3K3QB

Crystal structure of a llama antibody complexed with the c. botulinum neurotoxin serotype a catalytic domain
Total Genus 64
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
64
sequence length
249
structure length
238
Chain Sequence
QFVNKQFNYKDPVNGVDIAYIKIPNVGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A Single-Domain Llama Antibody Potently Inhibits the Enzymatic Activity of Botulinum Neurotoxin by Binding to the Non-Catalytic alpha-Exosite Binding Region.
pubmed doi rcsb
molecule tags Immune system
source organism Lama glama
molecule keywords llama Aa1 VHH domain
total genus 64
structure length 238
sequence length 249
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2009-10-04
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 3k3qB00
2ILPA 1S0DA 1G9BA 1E1HA 3BTAA 4ELCA 1ZKWA 3BONA 3FIEA 4ZKTB 3QW6A 2G7QA 2ISEA 1S0GA 2IMBA 1T3AA 3D3XA 1F82A 1T3CA 1I1EA 3DS9A 3QW7A 3C89A 4KUFA 5BQNA 2A8AA 3ZUQA 3QIXA 3VUOA 3ZUSA 2ISGA 3FIIA 3FFZA 3QJ0A 3QW8A 1G9AA 3C88A 3ZURA 2W2DA 1ZN3A 3BOOA 3BOKA 1Z7HA 1ZL5A 3DEBA 3V0AB 1F31A 1S0FA 2A97A 2NYYA 2XHLA 3C8AA 3V0BB 3NF3A 3DSEA 1G9DA 1YVGA 4HEVA 5BQMA 3DDBA 4ZJXA 2IMCA 2QN0A 4EJ5A 1G9CA 2G7PA 2ISHA 2FPQA 1ZKXA 2NZ9A 4J1LA 4KS6A 3DDAA 1S0CA 2ETFA 2IMAA 1EPWA 2G7NA 1S0EA 2G7KA 3QIYA 2NP0A 1S0BA 3QIZA 4EL4A 3C8BA 3K3QB 1XTFA 4KTXA 3QW5A 1ZL6A 1XTGA 3V0AA 3BWIA 1ZB7A 3V0BA
chains in the Genus database with same CATH superfamily
2ILPA 1S0DA 4QHFA 1G9BA 1E1HA 3BTAA 4ELCA 1ZKWA 3BONA 3FIEA 4ZKTB 3QW6A 2G7QA 2ISEA 1S0GA 2IMBA 1T3AA 3D3XA 1F82A 1T3CA 1I1EA 3DS9A 3QW7A 3C89A 4KUFA 5BQNA 2A8AA 3ZUQA 3QIXA 4AW6A 3VUOA 3ZUSA 2ISGA 3FIIA 3FFZA 3QJ0A 3QW8A 1G9AA 3C88A 3ZURA 2W2DA 1ZN3A 3CQBA 4IL3A 3BOOA 3BOKA 1Z7HA 1ZL5A 3DEBA 3V0AB 4JIXA 1F31A 1S0FA 2A97A 3E11A 2NYYA 2XHLA 3C8AA 3V0BB 3NF3A 3DSEA 2EJQA 1G9DA 1YVGA 4HEVA 5BQMA 3DDBA 4ZJXA 2IMCA 2QN0A 4EJ5A 1G9CA 2G7PA 4JIUA 2ISHA 2FPQA 1ZKXA 2NZ9A 4J1LA 4KS6A 3DDAA 1S0CA 2ETFA 2IMAA 1EPWA 2G7NA 1S0EA 2G7KA 3QIYA 2NP0A 1S0BA 3QIZA 4EL4A 3C8BA 3K3QB 1XTFA 2YPTA 4KTXA 3QW5A 1ZL6A 1XTGA 3V0AA 3BWIA 1ZB7A 3V0BA
chains in the Genus database with same CATH topology
2ILPA 1S0DA 1G9BA 1E1HA 3BTAA 4ELCA 1ZKWA 3BONA 3FIEA 4ZKTB 3QW6A 2G7QA 2ISEA 1S0GA 2IMBA 1T3AA 3D3XA 1F82A 1T3CA 1I1EA 3DS9A 3QW7A 3C89A 4KUFA 5BQNA 2A8AA 3ZUQA 3QIXA 3VUOA 3ZUSA 2ISGA 3FIIA 3FFZA 3QJ0A 3QW8A 1G9AA 3C88A 3ZURA 2W2DA 1ZN3A 3BOOA 3BOKA 1Z7HA 1ZL5A 3DEBA 3V0AB 1F31A 1S0FA 2A97A 2NYYA 2XHLA 3C8AA 3V0BB 3NF3A 3DSEA 1G9DA 1YVGA 4HEVA 5BQMA 3DDBA 4ZJXA 2IMCA 2QN0A 4EJ5A 1G9CA 2G7PA 2ISHA 2FPQA 1ZKXA 2NZ9A 4J1LA 4KS6A 3DDAA 1S0CA 2ETFA 2IMAA 1EPWA 2G7NA 1S0EA 2G7KA 3QIYA 2NP0A 1S0BA 3QIZA 4EL4A 3C8BA 3K3QB 1XTFA 4KTXA 3QW5A 1ZL6A 1XTGA 3V0AA 3BWIA 1ZB7A 3V0BA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ILP A;  1S0D A;  1G9B A;  1E1H A;  3BTA A;  4ELC A;  1ZKW A;  3BON A;  3FIE A;  4ZKT B;  3QW6 A;  2G7Q A;  2ISE A;  1S0G A;  2IMB A;  1T3A A;  3D3X A;  1F82 A;  1T3C A;  1I1E A;  3DS9 A;  3QW7 A;  3C89 A;  4KUF A;  5BQN A;  2A8A A;  3ZUQ A;  3QIX A;  3VUO A;  3ZUS A;  2ISG A;  3FII A;  3FFZ A;  3QJ0 A;  3QW8 A;  1G9A A;  3C88 A;  3ZUR A;  2W2D A;  1ZN3 A;  3BOO A;  3BOK A;  1Z7H A;  1ZL5 A;  3DEB A;  3V0A B;  1F31 A;  1S0F A;  2A97 A;  2NYY A;  2XHL A;  3C8A A;  3V0B B;  3NF3 A;  3DSE A;  1G9D A;  1YVG A;  4HEV A;  5BQM A;  3DDB A;  4ZJX A;  2IMC A;  2QN0 A;  4EJ5 A;  1G9C A;  2G7P A;  2ISH A;  2FPQ A;  1ZKX A;  2NZ9 A;  4J1L A;  4KS6 A;  3DDA A;  1S0C A;  2ETF A;  2IMA A;  1EPW A;  2G7N A;  1S0E A;  2G7K A;  3QIY A;  2NP0 A;  1S0B A;  3QIZ A;  4EL4 A;  3C8B A;  3K3Q B;  1XTF A;  4KTX A;  3QW5 A;  1ZL6 A;  1XTG A;  3V0A A;  3BWI A;  1ZB7 A;  3V0B A; 
#chains in the Genus database with same CATH topology
 2ILP A;  1S0D A;  4QHF A;  1G9B A;  1E1H A;  3BTA A;  4ELC A;  1ZKW A;  3BON A;  3FIE A;  4ZKT B;  3QW6 A;  2G7Q A;  2ISE A;  1S0G A;  2IMB A;  1T3A A;  3D3X A;  1F82 A;  1T3C A;  1I1E A;  3DS9 A;  3QW7 A;  3C89 A;  4KUF A;  5BQN A;  2A8A A;  3ZUQ A;  3QIX A;  4AW6 A;  3VUO A;  3ZUS A;  2ISG A;  3FII A;  3FFZ A;  3QJ0 A;  3QW8 A;  1G9A A;  3C88 A;  3ZUR A;  2W2D A;  1ZN3 A;  3CQB A;  4IL3 A;  3BOO A;  3BOK A;  1Z7H A;  1ZL5 A;  3DEB A;  3V0A B;  4JIX A;  1F31 A;  1S0F A;  2A97 A;  3E11 A;  2NYY A;  2XHL A;  3C8A A;  3V0B B;  3NF3 A;  3DSE A;  2EJQ A;  1G9D A;  1YVG A;  4HEV A;  5BQM A;  3DDB A;  4ZJX A;  2IMC A;  2QN0 A;  4EJ5 A;  1G9C A;  2G7P A;  4JIU A;  2ISH A;  2FPQ A;  1ZKX A;  2NZ9 A;  4J1L A;  4KS6 A;  3DDA A;  1S0C A;  2ETF A;  2IMA A;  1EPW A;  2G7N A;  1S0E A;  2G7K A;  3QIY A;  2NP0 A;  1S0B A;  3QIZ A;  4EL4 A;  3C8B A;  3K3Q B;  1XTF A;  2YPT A;  4KTX A;  3QW5 A;  1ZL6 A;  1XTG A;  3V0A A;  3BWI A;  1ZB7 A;  3V0B A; 
#chains in the Genus database with same CATH homology
 2ILP A;  1S0D A;  1G9B A;  1E1H A;  3BTA A;  4ELC A;  1ZKW A;  3BON A;  3FIE A;  4ZKT B;  3QW6 A;  2G7Q A;  2ISE A;  1S0G A;  2IMB A;  1T3A A;  3D3X A;  1F82 A;  1T3C A;  1I1E A;  3DS9 A;  3QW7 A;  3C89 A;  4KUF A;  5BQN A;  2A8A A;  3ZUQ A;  3QIX A;  3VUO A;  3ZUS A;  2ISG A;  3FII A;  3FFZ A;  3QJ0 A;  3QW8 A;  1G9A A;  3C88 A;  3ZUR A;  2W2D A;  1ZN3 A;  3BOO A;  3BOK A;  1Z7H A;  1ZL5 A;  3DEB A;  3V0A B;  1F31 A;  1S0F A;  2A97 A;  2NYY A;  2XHL A;  3C8A A;  3V0B B;  3NF3 A;  3DSE A;  1G9D A;  1YVG A;  4HEV A;  5BQM A;  3DDB A;  4ZJX A;  2IMC A;  2QN0 A;  4EJ5 A;  1G9C A;  2G7P A;  2ISH A;  2FPQ A;  1ZKX A;  2NZ9 A;  4J1L A;  4KS6 A;  3DDA A;  1S0C A;  2ETF A;  2IMA A;  1EPW A;  2G7N A;  1S0E A;  2G7K A;  3QIY A;  2NP0 A;  1S0B A;  3QIZ A;  4EL4 A;  3C8B A;  3K3Q B;  1XTF A;  4KTX A;  3QW5 A;  1ZL6 A;  1XTG A;  3V0A A;  3BWI A;  1ZB7 A;  3V0B A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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