5A7JA

Crystal structure of inpp5b in complex with benzene 1,2,4,5- tetrakisphosphate
Total Genus 85
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
85
sequence length
309
structure length
309
Chain Sequence
MYTYIQNFRFFAGTYNVNGQSPKECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDVILWLGDLNYRIEELDVEKVKKLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTGSDDWDTSEKCRAPAWCDRILWKGKNITQLSYQSHMALKTSDHKPVSSVFDIGVRVVAHH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase Inpp5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE
total genus 85
structure length 309
sequence length 309
chains with identical sequence B
ec nomenclature ec 3.1.3.36: Phosphoinositide 5-phosphatase.
pdb deposition date 2015-07-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03372 Exo_endo_phos Endonuclease/Exonuclease/phosphatase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.10.10 Alpha Beta 4-Layer Sandwich Deoxyribonuclease I; Chain A Endonuclease/exonuclease/phosphatase 5a7jA00
1ATND 4IEMA 4B5IA 3U8UA 5J3PA 3L1WA 3K55A 3NGNA 1ZWXA 2DDSA 2JC4A 2V0RA 5INOA 5A7JA 3CJCD 5INMA 1E9NA 5DV2A 5DV4A 3NGOA 4QH9A 4PUQA 3G2CA 4K6LF 2DNJA 2EI9A 3G6SA 4GEWA 3G0RA 5DFJA 1DNKA 1BIXA 4L1ZA 3G0AA 5INNA 2A41B 3G91A 4JG3A 1I9ZA 3I48A 2DDTA 1I9YA 4C1RA 2A3ZB 2O3HA 5DFFA 3G4TA 3W2XA 5CFGA 4LNDA 4CMLA 3GA6A 2A42B 5INPA 1VYBA 2F2FB 3W3DB 4F1HB 5J3SA 2F1NA 2JC5A 2D1KB 2O3CA 4B5HA 5INKA 3G38A 3G8VA 4AWNA 5DFIA 4FVAA 2IMQX 4F1RA 5A7IA 3G1KA 3G00A 5DG0A 4B5FA 5CFEA 2ISIA 3TEBA 1WDUA 4L21A 1YJHA 3N9VA 4GZ0A 1SI6X 3I41A 4B5GA 3MTCA 2XSWA 4GZ2A 3FZIA 1HD7A 4GZ1A 2VOAA 4RUWA 3DNIA 3I5VA 3NGQA 5J42A 4F1IA 2A40B 3NR8A 1DE9A 3G3YA 2UYRX 3WCXA 4L1YA 4A9CA 4CMNA 5J3ZA 5J8NA 4L20A 3MPRA 4QHDA 3G2DA 4B5MA 2DDRA 4GYZA 1DE8A 3I46A 5INQA 1NTFA 5DFHA 4F1HA 5HT2A 1DEWA 3W2YA 2V0SA 2J63A 5EWTA 3G3CA 1SR4B 1AKOA 4FPVA 1Y21A 5INLA 4QHEA 4B5JA
chains in the Genus database with same CATH superfamily
1ATND 4IEMA 4B5IA 3U8UA 5J3PA 3L1WA 3K55A 3NGNA 1ZWXA 2DDSA 2JC4A 2V0RA 5INOA 5A7JA 3CJCD 5INMA 1E9NA 5DV2A 5DV4A 3NGOA 4QH9A 4PUQA 3G2CA 4K6LF 2DNJA 2EI9A 3G6SA 4GEWA 3G0RA 5DFJA 1DNKA 1BIXA 4L1ZA 3G0AA 5INNA 2A41B 3G91A 4JG3A 1I9ZA 3I48A 2DDTA 1I9YA 4C1RA 2A3ZB 2O3HA 5DFFA 3G4TA 3W2XA 5CFGA 4LNDA 4CMLA 3GA6A 2A42B 5INPA 1VYBA 2F2FB 3W3DB 4F1HB 5J3SA 2F1NA 2JC5A 2D1KB 2O3CA 4B5HA 5INKA 3G38A 3G8VA 4AWNA 5DFIA 4FVAA 2IMQX 4F1RA 5A7IA 3G1KA 3G00A 5DG0A 4B5FA 5CFEA 2ISIA 3TEBA 1WDUA 4L21A 1YJHA 3N9VA 4GZ0A 1SI6X 3I41A 4B5GA 3MTCA 2XSWA 4GZ2A 3FZIA 1HD7A 4GZ1A 2VOAA 4RUWA 3DNIA 3I5VA 3NGQA 5J42A 4F1IA 2A40B 3NR8A 1DE9A 3G3YA 2UYRX 3WCXA 4L1YA 4A9CA 4CMNA 5J3ZA 5J8NA 4L20A 3MPRA 4QHDA 3G2DA 4B5MA 2DDRA 4GYZA 1DE8A 3I46A 5INQA 1NTFA 5DFHA 4F1HA 5HT2A 1DEWA 3W2YA 2V0SA 2J63A 5EWTA 3G3CA 1SR4B 1AKOA 4FPVA 1Y21A 5INLA 4QHEA 4B5JA
chains in the Genus database with same CATH topology
1ATND 4IEMA 4B5IA 3U8UA 5J3PA 3L1WA 3K55A 3NGNA 1ZWXA 2DDSA 2JC4A 2V0RA 5INOA 5A7JA 3CJCD 5INMA 1E9NA 5DV2A 5DV4A 3NGOA 4QH9A 4PUQA 3G2CA 4K6LF 2DNJA 2EI9A 3G6SA 4GEWA 3G0RA 5DFJA 1DNKA 1BIXA 4L1ZA 3G0AA 5INNA 2A41B 3G91A 4JG3A 1I9ZA 3I48A 2DDTA 1I9YA 4C1RA 2A3ZB 2O3HA 5DFFA 3G4TA 3W2XA 5CFGA 4LNDA 4CMLA 3GA6A 2A42B 5INPA 1VYBA 2F2FB 3W3DB 4F1HB 5J3SA 2F1NA 2JC5A 2D1KB 2O3CA 4B5HA 5INKA 3G38A 3G8VA 4AWNA 5DFIA 4FVAA 2IMQX 4F1RA 5A7IA 3G1KA 3G00A 5DG0A 4B5FA 5CFEA 2ISIA 3TEBA 1WDUA 4L21A 1YJHA 3N9VA 4GZ0A 1SI6X 3I41A 4B5GA 3MTCA 2XSWA 4GZ2A 3FZIA 1HD7A 4GZ1A 2VOAA 4RUWA 3DNIA 3I5VA 3NGQA 5J42A 4F1IA 2A40B 3NR8A 1DE9A 3G3YA 2UYRX 3WCXA 4L1YA 4A9CA 4CMNA 5J3ZA 5J8NA 4L20A 3MPRA 4QHDA 3G2DA 4B5MA 2DDRA 4GYZA 1DE8A 3I46A 5INQA 1NTFA 5DFHA 4F1HA 5HT2A 1DEWA 3W2YA 2V0SA 2J63A 5EWTA 3G3CA 1SR4B 1AKOA 4FPVA 1Y21A 5INLA 4QHEA 4B5JA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ATN D;  4IEM A;  4B5I A;  3U8U A;  5J3P A;  3L1W A;  3K55 A;  3NGN A;  1ZWX A;  2DDS A;  2JC4 A;  2V0R A;  5INO A;  5A7J A;  3CJC D;  5INM A;  1E9N A;  5DV2 A;  5DV4 A;  3NGO A;  4QH9 A;  4PUQ A;  3G2C A;  4K6L F;  2DNJ A;  2EI9 A;  3G6S A;  4GEW A;  3G0R A;  5DFJ A;  1DNK A;  1BIX A;  4L1Z A;  3G0A A;  5INN A;  2A41 B;  3G91 A;  4JG3 A;  1I9Z A;  3I48 A;  2DDT A;  1I9Y A;  4C1R A;  2A3Z B;  2O3H A;  5DFF A;  3G4T A;  3W2X A;  5CFG A;  4LND A;  4CML A;  3GA6 A;  2A42 B;  5INP A;  1VYB A;  2F2F B;  3W3D B;  4F1H B;  5J3S A;  2F1N A;  2JC5 A;  2D1K B;  2O3C A;  4B5H A;  5INK A;  3G38 A;  3G8V A;  4AWN A;  5DFI A;  4FVA A;  2IMQ X;  4F1R A;  5A7I A;  3G1K A;  3G00 A;  5DG0 A;  4B5F A;  5CFE A;  2ISI A;  3TEB A;  1WDU A;  4L21 A;  1YJH A;  3N9V A;  4GZ0 A;  1SI6 X;  3I41 A;  4B5G A;  3MTC A;  2XSW A;  4GZ2 A;  3FZI A;  1HD7 A;  4GZ1 A;  2VOA A;  4RUW A;  3DNI A;  3I5V A;  3NGQ A;  5J42 A;  4F1I A;  2A40 B;  3NR8 A;  1DE9 A;  3G3Y A;  2UYR X;  3WCX A;  4L1Y A;  4A9C A;  4CMN A;  5J3Z A;  5J8N A;  4L20 A;  3MPR A;  4QHD A;  3G2D A;  4B5M A;  2DDR A;  4GYZ A;  1DE8 A;  3I46 A;  5INQ A;  1NTF A;  5DFH A;  4F1H A;  5HT2 A;  1DEW A;  3W2Y A;  2V0S A;  2J63 A;  5EWT A;  3G3C A;  1SR4 B;  1AKO A;  4FPV A;  1Y21 A;  5INL A;  4QHE A;  4B5J A; 
#chains in the Genus database with same CATH topology
 1ATN D;  4IEM A;  4B5I A;  3U8U A;  5J3P A;  3L1W A;  3K55 A;  3NGN A;  1ZWX A;  2DDS A;  2JC4 A;  2V0R A;  5INO A;  5A7J A;  3CJC D;  5INM A;  1E9N A;  5DV2 A;  5DV4 A;  3NGO A;  4QH9 A;  4PUQ A;  3G2C A;  4K6L F;  2DNJ A;  2EI9 A;  3G6S A;  4GEW A;  3G0R A;  5DFJ A;  1DNK A;  1BIX A;  4L1Z A;  3G0A A;  5INN A;  2A41 B;  3G91 A;  4JG3 A;  1I9Z A;  3I48 A;  2DDT A;  1I9Y A;  4C1R A;  2A3Z B;  2O3H A;  5DFF A;  3G4T A;  3W2X A;  5CFG A;  4LND A;  4CML A;  3GA6 A;  2A42 B;  5INP A;  1VYB A;  2F2F B;  3W3D B;  4F1H B;  5J3S A;  2F1N A;  2JC5 A;  2D1K B;  2O3C A;  4B5H A;  5INK A;  3G38 A;  3G8V A;  4AWN A;  5DFI A;  4FVA A;  2IMQ X;  4F1R A;  5A7I A;  3G1K A;  3G00 A;  5DG0 A;  4B5F A;  5CFE A;  2ISI A;  3TEB A;  1WDU A;  4L21 A;  1YJH A;  3N9V A;  4GZ0 A;  1SI6 X;  3I41 A;  4B5G A;  3MTC A;  2XSW A;  4GZ2 A;  3FZI A;  1HD7 A;  4GZ1 A;  2VOA A;  4RUW A;  3DNI A;  3I5V A;  3NGQ A;  5J42 A;  4F1I A;  2A40 B;  3NR8 A;  1DE9 A;  3G3Y A;  2UYR X;  3WCX A;  4L1Y A;  4A9C A;  4CMN A;  5J3Z A;  5J8N A;  4L20 A;  3MPR A;  4QHD A;  3G2D A;  4B5M A;  2DDR A;  4GYZ A;  1DE8 A;  3I46 A;  5INQ A;  1NTF A;  5DFH A;  4F1H A;  5HT2 A;  1DEW A;  3W2Y A;  2V0S A;  2J63 A;  5EWT A;  3G3C A;  1SR4 B;  1AKO A;  4FPV A;  1Y21 A;  5INL A;  4QHE A;  4B5J A; 
#chains in the Genus database with same CATH homology
 1ATN D;  4IEM A;  4B5I A;  3U8U A;  5J3P A;  3L1W A;  3K55 A;  3NGN A;  1ZWX A;  2DDS A;  2JC4 A;  2V0R A;  5INO A;  5A7J A;  3CJC D;  5INM A;  1E9N A;  5DV2 A;  5DV4 A;  3NGO A;  4QH9 A;  4PUQ A;  3G2C A;  4K6L F;  2DNJ A;  2EI9 A;  3G6S A;  4GEW A;  3G0R A;  5DFJ A;  1DNK A;  1BIX A;  4L1Z A;  3G0A A;  5INN A;  2A41 B;  3G91 A;  4JG3 A;  1I9Z A;  3I48 A;  2DDT A;  1I9Y A;  4C1R A;  2A3Z B;  2O3H A;  5DFF A;  3G4T A;  3W2X A;  5CFG A;  4LND A;  4CML A;  3GA6 A;  2A42 B;  5INP A;  1VYB A;  2F2F B;  3W3D B;  4F1H B;  5J3S A;  2F1N A;  2JC5 A;  2D1K B;  2O3C A;  4B5H A;  5INK A;  3G38 A;  3G8V A;  4AWN A;  5DFI A;  4FVA A;  2IMQ X;  4F1R A;  5A7I A;  3G1K A;  3G00 A;  5DG0 A;  4B5F A;  5CFE A;  2ISI A;  3TEB A;  1WDU A;  4L21 A;  1YJH A;  3N9V A;  4GZ0 A;  1SI6 X;  3I41 A;  4B5G A;  3MTC A;  2XSW A;  4GZ2 A;  3FZI A;  1HD7 A;  4GZ1 A;  2VOA A;  4RUW A;  3DNI A;  3I5V A;  3NGQ A;  5J42 A;  4F1I A;  2A40 B;  3NR8 A;  1DE9 A;  3G3Y A;  2UYR X;  3WCX A;  4L1Y A;  4A9C A;  4CMN A;  5J3Z A;  5J8N A;  4L20 A;  3MPR A;  4QHD A;  3G2D A;  4B5M A;  2DDR A;  4GYZ A;  1DE8 A;  3I46 A;  5INQ A;  1NTF A;  5DFH A;  4F1H A;  5HT2 A;  1DEW A;  3W2Y A;  2V0S A;  2J63 A;  5EWT A;  3G3C A;  1SR4 B;  1AKO A;  4FPV A;  1Y21 A;  5INL A;  4QHE A;  4B5J A; 
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similar chains in the Genus database (?% sequence similarity)
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