubmed doi rcsb
molecule keywords Botulinum neurotoxin type A
total genus 133
structure length 398
sequence length 415
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2008-07-11
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 3ds9A00
3NF3A 1G9CA 3V0AB 3FFZA 1G9DA 1YVGA 4ELCA 2NP0A 1T3CA 2W2DA 2ETFA 1G9BA 4KTXA 1S0EA 3V0AA 1XTFA 2XHLA 1S0DA 3BOKA 3DDAA 2QN0A 1ZN3A 3BTAA 3V0BB 1Z7HA 1S0BA 3C88A 3BOOA 1ZKWA 1ZL5A 2G7QA 5BQNA 2ISGA 3FIEA 3DSEA 3V0BA 4ZJXA 2IMBA 3VUOA 1S0GA 1E1HA 2ILPA 4EL4A 1G9AA 3QIXA 3QIYA 1EPWA 3QW8A 5BQMA 3C8BA 2NYYA 1ZL6A 3FIIA 2IMAA 3DEBA 3BWIA 2G7NA 2ISHA 3D3XA 3C89A 2G7KA 4ZKTB 2A97A 2A8AA 3QW7A 4EJ5A 1F31A 1ZB7A 1S0FA 3BONA 3QJ0A 3ZUSA 1XTGA 2G7PA 3C8AA 3K3QB 2FPQA 3ZUQA 3QW6A 2IMCA 1I1EA 4HEVA 3DS9A 1T3AA 2ISEA 3ZURA 3QW5A 3QIZA 1F82A 1ZKXA 3DDBA 4KUFA 2NZ9A 4J1LA 1S0CA 4KS6A
chains in the Genus database with same CATH superfamily
2YPTA 3NF3A 1G9CA 3V0AB 3FFZA 1G9DA 1YVGA 4ELCA 2NP0A 1T3CA 4QHFA 2W2DA 2ETFA 1G9BA 4KTXA 1S0EA 3V0AA 1XTFA 2XHLA 1S0DA 3E11A 3BOKA 3DDAA 2QN0A 1ZN3A 3BTAA 3V0BB 1Z7HA 1S0BA 3C88A 4JIXA 3BOOA 1ZKWA 1ZL5A 2G7QA 5BQNA 2ISGA 4JIUA 3FIEA 3DSEA 3V0BA 4ZJXA 2IMBA 3VUOA 1S0GA 1E1HA 2ILPA 4EL4A 1G9AA 3QIXA 3QIYA 1EPWA 3QW8A 5BQMA 3C8BA 2NYYA 1ZL6A 3FIIA 2IMAA 3DEBA 3BWIA 2G7NA 2ISHA 3D3XA 3C89A 2G7KA 4ZKTB 2A97A 2A8AA 3QW7A 4EJ5A 1F31A 1ZB7A 1S0FA 3BONA 3QJ0A 3ZUSA 1XTGA 2G7PA 3C8AA 3K3QB 2FPQA 3ZUQA 4AW6A 3QW6A 2IMCA 1I1EA 4HEVA 3DS9A 1T3AA 2ISEA 3ZURA 3CQBA 3QW5A 3QIZA 1F82A 1ZKXA 3DDBA 4KUFA 2NZ9A 4IL3A 4J1LA 2EJQA 1S0CA 4KS6A
chains in the Genus database with same CATH topology
3NF3A 1G9CA 3V0AB 3FFZA 1G9DA 1YVGA 4ELCA 2NP0A 1T3CA 2W2DA 2ETFA 1G9BA 4KTXA 1S0EA 3V0AA 1XTFA 2XHLA 1S0DA 3BOKA 3DDAA 2QN0A 1ZN3A 3BTAA 3V0BB 1Z7HA 1S0BA 3C88A 3BOOA 1ZKWA 1ZL5A 2G7QA 5BQNA 2ISGA 3FIEA 3DSEA 3V0BA 4ZJXA 2IMBA 3VUOA 1S0GA 1E1HA 2ILPA 4EL4A 1G9AA 3QIXA 3QIYA 1EPWA 3QW8A 5BQMA 3C8BA 2NYYA 1ZL6A 3FIIA 2IMAA 3DEBA 3BWIA 2G7NA 2ISHA 3D3XA 3C89A 2G7KA 4ZKTB 2A97A 2A8AA 3QW7A 4EJ5A 1F31A 1ZB7A 1S0FA 3BONA 3QJ0A 3ZUSA 1XTGA 2G7PA 3C8AA 3K3QB 2FPQA 3ZUQA 3QW6A 2IMCA 1I1EA 4HEVA 3DS9A 1T3AA 2ISEA 3ZURA 3QW5A 3QIZA 1F82A 1ZKXA 3DDBA 4KUFA 2NZ9A 4J1LA 1S0CA 4KS6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3NF3 A;  1G9C A;  3V0A B;  3FFZ A;  1G9D A;  1YVG A;  4ELC A;  2NP0 A;  1T3C A;  2W2D A;  2ETF A;  1G9B A;  4KTX A;  1S0E A;  3V0A A;  1XTF A;  2XHL A;  1S0D A;  3BOK A;  3DDA A;  2QN0 A;  1ZN3 A;  3BTA A;  3V0B B;  1Z7H A;  1S0B A;  3C88 A;  3BOO A;  1ZKW A;  1ZL5 A;  2G7Q A;  5BQN A;  2ISG A;  3FIE A;  3DSE A;  3V0B A;  4ZJX A;  2IMB A;  3VUO A;  1S0G A;  1E1H A;  2ILP A;  4EL4 A;  1G9A A;  3QIX A;  3QIY A;  1EPW A;  3QW8 A;  5BQM A;  3C8B A;  2NYY A;  1ZL6 A;  3FII A;  2IMA A;  3DEB A;  3BWI A;  2G7N A;  2ISH A;  3D3X A;  3C89 A;  2G7K A;  4ZKT B;  2A97 A;  2A8A A;  3QW7 A;  4EJ5 A;  1F31 A;  1ZB7 A;  1S0F A;  3BON A;  3QJ0 A;  3ZUS A;  1XTG A;  2G7P A;  3C8A A;  3K3Q B;  2FPQ A;  3ZUQ A;  3QW6 A;  2IMC A;  1I1E A;  4HEV A;  3DS9 A;  1T3A A;  2ISE A;  3ZUR A;  3QW5 A;  3QIZ A;  1F82 A;  1ZKX A;  3DDB A;  4KUF A;  2NZ9 A;  4J1L A;  1S0C A;  4KS6 A; 
#chains in the Genus database with same CATH topology
 2YPT A;  3NF3 A;  1G9C A;  3V0A B;  3FFZ A;  1G9D A;  1YVG A;  4ELC A;  2NP0 A;  1T3C A;  4QHF A;  2W2D A;  2ETF A;  1G9B A;  4KTX A;  1S0E A;  3V0A A;  1XTF A;  2XHL A;  1S0D A;  3E11 A;  3BOK A;  3DDA A;  2QN0 A;  1ZN3 A;  3BTA A;  3V0B B;  1Z7H A;  1S0B A;  3C88 A;  4JIX A;  3BOO A;  1ZKW A;  1ZL5 A;  2G7Q A;  5BQN A;  2ISG A;  4JIU A;  3FIE A;  3DSE A;  3V0B A;  4ZJX A;  2IMB A;  3VUO A;  1S0G A;  1E1H A;  2ILP A;  4EL4 A;  1G9A A;  3QIX A;  3QIY A;  1EPW A;  3QW8 A;  5BQM A;  3C8B A;  2NYY A;  1ZL6 A;  3FII A;  2IMA A;  3DEB A;  3BWI A;  2G7N A;  2ISH A;  3D3X A;  3C89 A;  2G7K A;  4ZKT B;  2A97 A;  2A8A A;  3QW7 A;  4EJ5 A;  1F31 A;  1ZB7 A;  1S0F A;  3BON A;  3QJ0 A;  3ZUS A;  1XTG A;  2G7P A;  3C8A A;  3K3Q B;  2FPQ A;  3ZUQ A;  4AW6 A;  3QW6 A;  2IMC A;  1I1E A;  4HEV A;  3DS9 A;  1T3A A;  2ISE A;  3ZUR A;  3CQB A;  3QW5 A;  3QIZ A;  1F82 A;  1ZKX A;  3DDB A;  4KUF A;  2NZ9 A;  4IL3 A;  4J1L A;  2EJQ A;  1S0C A;  4KS6 A; 
#chains in the Genus database with same CATH homology
 3NF3 A;  1G9C A;  3V0A B;  3FFZ A;  1G9D A;  1YVG A;  4ELC A;  2NP0 A;  1T3C A;  2W2D A;  2ETF A;  1G9B A;  4KTX A;  1S0E A;  3V0A A;  1XTF A;  2XHL A;  1S0D A;  3BOK A;  3DDA A;  2QN0 A;  1ZN3 A;  3BTA A;  3V0B B;  1Z7H A;  1S0B A;  3C88 A;  3BOO A;  1ZKW A;  1ZL5 A;  2G7Q A;  5BQN A;  2ISG A;  3FIE A;  3DSE A;  3V0B A;  4ZJX A;  2IMB A;  3VUO A;  1S0G A;  1E1H A;  2ILP A;  4EL4 A;  1G9A A;  3QIX A;  3QIY A;  1EPW A;  3QW8 A;  5BQM A;  3C8B A;  2NYY A;  1ZL6 A;  3FII A;  2IMA A;  3DEB A;  3BWI A;  2G7N A;  2ISH A;  3D3X A;  3C89 A;  2G7K A;  4ZKT B;  2A97 A;  2A8A A;  3QW7 A;  4EJ5 A;  1F31 A;  1ZB7 A;  1S0F A;  3BON A;  3QJ0 A;  3ZUS A;  1XTG A;  2G7P A;  3C8A A;  3K3Q B;  2FPQ A;  3ZUQ A;  3QW6 A;  2IMC A;  1I1E A;  4HEV A;  3DS9 A;  1T3A A;  2ISE A;  3ZUR A;  3QW5 A;  3QIZ A;  1F82 A;  1ZKX A;  3DDB A;  4KUF A;  2NZ9 A;  4J1L A;  1S0C A;  4KS6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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