4CMLA

Crystal structure of inpp5b in complex with phosphatidylinositol 3,4- bisphosphate
Total Genus 93
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
93
sequence length
310
structure length
310
Chain Sequence
MYTYIQNFRFFAGTYNVNGQSPKECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDVILWLGDLNYRIEELDVEKVKKLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTGSDDWDTSEKCRAPAWCDRILWKGKNITQLSYQSHMALKTSDHKPVSSVFDIGVRVVAHHH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis for Phosphoinositide Substrate Recognition, Catalysis, and Membrane Interactions in Human Inositol Polyphosphate 5-Phosphatases.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5- PHOSPHATASE, ISOFORM
total genus 93
structure length 310
sequence length 310
ec nomenclature ec 3.1.3.36: Phosphoinositide 5-phosphatase.
pdb deposition date 2014-01-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03372 Exo_endo_phos Endonuclease/Exonuclease/phosphatase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.10.10 Alpha Beta 4-Layer Sandwich Deoxyribonuclease I; Chain A Endonuclease/exonuclease/phosphatase 4cmlA00
1DNKA 4JG3A 1I9YA 4GEWA 3G2CA 3GA6A 2EI9A 2A40B 4GZ0A 5J3ZA 3WCXA 4FPVA 1AKOA 2JC5A 3G91A 4AWNA 3NR8A 5A7JA 4GZ1A 5EWTA 2DDSA 3DNIA 3I48A 3MPRA 3TEBA 5DFHA 4B5HA 1BIXA 4B5JA 2VOAA 3W3DB 5A7IA 2DDRA 5INNA 1ATND 4QHDA 4F1HA 4B5MA 1DE8A 3NGQA 2D1KB 5CFGA 5CFEA 4IEMA 3G00A 5INLA 1Y21A 3CJCD 1ZWXA 1E9NA 4L1ZA 4F1HB 5J3SA 3U8UA 5DV2A 1HD7A 4F1IA 5INOA 2A3ZB 3G38A 3G8VA 1DE9A 5INKA 1WDUA 4CMNA 3G0AA 1VYBA 4L21A 2A41B 4LNDA 3W2XA 1I9ZA 5INMA 4B5GA 3NGOA 1NTFA 5DFFA 3I41A 2JC4A 5INQA 5DG0A 5DV4A 1DEWA 4C1RA 3K55A 3G4TA 1YJHA 2XSWA 5DFIA 4GZ2A 4RUWA 3FZIA 2DNJA 5J8NA 4B5IA 2O3CA 3I5VA 3MTCA 5HT2A 3N9VA 4FVAA 2A42B 2J63A 2O3HA 2ISIA 3G2DA 2V0RA 4L1YA 3G3CA 5INPA 4K6LF 2DDTA 2UYRX 3I46A 4A9CA 2IMQX 3G0RA 3NGNA 2V0SA 4GYZA 2F2FB 4F1RA 3L1WA 3W2YA 4CMLA 3G6SA 5J3PA 4L20A 3G1KA 5J42A 4PUQA 4QHEA 1SR4B 2F1NA 4B5FA 5DFJA 3G3YA 1SI6X 4QH9A
chains in the Genus database with same CATH superfamily
1DNKA 4JG3A 1I9YA 4GEWA 3G2CA 3GA6A 2EI9A 2A40B 4GZ0A 5J3ZA 3WCXA 4FPVA 1AKOA 2JC5A 3G91A 4AWNA 3NR8A 5A7JA 4GZ1A 5EWTA 2DDSA 3DNIA 3I48A 3MPRA 3TEBA 5DFHA 4B5HA 1BIXA 4B5JA 2VOAA 3W3DB 5A7IA 2DDRA 5INNA 1ATND 4QHDA 4F1HA 4B5MA 1DE8A 3NGQA 2D1KB 5CFGA 5CFEA 4IEMA 3G00A 5INLA 1Y21A 3CJCD 1ZWXA 1E9NA 4L1ZA 4F1HB 5J3SA 3U8UA 5DV2A 1HD7A 4F1IA 5INOA 2A3ZB 3G38A 3G8VA 1DE9A 5INKA 1WDUA 4CMNA 3G0AA 1VYBA 4L21A 2A41B 4LNDA 3W2XA 1I9ZA 5INMA 4B5GA 3NGOA 1NTFA 5DFFA 3I41A 2JC4A 5INQA 5DG0A 5DV4A 1DEWA 4C1RA 3K55A 3G4TA 1YJHA 2XSWA 5DFIA 4GZ2A 4RUWA 3FZIA 2DNJA 5J8NA 4B5IA 2O3CA 3I5VA 3MTCA 5HT2A 3N9VA 4FVAA 2A42B 2J63A 2O3HA 2ISIA 3G2DA 2V0RA 4L1YA 3G3CA 5INPA 4K6LF 2DDTA 2UYRX 3I46A 4A9CA 2IMQX 3G0RA 3NGNA 2V0SA 4GYZA 2F2FB 4F1RA 3L1WA 3W2YA 4CMLA 3G6SA 5J3PA 4L20A 3G1KA 5J42A 4PUQA 4QHEA 1SR4B 2F1NA 4B5FA 5DFJA 3G3YA 1SI6X 4QH9A
chains in the Genus database with same CATH topology
1DNKA 4JG3A 1I9YA 4GEWA 3G2CA 3GA6A 2EI9A 2A40B 4GZ0A 5J3ZA 3WCXA 4FPVA 1AKOA 2JC5A 3G91A 4AWNA 3NR8A 5A7JA 4GZ1A 5EWTA 2DDSA 3DNIA 3I48A 3MPRA 3TEBA 5DFHA 4B5HA 1BIXA 4B5JA 2VOAA 3W3DB 5A7IA 2DDRA 5INNA 1ATND 4QHDA 4F1HA 4B5MA 1DE8A 3NGQA 2D1KB 5CFGA 5CFEA 4IEMA 3G00A 5INLA 1Y21A 3CJCD 1ZWXA 1E9NA 4L1ZA 4F1HB 5J3SA 3U8UA 5DV2A 1HD7A 4F1IA 5INOA 2A3ZB 3G38A 3G8VA 1DE9A 5INKA 1WDUA 4CMNA 3G0AA 1VYBA 4L21A 2A41B 4LNDA 3W2XA 1I9ZA 5INMA 4B5GA 3NGOA 1NTFA 5DFFA 3I41A 2JC4A 5INQA 5DG0A 5DV4A 1DEWA 4C1RA 3K55A 3G4TA 1YJHA 2XSWA 5DFIA 4GZ2A 4RUWA 3FZIA 2DNJA 5J8NA 4B5IA 2O3CA 3I5VA 3MTCA 5HT2A 3N9VA 4FVAA 2A42B 2J63A 2O3HA 2ISIA 3G2DA 2V0RA 4L1YA 3G3CA 5INPA 4K6LF 2DDTA 2UYRX 3I46A 4A9CA 2IMQX 3G0RA 3NGNA 2V0SA 4GYZA 2F2FB 4F1RA 3L1WA 3W2YA 4CMLA 3G6SA 5J3PA 4L20A 3G1KA 5J42A 4PUQA 4QHEA 1SR4B 2F1NA 4B5FA 5DFJA 3G3YA 1SI6X 4QH9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DNK A;  4JG3 A;  1I9Y A;  4GEW A;  3G2C A;  3GA6 A;  2EI9 A;  2A40 B;  4GZ0 A;  5J3Z A;  3WCX A;  4FPV A;  1AKO A;  2JC5 A;  3G91 A;  4AWN A;  3NR8 A;  5A7J A;  4GZ1 A;  5EWT A;  2DDS A;  3DNI A;  3I48 A;  3MPR A;  3TEB A;  5DFH A;  4B5H A;  1BIX A;  4B5J A;  2VOA A;  3W3D B;  5A7I A;  2DDR A;  5INN A;  1ATN D;  4QHD A;  4F1H A;  4B5M A;  1DE8 A;  3NGQ A;  2D1K B;  5CFG A;  5CFE A;  4IEM A;  3G00 A;  5INL A;  1Y21 A;  3CJC D;  1ZWX A;  1E9N A;  4L1Z A;  4F1H B;  5J3S A;  3U8U A;  5DV2 A;  1HD7 A;  4F1I A;  5INO A;  2A3Z B;  3G38 A;  3G8V A;  1DE9 A;  5INK A;  1WDU A;  4CMN A;  3G0A A;  1VYB A;  4L21 A;  2A41 B;  4LND A;  3W2X A;  1I9Z A;  5INM A;  4B5G A;  3NGO A;  1NTF A;  5DFF A;  3I41 A;  2JC4 A;  5INQ A;  5DG0 A;  5DV4 A;  1DEW A;  4C1R A;  3K55 A;  3G4T A;  1YJH A;  2XSW A;  5DFI A;  4GZ2 A;  4RUW A;  3FZI A;  2DNJ A;  5J8N A;  4B5I A;  2O3C A;  3I5V A;  3MTC A;  5HT2 A;  3N9V A;  4FVA A;  2A42 B;  2J63 A;  2O3H A;  2ISI A;  3G2D A;  2V0R A;  4L1Y A;  3G3C A;  5INP A;  4K6L F;  2DDT A;  2UYR X;  3I46 A;  4A9C A;  2IMQ X;  3G0R A;  3NGN A;  2V0S A;  4GYZ A;  2F2F B;  4F1R A;  3L1W A;  3W2Y A;  4CML A;  3G6S A;  5J3P A;  4L20 A;  3G1K A;  5J42 A;  4PUQ A;  4QHE A;  1SR4 B;  2F1N A;  4B5F A;  5DFJ A;  3G3Y A;  1SI6 X;  4QH9 A; 
#chains in the Genus database with same CATH topology
 1DNK A;  4JG3 A;  1I9Y A;  4GEW A;  3G2C A;  3GA6 A;  2EI9 A;  2A40 B;  4GZ0 A;  5J3Z A;  3WCX A;  4FPV A;  1AKO A;  2JC5 A;  3G91 A;  4AWN A;  3NR8 A;  5A7J A;  4GZ1 A;  5EWT A;  2DDS A;  3DNI A;  3I48 A;  3MPR A;  3TEB A;  5DFH A;  4B5H A;  1BIX A;  4B5J A;  2VOA A;  3W3D B;  5A7I A;  2DDR A;  5INN A;  1ATN D;  4QHD A;  4F1H A;  4B5M A;  1DE8 A;  3NGQ A;  2D1K B;  5CFG A;  5CFE A;  4IEM A;  3G00 A;  5INL A;  1Y21 A;  3CJC D;  1ZWX A;  1E9N A;  4L1Z A;  4F1H B;  5J3S A;  3U8U A;  5DV2 A;  1HD7 A;  4F1I A;  5INO A;  2A3Z B;  3G38 A;  3G8V A;  1DE9 A;  5INK A;  1WDU A;  4CMN A;  3G0A A;  1VYB A;  4L21 A;  2A41 B;  4LND A;  3W2X A;  1I9Z A;  5INM A;  4B5G A;  3NGO A;  1NTF A;  5DFF A;  3I41 A;  2JC4 A;  5INQ A;  5DG0 A;  5DV4 A;  1DEW A;  4C1R A;  3K55 A;  3G4T A;  1YJH A;  2XSW A;  5DFI A;  4GZ2 A;  4RUW A;  3FZI A;  2DNJ A;  5J8N A;  4B5I A;  2O3C A;  3I5V A;  3MTC A;  5HT2 A;  3N9V A;  4FVA A;  2A42 B;  2J63 A;  2O3H A;  2ISI A;  3G2D A;  2V0R A;  4L1Y A;  3G3C A;  5INP A;  4K6L F;  2DDT A;  2UYR X;  3I46 A;  4A9C A;  2IMQ X;  3G0R A;  3NGN A;  2V0S A;  4GYZ A;  2F2F B;  4F1R A;  3L1W A;  3W2Y A;  4CML A;  3G6S A;  5J3P A;  4L20 A;  3G1K A;  5J42 A;  4PUQ A;  4QHE A;  1SR4 B;  2F1N A;  4B5F A;  5DFJ A;  3G3Y A;  1SI6 X;  4QH9 A; 
#chains in the Genus database with same CATH homology
 1DNK A;  4JG3 A;  1I9Y A;  4GEW A;  3G2C A;  3GA6 A;  2EI9 A;  2A40 B;  4GZ0 A;  5J3Z A;  3WCX A;  4FPV A;  1AKO A;  2JC5 A;  3G91 A;  4AWN A;  3NR8 A;  5A7J A;  4GZ1 A;  5EWT A;  2DDS A;  3DNI A;  3I48 A;  3MPR A;  3TEB A;  5DFH A;  4B5H A;  1BIX A;  4B5J A;  2VOA A;  3W3D B;  5A7I A;  2DDR A;  5INN A;  1ATN D;  4QHD A;  4F1H A;  4B5M A;  1DE8 A;  3NGQ A;  2D1K B;  5CFG A;  5CFE A;  4IEM A;  3G00 A;  5INL A;  1Y21 A;  3CJC D;  1ZWX A;  1E9N A;  4L1Z A;  4F1H B;  5J3S A;  3U8U A;  5DV2 A;  1HD7 A;  4F1I A;  5INO A;  2A3Z B;  3G38 A;  3G8V A;  1DE9 A;  5INK A;  1WDU A;  4CMN A;  3G0A A;  1VYB A;  4L21 A;  2A41 B;  4LND A;  3W2X A;  1I9Z A;  5INM A;  4B5G A;  3NGO A;  1NTF A;  5DFF A;  3I41 A;  2JC4 A;  5INQ A;  5DG0 A;  5DV4 A;  1DEW A;  4C1R A;  3K55 A;  3G4T A;  1YJH A;  2XSW A;  5DFI A;  4GZ2 A;  4RUW A;  3FZI A;  2DNJ A;  5J8N A;  4B5I A;  2O3C A;  3I5V A;  3MTC A;  5HT2 A;  3N9V A;  4FVA A;  2A42 B;  2J63 A;  2O3H A;  2ISI A;  3G2D A;  2V0R A;  4L1Y A;  3G3C A;  5INP A;  4K6L F;  2DDT A;  2UYR X;  3I46 A;  4A9C A;  2IMQ X;  3G0R A;  3NGN A;  2V0S A;  4GYZ A;  2F2F B;  4F1R A;  3L1W A;  3W2Y A;  4CML A;  3G6S A;  5J3P A;  4L20 A;  3G1K A;  5J42 A;  4PUQ A;  4QHE A;  1SR4 B;  2F1N A;  4B5F A;  5DFJ A;  3G3Y A;  1SI6 X;  4QH9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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