4CMLA

Crystal structure of inpp5b in complex with phosphatidylinositol 3,4- bisphosphate
Total Genus 93
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
93
sequence length
310
structure length
310
Chain Sequence
MYTYIQNFRFFAGTYNVNGQSPKECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDVILWLGDLNYRIEELDVEKVKKLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTGSDDWDTSEKCRAPAWCDRILWKGKNITQLSYQSHMALKTSDHKPVSSVFDIGVRVVAHHH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis for Phosphoinositide Substrate Recognition, Catalysis, and Membrane Interactions in Human Inositol Polyphosphate 5-Phosphatases.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5- PHOSPHATASE, ISOFORM
total genus 93
structure length 310
sequence length 310
ec nomenclature ec 3.1.3.36: Phosphoinositide 5-phosphatase.
pdb deposition date 2014-01-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03372 Exo_endo_phos Endonuclease/Exonuclease/phosphatase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.10.10 Alpha Beta 4-Layer Sandwich Deoxyribonuclease I; Chain A Endonuclease/exonuclease/phosphatase 4cmlA00
3G0RA 3NGQA 4C1RA 4B5IA 5J3ZA 5DFJA 2A3ZB 2IMQX 5DG0A 4LNDA 5DFIA 1Y21A 1DE9A 5CFEA 5DFHA 3I46A 5CFGA 1NTFA 3I41A 4AWNA 1AKOA 2JC4A 3NR8A 5DFFA 2F2FB 5A7JA 4F1RA 1YJHA 4JG3A 4A9CA 4B5HA 4GZ1A 4PUQA 3NGOA 2ISIA 4RUWA 2JC5A 4GEWA 2A40B 2EI9A 1SR4B 3N9VA 4QHDA 1HD7A 4FVAA 4CMLA 1ZWXA 3G2DA 1BIXA 4CMNA 5INPA 4F1IA 5INLA 3W2XA 3W3DB 1WDUA 4GZ0A 3G0AA 4L1YA 3NGNA 4FPVA 2V0RA 1VYBA 3I48A 5J8NA 4GZ2A 5INNA 5DV2A 3TEBA 5HT2A 2DDRA 5INKA 5DV4A 3I5VA 1SI6X 4GYZA 5J3PA 2DNJA 4QH9A 3WCXA 2DDTA 1E9NA 4L21A 2A41B 3G6SA 2DDSA 4F1HB 1I9YA 3MPRA 1I9ZA 3G38A 5A7IA 2V0SA 4B5GA 2VOAA 2XSWA 2A42B 5INMA 4QHEA 2D1KB 3G1KA 1DEWA 3G8VA 3U8UA 4K6LF 3GA6A 4F1HA 2J63A 3G2CA 2O3HA 3MTCA 3L1WA 3G91A 3W2YA 4L1ZA 3G4TA 5INOA 5J42A 4IEMA 4B5FA 3FZIA 5INQA 5EWTA 3G3CA 1DNKA 3K55A 1ATND 2O3CA 3DNIA 4B5JA 1DE8A 4B5MA 2UYRX 3G3YA 4L20A 5J3SA 3G00A 3CJCD 2F1NA
chains in the Genus database with same CATH superfamily
3G0RA 3NGQA 4C1RA 4B5IA 5J3ZA 5DFJA 2A3ZB 2IMQX 5DG0A 4LNDA 5DFIA 1Y21A 1DE9A 5CFEA 5DFHA 3I46A 5CFGA 1NTFA 3I41A 4AWNA 1AKOA 2JC4A 3NR8A 5DFFA 2F2FB 5A7JA 4F1RA 1YJHA 4JG3A 4A9CA 4B5HA 4GZ1A 4PUQA 3NGOA 2ISIA 4RUWA 2JC5A 4GEWA 2A40B 2EI9A 1SR4B 3N9VA 4QHDA 1HD7A 4FVAA 4CMLA 1ZWXA 3G2DA 1BIXA 4CMNA 5INPA 4F1IA 5INLA 3W2XA 3W3DB 1WDUA 4GZ0A 3G0AA 4L1YA 3NGNA 4FPVA 2V0RA 1VYBA 3I48A 5J8NA 4GZ2A 5INNA 5DV2A 3TEBA 5HT2A 2DDRA 5INKA 5DV4A 3I5VA 1SI6X 4GYZA 5J3PA 2DNJA 4QH9A 3WCXA 2DDTA 1E9NA 4L21A 2A41B 3G6SA 2DDSA 4F1HB 1I9YA 3MPRA 1I9ZA 3G38A 5A7IA 2V0SA 4B5GA 2VOAA 2XSWA 2A42B 5INMA 4QHEA 2D1KB 3G1KA 1DEWA 3G8VA 3U8UA 4K6LF 3GA6A 4F1HA 2J63A 3G2CA 2O3HA 3MTCA 3L1WA 3G91A 3W2YA 4L1ZA 3G4TA 5INOA 5J42A 4IEMA 4B5FA 3FZIA 5INQA 5EWTA 3G3CA 1DNKA 3K55A 1ATND 2O3CA 3DNIA 4B5JA 1DE8A 4B5MA 2UYRX 3G3YA 4L20A 5J3SA 3G00A 3CJCD 2F1NA
chains in the Genus database with same CATH topology
3G0RA 3NGQA 4C1RA 4B5IA 5J3ZA 5DFJA 2A3ZB 2IMQX 5DG0A 4LNDA 5DFIA 1Y21A 1DE9A 5CFEA 5DFHA 3I46A 5CFGA 1NTFA 3I41A 4AWNA 1AKOA 2JC4A 3NR8A 5DFFA 2F2FB 5A7JA 4F1RA 1YJHA 4JG3A 4A9CA 4B5HA 4GZ1A 4PUQA 3NGOA 2ISIA 4RUWA 2JC5A 4GEWA 2A40B 2EI9A 1SR4B 3N9VA 4QHDA 1HD7A 4FVAA 4CMLA 1ZWXA 3G2DA 1BIXA 4CMNA 5INPA 4F1IA 5INLA 3W2XA 3W3DB 1WDUA 4GZ0A 3G0AA 4L1YA 3NGNA 4FPVA 2V0RA 1VYBA 3I48A 5J8NA 4GZ2A 5INNA 5DV2A 3TEBA 5HT2A 2DDRA 5INKA 5DV4A 3I5VA 1SI6X 4GYZA 5J3PA 2DNJA 4QH9A 3WCXA 2DDTA 1E9NA 4L21A 2A41B 3G6SA 2DDSA 4F1HB 1I9YA 3MPRA 1I9ZA 3G38A 5A7IA 2V0SA 4B5GA 2VOAA 2XSWA 2A42B 5INMA 4QHEA 2D1KB 3G1KA 1DEWA 3G8VA 3U8UA 4K6LF 3GA6A 4F1HA 2J63A 3G2CA 2O3HA 3MTCA 3L1WA 3G91A 3W2YA 4L1ZA 3G4TA 5INOA 5J42A 4IEMA 4B5FA 3FZIA 5INQA 5EWTA 3G3CA 1DNKA 3K55A 1ATND 2O3CA 3DNIA 4B5JA 1DE8A 4B5MA 2UYRX 3G3YA 4L20A 5J3SA 3G00A 3CJCD 2F1NA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3G0R A;  3NGQ A;  4C1R A;  4B5I A;  5J3Z A;  5DFJ A;  2A3Z B;  2IMQ X;  5DG0 A;  4LND A;  5DFI A;  1Y21 A;  1DE9 A;  5CFE A;  5DFH A;  3I46 A;  5CFG A;  1NTF A;  3I41 A;  4AWN A;  1AKO A;  2JC4 A;  3NR8 A;  5DFF A;  2F2F B;  5A7J A;  4F1R A;  1YJH A;  4JG3 A;  4A9C A;  4B5H A;  4GZ1 A;  4PUQ A;  3NGO A;  2ISI A;  4RUW A;  2JC5 A;  4GEW A;  2A40 B;  2EI9 A;  1SR4 B;  3N9V A;  4QHD A;  1HD7 A;  4FVA A;  4CML A;  1ZWX A;  3G2D A;  1BIX A;  4CMN A;  5INP A;  4F1I A;  5INL A;  3W2X A;  3W3D B;  1WDU A;  4GZ0 A;  3G0A A;  4L1Y A;  3NGN A;  4FPV A;  2V0R A;  1VYB A;  3I48 A;  5J8N A;  4GZ2 A;  5INN A;  5DV2 A;  3TEB A;  5HT2 A;  2DDR A;  5INK A;  5DV4 A;  3I5V A;  1SI6 X;  4GYZ A;  5J3P A;  2DNJ A;  4QH9 A;  3WCX A;  2DDT A;  1E9N A;  4L21 A;  2A41 B;  3G6S A;  2DDS A;  4F1H B;  1I9Y A;  3MPR A;  1I9Z A;  3G38 A;  5A7I A;  2V0S A;  4B5G A;  2VOA A;  2XSW A;  2A42 B;  5INM A;  4QHE A;  2D1K B;  3G1K A;  1DEW A;  3G8V A;  3U8U A;  4K6L F;  3GA6 A;  4F1H A;  2J63 A;  3G2C A;  2O3H A;  3MTC A;  3L1W A;  3G91 A;  3W2Y A;  4L1Z A;  3G4T A;  5INO A;  5J42 A;  4IEM A;  4B5F A;  3FZI A;  5INQ A;  5EWT A;  3G3C A;  1DNK A;  3K55 A;  1ATN D;  2O3C A;  3DNI A;  4B5J A;  1DE8 A;  4B5M A;  2UYR X;  3G3Y A;  4L20 A;  5J3S A;  3G00 A;  3CJC D;  2F1N A; 
#chains in the Genus database with same CATH topology
 3G0R A;  3NGQ A;  4C1R A;  4B5I A;  5J3Z A;  5DFJ A;  2A3Z B;  2IMQ X;  5DG0 A;  4LND A;  5DFI A;  1Y21 A;  1DE9 A;  5CFE A;  5DFH A;  3I46 A;  5CFG A;  1NTF A;  3I41 A;  4AWN A;  1AKO A;  2JC4 A;  3NR8 A;  5DFF A;  2F2F B;  5A7J A;  4F1R A;  1YJH A;  4JG3 A;  4A9C A;  4B5H A;  4GZ1 A;  4PUQ A;  3NGO A;  2ISI A;  4RUW A;  2JC5 A;  4GEW A;  2A40 B;  2EI9 A;  1SR4 B;  3N9V A;  4QHD A;  1HD7 A;  4FVA A;  4CML A;  1ZWX A;  3G2D A;  1BIX A;  4CMN A;  5INP A;  4F1I A;  5INL A;  3W2X A;  3W3D B;  1WDU A;  4GZ0 A;  3G0A A;  4L1Y A;  3NGN A;  4FPV A;  2V0R A;  1VYB A;  3I48 A;  5J8N A;  4GZ2 A;  5INN A;  5DV2 A;  3TEB A;  5HT2 A;  2DDR A;  5INK A;  5DV4 A;  3I5V A;  1SI6 X;  4GYZ A;  5J3P A;  2DNJ A;  4QH9 A;  3WCX A;  2DDT A;  1E9N A;  4L21 A;  2A41 B;  3G6S A;  2DDS A;  4F1H B;  1I9Y A;  3MPR A;  1I9Z A;  3G38 A;  5A7I A;  2V0S A;  4B5G A;  2VOA A;  2XSW A;  2A42 B;  5INM A;  4QHE A;  2D1K B;  3G1K A;  1DEW A;  3G8V A;  3U8U A;  4K6L F;  3GA6 A;  4F1H A;  2J63 A;  3G2C A;  2O3H A;  3MTC A;  3L1W A;  3G91 A;  3W2Y A;  4L1Z A;  3G4T A;  5INO A;  5J42 A;  4IEM A;  4B5F A;  3FZI A;  5INQ A;  5EWT A;  3G3C A;  1DNK A;  3K55 A;  1ATN D;  2O3C A;  3DNI A;  4B5J A;  1DE8 A;  4B5M A;  2UYR X;  3G3Y A;  4L20 A;  5J3S A;  3G00 A;  3CJC D;  2F1N A; 
#chains in the Genus database with same CATH homology
 3G0R A;  3NGQ A;  4C1R A;  4B5I A;  5J3Z A;  5DFJ A;  2A3Z B;  2IMQ X;  5DG0 A;  4LND A;  5DFI A;  1Y21 A;  1DE9 A;  5CFE A;  5DFH A;  3I46 A;  5CFG A;  1NTF A;  3I41 A;  4AWN A;  1AKO A;  2JC4 A;  3NR8 A;  5DFF A;  2F2F B;  5A7J A;  4F1R A;  1YJH A;  4JG3 A;  4A9C A;  4B5H A;  4GZ1 A;  4PUQ A;  3NGO A;  2ISI A;  4RUW A;  2JC5 A;  4GEW A;  2A40 B;  2EI9 A;  1SR4 B;  3N9V A;  4QHD A;  1HD7 A;  4FVA A;  4CML A;  1ZWX A;  3G2D A;  1BIX A;  4CMN A;  5INP A;  4F1I A;  5INL A;  3W2X A;  3W3D B;  1WDU A;  4GZ0 A;  3G0A A;  4L1Y A;  3NGN A;  4FPV A;  2V0R A;  1VYB A;  3I48 A;  5J8N A;  4GZ2 A;  5INN A;  5DV2 A;  3TEB A;  5HT2 A;  2DDR A;  5INK A;  5DV4 A;  3I5V A;  1SI6 X;  4GYZ A;  5J3P A;  2DNJ A;  4QH9 A;  3WCX A;  2DDT A;  1E9N A;  4L21 A;  2A41 B;  3G6S A;  2DDS A;  4F1H B;  1I9Y A;  3MPR A;  1I9Z A;  3G38 A;  5A7I A;  2V0S A;  4B5G A;  2VOA A;  2XSW A;  2A42 B;  5INM A;  4QHE A;  2D1K B;  3G1K A;  1DEW A;  3G8V A;  3U8U A;  4K6L F;  3GA6 A;  4F1H A;  2J63 A;  3G2C A;  2O3H A;  3MTC A;  3L1W A;  3G91 A;  3W2Y A;  4L1Z A;  3G4T A;  5INO A;  5J42 A;  4IEM A;  4B5F A;  3FZI A;  5INQ A;  5EWT A;  3G3C A;  1DNK A;  3K55 A;  1ATN D;  2O3C A;  3DNI A;  4B5J A;  1DE8 A;  4B5M A;  2UYR X;  3G3Y A;  4L20 A;  5J3S A;  3G00 A;  3CJC D;  2F1N A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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