4ZJXA

Crystal structure of the catalytic domain of botulinum neurotoxin serotype a with a novel cyclic peptide inhibitor
Total Genus 135
50100150200250300350400020406080100120140
Genus TraceResidueGenus

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
135
sequence length
423
structure length
417
Chain Sequence
MPFVNKQFNYKDPVNGVDIAYIKIPNVGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
S2 (33-39)TVIII1 (2-5)EMPTYTIV1 (15-18)TI1 (9-12)AH1 (81-100)S1 (19-23)S6 (144-148)O1 (24-26)TIV4 (49-52)TII1 (39-42)S7 (151-155)S3 (42-48)S8 (164-167)S9 (184-187)TI2 (53-56)TI3 (63-66)TIV8 (68-71)TIV9 (156-159)TVIII3 (157-160)TI4 (74-77)TII2 (76-79)TI14 (380-383)AH2 (102-113)AH4 (217-233)AH8 (335-348)AH7 (310-321)TI5 (123-126)S4 (126-127)3H1 (131-133)S5 (134-138)TI6 (139-142)TI7 (159-162)TI8 (174-177)TI9 (175-178)TIV11 (176-179)TI10 (189-192)S10 (192-196)S11 (213-214)AH3 (200-204)TI11 (205-208)S18 (413-418)TIV14 (365-368)TIV19 (406-409)TIV17 (398-401)TI18 (395-398)3H2 (270-273)TI12 (238-241)S12 (242-244)AH5 (260-266)S13 (257-259)AH6 (276-299)S15 (323-325)TI13 (326-329)TIV13 (327-330)TI19 (405-408)TI15 (381-384)TI16 (385-388)TI17 (386-389)TII'2 (388-391)TIV15 (389-392)TIV16 (396-399)3H3 (402-404)3H4 (410-412)TIV5 (50-53)S17 (372-376)TIV10 (170-173)O3 (196-202)TII'1 (267-270)TIV12 (306-309)S14 (302-303)TII3 (392-395)S16 (331-333)AH9 (351-358)Updating...
connected with : NaN
molecule tags Hydrolase/hydrolase inhibitor
source organism Clostridium botulinum
publication title Crystal structure of the catalytic domain of botulinum neurotoxin serotype A with a Novel Cyclic Peptide Inhibitor
rcsb
molecule keywords Botulinum neurotoxin type A
total genus 135
structure length 417
sequence length 423
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2015-04-29
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 4zjxA00
3DS9A 4KS6A 4HEVA 2XHLA 5BQNA 3ZURA 1EPWA 2FPQA 3DEBA 1T3CA 4ZJXA 2G7QA 1XTFA 1YVGA 2NYYA 3NF3A 3FIEA 3FIIA 2G7KA 3C8BA 1ZL5A 1G9CA 4EL4A 1ZKWA 4J1LA 3QIYA 2IMCA 3BTAA 3FFZA 1S0EA 2W2DA 3QW6A 3BONA 1Z7HA 2NZ9A 1XTGA 1G9BA 3DDBA 3QIXA 3K3QB 2QN0A 3BWIA 3QIZA 1ZN3A 3C89A 1G9DA 3DDAA 3C8AA 1S0BA 3V0AB 1S0DA 1ZKXA 3ZUQA 3VUOA 1S0GA 1G9AA 3QW5A 3BOOA 1T3AA 2ILPA 3QW7A 2A8AA 3QJ0A 1ZL6A 1S0CA 3D3XA 3C88A 2G7PA 2A97A 1F82A 3ZUSA 3V0BB 3BOKA 1ZB7A 2ISHA 3DSEA 2ISEA 1I1EA 2NP0A 4ELCA 1E1HA 1S0FA 3QW8A 2ISGA 4KTXA 3V0BA 5BQMA 4KUFA 4EJ5A 3V0AA 2G7NA 4ZKTB 2IMAA 1F31A 2IMBA 2ETFA
chains in the Genus database with same CATH superfamily
3DS9A 4KS6A 4HEVA 2XHLA 5BQNA 3ZURA 1EPWA 2FPQA 3DEBA 1T3CA 4ZJXA 2G7QA 1XTFA 1YVGA 2NYYA 3NF3A 4QHFA 3FIEA 3FIIA 2G7KA 3C8BA 1ZL5A 1G9CA 4EL4A 1ZKWA 4J1LA 3QIYA 2IMCA 3BTAA 3FFZA 1S0EA 2W2DA 3QW6A 3BONA 2YPTA 1Z7HA 2NZ9A 1XTGA 1G9BA 3DDBA 3QIXA 3CQBA 3K3QB 2QN0A 3BWIA 3QIZA 4AW6A 3E11A 1ZN3A 3C89A 1G9DA 3DDAA 3C8AA 1S0BA 3V0AB 1S0DA 1ZKXA 4JIUA 3ZUQA 3VUOA 1S0GA 1G9AA 3QW5A 3BOOA 1T3AA 2ILPA 3QW7A 2A8AA 3QJ0A 1ZL6A 1S0CA 3D3XA 3C88A 2G7PA 2A97A 4JIXA 1F82A 3ZUSA 3V0BB 3BOKA 1ZB7A 2ISHA 3DSEA 2ISEA 1I1EA 2NP0A 2IMBA 4ELCA 1E1HA 1S0FA 3QW8A 2ISGA 4KTXA 2EJQA 3V0BA 5BQMA 4KUFA 4EJ5A 3V0AA 2G7NA 4ZKTB 2IMAA 1F31A 4IL3A 2ETFA
chains in the Genus database with same CATH topology
3DS9A 4KS6A 4HEVA 2XHLA 5BQNA 3ZURA 1EPWA 2FPQA 3DEBA 1T3CA 4ZJXA 2G7QA 1XTFA 1YVGA 2NYYA 3NF3A 3FIEA 3FIIA 2G7KA 3C8BA 1ZL5A 1G9CA 4EL4A 1ZKWA 4J1LA 3QIYA 2IMCA 3BTAA 3FFZA 1S0EA 2W2DA 3QW6A 3BONA 1Z7HA 2NZ9A 1XTGA 1G9BA 3DDBA 3QIXA 3K3QB 2QN0A 3BWIA 3QIZA 1ZN3A 3C89A 1G9DA 3DDAA 3C8AA 1S0BA 3V0AB 1S0DA 1ZKXA 3ZUQA 3VUOA 1S0GA 1G9AA 3QW5A 3BOOA 1T3AA 2ILPA 3QW7A 2A8AA 3QJ0A 1ZL6A 1S0CA 3D3XA 3C88A 2G7PA 2A97A 1F82A 3ZUSA 3V0BB 3BOKA 1ZB7A 2ISHA 3DSEA 2ISEA 1I1EA 2NP0A 4ELCA 1E1HA 1S0FA 3QW8A 2ISGA 4KTXA 3V0BA 5BQMA 4KUFA 4EJ5A 3V0AA 2G7NA 4ZKTB 2IMAA 1F31A 2IMBA 2ETFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3DS9 A;  4KS6 A;  4HEV A;  2XHL A;  5BQN A;  3ZUR A;  1EPW A;  2FPQ A;  3DEB A;  1T3C A;  4ZJX A;  2G7Q A;  1XTF A;  1YVG A;  2NYY A;  3NF3 A;  3FIE A;  3FII A;  2G7K A;  3C8B A;  1ZL5 A;  1G9C A;  4EL4 A;  1ZKW A;  4J1L A;  3QIY A;  2IMC A;  3BTA A;  3FFZ A;  1S0E A;  2W2D A;  3QW6 A;  3BON A;  1Z7H A;  2NZ9 A;  1XTG A;  1G9B A;  3DDB A;  3QIX A;  3K3Q B;  2QN0 A;  3BWI A;  3QIZ A;  1ZN3 A;  3C89 A;  1G9D A;  3DDA A;  3C8A A;  1S0B A;  3V0A B;  1S0D A;  1ZKX A;  3ZUQ A;  3VUO A;  1S0G A;  1G9A A;  3QW5 A;  3BOO A;  1T3A A;  2ILP A;  3QW7 A;  2A8A A;  3QJ0 A;  1ZL6 A;  1S0C A;  3D3X A;  3C88 A;  2G7P A;  2A97 A;  1F82 A;  3ZUS A;  3V0B B;  3BOK A;  1ZB7 A;  2ISH A;  3DSE A;  2ISE A;  1I1E A;  2NP0 A;  4ELC A;  1E1H A;  1S0F A;  3QW8 A;  2ISG A;  4KTX A;  3V0B A;  5BQM A;  4KUF A;  4EJ5 A;  3V0A A;  2G7N A;  4ZKT B;  2IMA A;  1F31 A;  2IMB A;  2ETF A; 
#chains in the Genus database with same CATH topology
 3DS9 A;  4KS6 A;  4HEV A;  2XHL A;  5BQN A;  3ZUR A;  1EPW A;  2FPQ A;  3DEB A;  1T3C A;  4ZJX A;  2G7Q A;  1XTF A;  1YVG A;  2NYY A;  3NF3 A;  4QHF A;  3FIE A;  3FII A;  2G7K A;  3C8B A;  1ZL5 A;  1G9C A;  4EL4 A;  1ZKW A;  4J1L A;  3QIY A;  2IMC A;  3BTA A;  3FFZ A;  1S0E A;  2W2D A;  3QW6 A;  3BON A;  2YPT A;  1Z7H A;  2NZ9 A;  1XTG A;  1G9B A;  3DDB A;  3QIX A;  3CQB A;  3K3Q B;  2QN0 A;  3BWI A;  3QIZ A;  4AW6 A;  3E11 A;  1ZN3 A;  3C89 A;  1G9D A;  3DDA A;  3C8A A;  1S0B A;  3V0A B;  1S0D A;  1ZKX A;  4JIU A;  3ZUQ A;  3VUO A;  1S0G A;  1G9A A;  3QW5 A;  3BOO A;  1T3A A;  2ILP A;  3QW7 A;  2A8A A;  3QJ0 A;  1ZL6 A;  1S0C A;  3D3X A;  3C88 A;  2G7P A;  2A97 A;  4JIX A;  1F82 A;  3ZUS A;  3V0B B;  3BOK A;  1ZB7 A;  2ISH A;  3DSE A;  2ISE A;  1I1E A;  2NP0 A;  2IMB A;  4ELC A;  1E1H A;  1S0F A;  3QW8 A;  2ISG A;  4KTX A;  2EJQ A;  3V0B A;  5BQM A;  4KUF A;  4EJ5 A;  3V0A A;  2G7N A;  4ZKT B;  2IMA A;  1F31 A;  4IL3 A;  2ETF A; 
#chains in the Genus database with same CATH homology
 3DS9 A;  4KS6 A;  4HEV A;  2XHL A;  5BQN A;  3ZUR A;  1EPW A;  2FPQ A;  3DEB A;  1T3C A;  4ZJX A;  2G7Q A;  1XTF A;  1YVG A;  2NYY A;  3NF3 A;  3FIE A;  3FII A;  2G7K A;  3C8B A;  1ZL5 A;  1G9C A;  4EL4 A;  1ZKW A;  4J1L A;  3QIY A;  2IMC A;  3BTA A;  3FFZ A;  1S0E A;  2W2D A;  3QW6 A;  3BON A;  1Z7H A;  2NZ9 A;  1XTG A;  1G9B A;  3DDB A;  3QIX A;  3K3Q B;  2QN0 A;  3BWI A;  3QIZ A;  1ZN3 A;  3C89 A;  1G9D A;  3DDA A;  3C8A A;  1S0B A;  3V0A B;  1S0D A;  1ZKX A;  3ZUQ A;  3VUO A;  1S0G A;  1G9A A;  3QW5 A;  3BOO A;  1T3A A;  2ILP A;  3QW7 A;  2A8A A;  3QJ0 A;  1ZL6 A;  1S0C A;  3D3X A;  3C88 A;  2G7P A;  2A97 A;  1F82 A;  3ZUS A;  3V0B B;  3BOK A;  1ZB7 A;  2ISH A;  3DSE A;  2ISE A;  1I1E A;  2NP0 A;  4ELC A;  1E1H A;  1S0F A;  3QW8 A;  2ISG A;  4KTX A;  3V0B A;  5BQM A;  4KUF A;  4EJ5 A;  3V0A A;  2G7N A;  4ZKT B;  2IMA A;  1F31 A;  2IMB A;  2ETF A; 
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