4CMLA

Crystal structure of inpp5b in complex with phosphatidylinositol 3,4- bisphosphate
Total Genus 93
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
93
sequence length
310
structure length
310
Chain Sequence
MYTYIQNFRFFAGTYNVNGQSPKECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDVILWLGDLNYRIEELDVEKVKKLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTGSDDWDTSEKCRAPAWCDRILWKGKNITQLSYQSHMALKTSDHKPVSSVFDIGVRVVAHHH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis for Phosphoinositide Substrate Recognition, Catalysis, and Membrane Interactions in Human Inositol Polyphosphate 5-Phosphatases.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5- PHOSPHATASE, ISOFORM
total genus 93
structure length 310
sequence length 310
ec nomenclature ec 3.1.3.36: Phosphoinositide 5-phosphatase.
pdb deposition date 2014-01-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03372 Exo_endo_phos Endonuclease/Exonuclease/phosphatase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.10.10 Alpha Beta 4-Layer Sandwich Deoxyribonuclease I; Chain A Endonuclease/exonuclease/phosphatase 4cmlA00
3G0RA 5A7IA 2VOAA 4A9CA 4QHEA 1DNKA 3I48A 1NTFA 2DNJA 5INMA 1ZWXA 4L20A 1DE9A 5DFHA 2F2FB 5INPA 1SR4B 1E9NA 5DV4A 1BIXA 5INLA 3CJCD 3G6SA 5J3PA 3DNIA 4GZ0A 2IMQX 4FPVA 1HD7A 3U8UA 2XSWA 2F1NA 3NGOA 1I9YA 5INKA 4B5GA 1DE8A 5HT2A 4FVAA 4GYZA 2O3CA 4L1ZA 5J3ZA 3K55A 2J63A 3WCXA 5A7JA 5DFJA 4B5IA 1I9ZA 5CFGA 2JC4A 5DFFA 4B5MA 4AWNA 3I46A 2A40B 3W2YA 4L1YA 5DV2A 1AKOA 2A41B 1DEWA 2EI9A 1VYBA 3G2CA 4QHDA 5DG0A 5J42A 3I5VA 4JG3A 4CMLA 2DDSA 2V0RA 3G38A 4LNDA 3NGNA 1YJHA 3GA6A 3G4TA 4L21A 3G91A 3TEBA 4GEWA 3MTCA 2A3ZB 3FZIA 4F1HB 3NGQA 2D1KB 2DDRA 2JC5A 5INQA 3NR8A 2ISIA 3W3DB 3N9VA 2DDTA 4F1IA 4GZ1A 3W2XA 1WDUA 2UYRX 1Y21A 1SI6X 3G0AA 5INNA 2A42B 3G3CA 2O3HA 4B5HA 4PUQA 2V0SA 3G1KA 5INOA 3G3YA 5EWTA 3G2DA 5J3SA 4C1RA 4F1HA 4GZ2A 4B5JA 4B5FA 5DFIA 1ATND 5J8NA 4QH9A 3G8VA 4CMNA 5CFEA 4IEMA 4F1RA 3G00A 3MPRA 4RUWA 3I41A 4K6LF 3L1WA
chains in the Genus database with same CATH superfamily
3G0RA 5A7IA 2VOAA 4A9CA 4QHEA 1DNKA 3I48A 1NTFA 2DNJA 5INMA 1ZWXA 4L20A 1DE9A 5DFHA 2F2FB 5INPA 1SR4B 1E9NA 5DV4A 1BIXA 5INLA 3CJCD 3G6SA 5J3PA 3DNIA 4GZ0A 2IMQX 4FPVA 1HD7A 3U8UA 2XSWA 2F1NA 3NGOA 1I9YA 5INKA 4B5GA 1DE8A 5HT2A 4FVAA 4GYZA 2O3CA 4L1ZA 5J3ZA 3K55A 2J63A 3WCXA 5A7JA 5DFJA 4B5IA 1I9ZA 5CFGA 2JC4A 5DFFA 4B5MA 4AWNA 3I46A 2A40B 3W2YA 4L1YA 5DV2A 1AKOA 2A41B 1DEWA 2EI9A 1VYBA 3G2CA 4QHDA 5DG0A 5J42A 3I5VA 4JG3A 4CMLA 2DDSA 2V0RA 3G38A 4LNDA 3NGNA 1YJHA 3GA6A 3G4TA 4L21A 3G91A 3TEBA 4GEWA 3MTCA 2A3ZB 3FZIA 4F1HB 3NGQA 2D1KB 2DDRA 2JC5A 5INQA 3NR8A 2ISIA 3W3DB 3N9VA 2DDTA 4F1IA 4GZ1A 3W2XA 1WDUA 2UYRX 1Y21A 1SI6X 3G0AA 5INNA 2A42B 3G3CA 2O3HA 4B5HA 4PUQA 2V0SA 3G1KA 5INOA 3G3YA 5EWTA 3G2DA 5J3SA 4C1RA 4F1HA 4GZ2A 4B5JA 4B5FA 5DFIA 1ATND 5J8NA 4QH9A 3G8VA 4CMNA 5CFEA 4IEMA 4F1RA 3G00A 3MPRA 4RUWA 3I41A 4K6LF 3L1WA
chains in the Genus database with same CATH topology
3G0RA 5A7IA 2VOAA 4A9CA 4QHEA 1DNKA 3I48A 1NTFA 2DNJA 5INMA 1ZWXA 4L20A 1DE9A 5DFHA 2F2FB 5INPA 1SR4B 1E9NA 5DV4A 1BIXA 5INLA 3CJCD 3G6SA 5J3PA 3DNIA 4GZ0A 2IMQX 4FPVA 1HD7A 3U8UA 2XSWA 2F1NA 3NGOA 1I9YA 5INKA 4B5GA 1DE8A 5HT2A 4FVAA 4GYZA 2O3CA 4L1ZA 5J3ZA 3K55A 2J63A 3WCXA 5A7JA 5DFJA 4B5IA 1I9ZA 5CFGA 2JC4A 5DFFA 4B5MA 4AWNA 3I46A 2A40B 3W2YA 4L1YA 5DV2A 1AKOA 2A41B 1DEWA 2EI9A 1VYBA 3G2CA 4QHDA 5DG0A 5J42A 3I5VA 4JG3A 4CMLA 2DDSA 2V0RA 3G38A 4LNDA 3NGNA 1YJHA 3GA6A 3G4TA 4L21A 3G91A 3TEBA 4GEWA 3MTCA 2A3ZB 3FZIA 4F1HB 3NGQA 2D1KB 2DDRA 2JC5A 5INQA 3NR8A 2ISIA 3W3DB 3N9VA 2DDTA 4F1IA 4GZ1A 3W2XA 1WDUA 2UYRX 1Y21A 1SI6X 3G0AA 5INNA 2A42B 3G3CA 2O3HA 4B5HA 4PUQA 2V0SA 3G1KA 5INOA 3G3YA 5EWTA 3G2DA 5J3SA 4C1RA 4F1HA 4GZ2A 4B5JA 4B5FA 5DFIA 1ATND 5J8NA 4QH9A 3G8VA 4CMNA 5CFEA 4IEMA 4F1RA 3G00A 3MPRA 4RUWA 3I41A 4K6LF 3L1WA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3G0R A;  5A7I A;  2VOA A;  4A9C A;  4QHE A;  1DNK A;  3I48 A;  1NTF A;  2DNJ A;  5INM A;  1ZWX A;  4L20 A;  1DE9 A;  5DFH A;  2F2F B;  5INP A;  1SR4 B;  1E9N A;  5DV4 A;  1BIX A;  5INL A;  3CJC D;  3G6S A;  5J3P A;  3DNI A;  4GZ0 A;  2IMQ X;  4FPV A;  1HD7 A;  3U8U A;  2XSW A;  2F1N A;  3NGO A;  1I9Y A;  5INK A;  4B5G A;  1DE8 A;  5HT2 A;  4FVA A;  4GYZ A;  2O3C A;  4L1Z A;  5J3Z A;  3K55 A;  2J63 A;  3WCX A;  5A7J A;  5DFJ A;  4B5I A;  1I9Z A;  5CFG A;  2JC4 A;  5DFF A;  4B5M A;  4AWN A;  3I46 A;  2A40 B;  3W2Y A;  4L1Y A;  5DV2 A;  1AKO A;  2A41 B;  1DEW A;  2EI9 A;  1VYB A;  3G2C A;  4QHD A;  5DG0 A;  5J42 A;  3I5V A;  4JG3 A;  4CML A;  2DDS A;  2V0R A;  3G38 A;  4LND A;  3NGN A;  1YJH A;  3GA6 A;  3G4T A;  4L21 A;  3G91 A;  3TEB A;  4GEW A;  3MTC A;  2A3Z B;  3FZI A;  4F1H B;  3NGQ A;  2D1K B;  2DDR A;  2JC5 A;  5INQ A;  3NR8 A;  2ISI A;  3W3D B;  3N9V A;  2DDT A;  4F1I A;  4GZ1 A;  3W2X A;  1WDU A;  2UYR X;  1Y21 A;  1SI6 X;  3G0A A;  5INN A;  2A42 B;  3G3C A;  2O3H A;  4B5H A;  4PUQ A;  2V0S A;  3G1K A;  5INO A;  3G3Y A;  5EWT A;  3G2D A;  5J3S A;  4C1R A;  4F1H A;  4GZ2 A;  4B5J A;  4B5F A;  5DFI A;  1ATN D;  5J8N A;  4QH9 A;  3G8V A;  4CMN A;  5CFE A;  4IEM A;  4F1R A;  3G00 A;  3MPR A;  4RUW A;  3I41 A;  4K6L F;  3L1W A; 
#chains in the Genus database with same CATH topology
 3G0R A;  5A7I A;  2VOA A;  4A9C A;  4QHE A;  1DNK A;  3I48 A;  1NTF A;  2DNJ A;  5INM A;  1ZWX A;  4L20 A;  1DE9 A;  5DFH A;  2F2F B;  5INP A;  1SR4 B;  1E9N A;  5DV4 A;  1BIX A;  5INL A;  3CJC D;  3G6S A;  5J3P A;  3DNI A;  4GZ0 A;  2IMQ X;  4FPV A;  1HD7 A;  3U8U A;  2XSW A;  2F1N A;  3NGO A;  1I9Y A;  5INK A;  4B5G A;  1DE8 A;  5HT2 A;  4FVA A;  4GYZ A;  2O3C A;  4L1Z A;  5J3Z A;  3K55 A;  2J63 A;  3WCX A;  5A7J A;  5DFJ A;  4B5I A;  1I9Z A;  5CFG A;  2JC4 A;  5DFF A;  4B5M A;  4AWN A;  3I46 A;  2A40 B;  3W2Y A;  4L1Y A;  5DV2 A;  1AKO A;  2A41 B;  1DEW A;  2EI9 A;  1VYB A;  3G2C A;  4QHD A;  5DG0 A;  5J42 A;  3I5V A;  4JG3 A;  4CML A;  2DDS A;  2V0R A;  3G38 A;  4LND A;  3NGN A;  1YJH A;  3GA6 A;  3G4T A;  4L21 A;  3G91 A;  3TEB A;  4GEW A;  3MTC A;  2A3Z B;  3FZI A;  4F1H B;  3NGQ A;  2D1K B;  2DDR A;  2JC5 A;  5INQ A;  3NR8 A;  2ISI A;  3W3D B;  3N9V A;  2DDT A;  4F1I A;  4GZ1 A;  3W2X A;  1WDU A;  2UYR X;  1Y21 A;  1SI6 X;  3G0A A;  5INN A;  2A42 B;  3G3C A;  2O3H A;  4B5H A;  4PUQ A;  2V0S A;  3G1K A;  5INO A;  3G3Y A;  5EWT A;  3G2D A;  5J3S A;  4C1R A;  4F1H A;  4GZ2 A;  4B5J A;  4B5F A;  5DFI A;  1ATN D;  5J8N A;  4QH9 A;  3G8V A;  4CMN A;  5CFE A;  4IEM A;  4F1R A;  3G00 A;  3MPR A;  4RUW A;  3I41 A;  4K6L F;  3L1W A; 
#chains in the Genus database with same CATH homology
 3G0R A;  5A7I A;  2VOA A;  4A9C A;  4QHE A;  1DNK A;  3I48 A;  1NTF A;  2DNJ A;  5INM A;  1ZWX A;  4L20 A;  1DE9 A;  5DFH A;  2F2F B;  5INP A;  1SR4 B;  1E9N A;  5DV4 A;  1BIX A;  5INL A;  3CJC D;  3G6S A;  5J3P A;  3DNI A;  4GZ0 A;  2IMQ X;  4FPV A;  1HD7 A;  3U8U A;  2XSW A;  2F1N A;  3NGO A;  1I9Y A;  5INK A;  4B5G A;  1DE8 A;  5HT2 A;  4FVA A;  4GYZ A;  2O3C A;  4L1Z A;  5J3Z A;  3K55 A;  2J63 A;  3WCX A;  5A7J A;  5DFJ A;  4B5I A;  1I9Z A;  5CFG A;  2JC4 A;  5DFF A;  4B5M A;  4AWN A;  3I46 A;  2A40 B;  3W2Y A;  4L1Y A;  5DV2 A;  1AKO A;  2A41 B;  1DEW A;  2EI9 A;  1VYB A;  3G2C A;  4QHD A;  5DG0 A;  5J42 A;  3I5V A;  4JG3 A;  4CML A;  2DDS A;  2V0R A;  3G38 A;  4LND A;  3NGN A;  1YJH A;  3GA6 A;  3G4T A;  4L21 A;  3G91 A;  3TEB A;  4GEW A;  3MTC A;  2A3Z B;  3FZI A;  4F1H B;  3NGQ A;  2D1K B;  2DDR A;  2JC5 A;  5INQ A;  3NR8 A;  2ISI A;  3W3D B;  3N9V A;  2DDT A;  4F1I A;  4GZ1 A;  3W2X A;  1WDU A;  2UYR X;  1Y21 A;  1SI6 X;  3G0A A;  5INN A;  2A42 B;  3G3C A;  2O3H A;  4B5H A;  4PUQ A;  2V0S A;  3G1K A;  5INO A;  3G3Y A;  5EWT A;  3G2D A;  5J3S A;  4C1R A;  4F1H A;  4GZ2 A;  4B5J A;  4B5F A;  5DFI A;  1ATN D;  5J8N A;  4QH9 A;  3G8V A;  4CMN A;  5CFE A;  4IEM A;  4F1R A;  3G00 A;  3MPR A;  4RUW A;  3I41 A;  4K6L F;  3L1W A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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