5A7JA

Crystal structure of inpp5b in complex with benzene 1,2,4,5- tetrakisphosphate
Total Genus 85
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
85
sequence length
309
structure length
309
Chain Sequence
MYTYIQNFRFFAGTYNVNGQSPKECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDVILWLGDLNYRIEELDVEKVKKLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTGSDDWDTSEKCRAPAWCDRILWKGKNITQLSYQSHMALKTSDHKPVSSVFDIGVRVVAHH
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase Inpp5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE
total genus 85
structure length 309
sequence length 309
chains with identical sequence B
ec nomenclature ec 3.1.3.36: Phosphoinositide 5-phosphatase.
pdb deposition date 2015-07-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03372 Exo_endo_phos Endonuclease/Exonuclease/phosphatase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.10.10 Alpha Beta 4-Layer Sandwich Deoxyribonuclease I; Chain A Endonuclease/exonuclease/phosphatase 5a7jA00
2EI9A 5INLA 4FVAA 1ZWXA 4K6LF 4GZ1A 5J42A 4PUQA 3G0AA 4JG3A 5DFHA 3W2YA 5CFGA 3K55A 4CMNA 4L1YA 3W3DB 3G91A 4RUWA 3MTCA 1HD7A 4AWNA 2JC5A 2DDSA 2O3HA 3G2DA 2XSWA 1DEWA 5DFFA 3I46A 2ISIA 1YJHA 4B5GA 3FZIA 1I9YA 4L21A 5J3ZA 5A7JA 5EWTA 3MPRA 3U8UA 2UYRX 2IMQX 5J3SA 1DE8A 5INOA 3G38A 3GA6A 3NR8A 5DV4A 3L1WA 4GZ0A 4B5IA 5DV2A 1AKOA 1Y21A 5INNA 3G8VA 1SI6X 3NGOA 3G2CA 4LNDA 5J3PA 1BIXA 3G0RA 2A40B 2A3ZB 2A41B 4QHEA 3G1KA 4B5MA 4C1RA 3I48A 4L20A 5INQA 5INMA 5CFEA 4B5FA 3G4TA 3I41A 3DNIA 4F1HB 5INPA 1ATND 4CMLA 5A7IA 5INKA 3CJCD 3G6SA 4QHDA 1WDUA 2V0SA 4GYZA 1I9ZA 5HT2A 4GEWA 1E9NA 5DG0A 4F1IA 2A42B 3WCXA 3I5VA 4IEMA 1DNKA 4A9CA 3G00A 3N9VA 2V0RA 2O3CA 3G3YA 2JC4A 2DNJA 4FPVA 2D1KB 5DFIA 3NGQA 4B5HA 5J8NA 1VYBA 1NTFA 4F1HA 5DFJA 2F2FB 2J63A 4QH9A 3W2XA 4L1ZA 2F1NA 4B5JA 1DE9A 2DDRA 4F1RA 3TEBA 2VOAA 4GZ2A 2DDTA 3NGNA 1SR4B 3G3CA
chains in the Genus database with same CATH superfamily
2EI9A 5INLA 4FVAA 1ZWXA 4K6LF 4GZ1A 5J42A 4PUQA 3G0AA 4JG3A 5DFHA 3W2YA 5CFGA 3K55A 4CMNA 4L1YA 3W3DB 3G91A 4RUWA 3MTCA 1HD7A 4AWNA 2JC5A 2DDSA 2O3HA 3G2DA 2XSWA 1DEWA 5DFFA 3I46A 2ISIA 1YJHA 4B5GA 3FZIA 1I9YA 4L21A 5J3ZA 5A7JA 5EWTA 3MPRA 3U8UA 2UYRX 2IMQX 5J3SA 1DE8A 5INOA 3G38A 3GA6A 3NR8A 5DV4A 3L1WA 4GZ0A 4B5IA 5DV2A 1AKOA 1Y21A 5INNA 3G8VA 1SI6X 3NGOA 3G2CA 4LNDA 5J3PA 1BIXA 3G0RA 2A40B 2A3ZB 2A41B 4QHEA 3G1KA 4B5MA 4C1RA 3I48A 4L20A 5INQA 5INMA 5CFEA 4B5FA 3G4TA 3I41A 3DNIA 4F1HB 5INPA 1ATND 4CMLA 5A7IA 5INKA 3CJCD 3G6SA 4QHDA 1WDUA 2V0SA 4GYZA 1I9ZA 5HT2A 4GEWA 1E9NA 5DG0A 4F1IA 2A42B 3WCXA 3I5VA 4IEMA 1DNKA 4A9CA 3G00A 3N9VA 2V0RA 2O3CA 3G3YA 2JC4A 2DNJA 4FPVA 2D1KB 5DFIA 3NGQA 4B5HA 5J8NA 1VYBA 1NTFA 4F1HA 5DFJA 2F2FB 2J63A 4QH9A 3W2XA 4L1ZA 2F1NA 4B5JA 1DE9A 2DDRA 4F1RA 3TEBA 2VOAA 4GZ2A 2DDTA 3NGNA 1SR4B 3G3CA
chains in the Genus database with same CATH topology
2EI9A 5INLA 4FVAA 1ZWXA 4K6LF 4GZ1A 5J42A 4PUQA 3G0AA 4JG3A 5DFHA 3W2YA 5CFGA 3K55A 4CMNA 4L1YA 3W3DB 3G91A 4RUWA 3MTCA 1HD7A 4AWNA 2JC5A 2DDSA 2O3HA 3G2DA 2XSWA 1DEWA 5DFFA 3I46A 2ISIA 1YJHA 4B5GA 3FZIA 1I9YA 4L21A 5J3ZA 5A7JA 5EWTA 3MPRA 3U8UA 2UYRX 2IMQX 5J3SA 1DE8A 5INOA 3G38A 3GA6A 3NR8A 5DV4A 3L1WA 4GZ0A 4B5IA 5DV2A 1AKOA 1Y21A 5INNA 3G8VA 1SI6X 3NGOA 3G2CA 4LNDA 5J3PA 1BIXA 3G0RA 2A40B 2A3ZB 2A41B 4QHEA 3G1KA 4B5MA 4C1RA 3I48A 4L20A 5INQA 5INMA 5CFEA 4B5FA 3G4TA 3I41A 3DNIA 4F1HB 5INPA 1ATND 4CMLA 5A7IA 5INKA 3CJCD 3G6SA 4QHDA 1WDUA 2V0SA 4GYZA 1I9ZA 5HT2A 4GEWA 1E9NA 5DG0A 4F1IA 2A42B 3WCXA 3I5VA 4IEMA 1DNKA 4A9CA 3G00A 3N9VA 2V0RA 2O3CA 3G3YA 2JC4A 2DNJA 4FPVA 2D1KB 5DFIA 3NGQA 4B5HA 5J8NA 1VYBA 1NTFA 4F1HA 5DFJA 2F2FB 2J63A 4QH9A 3W2XA 4L1ZA 2F1NA 4B5JA 1DE9A 2DDRA 4F1RA 3TEBA 2VOAA 4GZ2A 2DDTA 3NGNA 1SR4B 3G3CA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2EI9 A;  5INL A;  4FVA A;  1ZWX A;  4K6L F;  4GZ1 A;  5J42 A;  4PUQ A;  3G0A A;  4JG3 A;  5DFH A;  3W2Y A;  5CFG A;  3K55 A;  4CMN A;  4L1Y A;  3W3D B;  3G91 A;  4RUW A;  3MTC A;  1HD7 A;  4AWN A;  2JC5 A;  2DDS A;  2O3H A;  3G2D A;  2XSW A;  1DEW A;  5DFF A;  3I46 A;  2ISI A;  1YJH A;  4B5G A;  3FZI A;  1I9Y A;  4L21 A;  5J3Z A;  5A7J A;  5EWT A;  3MPR A;  3U8U A;  2UYR X;  2IMQ X;  5J3S A;  1DE8 A;  5INO A;  3G38 A;  3GA6 A;  3NR8 A;  5DV4 A;  3L1W A;  4GZ0 A;  4B5I A;  5DV2 A;  1AKO A;  1Y21 A;  5INN A;  3G8V A;  1SI6 X;  3NGO A;  3G2C A;  4LND A;  5J3P A;  1BIX A;  3G0R A;  2A40 B;  2A3Z B;  2A41 B;  4QHE A;  3G1K A;  4B5M A;  4C1R A;  3I48 A;  4L20 A;  5INQ A;  5INM A;  5CFE A;  4B5F A;  3G4T A;  3I41 A;  3DNI A;  4F1H B;  5INP A;  1ATN D;  4CML A;  5A7I A;  5INK A;  3CJC D;  3G6S A;  4QHD A;  1WDU A;  2V0S A;  4GYZ A;  1I9Z A;  5HT2 A;  4GEW A;  1E9N A;  5DG0 A;  4F1I A;  2A42 B;  3WCX A;  3I5V A;  4IEM A;  1DNK A;  4A9C A;  3G00 A;  3N9V A;  2V0R A;  2O3C A;  3G3Y A;  2JC4 A;  2DNJ A;  4FPV A;  2D1K B;  5DFI A;  3NGQ A;  4B5H A;  5J8N A;  1VYB A;  1NTF A;  4F1H A;  5DFJ A;  2F2F B;  2J63 A;  4QH9 A;  3W2X A;  4L1Z A;  2F1N A;  4B5J A;  1DE9 A;  2DDR A;  4F1R A;  3TEB A;  2VOA A;  4GZ2 A;  2DDT A;  3NGN A;  1SR4 B;  3G3C A; 
#chains in the Genus database with same CATH topology
 2EI9 A;  5INL A;  4FVA A;  1ZWX A;  4K6L F;  4GZ1 A;  5J42 A;  4PUQ A;  3G0A A;  4JG3 A;  5DFH A;  3W2Y A;  5CFG A;  3K55 A;  4CMN A;  4L1Y A;  3W3D B;  3G91 A;  4RUW A;  3MTC A;  1HD7 A;  4AWN A;  2JC5 A;  2DDS A;  2O3H A;  3G2D A;  2XSW A;  1DEW A;  5DFF A;  3I46 A;  2ISI A;  1YJH A;  4B5G A;  3FZI A;  1I9Y A;  4L21 A;  5J3Z A;  5A7J A;  5EWT A;  3MPR A;  3U8U A;  2UYR X;  2IMQ X;  5J3S A;  1DE8 A;  5INO A;  3G38 A;  3GA6 A;  3NR8 A;  5DV4 A;  3L1W A;  4GZ0 A;  4B5I A;  5DV2 A;  1AKO A;  1Y21 A;  5INN A;  3G8V A;  1SI6 X;  3NGO A;  3G2C A;  4LND A;  5J3P A;  1BIX A;  3G0R A;  2A40 B;  2A3Z B;  2A41 B;  4QHE A;  3G1K A;  4B5M A;  4C1R A;  3I48 A;  4L20 A;  5INQ A;  5INM A;  5CFE A;  4B5F A;  3G4T A;  3I41 A;  3DNI A;  4F1H B;  5INP A;  1ATN D;  4CML A;  5A7I A;  5INK A;  3CJC D;  3G6S A;  4QHD A;  1WDU A;  2V0S A;  4GYZ A;  1I9Z A;  5HT2 A;  4GEW A;  1E9N A;  5DG0 A;  4F1I A;  2A42 B;  3WCX A;  3I5V A;  4IEM A;  1DNK A;  4A9C A;  3G00 A;  3N9V A;  2V0R A;  2O3C A;  3G3Y A;  2JC4 A;  2DNJ A;  4FPV A;  2D1K B;  5DFI A;  3NGQ A;  4B5H A;  5J8N A;  1VYB A;  1NTF A;  4F1H A;  5DFJ A;  2F2F B;  2J63 A;  4QH9 A;  3W2X A;  4L1Z A;  2F1N A;  4B5J A;  1DE9 A;  2DDR A;  4F1R A;  3TEB A;  2VOA A;  4GZ2 A;  2DDT A;  3NGN A;  1SR4 B;  3G3C A; 
#chains in the Genus database with same CATH homology
 2EI9 A;  5INL A;  4FVA A;  1ZWX A;  4K6L F;  4GZ1 A;  5J42 A;  4PUQ A;  3G0A A;  4JG3 A;  5DFH A;  3W2Y A;  5CFG A;  3K55 A;  4CMN A;  4L1Y A;  3W3D B;  3G91 A;  4RUW A;  3MTC A;  1HD7 A;  4AWN A;  2JC5 A;  2DDS A;  2O3H A;  3G2D A;  2XSW A;  1DEW A;  5DFF A;  3I46 A;  2ISI A;  1YJH A;  4B5G A;  3FZI A;  1I9Y A;  4L21 A;  5J3Z A;  5A7J A;  5EWT A;  3MPR A;  3U8U A;  2UYR X;  2IMQ X;  5J3S A;  1DE8 A;  5INO A;  3G38 A;  3GA6 A;  3NR8 A;  5DV4 A;  3L1W A;  4GZ0 A;  4B5I A;  5DV2 A;  1AKO A;  1Y21 A;  5INN A;  3G8V A;  1SI6 X;  3NGO A;  3G2C A;  4LND A;  5J3P A;  1BIX A;  3G0R A;  2A40 B;  2A3Z B;  2A41 B;  4QHE A;  3G1K A;  4B5M A;  4C1R A;  3I48 A;  4L20 A;  5INQ A;  5INM A;  5CFE A;  4B5F A;  3G4T A;  3I41 A;  3DNI A;  4F1H B;  5INP A;  1ATN D;  4CML A;  5A7I A;  5INK A;  3CJC D;  3G6S A;  4QHD A;  1WDU A;  2V0S A;  4GYZ A;  1I9Z A;  5HT2 A;  4GEW A;  1E9N A;  5DG0 A;  4F1I A;  2A42 B;  3WCX A;  3I5V A;  4IEM A;  1DNK A;  4A9C A;  3G00 A;  3N9V A;  2V0R A;  2O3C A;  3G3Y A;  2JC4 A;  2DNJ A;  4FPV A;  2D1K B;  5DFI A;  3NGQ A;  4B5H A;  5J8N A;  1VYB A;  1NTF A;  4F1H A;  5DFJ A;  2F2F B;  2J63 A;  4QH9 A;  3W2X A;  4L1Z A;  2F1N A;  4B5J A;  1DE9 A;  2DDR A;  4F1R A;  3TEB A;  2VOA A;  4GZ2 A;  2DDT A;  3NGN A;  1SR4 B;  3G3C A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...