3K3QB

Crystal structure of a llama antibody complexed with the c. botulinum neurotoxin serotype a catalytic domain
Total Genus 64
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
64
sequence length
249
structure length
238
Chain Sequence
QFVNKQFNYKDPVNGVDIAYIKIPNVGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A Single-Domain Llama Antibody Potently Inhibits the Enzymatic Activity of Botulinum Neurotoxin by Binding to the Non-Catalytic alpha-Exosite Binding Region.
pubmed doi rcsb
molecule tags Immune system
source organism Lama glama
molecule keywords llama Aa1 VHH domain
total genus 64
structure length 238
sequence length 249
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2009-10-04
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 3k3qB00
1T3AA 2A8AA 3NF3A 4EJ5A 3ZURA 1S0EA 3QIYA 3DS9A 3K3QB 1S0BA 1EPWA 1Z7HA 3QIXA 2ISEA 3C89A 3C8BA 1ZL6A 2ISGA 2NP0A 2NZ9A 3BONA 1ZL5A 3QW6A 2FPQA 3QJ0A 1S0FA 4ELCA 1F82A 4KUFA 2ILPA 3ZUSA 3DEBA 3D3XA 2IMCA 3QIZA 1ZKWA 3QW8A 3DSEA 1E1HA 3VUOA 5BQNA 4J1LA 4KS6A 3BTAA 1YVGA 3C88A 3V0AA 4ZJXA 3BOOA 4KTXA 4EL4A 2G7PA 2G7KA 3BWIA 2IMBA 1S0CA 1G9BA 3V0AB 4HEVA 3V0BA 5BQMA 1I1EA 4ZKTB 2QN0A 3C8AA 2XHLA 3V0BB 3ZUQA 3QW7A 3FFZA 3FIEA 2A97A 1S0DA 3QW5A 2ISHA 1ZN3A 1G9DA 2NYYA 3DDBA 3DDAA 1T3CA 3FIIA 2G7NA 1XTFA 1F31A 1G9CA 2W2DA 1G9AA 2IMAA 2G7QA 1S0GA 3BOKA 1ZB7A 1XTGA 2ETFA 1ZKXA
chains in the Genus database with same CATH superfamily
1T3AA 4QHFA 2A8AA 3NF3A 4EJ5A 3ZURA 1S0EA 3QIYA 3DS9A 3K3QB 1S0BA 1EPWA 1Z7HA 3QIXA 3CQBA 2ISEA 3C89A 3C8BA 1ZL6A 2ISGA 2NP0A 2NZ9A 3BONA 1ZL5A 3QW6A 2FPQA 3QJ0A 1S0FA 4ELCA 1F82A 4KUFA 2ILPA 3ZUSA 3DEBA 3D3XA 2IMCA 3QIZA 4IL3A 1ZKWA 3QW8A 3DSEA 1E1HA 3VUOA 5BQNA 4J1LA 4KS6A 3BTAA 1YVGA 3C88A 3V0AA 4ZJXA 3BOOA 4JIUA 4KTXA 4EL4A 2G7PA 2G7KA 3BWIA 2IMBA 1S0CA 1G9BA 3E11A 3V0AB 4HEVA 3V0BA 4AW6A 5BQMA 1I1EA 2YPTA 4ZKTB 2QN0A 3C8AA 2XHLA 3V0BB 3ZUQA 3QW7A 3FFZA 3FIEA 2A97A 1S0DA 3QW5A 2ISHA 1ZN3A 1G9DA 2NYYA 3DDBA 3DDAA 1T3CA 3FIIA 2G7NA 1XTFA 1F31A 1G9CA 2W2DA 1G9AA 2IMAA 2G7QA 1S0GA 4JIXA 3BOKA 1ZB7A 1XTGA 2ETFA 1ZKXA 2EJQA
chains in the Genus database with same CATH topology
1T3AA 2A8AA 3NF3A 4EJ5A 3ZURA 1S0EA 3QIYA 3DS9A 3K3QB 1S0BA 1EPWA 1Z7HA 3QIXA 2ISEA 3C89A 3C8BA 1ZL6A 2ISGA 2NP0A 2NZ9A 3BONA 1ZL5A 3QW6A 2FPQA 3QJ0A 1S0FA 4ELCA 1F82A 4KUFA 2ILPA 3ZUSA 3DEBA 3D3XA 2IMCA 3QIZA 1ZKWA 3QW8A 3DSEA 1E1HA 3VUOA 5BQNA 4J1LA 4KS6A 3BTAA 1YVGA 3C88A 3V0AA 4ZJXA 3BOOA 4KTXA 4EL4A 2G7PA 2G7KA 3BWIA 2IMBA 1S0CA 1G9BA 3V0AB 4HEVA 3V0BA 5BQMA 1I1EA 4ZKTB 2QN0A 3C8AA 2XHLA 3V0BB 3ZUQA 3QW7A 3FFZA 3FIEA 2A97A 1S0DA 3QW5A 2ISHA 1ZN3A 1G9DA 2NYYA 3DDBA 3DDAA 1T3CA 3FIIA 2G7NA 1XTFA 1F31A 1G9CA 2W2DA 1G9AA 2IMAA 2G7QA 1S0GA 3BOKA 1ZB7A 1XTGA 2ETFA 1ZKXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1T3A A;  2A8A A;  3NF3 A;  4EJ5 A;  3ZUR A;  1S0E A;  3QIY A;  3DS9 A;  3K3Q B;  1S0B A;  1EPW A;  1Z7H A;  3QIX A;  2ISE A;  3C89 A;  3C8B A;  1ZL6 A;  2ISG A;  2NP0 A;  2NZ9 A;  3BON A;  1ZL5 A;  3QW6 A;  2FPQ A;  3QJ0 A;  1S0F A;  4ELC A;  1F82 A;  4KUF A;  2ILP A;  3ZUS A;  3DEB A;  3D3X A;  2IMC A;  3QIZ A;  1ZKW A;  3QW8 A;  3DSE A;  1E1H A;  3VUO A;  5BQN A;  4J1L A;  4KS6 A;  3BTA A;  1YVG A;  3C88 A;  3V0A A;  4ZJX A;  3BOO A;  4KTX A;  4EL4 A;  2G7P A;  2G7K A;  3BWI A;  2IMB A;  1S0C A;  1G9B A;  3V0A B;  4HEV A;  3V0B A;  5BQM A;  1I1E A;  4ZKT B;  2QN0 A;  3C8A A;  2XHL A;  3V0B B;  3ZUQ A;  3QW7 A;  3FFZ A;  3FIE A;  2A97 A;  1S0D A;  3QW5 A;  2ISH A;  1ZN3 A;  1G9D A;  2NYY A;  3DDB A;  3DDA A;  1T3C A;  3FII A;  2G7N A;  1XTF A;  1F31 A;  1G9C A;  2W2D A;  1G9A A;  2IMA A;  2G7Q A;  1S0G A;  3BOK A;  1ZB7 A;  1XTG A;  2ETF A;  1ZKX A; 
#chains in the Genus database with same CATH topology
 1T3A A;  4QHF A;  2A8A A;  3NF3 A;  4EJ5 A;  3ZUR A;  1S0E A;  3QIY A;  3DS9 A;  3K3Q B;  1S0B A;  1EPW A;  1Z7H A;  3QIX A;  3CQB A;  2ISE A;  3C89 A;  3C8B A;  1ZL6 A;  2ISG A;  2NP0 A;  2NZ9 A;  3BON A;  1ZL5 A;  3QW6 A;  2FPQ A;  3QJ0 A;  1S0F A;  4ELC A;  1F82 A;  4KUF A;  2ILP A;  3ZUS A;  3DEB A;  3D3X A;  2IMC A;  3QIZ A;  4IL3 A;  1ZKW A;  3QW8 A;  3DSE A;  1E1H A;  3VUO A;  5BQN A;  4J1L A;  4KS6 A;  3BTA A;  1YVG A;  3C88 A;  3V0A A;  4ZJX A;  3BOO A;  4JIU A;  4KTX A;  4EL4 A;  2G7P A;  2G7K A;  3BWI A;  2IMB A;  1S0C A;  1G9B A;  3E11 A;  3V0A B;  4HEV A;  3V0B A;  4AW6 A;  5BQM A;  1I1E A;  2YPT A;  4ZKT B;  2QN0 A;  3C8A A;  2XHL A;  3V0B B;  3ZUQ A;  3QW7 A;  3FFZ A;  3FIE A;  2A97 A;  1S0D A;  3QW5 A;  2ISH A;  1ZN3 A;  1G9D A;  2NYY A;  3DDB A;  3DDA A;  1T3C A;  3FII A;  2G7N A;  1XTF A;  1F31 A;  1G9C A;  2W2D A;  1G9A A;  2IMA A;  2G7Q A;  1S0G A;  4JIX A;  3BOK A;  1ZB7 A;  1XTG A;  2ETF A;  1ZKX A;  2EJQ A; 
#chains in the Genus database with same CATH homology
 1T3A A;  2A8A A;  3NF3 A;  4EJ5 A;  3ZUR A;  1S0E A;  3QIY A;  3DS9 A;  3K3Q B;  1S0B A;  1EPW A;  1Z7H A;  3QIX A;  2ISE A;  3C89 A;  3C8B A;  1ZL6 A;  2ISG A;  2NP0 A;  2NZ9 A;  3BON A;  1ZL5 A;  3QW6 A;  2FPQ A;  3QJ0 A;  1S0F A;  4ELC A;  1F82 A;  4KUF A;  2ILP A;  3ZUS A;  3DEB A;  3D3X A;  2IMC A;  3QIZ A;  1ZKW A;  3QW8 A;  3DSE A;  1E1H A;  3VUO A;  5BQN A;  4J1L A;  4KS6 A;  3BTA A;  1YVG A;  3C88 A;  3V0A A;  4ZJX A;  3BOO A;  4KTX A;  4EL4 A;  2G7P A;  2G7K A;  3BWI A;  2IMB A;  1S0C A;  1G9B A;  3V0A B;  4HEV A;  3V0B A;  5BQM A;  1I1E A;  4ZKT B;  2QN0 A;  3C8A A;  2XHL A;  3V0B B;  3ZUQ A;  3QW7 A;  3FFZ A;  3FIE A;  2A97 A;  1S0D A;  3QW5 A;  2ISH A;  1ZN3 A;  1G9D A;  2NYY A;  3DDB A;  3DDA A;  1T3C A;  3FII A;  2G7N A;  1XTF A;  1F31 A;  1G9C A;  2W2D A;  1G9A A;  2IMA A;  2G7Q A;  1S0G A;  3BOK A;  1ZB7 A;  1XTG A;  2ETF A;  1ZKX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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