5A7JA

Crystal structure of inpp5b in complex with benzene 1,2,4,5- tetrakisphosphate
Total Genus 85
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
85
sequence length
309
structure length
309
Chain Sequence
MYTYIQNFRFFAGTYNVNGQSPKECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDVILWLGDLNYRIEELDVEKVKKLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTGSDDWDTSEKCRAPAWCDRILWKGKNITQLSYQSHMALKTSDHKPVSSVFDIGVRVVAHH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase Inpp5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE
total genus 85
structure length 309
sequence length 309
chains with identical sequence B
ec nomenclature ec 3.1.3.36: Phosphoinositide 5-phosphatase.
pdb deposition date 2015-07-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03372 Exo_endo_phos Endonuclease/Exonuclease/phosphatase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.10.10 Alpha Beta 4-Layer Sandwich Deoxyribonuclease I; Chain A Endonuclease/exonuclease/phosphatase 5a7jA00
3I5VA 4B5IA 2J63A 4QHEA 5DFJA 3G1KA 5INMA 4L20A 4L21A 4F1HA 5DFFA 3G91A 1E9NA 3G6SA 4CMNA 1BIXA 3I48A 2V0SA 2DDTA 2A41B 2DNJA 2UYRX 4K6LF 4L1YA 2VOAA 3TEBA 3CJCD 4A9CA 4QH9A 1DNKA 4FPVA 2A42B 3U8UA 5HT2A 1ZWXA 3I41A 1WDUA 2JC5A 3NR8A 4F1IA 3WCXA 5J42A 4B5JA 4GYZA 4CMLA 1SR4B 5J3SA 1VYBA 2V0RA 5INPA 3I46A 1ATND 5EWTA 4C1RA 5INLA 3G3YA 3DNIA 3K55A 4L1ZA 3NGNA 3G8VA 4AWNA 3G0AA 5DG0A 4B5MA 3G4TA 4B5FA 4F1RA 4LNDA 4PUQA 5DFIA 1DE8A 2ISIA 3G0RA 5J3PA 4JG3A 3G2CA 1I9YA 3GA6A 4GZ0A 3L1WA 4RUWA 4GZ2A 2F1NA 5J3ZA 5INKA 2DDSA 4QHDA 1YJHA 3N9VA 3FZIA 1DEWA 1HD7A 5DFHA 2A40B 2IMQX 3MTCA 3W2XA 4FVAA 2F2FB 5CFGA 5J8NA 5CFEA 1Y21A 3W2YA 2DDRA 1NTFA 2O3HA 5DV2A 3G00A 4B5GA 1AKOA 5DV4A 3G38A 3G3CA 2JC4A 4IEMA 4GZ1A 4GEWA 5A7IA 3W3DB 5INQA 5INOA 3MPRA 3NGOA 5INNA 4F1HB 2O3CA 1DE9A 2XSWA 5A7JA 2D1KB 2A3ZB 3G2DA 4B5HA 1SI6X 1I9ZA 2EI9A 3NGQA
chains in the Genus database with same CATH superfamily
3I5VA 4B5IA 2J63A 4QHEA 5DFJA 3G1KA 5INMA 4L20A 4L21A 4F1HA 5DFFA 3G91A 1E9NA 3G6SA 4CMNA 1BIXA 3I48A 2V0SA 2DDTA 2A41B 2DNJA 2UYRX 4K6LF 4L1YA 2VOAA 3TEBA 3CJCD 4A9CA 4QH9A 1DNKA 4FPVA 2A42B 3U8UA 5HT2A 1ZWXA 3I41A 1WDUA 2JC5A 3NR8A 4F1IA 3WCXA 5J42A 4B5JA 4GYZA 4CMLA 1SR4B 5J3SA 1VYBA 2V0RA 5INPA 3I46A 1ATND 5EWTA 4C1RA 5INLA 3G3YA 3DNIA 3K55A 4L1ZA 3NGNA 3G8VA 4AWNA 3G0AA 5DG0A 4B5MA 3G4TA 4B5FA 4F1RA 4LNDA 4PUQA 5DFIA 1DE8A 2ISIA 3G0RA 5J3PA 4JG3A 3G2CA 1I9YA 3GA6A 4GZ0A 3L1WA 4RUWA 4GZ2A 2F1NA 5J3ZA 5INKA 2DDSA 4QHDA 1YJHA 3N9VA 3FZIA 1DEWA 1HD7A 5DFHA 2A40B 2IMQX 3MTCA 3W2XA 4FVAA 2F2FB 5CFGA 5J8NA 5CFEA 1Y21A 3W2YA 2DDRA 1NTFA 2O3HA 5DV2A 3G00A 4B5GA 1AKOA 5DV4A 3G38A 3G3CA 2JC4A 4IEMA 4GZ1A 4GEWA 5A7IA 3W3DB 5INQA 5INOA 3MPRA 3NGOA 5INNA 4F1HB 2O3CA 1DE9A 2XSWA 5A7JA 2D1KB 2A3ZB 3G2DA 4B5HA 1SI6X 1I9ZA 2EI9A 3NGQA
chains in the Genus database with same CATH topology
3I5VA 4B5IA 2J63A 4QHEA 5DFJA 3G1KA 5INMA 4L20A 4L21A 4F1HA 5DFFA 3G91A 1E9NA 3G6SA 4CMNA 1BIXA 3I48A 2V0SA 2DDTA 2A41B 2DNJA 2UYRX 4K6LF 4L1YA 2VOAA 3TEBA 3CJCD 4A9CA 4QH9A 1DNKA 4FPVA 2A42B 3U8UA 5HT2A 1ZWXA 3I41A 1WDUA 2JC5A 3NR8A 4F1IA 3WCXA 5J42A 4B5JA 4GYZA 4CMLA 1SR4B 5J3SA 1VYBA 2V0RA 5INPA 3I46A 1ATND 5EWTA 4C1RA 5INLA 3G3YA 3DNIA 3K55A 4L1ZA 3NGNA 3G8VA 4AWNA 3G0AA 5DG0A 4B5MA 3G4TA 4B5FA 4F1RA 4LNDA 4PUQA 5DFIA 1DE8A 2ISIA 3G0RA 5J3PA 4JG3A 3G2CA 1I9YA 3GA6A 4GZ0A 3L1WA 4RUWA 4GZ2A 2F1NA 5J3ZA 5INKA 2DDSA 4QHDA 1YJHA 3N9VA 3FZIA 1DEWA 1HD7A 5DFHA 2A40B 2IMQX 3MTCA 3W2XA 4FVAA 2F2FB 5CFGA 5J8NA 5CFEA 1Y21A 3W2YA 2DDRA 1NTFA 2O3HA 5DV2A 3G00A 4B5GA 1AKOA 5DV4A 3G38A 3G3CA 2JC4A 4IEMA 4GZ1A 4GEWA 5A7IA 3W3DB 5INQA 5INOA 3MPRA 3NGOA 5INNA 4F1HB 2O3CA 1DE9A 2XSWA 5A7JA 2D1KB 2A3ZB 3G2DA 4B5HA 1SI6X 1I9ZA 2EI9A 3NGQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3I5V A;  4B5I A;  2J63 A;  4QHE A;  5DFJ A;  3G1K A;  5INM A;  4L20 A;  4L21 A;  4F1H A;  5DFF A;  3G91 A;  1E9N A;  3G6S A;  4CMN A;  1BIX A;  3I48 A;  2V0S A;  2DDT A;  2A41 B;  2DNJ A;  2UYR X;  4K6L F;  4L1Y A;  2VOA A;  3TEB A;  3CJC D;  4A9C A;  4QH9 A;  1DNK A;  4FPV A;  2A42 B;  3U8U A;  5HT2 A;  1ZWX A;  3I41 A;  1WDU A;  2JC5 A;  3NR8 A;  4F1I A;  3WCX A;  5J42 A;  4B5J A;  4GYZ A;  4CML A;  1SR4 B;  5J3S A;  1VYB A;  2V0R A;  5INP A;  3I46 A;  1ATN D;  5EWT A;  4C1R A;  5INL A;  3G3Y A;  3DNI A;  3K55 A;  4L1Z A;  3NGN A;  3G8V A;  4AWN A;  3G0A A;  5DG0 A;  4B5M A;  3G4T A;  4B5F A;  4F1R A;  4LND A;  4PUQ A;  5DFI A;  1DE8 A;  2ISI A;  3G0R A;  5J3P A;  4JG3 A;  3G2C A;  1I9Y A;  3GA6 A;  4GZ0 A;  3L1W A;  4RUW A;  4GZ2 A;  2F1N A;  5J3Z A;  5INK A;  2DDS A;  4QHD A;  1YJH A;  3N9V A;  3FZI A;  1DEW A;  1HD7 A;  5DFH A;  2A40 B;  2IMQ X;  3MTC A;  3W2X A;  4FVA A;  2F2F B;  5CFG A;  5J8N A;  5CFE A;  1Y21 A;  3W2Y A;  2DDR A;  1NTF A;  2O3H A;  5DV2 A;  3G00 A;  4B5G A;  1AKO A;  5DV4 A;  3G38 A;  3G3C A;  2JC4 A;  4IEM A;  4GZ1 A;  4GEW A;  5A7I A;  3W3D B;  5INQ A;  5INO A;  3MPR A;  3NGO A;  5INN A;  4F1H B;  2O3C A;  1DE9 A;  2XSW A;  5A7J A;  2D1K B;  2A3Z B;  3G2D A;  4B5H A;  1SI6 X;  1I9Z A;  2EI9 A;  3NGQ A; 
#chains in the Genus database with same CATH topology
 3I5V A;  4B5I A;  2J63 A;  4QHE A;  5DFJ A;  3G1K A;  5INM A;  4L20 A;  4L21 A;  4F1H A;  5DFF A;  3G91 A;  1E9N A;  3G6S A;  4CMN A;  1BIX A;  3I48 A;  2V0S A;  2DDT A;  2A41 B;  2DNJ A;  2UYR X;  4K6L F;  4L1Y A;  2VOA A;  3TEB A;  3CJC D;  4A9C A;  4QH9 A;  1DNK A;  4FPV A;  2A42 B;  3U8U A;  5HT2 A;  1ZWX A;  3I41 A;  1WDU A;  2JC5 A;  3NR8 A;  4F1I A;  3WCX A;  5J42 A;  4B5J A;  4GYZ A;  4CML A;  1SR4 B;  5J3S A;  1VYB A;  2V0R A;  5INP A;  3I46 A;  1ATN D;  5EWT A;  4C1R A;  5INL A;  3G3Y A;  3DNI A;  3K55 A;  4L1Z A;  3NGN A;  3G8V A;  4AWN A;  3G0A A;  5DG0 A;  4B5M A;  3G4T A;  4B5F A;  4F1R A;  4LND A;  4PUQ A;  5DFI A;  1DE8 A;  2ISI A;  3G0R A;  5J3P A;  4JG3 A;  3G2C A;  1I9Y A;  3GA6 A;  4GZ0 A;  3L1W A;  4RUW A;  4GZ2 A;  2F1N A;  5J3Z A;  5INK A;  2DDS A;  4QHD A;  1YJH A;  3N9V A;  3FZI A;  1DEW A;  1HD7 A;  5DFH A;  2A40 B;  2IMQ X;  3MTC A;  3W2X A;  4FVA A;  2F2F B;  5CFG A;  5J8N A;  5CFE A;  1Y21 A;  3W2Y A;  2DDR A;  1NTF A;  2O3H A;  5DV2 A;  3G00 A;  4B5G A;  1AKO A;  5DV4 A;  3G38 A;  3G3C A;  2JC4 A;  4IEM A;  4GZ1 A;  4GEW A;  5A7I A;  3W3D B;  5INQ A;  5INO A;  3MPR A;  3NGO A;  5INN A;  4F1H B;  2O3C A;  1DE9 A;  2XSW A;  5A7J A;  2D1K B;  2A3Z B;  3G2D A;  4B5H A;  1SI6 X;  1I9Z A;  2EI9 A;  3NGQ A; 
#chains in the Genus database with same CATH homology
 3I5V A;  4B5I A;  2J63 A;  4QHE A;  5DFJ A;  3G1K A;  5INM A;  4L20 A;  4L21 A;  4F1H A;  5DFF A;  3G91 A;  1E9N A;  3G6S A;  4CMN A;  1BIX A;  3I48 A;  2V0S A;  2DDT A;  2A41 B;  2DNJ A;  2UYR X;  4K6L F;  4L1Y A;  2VOA A;  3TEB A;  3CJC D;  4A9C A;  4QH9 A;  1DNK A;  4FPV A;  2A42 B;  3U8U A;  5HT2 A;  1ZWX A;  3I41 A;  1WDU A;  2JC5 A;  3NR8 A;  4F1I A;  3WCX A;  5J42 A;  4B5J A;  4GYZ A;  4CML A;  1SR4 B;  5J3S A;  1VYB A;  2V0R A;  5INP A;  3I46 A;  1ATN D;  5EWT A;  4C1R A;  5INL A;  3G3Y A;  3DNI A;  3K55 A;  4L1Z A;  3NGN A;  3G8V A;  4AWN A;  3G0A A;  5DG0 A;  4B5M A;  3G4T A;  4B5F A;  4F1R A;  4LND A;  4PUQ A;  5DFI A;  1DE8 A;  2ISI A;  3G0R A;  5J3P A;  4JG3 A;  3G2C A;  1I9Y A;  3GA6 A;  4GZ0 A;  3L1W A;  4RUW A;  4GZ2 A;  2F1N A;  5J3Z A;  5INK A;  2DDS A;  4QHD A;  1YJH A;  3N9V A;  3FZI A;  1DEW A;  1HD7 A;  5DFH A;  2A40 B;  2IMQ X;  3MTC A;  3W2X A;  4FVA A;  2F2F B;  5CFG A;  5J8N A;  5CFE A;  1Y21 A;  3W2Y A;  2DDR A;  1NTF A;  2O3H A;  5DV2 A;  3G00 A;  4B5G A;  1AKO A;  5DV4 A;  3G38 A;  3G3C A;  2JC4 A;  4IEM A;  4GZ1 A;  4GEW A;  5A7I A;  3W3D B;  5INQ A;  5INO A;  3MPR A;  3NGO A;  5INN A;  4F1H B;  2O3C A;  1DE9 A;  2XSW A;  5A7J A;  2D1K B;  2A3Z B;  3G2D A;  4B5H A;  1SI6 X;  1I9Z A;  2EI9 A;  3NGQ A; 
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similar chains in the Genus database (?% sequence similarity)
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