4KS6A

Crystal structure of the catalytic domain of botulinum neurotoxin bont/a c134s mutant with covalent inhibitor that modifies cys-165 causing disorder in 166-174 stretch
Total Genus 141
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
141
sequence length
428
structure length
428
Chain Sequence
GSHMPFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNSINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLFEF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Covalent modification of the active site cysteine stresses Clostridium botulinum neurotoxin A
rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Clostridium botulinum a
molecule keywords Botulinum neurotoxin A light chain
total genus 141
structure length 428
sequence length 428
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2013-05-17
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 4ks6A00
1ZKXA 1F82A 2G7PA 1E1HA 4ZJXA 4J1LA 1G9CA 1G9BA 2ISHA 3K3QB 3V0BA 3V0AB 1S0BA 3QW8A 1ZL5A 2G7KA 3QIXA 1I1EA 1F31A 3DSEA 1S0CA 2IMAA 3FFZA 3QIZA 2FPQA 3C89A 2XHLA 3C8AA 3BOOA 1G9AA 1ZL6A 2ETFA 2IMBA 2G7NA 2ISGA 3V0AA 2QN0A 1T3CA 4EL4A 3BOKA 2NP0A 3DDBA 3BTAA 2A97A 1ZN3A 3NF3A 4HEVA 4ELCA 2NYYA 2W2DA 3ZUSA 1Z7HA 2NZ9A 3C8BA 1S0EA 2A8AA 3QJ0A 5BQNA 1EPWA 1ZB7A 3ZUQA 1XTFA 4KS6A 3FIEA 3FIIA 3D3XA 4EJ5A 1T3AA 1S0DA 3VUOA 2IMCA 2G7QA 3DDAA 1YVGA 1S0FA 3QW7A 1ZKWA 4KUFA 3C88A 1S0GA 1G9DA 3BONA 3QW5A 4ZKTB 3BWIA 5BQMA 3V0BB 1XTGA 3DEBA 3QW6A 2ISEA 3QIYA 3DS9A 3ZURA 2ILPA 4KTXA
chains in the Genus database with same CATH superfamily
1ZKXA 1F82A 2G7PA 1E1HA 4J1LA 4ZJXA 1G9CA 1G9BA 2ISHA 4KTXA 2YPTA 3K3QB 3V0BA 3V0AB 1S0BA 3QW8A 1ZL5A 2G7KA 4JIUA 3QIXA 1I1EA 1F31A 3DSEA 4JIXA 1S0CA 2IMAA 3FFZA 3QIZA 2FPQA 3C89A 3E11A 2EJQA 2XHLA 3C8AA 3BOOA 1G9AA 1ZL6A 2ETFA 2IMBA 2G7NA 2ISGA 3V0AA 4IL3A 2QN0A 4EL4A 3BOKA 2NP0A 3DDBA 3BTAA 2A97A 1ZN3A 3NF3A 4HEVA 4ELCA 2NYYA 2W2DA 3ZUSA 1Z7HA 2NZ9A 3C8BA 1S0EA 2A8AA 3QJ0A 5BQNA 1EPWA 1ZB7A 3ZUQA 1XTFA 4KS6A 3FIEA 3FIIA 3D3XA 4EJ5A 1T3AA 1S0DA 3VUOA 2IMCA 2G7QA 3DDAA 1YVGA 1S0FA 3QW7A 1ZKWA 4KUFA 3C88A 1S0GA 1G9DA 3CQBA 3BONA 3QW5A 4ZKTB 3BWIA 5BQMA 3V0BB 1XTGA 3DEBA 3QW6A 2ISEA 4AW6A 3QIYA 4QHFA 3DS9A 3ZURA 2ILPA 1T3CA
chains in the Genus database with same CATH topology
1ZKXA 1F82A 2G7PA 1E1HA 4ZJXA 4J1LA 1G9CA 1G9BA 2ISHA 3K3QB 3V0BA 3V0AB 1S0BA 3QW8A 1ZL5A 2G7KA 3QIXA 1I1EA 1F31A 3DSEA 1S0CA 2IMAA 3FFZA 3QIZA 2FPQA 3C89A 2XHLA 3C8AA 3BOOA 1G9AA 1ZL6A 2ETFA 2IMBA 2G7NA 2ISGA 3V0AA 2QN0A 1T3CA 4EL4A 3BOKA 2NP0A 3DDBA 3BTAA 2A97A 1ZN3A 3NF3A 4HEVA 4ELCA 2NYYA 2W2DA 3ZUSA 1Z7HA 2NZ9A 3C8BA 1S0EA 2A8AA 3QJ0A 5BQNA 1EPWA 1ZB7A 3ZUQA 1XTFA 4KS6A 3FIEA 3FIIA 3D3XA 4EJ5A 1T3AA 1S0DA 3VUOA 2IMCA 2G7QA 3DDAA 1YVGA 1S0FA 3QW7A 1ZKWA 4KUFA 3C88A 1S0GA 1G9DA 3BONA 3QW5A 4ZKTB 3BWIA 5BQMA 3V0BB 1XTGA 3DEBA 3QW6A 2ISEA 3QIYA 3DS9A 3ZURA 2ILPA 4KTXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ZKX A;  1F82 A;  2G7P A;  1E1H A;  4ZJX A;  4J1L A;  1G9C A;  1G9B A;  2ISH A;  3K3Q B;  3V0B A;  3V0A B;  1S0B A;  3QW8 A;  1ZL5 A;  2G7K A;  3QIX A;  1I1E A;  1F31 A;  3DSE A;  1S0C A;  2IMA A;  3FFZ A;  3QIZ A;  2FPQ A;  3C89 A;  2XHL A;  3C8A A;  3BOO A;  1G9A A;  1ZL6 A;  2ETF A;  2IMB A;  2G7N A;  2ISG A;  3V0A A;  2QN0 A;  1T3C A;  4EL4 A;  3BOK A;  2NP0 A;  3DDB A;  3BTA A;  2A97 A;  1ZN3 A;  3NF3 A;  4HEV A;  4ELC A;  2NYY A;  2W2D A;  3ZUS A;  1Z7H A;  2NZ9 A;  3C8B A;  1S0E A;  2A8A A;  3QJ0 A;  5BQN A;  1EPW A;  1ZB7 A;  3ZUQ A;  1XTF A;  4KS6 A;  3FIE A;  3FII A;  3D3X A;  4EJ5 A;  1T3A A;  1S0D A;  3VUO A;  2IMC A;  2G7Q A;  3DDA A;  1YVG A;  1S0F A;  3QW7 A;  1ZKW A;  4KUF A;  3C88 A;  1S0G A;  1G9D A;  3BON A;  3QW5 A;  4ZKT B;  3BWI A;  5BQM A;  3V0B B;  1XTG A;  3DEB A;  3QW6 A;  2ISE A;  3QIY A;  3DS9 A;  3ZUR A;  2ILP A;  4KTX A; 
#chains in the Genus database with same CATH topology
 1ZKX A;  1F82 A;  2G7P A;  1E1H A;  4J1L A;  4ZJX A;  1G9C A;  1G9B A;  2ISH A;  4KTX A;  2YPT A;  3K3Q B;  3V0B A;  3V0A B;  1S0B A;  3QW8 A;  1ZL5 A;  2G7K A;  4JIU A;  3QIX A;  1I1E A;  1F31 A;  3DSE A;  4JIX A;  1S0C A;  2IMA A;  3FFZ A;  3QIZ A;  2FPQ A;  3C89 A;  3E11 A;  2EJQ A;  2XHL A;  3C8A A;  3BOO A;  1G9A A;  1ZL6 A;  2ETF A;  2IMB A;  2G7N A;  2ISG A;  3V0A A;  4IL3 A;  2QN0 A;  4EL4 A;  3BOK A;  2NP0 A;  3DDB A;  3BTA A;  2A97 A;  1ZN3 A;  3NF3 A;  4HEV A;  4ELC A;  2NYY A;  2W2D A;  3ZUS A;  1Z7H A;  2NZ9 A;  3C8B A;  1S0E A;  2A8A A;  3QJ0 A;  5BQN A;  1EPW A;  1ZB7 A;  3ZUQ A;  1XTF A;  4KS6 A;  3FIE A;  3FII A;  3D3X A;  4EJ5 A;  1T3A A;  1S0D A;  3VUO A;  2IMC A;  2G7Q A;  3DDA A;  1YVG A;  1S0F A;  3QW7 A;  1ZKW A;  4KUF A;  3C88 A;  1S0G A;  1G9D A;  3CQB A;  3BON A;  3QW5 A;  4ZKT B;  3BWI A;  5BQM A;  3V0B B;  1XTG A;  3DEB A;  3QW6 A;  2ISE A;  4AW6 A;  3QIY A;  4QHF A;  3DS9 A;  3ZUR A;  2ILP A;  1T3C A; 
#chains in the Genus database with same CATH homology
 1ZKX A;  1F82 A;  2G7P A;  1E1H A;  4ZJX A;  4J1L A;  1G9C A;  1G9B A;  2ISH A;  3K3Q B;  3V0B A;  3V0A B;  1S0B A;  3QW8 A;  1ZL5 A;  2G7K A;  3QIX A;  1I1E A;  1F31 A;  3DSE A;  1S0C A;  2IMA A;  3FFZ A;  3QIZ A;  2FPQ A;  3C89 A;  2XHL A;  3C8A A;  3BOO A;  1G9A A;  1ZL6 A;  2ETF A;  2IMB A;  2G7N A;  2ISG A;  3V0A A;  2QN0 A;  1T3C A;  4EL4 A;  3BOK A;  2NP0 A;  3DDB A;  3BTA A;  2A97 A;  1ZN3 A;  3NF3 A;  4HEV A;  4ELC A;  2NYY A;  2W2D A;  3ZUS A;  1Z7H A;  2NZ9 A;  3C8B A;  1S0E A;  2A8A A;  3QJ0 A;  5BQN A;  1EPW A;  1ZB7 A;  3ZUQ A;  1XTF A;  4KS6 A;  3FIE A;  3FII A;  3D3X A;  4EJ5 A;  1T3A A;  1S0D A;  3VUO A;  2IMC A;  2G7Q A;  3DDA A;  1YVG A;  1S0F A;  3QW7 A;  1ZKW A;  4KUF A;  3C88 A;  1S0G A;  1G9D A;  3BON A;  3QW5 A;  4ZKT B;  3BWI A;  5BQM A;  3V0B B;  1XTG A;  3DEB A;  3QW6 A;  2ISE A;  3QIY A;  3DS9 A;  3ZUR A;  2ILP A;  4KTX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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