3K3QB

Crystal structure of a llama antibody complexed with the c. botulinum neurotoxin serotype a catalytic domain
Total Genus 64
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
64
sequence length
249
structure length
238
Chain Sequence
QFVNKQFNYKDPVNGVDIAYIKIPNVGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A Single-Domain Llama Antibody Potently Inhibits the Enzymatic Activity of Botulinum Neurotoxin by Binding to the Non-Catalytic alpha-Exosite Binding Region.
pubmed doi rcsb
molecule tags Immune system
source organism Lama glama
molecule keywords llama Aa1 VHH domain
total genus 64
structure length 238
sequence length 249
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2009-10-04
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 3k3qB00
3FIEA 1E1HA 1F31A 1I1EA 3BOOA 1YVGA 3DDBA 1G9BA 2QN0A 4ELCA 3DS9A 2IMAA 1S0EA 4EJ5A 3C8BA 3K3QB 2ISGA 5BQNA 2G7QA 3QW6A 2ISEA 3BWIA 3DDAA 1S0DA 3NF3A 1XTFA 2NYYA 4HEVA 4ZKTB 3V0AA 4ZJXA 1G9DA 3V0BB 3BTAA 3C89A 1G9AA 1ZKWA 4KUFA 1S0CA 2FPQA 3VUOA 3QIXA 3QJ0A 1ZL5A 1Z7HA 3ZURA 2G7PA 3BOKA 3D3XA 1ZN3A 3QW7A 2ETFA 1S0FA 1F82A 2ILPA 2A8AA 3C88A 1XTGA 1ZKXA 3DSEA 3FFZA 1G9CA 1S0BA 1S0GA 4KTXA 1EPWA 4KS6A 2XHLA 2NZ9A 4EL4A 3QW5A 3BONA 4J1LA 3QIZA 3ZUSA 2A97A 3FIIA 2IMCA 2G7NA 3C8AA 3DEBA 2IMBA 1T3CA 3V0BA 1ZB7A 2W2DA 3V0AB 1T3AA 2NP0A 5BQMA 2ISHA 1ZL6A 2G7KA 3QW8A 3QIYA 3ZUQA
chains in the Genus database with same CATH superfamily
3FIEA 1E1HA 1F31A 1I1EA 3BOOA 1YVGA 3DDBA 1G9BA 2QN0A 4ELCA 3DS9A 2IMAA 1S0EA 4EJ5A 3C8BA 3K3QB 4JIXA 2ISGA 4QHFA 5BQNA 2G7QA 3QW6A 4IL3A 2ISEA 3BWIA 3DDAA 1S0DA 3NF3A 1XTFA 2NYYA 4HEVA 4ZKTB 3V0AA 4ZJXA 1G9DA 3V0BB 3BTAA 3C89A 1G9AA 3E11A 1ZKWA 4KUFA 1S0CA 2FPQA 3VUOA 3QIXA 3QJ0A 1ZL5A 1Z7HA 3ZURA 2G7PA 3BOKA 3D3XA 1ZN3A 3QW7A 2ETFA 1S0FA 2EJQA 1F82A 2ILPA 2A8AA 3C88A 1XTGA 1ZKXA 3DSEA 3FFZA 1G9CA 1S0BA 1S0GA 4KTXA 1EPWA 4KS6A 2XHLA 2NZ9A 4EL4A 4AW6A 3QW5A 3BONA 4J1LA 3QIZA 3ZUSA 2A97A 3FIIA 2IMCA 3CQBA 2G7NA 3C8AA 3DEBA 2IMBA 1T3CA 3V0BA 1ZB7A 2W2DA 3V0AB 1T3AA 2NP0A 5BQMA 2ISHA 4JIUA 1ZL6A 2G7KA 3QW8A 2YPTA 3QIYA 3ZUQA
chains in the Genus database with same CATH topology
3FIEA 1E1HA 1F31A 1I1EA 3BOOA 1YVGA 3DDBA 1G9BA 2QN0A 4ELCA 3DS9A 2IMAA 1S0EA 4EJ5A 3C8BA 3K3QB 2ISGA 5BQNA 2G7QA 3QW6A 2ISEA 3BWIA 3DDAA 1S0DA 3NF3A 1XTFA 2NYYA 4HEVA 4ZKTB 3V0AA 4ZJXA 1G9DA 3V0BB 3BTAA 3C89A 1G9AA 1ZKWA 4KUFA 1S0CA 2FPQA 3VUOA 3QIXA 3QJ0A 1ZL5A 1Z7HA 3ZURA 2G7PA 3BOKA 3D3XA 1ZN3A 3QW7A 2ETFA 1S0FA 1F82A 2ILPA 2A8AA 3C88A 1XTGA 1ZKXA 3DSEA 3FFZA 1G9CA 1S0BA 1S0GA 4KTXA 1EPWA 4KS6A 2XHLA 2NZ9A 4EL4A 3QW5A 3BONA 4J1LA 3QIZA 3ZUSA 2A97A 3FIIA 2IMCA 2G7NA 3C8AA 3DEBA 2IMBA 1T3CA 3V0BA 1ZB7A 2W2DA 3V0AB 1T3AA 2NP0A 5BQMA 2ISHA 1ZL6A 2G7KA 3QW8A 3QIYA 3ZUQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3FIE A;  1E1H A;  1F31 A;  1I1E A;  3BOO A;  1YVG A;  3DDB A;  1G9B A;  2QN0 A;  4ELC A;  3DS9 A;  2IMA A;  1S0E A;  4EJ5 A;  3C8B A;  3K3Q B;  2ISG A;  5BQN A;  2G7Q A;  3QW6 A;  2ISE A;  3BWI A;  3DDA A;  1S0D A;  3NF3 A;  1XTF A;  2NYY A;  4HEV A;  4ZKT B;  3V0A A;  4ZJX A;  1G9D A;  3V0B B;  3BTA A;  3C89 A;  1G9A A;  1ZKW A;  4KUF A;  1S0C A;  2FPQ A;  3VUO A;  3QIX A;  3QJ0 A;  1ZL5 A;  1Z7H A;  3ZUR A;  2G7P A;  3BOK A;  3D3X A;  1ZN3 A;  3QW7 A;  2ETF A;  1S0F A;  1F82 A;  2ILP A;  2A8A A;  3C88 A;  1XTG A;  1ZKX A;  3DSE A;  3FFZ A;  1G9C A;  1S0B A;  1S0G A;  4KTX A;  1EPW A;  4KS6 A;  2XHL A;  2NZ9 A;  4EL4 A;  3QW5 A;  3BON A;  4J1L A;  3QIZ A;  3ZUS A;  2A97 A;  3FII A;  2IMC A;  2G7N A;  3C8A A;  3DEB A;  2IMB A;  1T3C A;  3V0B A;  1ZB7 A;  2W2D A;  3V0A B;  1T3A A;  2NP0 A;  5BQM A;  2ISH A;  1ZL6 A;  2G7K A;  3QW8 A;  3QIY A;  3ZUQ A; 
#chains in the Genus database with same CATH topology
 3FIE A;  1E1H A;  1F31 A;  1I1E A;  3BOO A;  1YVG A;  3DDB A;  1G9B A;  2QN0 A;  4ELC A;  3DS9 A;  2IMA A;  1S0E A;  4EJ5 A;  3C8B A;  3K3Q B;  4JIX A;  2ISG A;  4QHF A;  5BQN A;  2G7Q A;  3QW6 A;  4IL3 A;  2ISE A;  3BWI A;  3DDA A;  1S0D A;  3NF3 A;  1XTF A;  2NYY A;  4HEV A;  4ZKT B;  3V0A A;  4ZJX A;  1G9D A;  3V0B B;  3BTA A;  3C89 A;  1G9A A;  3E11 A;  1ZKW A;  4KUF A;  1S0C A;  2FPQ A;  3VUO A;  3QIX A;  3QJ0 A;  1ZL5 A;  1Z7H A;  3ZUR A;  2G7P A;  3BOK A;  3D3X A;  1ZN3 A;  3QW7 A;  2ETF A;  1S0F A;  2EJQ A;  1F82 A;  2ILP A;  2A8A A;  3C88 A;  1XTG A;  1ZKX A;  3DSE A;  3FFZ A;  1G9C A;  1S0B A;  1S0G A;  4KTX A;  1EPW A;  4KS6 A;  2XHL A;  2NZ9 A;  4EL4 A;  4AW6 A;  3QW5 A;  3BON A;  4J1L A;  3QIZ A;  3ZUS A;  2A97 A;  3FII A;  2IMC A;  3CQB A;  2G7N A;  3C8A A;  3DEB A;  2IMB A;  1T3C A;  3V0B A;  1ZB7 A;  2W2D A;  3V0A B;  1T3A A;  2NP0 A;  5BQM A;  2ISH A;  4JIU A;  1ZL6 A;  2G7K A;  3QW8 A;  2YPT A;  3QIY A;  3ZUQ A; 
#chains in the Genus database with same CATH homology
 3FIE A;  1E1H A;  1F31 A;  1I1E A;  3BOO A;  1YVG A;  3DDB A;  1G9B A;  2QN0 A;  4ELC A;  3DS9 A;  2IMA A;  1S0E A;  4EJ5 A;  3C8B A;  3K3Q B;  2ISG A;  5BQN A;  2G7Q A;  3QW6 A;  2ISE A;  3BWI A;  3DDA A;  1S0D A;  3NF3 A;  1XTF A;  2NYY A;  4HEV A;  4ZKT B;  3V0A A;  4ZJX A;  1G9D A;  3V0B B;  3BTA A;  3C89 A;  1G9A A;  1ZKW A;  4KUF A;  1S0C A;  2FPQ A;  3VUO A;  3QIX A;  3QJ0 A;  1ZL5 A;  1Z7H A;  3ZUR A;  2G7P A;  3BOK A;  3D3X A;  1ZN3 A;  3QW7 A;  2ETF A;  1S0F A;  1F82 A;  2ILP A;  2A8A A;  3C88 A;  1XTG A;  1ZKX A;  3DSE A;  3FFZ A;  1G9C A;  1S0B A;  1S0G A;  4KTX A;  1EPW A;  4KS6 A;  2XHL A;  2NZ9 A;  4EL4 A;  3QW5 A;  3BON A;  4J1L A;  3QIZ A;  3ZUS A;  2A97 A;  3FII A;  2IMC A;  2G7N A;  3C8A A;  3DEB A;  2IMB A;  1T3C A;  3V0B A;  1ZB7 A;  2W2D A;  3V0A B;  1T3A A;  2NP0 A;  5BQM A;  2ISH A;  1ZL6 A;  2G7K A;  3QW8 A;  3QIY A;  3ZUQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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