The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
133
|
sequence length |
420
|
structure length |
399
|
Chain Sequence |
GFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEEGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTG
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Structural Characterization of Three Novel Hydroxamate-Based Zinc Chelating Inhibitors of the Clostridium botulinum Serotype A Neurotoxin Light Chain Metalloprotease Reveals a Compact Binding Site Resulting from 60/70 Loop Flexibility.
pubmed doi rcsb |
| molecule keywords |
Botulinum neurotoxin type A
|
| molecule tags |
Hydrolase/hydrolase inhibitor
|
| source organism |
Clostridium botulinum
|
| total genus |
133
|
| structure length |
399
|
| sequence length |
420
|
| ec nomenclature |
ec
3.4.24.69: Bontoxilysin. |
| pdb deposition date | 2011-01-28 |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Alpha Beta | Alpha-Beta Complex | Zincin-like | Metalloproteases ("zincins"), catalytic domain like |
#chains in the Genus database with same CATH superfamily 2A97 A; 3NF3 A; 2IMC A; 3QW5 A; 1Z7H A; 2W2D A; 4ELC A; 3BTA A; 3DSE A; 3C8A A; 3C89 A; 2ILP A; 3BWI A; 3V0B B; 1F31 A; 5BQM A; 1XTF A; 2ISH A; 3BOO A; 1F82 A; 2G7K A; 3D3X A; 2FPQ A; 3ZUR A; 2XHL A; 1G9C A; 1S0G A; 1ZKW A; 1T3C A; 3QIY A; 3BON A; 1ZN3 A; 3DDA A; 3QJ0 A; 2ISG A; 2G7N A; 2A8A A; 2ETF A; 4EJ5 A; 1XTG A; 4KUF A; 5BQN A; 1ZL6 A; 2IMB A; 1ZB7 A; 1S0F A; 4J1L A; 1T3A A; 3QIX A; 3DDB A; 3C8B A; 3V0A B; 4ZKT B; 3DEB A; 3V0B A; 2G7Q A; 4KS6 A; 2QN0 A; 3K3Q B; 2G7P A; 1I1E A; 3QW8 A; 1S0E A; 1S0B A; 2IMA A; 1S0D A; 1G9A A; 1E1H A; 3FFZ A; 3QIZ A; 2NP0 A; 2NYY A; 1ZKX A; 1G9D A; 4HEV A; 3BOK A; 4KTX A; 3FIE A; 3QW7 A; 3ZUS A; 3DS9 A; 3C88 A; 1G9B A; 2ISE A; 3ZUQ A; 1YVG A; 3QW6 A; 1EPW A; 3VUO A; 1S0C A; 4EL4 A; 1ZL5 A; 3V0A A; 3FII A; 2NZ9 A; 4ZJX A; #chains in the Genus database with same CATH topology 2A97 A; 3CQB A; 3NF3 A; 2IMC A; 3QW5 A; 1Z7H A; 2W2D A; 4AW6 A; 4ELC A; 3BTA A; 3DSE A; 2YPT A; 3C8A A; 3C89 A; 2ILP A; 3BWI A; 3V0B B; 1F31 A; 5BQM A; 1XTF A; 2ISH A; 3BOO A; 1F82 A; 2G7K A; 4JIX A; 4IL3 A; 3D3X A; 2FPQ A; 3ZUR A; 2XHL A; 1G9C A; 1S0G A; 1ZKW A; 1T3C A; 3QIY A; 3BON A; 1ZN3 A; 3DDA A; 2EJQ A; 3QJ0 A; 2ISG A; 2G7N A; 2A8A A; 2ETF A; 3E11 A; 4EJ5 A; 1XTG A; 4KUF A; 5BQN A; 1ZL6 A; 2IMB A; 1ZB7 A; 4JIU A; 1S0F A; 4J1L A; 1T3A A; 3QIX A; 3DDB A; 3C8B A; 3V0A B; 4ZKT B; 3DEB A; 3V0B A; 2G7Q A; 4KS6 A; 2QN0 A; 3K3Q B; 2G7P A; 1I1E A; 3QW8 A; 1S0E A; 1S0B A; 2IMA A; 1S0D A; 1G9A A; 1E1H A; 3FFZ A; 3QIZ A; 2NP0 A; 2NYY A; 1ZKX A; 1G9D A; 4HEV A; 3BOK A; 4KTX A; 3FIE A; 3QW7 A; 3ZUS A; 3DS9 A; 3C88 A; 1G9B A; 2ISE A; 3ZUQ A; 1YVG A; 3QW6 A; 4QHF A; 1EPW A; 3VUO A; 1S0C A; 4EL4 A; 1ZL5 A; 3V0A A; 3FII A; 2NZ9 A; 4ZJX A; #chains in the Genus database with same CATH homology 2A97 A; 3NF3 A; 2IMC A; 3QW5 A; 1Z7H A; 2W2D A; 4ELC A; 3BTA A; 3DSE A; 3C8A A; 3C89 A; 2ILP A; 3BWI A; 3V0B B; 1F31 A; 5BQM A; 1XTF A; 2ISH A; 3BOO A; 1F82 A; 2G7K A; 3D3X A; 2FPQ A; 3ZUR A; 2XHL A; 1G9C A; 1S0G A; 1ZKW A; 1T3C A; 3QIY A; 3BON A; 1ZN3 A; 3DDA A; 3QJ0 A; 2ISG A; 2G7N A; 2A8A A; 2ETF A; 4EJ5 A; 1XTG A; 4KUF A; 5BQN A; 1ZL6 A; 2IMB A; 1ZB7 A; 1S0F A; 4J1L A; 1T3A A; 3QIX A; 3DDB A; 3C8B A; 3V0A B; 4ZKT B; 3DEB A; 3V0B A; 2G7Q A; 4KS6 A; 2QN0 A; 3K3Q B; 2G7P A; 1I1E A; 3QW8 A; 1S0E A; 1S0B A; 2IMA A; 1S0D A; 1G9A A; 1E1H A; 3FFZ A; 3QIZ A; 2NP0 A; 2NYY A; 1ZKX A; 1G9D A; 4HEV A; 3BOK A; 4KTX A; 3FIE A; 3QW7 A; 3ZUS A; 3DS9 A; 3C88 A; 1G9B A; 2ISE A; 3ZUQ A; 1YVG A; 3QW6 A; 1EPW A; 3VUO A; 1S0C A; 4EL4 A; 1ZL5 A; 3V0A A; 3FII A; 2NZ9 A; 4ZJX A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
