4AWNA

Structure of recombinant human dnase i (rhdnasei) in complex with magnesium and phosphate.
Total Genus 78
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
78
sequence length
260
structure length
260
Chain Sequence
LKIAAFNIQTFGETKMSNATLVSYIVQILSRYDIALVQEVRDSHLTAVGKLLDNLNQDAPDTYHYVVSEPLGRNSYKERYLFVYRPDQVSAVDSYYYDDGCEPCGNDTFNREPAIVRFFSRFTEVREFAIVPLHAAPGDAVAEIDALYDVYLDVQEKWGLEDVMLMGDFNAGCSYVRPSQWSSIRLWTSPTFQWLIPDSADTTATPTHCAYDRIVVAGMLLRGAVVPDSALPFNFQAAYGLSDQLAQAISDHYPVEVMLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The Structure of Human DNase I Bound to Magnesium and Phosphate Ions Points to a Catalytic Mechanism Common to Members of the DNase I-Like Superfamily.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords DEOXYRIBONUCLEASE-1
total genus 78
structure length 260
sequence length 260
ec nomenclature ec 3.1.21.1: Deoxyribonuclease I.
pdb deposition date 2012-06-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03372 Exo_endo_phos Endonuclease/Exonuclease/phosphatase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.10.10 Alpha Beta 4-Layer Sandwich Deoxyribonuclease I; Chain A Endonuclease/exonuclease/phosphatase 4awnA00
5DV4A 1Y21A 4K6LF 1DE9A 2DNJA 5J3SA 4B5HA 5A7IA 2DDTA 4FVAA 3TEBA 3FZIA 3I46A 4L20A 4F1IA 5DFFA 3CJCD 1ZWXA 1ATND 2XSWA 3G0AA 2O3CA 3G0RA 5INKA 5J3ZA 5EWTA 2F1NA 1I9YA 1SI6X 5DG0A 4QHDA 3I5VA 2EI9A 4FPVA 2IMQX 1DNKA 3W3DB 5INMA 3MTCA 5J42A 4CMNA 4AWNA 3G4TA 1AKOA 3G91A 5INOA 2V0RA 4IEMA 4GZ2A 5DFHA 2DDRA 5INNA 3G1KA 2A41B 3DNIA 4L1ZA 4A9CA 4JG3A 4B5JA 5CFGA 3G6SA 1DE8A 4GEWA 5DFIA 3W2XA 5DFJA 3W2YA 5A7JA 1YJHA 3G3YA 4F1HB 1WDUA 4B5IA 3G2CA 3N9VA 3G8VA 2D1KB 3NGQA 1E9NA 1SR4B 3GA6A 3G2DA 5INPA 4L21A 4B5GA 3I48A 3MPRA 5INQA 4QHEA 3NR8A 4GZ0A 4QH9A 3NGOA 2J63A 1DEWA 3WCXA 2DDSA 2F2FB 4PUQA 4C1RA 2JC5A 3U8UA 4L1YA 2UYRX 4B5FA 1HD7A 1VYBA 5DV2A 3G3CA 5J8NA 3K55A 2A42B 3NGNA 4F1RA 3I41A 4CMLA 4F1HA 2A40B 2O3HA 3L1WA 5INLA 2ISIA 2JC4A 1BIXA 2V0SA 2VOAA 4LNDA 4RUWA 1NTFA 5HT2A 3G00A 4B5MA 2A3ZB 4GYZA 5CFEA 3G38A 1I9ZA 4GZ1A 5J3PA
chains in the Genus database with same CATH superfamily
5DV4A 1Y21A 4K6LF 1DE9A 2DNJA 5J3SA 4B5HA 5A7IA 2DDTA 4FVAA 3TEBA 3FZIA 3I46A 4L20A 4F1IA 5DFFA 3CJCD 1ZWXA 1ATND 2XSWA 3G0AA 2O3CA 3G0RA 5INKA 5J3ZA 5EWTA 2F1NA 1I9YA 1SI6X 5DG0A 4QHDA 3I5VA 2EI9A 4FPVA 2IMQX 1DNKA 3W3DB 5INMA 3MTCA 5J42A 4CMNA 4AWNA 3G4TA 1AKOA 3G91A 5INOA 2V0RA 4IEMA 4GZ2A 5DFHA 2DDRA 5INNA 3G1KA 2A41B 3DNIA 4L1ZA 4A9CA 4JG3A 4B5JA 5CFGA 3G6SA 1DE8A 4GEWA 5DFIA 3W2XA 5DFJA 3W2YA 5A7JA 1YJHA 3G3YA 4F1HB 1WDUA 4B5IA 3G2CA 3N9VA 3G8VA 2D1KB 3NGQA 1E9NA 1SR4B 3GA6A 3G2DA 5INPA 4L21A 4B5GA 3I48A 3MPRA 5INQA 4QHEA 3NR8A 4GZ0A 4QH9A 3NGOA 2J63A 1DEWA 3WCXA 2DDSA 2F2FB 4PUQA 4C1RA 2JC5A 3U8UA 4L1YA 2UYRX 4B5FA 1HD7A 1VYBA 5DV2A 3G3CA 5J8NA 3K55A 2A42B 3NGNA 4F1RA 3I41A 4CMLA 4F1HA 2A40B 2O3HA 3L1WA 5INLA 2ISIA 2JC4A 1BIXA 2V0SA 2VOAA 4LNDA 4RUWA 1NTFA 5HT2A 3G00A 4B5MA 2A3ZB 4GYZA 5CFEA 3G38A 1I9ZA 4GZ1A 5J3PA
chains in the Genus database with same CATH topology
5DV4A 1Y21A 4K6LF 1DE9A 2DNJA 5J3SA 4B5HA 5A7IA 2DDTA 4FVAA 3TEBA 3FZIA 3I46A 4L20A 4F1IA 5DFFA 3CJCD 1ZWXA 1ATND 2XSWA 3G0AA 2O3CA 3G0RA 5INKA 5J3ZA 5EWTA 2F1NA 1I9YA 1SI6X 5DG0A 4QHDA 3I5VA 2EI9A 4FPVA 2IMQX 1DNKA 3W3DB 5INMA 3MTCA 5J42A 4CMNA 4AWNA 3G4TA 1AKOA 3G91A 5INOA 2V0RA 4IEMA 4GZ2A 5DFHA 2DDRA 5INNA 3G1KA 2A41B 3DNIA 4L1ZA 4A9CA 4JG3A 4B5JA 5CFGA 3G6SA 1DE8A 4GEWA 5DFIA 3W2XA 5DFJA 3W2YA 5A7JA 1YJHA 3G3YA 4F1HB 1WDUA 4B5IA 3G2CA 3N9VA 3G8VA 2D1KB 3NGQA 1E9NA 1SR4B 3GA6A 3G2DA 5INPA 4L21A 4B5GA 3I48A 3MPRA 5INQA 4QHEA 3NR8A 4GZ0A 4QH9A 3NGOA 2J63A 1DEWA 3WCXA 2DDSA 2F2FB 4PUQA 4C1RA 2JC5A 3U8UA 4L1YA 2UYRX 4B5FA 1HD7A 1VYBA 5DV2A 3G3CA 5J8NA 3K55A 2A42B 3NGNA 4F1RA 3I41A 4CMLA 4F1HA 2A40B 2O3HA 3L1WA 5INLA 2ISIA 2JC4A 1BIXA 2V0SA 2VOAA 4LNDA 4RUWA 1NTFA 5HT2A 3G00A 4B5MA 2A3ZB 4GYZA 5CFEA 3G38A 1I9ZA 4GZ1A 5J3PA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5DV4 A;  1Y21 A;  4K6L F;  1DE9 A;  2DNJ A;  5J3S A;  4B5H A;  5A7I A;  2DDT A;  4FVA A;  3TEB A;  3FZI A;  3I46 A;  4L20 A;  4F1I A;  5DFF A;  3CJC D;  1ZWX A;  1ATN D;  2XSW A;  3G0A A;  2O3C A;  3G0R A;  5INK A;  5J3Z A;  5EWT A;  2F1N A;  1I9Y A;  1SI6 X;  5DG0 A;  4QHD A;  3I5V A;  2EI9 A;  4FPV A;  2IMQ X;  1DNK A;  3W3D B;  5INM A;  3MTC A;  5J42 A;  4CMN A;  4AWN A;  3G4T A;  1AKO A;  3G91 A;  5INO A;  2V0R A;  4IEM A;  4GZ2 A;  5DFH A;  2DDR A;  5INN A;  3G1K A;  2A41 B;  3DNI A;  4L1Z A;  4A9C A;  4JG3 A;  4B5J A;  5CFG A;  3G6S A;  1DE8 A;  4GEW A;  5DFI A;  3W2X A;  5DFJ A;  3W2Y A;  5A7J A;  1YJH A;  3G3Y A;  4F1H B;  1WDU A;  4B5I A;  3G2C A;  3N9V A;  3G8V A;  2D1K B;  3NGQ A;  1E9N A;  1SR4 B;  3GA6 A;  3G2D A;  5INP A;  4L21 A;  4B5G A;  3I48 A;  3MPR A;  5INQ A;  4QHE A;  3NR8 A;  4GZ0 A;  4QH9 A;  3NGO A;  2J63 A;  1DEW A;  3WCX A;  2DDS A;  2F2F B;  4PUQ A;  4C1R A;  2JC5 A;  3U8U A;  4L1Y A;  2UYR X;  4B5F A;  1HD7 A;  1VYB A;  5DV2 A;  3G3C A;  5J8N A;  3K55 A;  2A42 B;  3NGN A;  4F1R A;  3I41 A;  4CML A;  4F1H A;  2A40 B;  2O3H A;  3L1W A;  5INL A;  2ISI A;  2JC4 A;  1BIX A;  2V0S A;  2VOA A;  4LND A;  4RUW A;  1NTF A;  5HT2 A;  3G00 A;  4B5M A;  2A3Z B;  4GYZ A;  5CFE A;  3G38 A;  1I9Z A;  4GZ1 A;  5J3P A; 
#chains in the Genus database with same CATH topology
 5DV4 A;  1Y21 A;  4K6L F;  1DE9 A;  2DNJ A;  5J3S A;  4B5H A;  5A7I A;  2DDT A;  4FVA A;  3TEB A;  3FZI A;  3I46 A;  4L20 A;  4F1I A;  5DFF A;  3CJC D;  1ZWX A;  1ATN D;  2XSW A;  3G0A A;  2O3C A;  3G0R A;  5INK A;  5J3Z A;  5EWT A;  2F1N A;  1I9Y A;  1SI6 X;  5DG0 A;  4QHD A;  3I5V A;  2EI9 A;  4FPV A;  2IMQ X;  1DNK A;  3W3D B;  5INM A;  3MTC A;  5J42 A;  4CMN A;  4AWN A;  3G4T A;  1AKO A;  3G91 A;  5INO A;  2V0R A;  4IEM A;  4GZ2 A;  5DFH A;  2DDR A;  5INN A;  3G1K A;  2A41 B;  3DNI A;  4L1Z A;  4A9C A;  4JG3 A;  4B5J A;  5CFG A;  3G6S A;  1DE8 A;  4GEW A;  5DFI A;  3W2X A;  5DFJ A;  3W2Y A;  5A7J A;  1YJH A;  3G3Y A;  4F1H B;  1WDU A;  4B5I A;  3G2C A;  3N9V A;  3G8V A;  2D1K B;  3NGQ A;  1E9N A;  1SR4 B;  3GA6 A;  3G2D A;  5INP A;  4L21 A;  4B5G A;  3I48 A;  3MPR A;  5INQ A;  4QHE A;  3NR8 A;  4GZ0 A;  4QH9 A;  3NGO A;  2J63 A;  1DEW A;  3WCX A;  2DDS A;  2F2F B;  4PUQ A;  4C1R A;  2JC5 A;  3U8U A;  4L1Y A;  2UYR X;  4B5F A;  1HD7 A;  1VYB A;  5DV2 A;  3G3C A;  5J8N A;  3K55 A;  2A42 B;  3NGN A;  4F1R A;  3I41 A;  4CML A;  4F1H A;  2A40 B;  2O3H A;  3L1W A;  5INL A;  2ISI A;  2JC4 A;  1BIX A;  2V0S A;  2VOA A;  4LND A;  4RUW A;  1NTF A;  5HT2 A;  3G00 A;  4B5M A;  2A3Z B;  4GYZ A;  5CFE A;  3G38 A;  1I9Z A;  4GZ1 A;  5J3P A; 
#chains in the Genus database with same CATH homology
 5DV4 A;  1Y21 A;  4K6L F;  1DE9 A;  2DNJ A;  5J3S A;  4B5H A;  5A7I A;  2DDT A;  4FVA A;  3TEB A;  3FZI A;  3I46 A;  4L20 A;  4F1I A;  5DFF A;  3CJC D;  1ZWX A;  1ATN D;  2XSW A;  3G0A A;  2O3C A;  3G0R A;  5INK A;  5J3Z A;  5EWT A;  2F1N A;  1I9Y A;  1SI6 X;  5DG0 A;  4QHD A;  3I5V A;  2EI9 A;  4FPV A;  2IMQ X;  1DNK A;  3W3D B;  5INM A;  3MTC A;  5J42 A;  4CMN A;  4AWN A;  3G4T A;  1AKO A;  3G91 A;  5INO A;  2V0R A;  4IEM A;  4GZ2 A;  5DFH A;  2DDR A;  5INN A;  3G1K A;  2A41 B;  3DNI A;  4L1Z A;  4A9C A;  4JG3 A;  4B5J A;  5CFG A;  3G6S A;  1DE8 A;  4GEW A;  5DFI A;  3W2X A;  5DFJ A;  3W2Y A;  5A7J A;  1YJH A;  3G3Y A;  4F1H B;  1WDU A;  4B5I A;  3G2C A;  3N9V A;  3G8V A;  2D1K B;  3NGQ A;  1E9N A;  1SR4 B;  3GA6 A;  3G2D A;  5INP A;  4L21 A;  4B5G A;  3I48 A;  3MPR A;  5INQ A;  4QHE A;  3NR8 A;  4GZ0 A;  4QH9 A;  3NGO A;  2J63 A;  1DEW A;  3WCX A;  2DDS A;  2F2F B;  4PUQ A;  4C1R A;  2JC5 A;  3U8U A;  4L1Y A;  2UYR X;  4B5F A;  1HD7 A;  1VYB A;  5DV2 A;  3G3C A;  5J8N A;  3K55 A;  2A42 B;  3NGN A;  4F1R A;  3I41 A;  4CML A;  4F1H A;  2A40 B;  2O3H A;  3L1W A;  5INL A;  2ISI A;  2JC4 A;  1BIX A;  2V0S A;  2VOA A;  4LND A;  4RUW A;  1NTF A;  5HT2 A;  3G00 A;  4B5M A;  2A3Z B;  4GYZ A;  5CFE A;  3G38 A;  1I9Z A;  4GZ1 A;  5J3P A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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