4AWNA

Structure of recombinant human dnase i (rhdnasei) in complex with magnesium and phosphate.
Total Genus 78
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
78
sequence length
260
structure length
260
Chain Sequence
LKIAAFNIQTFGETKMSNATLVSYIVQILSRYDIALVQEVRDSHLTAVGKLLDNLNQDAPDTYHYVVSEPLGRNSYKERYLFVYRPDQVSAVDSYYYDDGCEPCGNDTFNREPAIVRFFSRFTEVREFAIVPLHAAPGDAVAEIDALYDVYLDVQEKWGLEDVMLMGDFNAGCSYVRPSQWSSIRLWTSPTFQWLIPDSADTTATPTHCAYDRIVVAGMLLRGAVVPDSALPFNFQAAYGLSDQLAQAISDHYPVEVMLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The Structure of Human DNase I Bound to Magnesium and Phosphate Ions Points to a Catalytic Mechanism Common to Members of the DNase I-Like Superfamily.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords DEOXYRIBONUCLEASE-1
total genus 78
structure length 260
sequence length 260
ec nomenclature ec 3.1.21.1: Deoxyribonuclease I.
pdb deposition date 2012-06-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03372 Exo_endo_phos Endonuclease/Exonuclease/phosphatase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.10.10 Alpha Beta 4-Layer Sandwich Deoxyribonuclease I; Chain A Endonuclease/exonuclease/phosphatase 4awnA00
1I9YA 5DG0A 3G2CA 1DE8A 4GEWA 4B5HA 4JG3A 4L21A 5INOA 5DFJA 3CJCD 5J3SA 1Y21A 3GA6A 2O3CA 3G3YA 5DFFA 5DFHA 2A41B 5CFGA 3I41A 4B5MA 2JC4A 5J42A 2VOAA 1ZWXA 2JC5A 3G00A 4RUWA 1DE9A 4A9CA 4L1ZA 5INNA 4L1YA 1NTFA 3G0RA 2O3HA 4PUQA 3G6SA 2ISIA 4GYZA 5INKA 2J63A 3G8VA 4GZ0A 4FVAA 3FZIA 3U8UA 4CMLA 4IEMA 1WDUA 3I46A 5A7IA 5HT2A 3NGNA 3TEBA 4F1RA 1YJHA 3NGOA 3G2DA 3G38A 2DDRA 3NR8A 2XSWA 3MPRA 4F1HB 4C1RA 5INQA 2V0RA 1HD7A 1VYBA 5INPA 2EI9A 1I9ZA 2DNJA 2DDSA 2UYRX 1SI6X 4LNDA 4GZ2A 3W3DB 3K55A 4CMNA 1SR4B 3G3CA 4B5FA 5CFEA 5J8NA 5EWTA 4L20A 1BIXA 2F1NA 5DV4A 4B5GA 3I5VA 2A40B 4B5JA 1DEWA 2V0SA 3G0AA 3MTCA 4K6LF 1E9NA 4QHEA 2A42B 4QHDA 5DV2A 3W2YA 1ATND 5INMA 4FPVA 4QH9A 4B5IA 4AWNA 5INLA 3G4TA 3G91A 3I48A 3L1WA 3DNIA 5DFIA 3W2XA 2IMQX 3NGQA 2A3ZB 5J3PA 4F1IA 2F2FB 2DDTA 3G1KA 4F1HA 2D1KB 5J3ZA 4GZ1A 3N9VA 5A7JA 3WCXA 1AKOA 1DNKA
chains in the Genus database with same CATH superfamily
1I9YA 5DG0A 3G2CA 1DE8A 4GEWA 4B5HA 4JG3A 4L21A 5INOA 5DFJA 3CJCD 5J3SA 1Y21A 3GA6A 2O3CA 3G3YA 5DFFA 5DFHA 2A41B 5CFGA 3I41A 4B5MA 2JC4A 5J42A 2VOAA 1ZWXA 2JC5A 3G00A 4RUWA 1DE9A 4A9CA 4L1ZA 5INNA 4L1YA 1NTFA 3G0RA 2O3HA 4PUQA 3G6SA 2ISIA 4GYZA 5INKA 2J63A 3G8VA 4GZ0A 4FVAA 3FZIA 3U8UA 4CMLA 4IEMA 1WDUA 3I46A 5A7IA 5HT2A 3NGNA 3TEBA 4F1RA 1YJHA 3NGOA 3G2DA 3G38A 2DDRA 3NR8A 2XSWA 3MPRA 4F1HB 4C1RA 5INQA 2V0RA 1HD7A 1VYBA 5INPA 2EI9A 1I9ZA 2DNJA 2DDSA 2UYRX 1SI6X 4LNDA 4GZ2A 3W3DB 3K55A 4CMNA 1SR4B 3G3CA 4B5FA 5CFEA 5J8NA 5EWTA 4L20A 1BIXA 2F1NA 5DV4A 4B5GA 3I5VA 2A40B 4B5JA 1DEWA 2V0SA 3G0AA 3MTCA 4K6LF 1E9NA 4QHEA 2A42B 4QHDA 5DV2A 3W2YA 1ATND 5INMA 4FPVA 4QH9A 4B5IA 4AWNA 5INLA 3G4TA 3G91A 3I48A 3L1WA 3DNIA 5DFIA 3W2XA 2IMQX 3NGQA 2A3ZB 5J3PA 4F1IA 2F2FB 2DDTA 3G1KA 4F1HA 2D1KB 5J3ZA 4GZ1A 3N9VA 5A7JA 3WCXA 1AKOA 1DNKA
chains in the Genus database with same CATH topology
1I9YA 5DG0A 3G2CA 1DE8A 4GEWA 4B5HA 4JG3A 4L21A 5INOA 5DFJA 3CJCD 5J3SA 1Y21A 3GA6A 2O3CA 3G3YA 5DFFA 5DFHA 2A41B 5CFGA 3I41A 4B5MA 2JC4A 5J42A 2VOAA 1ZWXA 2JC5A 3G00A 4RUWA 1DE9A 4A9CA 4L1ZA 5INNA 4L1YA 1NTFA 3G0RA 2O3HA 4PUQA 3G6SA 2ISIA 4GYZA 5INKA 2J63A 3G8VA 4GZ0A 4FVAA 3FZIA 3U8UA 4CMLA 4IEMA 1WDUA 3I46A 5A7IA 5HT2A 3NGNA 3TEBA 4F1RA 1YJHA 3NGOA 3G2DA 3G38A 2DDRA 3NR8A 2XSWA 3MPRA 4F1HB 4C1RA 5INQA 2V0RA 1HD7A 1VYBA 5INPA 2EI9A 1I9ZA 2DNJA 2DDSA 2UYRX 1SI6X 4LNDA 4GZ2A 3W3DB 3K55A 4CMNA 1SR4B 3G3CA 4B5FA 5CFEA 5J8NA 5EWTA 4L20A 1BIXA 2F1NA 5DV4A 4B5GA 3I5VA 2A40B 4B5JA 1DEWA 2V0SA 3G0AA 3MTCA 4K6LF 1E9NA 4QHEA 2A42B 4QHDA 5DV2A 3W2YA 1ATND 5INMA 4FPVA 4QH9A 4B5IA 4AWNA 5INLA 3G4TA 3G91A 3I48A 3L1WA 3DNIA 5DFIA 3W2XA 2IMQX 3NGQA 2A3ZB 5J3PA 4F1IA 2F2FB 2DDTA 3G1KA 4F1HA 2D1KB 5J3ZA 4GZ1A 3N9VA 5A7JA 3WCXA 1AKOA 1DNKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1I9Y A;  5DG0 A;  3G2C A;  1DE8 A;  4GEW A;  4B5H A;  4JG3 A;  4L21 A;  5INO A;  5DFJ A;  3CJC D;  5J3S A;  1Y21 A;  3GA6 A;  2O3C A;  3G3Y A;  5DFF A;  5DFH A;  2A41 B;  5CFG A;  3I41 A;  4B5M A;  2JC4 A;  5J42 A;  2VOA A;  1ZWX A;  2JC5 A;  3G00 A;  4RUW A;  1DE9 A;  4A9C A;  4L1Z A;  5INN A;  4L1Y A;  1NTF A;  3G0R A;  2O3H A;  4PUQ A;  3G6S A;  2ISI A;  4GYZ A;  5INK A;  2J63 A;  3G8V A;  4GZ0 A;  4FVA A;  3FZI A;  3U8U A;  4CML A;  4IEM A;  1WDU A;  3I46 A;  5A7I A;  5HT2 A;  3NGN A;  3TEB A;  4F1R A;  1YJH A;  3NGO A;  3G2D A;  3G38 A;  2DDR A;  3NR8 A;  2XSW A;  3MPR A;  4F1H B;  4C1R A;  5INQ A;  2V0R A;  1HD7 A;  1VYB A;  5INP A;  2EI9 A;  1I9Z A;  2DNJ A;  2DDS A;  2UYR X;  1SI6 X;  4LND A;  4GZ2 A;  3W3D B;  3K55 A;  4CMN A;  1SR4 B;  3G3C A;  4B5F A;  5CFE A;  5J8N A;  5EWT A;  4L20 A;  1BIX A;  2F1N A;  5DV4 A;  4B5G A;  3I5V A;  2A40 B;  4B5J A;  1DEW A;  2V0S A;  3G0A A;  3MTC A;  4K6L F;  1E9N A;  4QHE A;  2A42 B;  4QHD A;  5DV2 A;  3W2Y A;  1ATN D;  5INM A;  4FPV A;  4QH9 A;  4B5I A;  4AWN A;  5INL A;  3G4T A;  3G91 A;  3I48 A;  3L1W A;  3DNI A;  5DFI A;  3W2X A;  2IMQ X;  3NGQ A;  2A3Z B;  5J3P A;  4F1I A;  2F2F B;  2DDT A;  3G1K A;  4F1H A;  2D1K B;  5J3Z A;  4GZ1 A;  3N9V A;  5A7J A;  3WCX A;  1AKO A;  1DNK A; 
#chains in the Genus database with same CATH topology
 1I9Y A;  5DG0 A;  3G2C A;  1DE8 A;  4GEW A;  4B5H A;  4JG3 A;  4L21 A;  5INO A;  5DFJ A;  3CJC D;  5J3S A;  1Y21 A;  3GA6 A;  2O3C A;  3G3Y A;  5DFF A;  5DFH A;  2A41 B;  5CFG A;  3I41 A;  4B5M A;  2JC4 A;  5J42 A;  2VOA A;  1ZWX A;  2JC5 A;  3G00 A;  4RUW A;  1DE9 A;  4A9C A;  4L1Z A;  5INN A;  4L1Y A;  1NTF A;  3G0R A;  2O3H A;  4PUQ A;  3G6S A;  2ISI A;  4GYZ A;  5INK A;  2J63 A;  3G8V A;  4GZ0 A;  4FVA A;  3FZI A;  3U8U A;  4CML A;  4IEM A;  1WDU A;  3I46 A;  5A7I A;  5HT2 A;  3NGN A;  3TEB A;  4F1R A;  1YJH A;  3NGO A;  3G2D A;  3G38 A;  2DDR A;  3NR8 A;  2XSW A;  3MPR A;  4F1H B;  4C1R A;  5INQ A;  2V0R A;  1HD7 A;  1VYB A;  5INP A;  2EI9 A;  1I9Z A;  2DNJ A;  2DDS A;  2UYR X;  1SI6 X;  4LND A;  4GZ2 A;  3W3D B;  3K55 A;  4CMN A;  1SR4 B;  3G3C A;  4B5F A;  5CFE A;  5J8N A;  5EWT A;  4L20 A;  1BIX A;  2F1N A;  5DV4 A;  4B5G A;  3I5V A;  2A40 B;  4B5J A;  1DEW A;  2V0S A;  3G0A A;  3MTC A;  4K6L F;  1E9N A;  4QHE A;  2A42 B;  4QHD A;  5DV2 A;  3W2Y A;  1ATN D;  5INM A;  4FPV A;  4QH9 A;  4B5I A;  4AWN A;  5INL A;  3G4T A;  3G91 A;  3I48 A;  3L1W A;  3DNI A;  5DFI A;  3W2X A;  2IMQ X;  3NGQ A;  2A3Z B;  5J3P A;  4F1I A;  2F2F B;  2DDT A;  3G1K A;  4F1H A;  2D1K B;  5J3Z A;  4GZ1 A;  3N9V A;  5A7J A;  3WCX A;  1AKO A;  1DNK A; 
#chains in the Genus database with same CATH homology
 1I9Y A;  5DG0 A;  3G2C A;  1DE8 A;  4GEW A;  4B5H A;  4JG3 A;  4L21 A;  5INO A;  5DFJ A;  3CJC D;  5J3S A;  1Y21 A;  3GA6 A;  2O3C A;  3G3Y A;  5DFF A;  5DFH A;  2A41 B;  5CFG A;  3I41 A;  4B5M A;  2JC4 A;  5J42 A;  2VOA A;  1ZWX A;  2JC5 A;  3G00 A;  4RUW A;  1DE9 A;  4A9C A;  4L1Z A;  5INN A;  4L1Y A;  1NTF A;  3G0R A;  2O3H A;  4PUQ A;  3G6S A;  2ISI A;  4GYZ A;  5INK A;  2J63 A;  3G8V A;  4GZ0 A;  4FVA A;  3FZI A;  3U8U A;  4CML A;  4IEM A;  1WDU A;  3I46 A;  5A7I A;  5HT2 A;  3NGN A;  3TEB A;  4F1R A;  1YJH A;  3NGO A;  3G2D A;  3G38 A;  2DDR A;  3NR8 A;  2XSW A;  3MPR A;  4F1H B;  4C1R A;  5INQ A;  2V0R A;  1HD7 A;  1VYB A;  5INP A;  2EI9 A;  1I9Z A;  2DNJ A;  2DDS A;  2UYR X;  1SI6 X;  4LND A;  4GZ2 A;  3W3D B;  3K55 A;  4CMN A;  1SR4 B;  3G3C A;  4B5F A;  5CFE A;  5J8N A;  5EWT A;  4L20 A;  1BIX A;  2F1N A;  5DV4 A;  4B5G A;  3I5V A;  2A40 B;  4B5J A;  1DEW A;  2V0S A;  3G0A A;  3MTC A;  4K6L F;  1E9N A;  4QHE A;  2A42 B;  4QHD A;  5DV2 A;  3W2Y A;  1ATN D;  5INM A;  4FPV A;  4QH9 A;  4B5I A;  4AWN A;  5INL A;  3G4T A;  3G91 A;  3I48 A;  3L1W A;  3DNI A;  5DFI A;  3W2X A;  2IMQ X;  3NGQ A;  2A3Z B;  5J3P A;  4F1I A;  2F2F B;  2DDT A;  3G1K A;  4F1H A;  2D1K B;  5J3Z A;  4GZ1 A;  3N9V A;  5A7J A;  3WCX A;  1AKO A;  1DNK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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