4KS6A

Crystal structure of the catalytic domain of botulinum neurotoxin bont/a c134s mutant with covalent inhibitor that modifies cys-165 causing disorder in 166-174 stretch
Total Genus 141
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
141
sequence length
428
structure length
428
Chain Sequence
GSHMPFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNSINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLFEF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Covalent modification of the active site cysteine stresses Clostridium botulinum neurotoxin A
rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Clostridium botulinum a
molecule keywords Botulinum neurotoxin A light chain
total genus 141
structure length 428
sequence length 428
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2013-05-17
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 4ks6A00
2QN0A 3V0AB 3BOKA 2W2DA 1S0DA 4ZJXA 1XTFA 1T3CA 3V0BB 4ELCA 2ISHA 2ETFA 1S0EA 1S0CA 1ZL6A 2XHLA 3ZUQA 5BQNA 1S0BA 4EL4A 1S0GA 3C8AA 1Z7HA 3BWIA 2A8AA 4HEVA 3QW5A 1F82A 3DSEA 4ZKTB 2IMBA 3QW6A 1ZKXA 1T3AA 3FFZA 3DS9A 3ZURA 1YVGA 3D3XA 3QW7A 5BQMA 1F31A 2NZ9A 2NYYA 1G9BA 3C8BA 3QIYA 3BTAA 2ILPA 3K3QB 1G9CA 3QIZA 3V0AA 1S0FA 3QW8A 1ZKWA 3FIIA 3DDAA 3QIXA 1I1EA 1G9AA 2A97A 1EPWA 3C88A 3BONA 4KS6A 2IMCA 4EJ5A 1XTGA 3V0BA 3C89A 3QJ0A 3FIEA 2ISGA 4KTXA 1ZN3A 2IMAA 3DDBA 2G7QA 2G7KA 3BOOA 2NP0A 2ISEA 4J1LA 1G9DA 1ZB7A 1E1HA 3VUOA 1ZL5A 3ZUSA 2G7PA 2G7NA 3DEBA 2FPQA 3NF3A 4KUFA
chains in the Genus database with same CATH superfamily
2QN0A 3V0AB 3BOKA 2W2DA 1S0DA 4ZJXA 1XTFA 1T3CA 3V0BB 4ELCA 2ISHA 2ETFA 1S0EA 1S0CA 1ZL6A 2YPTA 2XHLA 3ZUQA 5BQNA 1S0BA 4EL4A 1S0GA 3C8AA 1Z7HA 3BWIA 2A8AA 4HEVA 3QW5A 1F82A 3DSEA 4ZKTB 4JIXA 2IMBA 3QW6A 1ZKXA 1T3AA 3FFZA 3DS9A 3ZURA 1YVGA 3CQBA 3D3XA 3QW7A 5BQMA 1F31A 2EJQA 2NZ9A 2NYYA 1G9BA 3C8BA 3QIYA 3BTAA 2ILPA 3K3QB 1G9CA 3QIZA 3V0AA 1S0FA 3QW8A 1ZKWA 3FIIA 3DDAA 3QIXA 1I1EA 1G9AA 2A97A 1EPWA 3C88A 3BONA 4KS6A 2IMCA 4EJ5A 1XTGA 3V0BA 3C89A 3QJ0A 4IL3A 3FIEA 3E11A 2ISGA 4KTXA 1ZN3A 2IMAA 3DDBA 4JIUA 2G7QA 2G7KA 3BOOA 2NP0A 2ISEA 4J1LA 1G9DA 1ZB7A 1E1HA 3VUOA 1ZL5A 3ZUSA 4AW6A 2G7PA 2G7NA 3DEBA 2FPQA 4QHFA 3NF3A 4KUFA
chains in the Genus database with same CATH topology
2QN0A 3V0AB 3BOKA 2W2DA 1S0DA 4ZJXA 1XTFA 1T3CA 3V0BB 4ELCA 2ISHA 2ETFA 1S0EA 1S0CA 1ZL6A 2XHLA 3ZUQA 5BQNA 1S0BA 4EL4A 1S0GA 3C8AA 1Z7HA 3BWIA 2A8AA 4HEVA 3QW5A 1F82A 3DSEA 4ZKTB 2IMBA 3QW6A 1ZKXA 1T3AA 3FFZA 3DS9A 3ZURA 1YVGA 3D3XA 3QW7A 5BQMA 1F31A 2NZ9A 2NYYA 1G9BA 3C8BA 3QIYA 3BTAA 2ILPA 3K3QB 1G9CA 3QIZA 3V0AA 1S0FA 3QW8A 1ZKWA 3FIIA 3DDAA 3QIXA 1I1EA 1G9AA 2A97A 1EPWA 3C88A 3BONA 4KS6A 2IMCA 4EJ5A 1XTGA 3V0BA 3C89A 3QJ0A 3FIEA 2ISGA 4KTXA 1ZN3A 2IMAA 3DDBA 2G7QA 2G7KA 3BOOA 2NP0A 2ISEA 4J1LA 1G9DA 1ZB7A 1E1HA 3VUOA 1ZL5A 3ZUSA 2G7PA 2G7NA 3DEBA 2FPQA 3NF3A 4KUFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2QN0 A;  3V0A B;  3BOK A;  2W2D A;  1S0D A;  4ZJX A;  1XTF A;  1T3C A;  3V0B B;  4ELC A;  2ISH A;  2ETF A;  1S0E A;  1S0C A;  1ZL6 A;  2XHL A;  3ZUQ A;  5BQN A;  1S0B A;  4EL4 A;  1S0G A;  3C8A A;  1Z7H A;  3BWI A;  2A8A A;  4HEV A;  3QW5 A;  1F82 A;  3DSE A;  4ZKT B;  2IMB A;  3QW6 A;  1ZKX A;  1T3A A;  3FFZ A;  3DS9 A;  3ZUR A;  1YVG A;  3D3X A;  3QW7 A;  5BQM A;  1F31 A;  2NZ9 A;  2NYY A;  1G9B A;  3C8B A;  3QIY A;  3BTA A;  2ILP A;  3K3Q B;  1G9C A;  3QIZ A;  3V0A A;  1S0F A;  3QW8 A;  1ZKW A;  3FII A;  3DDA A;  3QIX A;  1I1E A;  1G9A A;  2A97 A;  1EPW A;  3C88 A;  3BON A;  4KS6 A;  2IMC A;  4EJ5 A;  1XTG A;  3V0B A;  3C89 A;  3QJ0 A;  3FIE A;  2ISG A;  4KTX A;  1ZN3 A;  2IMA A;  3DDB A;  2G7Q A;  2G7K A;  3BOO A;  2NP0 A;  2ISE A;  4J1L A;  1G9D A;  1ZB7 A;  1E1H A;  3VUO A;  1ZL5 A;  3ZUS A;  2G7P A;  2G7N A;  3DEB A;  2FPQ A;  3NF3 A;  4KUF A; 
#chains in the Genus database with same CATH topology
 2QN0 A;  3V0A B;  3BOK A;  2W2D A;  1S0D A;  4ZJX A;  1XTF A;  1T3C A;  3V0B B;  4ELC A;  2ISH A;  2ETF A;  1S0E A;  1S0C A;  1ZL6 A;  2YPT A;  2XHL A;  3ZUQ A;  5BQN A;  1S0B A;  4EL4 A;  1S0G A;  3C8A A;  1Z7H A;  3BWI A;  2A8A A;  4HEV A;  3QW5 A;  1F82 A;  3DSE A;  4ZKT B;  4JIX A;  2IMB A;  3QW6 A;  1ZKX A;  1T3A A;  3FFZ A;  3DS9 A;  3ZUR A;  1YVG A;  3CQB A;  3D3X A;  3QW7 A;  5BQM A;  1F31 A;  2EJQ A;  2NZ9 A;  2NYY A;  1G9B A;  3C8B A;  3QIY A;  3BTA A;  2ILP A;  3K3Q B;  1G9C A;  3QIZ A;  3V0A A;  1S0F A;  3QW8 A;  1ZKW A;  3FII A;  3DDA A;  3QIX A;  1I1E A;  1G9A A;  2A97 A;  1EPW A;  3C88 A;  3BON A;  4KS6 A;  2IMC A;  4EJ5 A;  1XTG A;  3V0B A;  3C89 A;  3QJ0 A;  4IL3 A;  3FIE A;  3E11 A;  2ISG A;  4KTX A;  1ZN3 A;  2IMA A;  3DDB A;  4JIU A;  2G7Q A;  2G7K A;  3BOO A;  2NP0 A;  2ISE A;  4J1L A;  1G9D A;  1ZB7 A;  1E1H A;  3VUO A;  1ZL5 A;  3ZUS A;  4AW6 A;  2G7P A;  2G7N A;  3DEB A;  2FPQ A;  4QHF A;  3NF3 A;  4KUF A; 
#chains in the Genus database with same CATH homology
 2QN0 A;  3V0A B;  3BOK A;  2W2D A;  1S0D A;  4ZJX A;  1XTF A;  1T3C A;  3V0B B;  4ELC A;  2ISH A;  2ETF A;  1S0E A;  1S0C A;  1ZL6 A;  2XHL A;  3ZUQ A;  5BQN A;  1S0B A;  4EL4 A;  1S0G A;  3C8A A;  1Z7H A;  3BWI A;  2A8A A;  4HEV A;  3QW5 A;  1F82 A;  3DSE A;  4ZKT B;  2IMB A;  3QW6 A;  1ZKX A;  1T3A A;  3FFZ A;  3DS9 A;  3ZUR A;  1YVG A;  3D3X A;  3QW7 A;  5BQM A;  1F31 A;  2NZ9 A;  2NYY A;  1G9B A;  3C8B A;  3QIY A;  3BTA A;  2ILP A;  3K3Q B;  1G9C A;  3QIZ A;  3V0A A;  1S0F A;  3QW8 A;  1ZKW A;  3FII A;  3DDA A;  3QIX A;  1I1E A;  1G9A A;  2A97 A;  1EPW A;  3C88 A;  3BON A;  4KS6 A;  2IMC A;  4EJ5 A;  1XTG A;  3V0B A;  3C89 A;  3QJ0 A;  3FIE A;  2ISG A;  4KTX A;  1ZN3 A;  2IMA A;  3DDB A;  2G7Q A;  2G7K A;  3BOO A;  2NP0 A;  2ISE A;  4J1L A;  1G9D A;  1ZB7 A;  1E1H A;  3VUO A;  1ZL5 A;  3ZUS A;  2G7P A;  2G7N A;  3DEB A;  2FPQ A;  3NF3 A;  4KUF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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