3ZUQ | Genus

Total Genus 273

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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	273
sequence length	892
structure length	850
Chain Sequence	MPVTINNFNYNDPIDNNNIIMMEPPFARGTGRYYKAFKITDRIWIIPERYTFGYKPEDFNKSSGIFNRDVCEYYDPDYLNTNDKKNIFLQTMIKLFNRIKSKPLGEKLLEMIINGIPYLGDRRVPLEEFNTNIASVTVNKLISNPGEVERKKGIFANLIIFGPGPVLNENETIDIGIQNHFASREGFGGIMQMKFCPEYVSVFNNVQENKGASIFNRRGYFSDPALILMHELIHVLHGLYGIKVDDLPIVPNEKKFFMQSTDAIQAEELYTFGGQDPSIITPSTDKSIYDKVLQNFRGIVDRLNKVLVCISDPNININIYKNKFKDKYKFVEDSEGKYSIDVESFDKLYKSLMFGFTETNIAENYKIKTRASYFSDSLPPVKIKNLLDNEIYTIEEGFNISDKDMEKEYRGQNKAINKQAYEEISKEHLAVYKIQMCVDLVLQCIDVDNEDLFFIADKNSFSDDLSKNERIEYNTQSNYIENDFPINELILDTDLISKIELPSENTESLTDFNVDVPVYEKQPAIKKIFTDENTIFQYLYSQTFPLDIRDISLTSSFDDALLFSNKVYSFFSMDYIKTANKVVEAGLFAGWVKQIVNDFVIEANKSNTDISLIVPYIGLALNVGNETAKGNFENAFEIAGASILLEFIPELLIPVVGAFLLESYIDNKNKIIKTIDNALTKRNEKWSDMYGLIVAQWLSTVNTQFYTIKEGMYKALNYQAQALEEIIKYRYNIYSEKEKSNINIDFNDINSKLNEGINQAIDNINNFINGCSVSYLMKKMIPLAVEKLLDFDNTLKKNLLNYIDENKLYLIGSAEYEKSKVNKYLKTIMPFDLSIYTNDTILIEMFNKYN

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Hydrolase
source organism	Clostridium botulinum
publication title	Structures of Engineered Clostridium Botulinum Neurotoxin Derivatives pubmed doi rcsb
molecule keywords	BOTULINUM NEUROTOXIN TYPE B
total genus	273
structure length	850
sequence length	892
ec nomenclature	ec 3.4.24.69: Bontoxilysin.
pdb deposition date	2011-07-19

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF01742	Peptidase_M27	Clostridial neurotoxin zinc protease
A	PF07952	Toxin_trans	Clostridium neurotoxin, Translocation domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.20.1120.10	Mainly Alpha	Up-down Bundle	Clostridium botulinum neurotoxin B, "coiled-coil" domain	Clostridium botulinum neurotoxin b, "coiled-coil" domain	3zuqA02
3.90.1240.10	Alpha Beta	Alpha-Beta Complex	Zincin-like	Metalloproteases ("zincins"), catalytic domain like	3zuqA01

3DS9A 3DSEA 1ZKXA 1ZN3A 4EL4A 2ILPA 3V0AB 3BONA 4ZJXA 3C89A 3QW5A 3FIEA 2G7PA 3C8BA 1F31A 1F82A 3D3XA 2W2DA 5BQNA 3BOKA 3C88A 2NZ9A 4ELCA 2W2DB 3BWIA 2A97A 2ISEA 3DDBA 1Z7HA 3V0AA 3QIZA 2NYYA 3DDAA 2ISGA 3QIXA 3QW7A 1ZL5A 2A8AA 2IMCA 1EPWA 3QW6A 2XHLA 2ETFA 4KTXA 3C8AA 1G9AA 2XHLB 2IMBA 1G9CA 4KUFA 1S0CA 4KS6A 3BTAA 4J1LA 3ZUQA 1I1EA 1S0EA 4HEVA 1G9DA 1S0FA 3V0BA 1S0BA 3V0BB 3VUOA 5BQMA 2G7QA 4EJ5A 5BQMB 1S0DA 4ZKTB 2IMAA 3QJ0A 1XTGA 1G9BA 2G7NA 1ZKWA 3QIYA 3BOOA 1YVGA 1ZB7A 3ZURA 2FPQA 1T3AA 3QW8A 2NP0A 1E1HA 3NF3A 3FFZA 3FIIA 1T3CA 1ZL6A 3DEBA 2G7KA 3ZUSA 2ISHA 1XTFA 3K3QB 1S0GA 2QN0A
chains in the Genus database with same CATH superfamily

3DS9A 3DSEA 1ZKXA 1ZN3A 4EL4A 2ILPA 3V0AB 3BONA 4ZJXA 3C89A 3QW5A 4JIXA 3FIEA 4JIUA 2G7PA 3C8BA 1F31A 1F82A 3D3XA 2W2DA 5BQNA 3BOKA 3C88A 4QHFA 2NZ9A 4ELCA 3CQBA 2W2DB 4AW6A 3BWIA 2A97A 2ISEA 3DDBA 1Z7HA 3V0AA 3QIZA 2NYYA 3DDAA 2ISGA 3QIXA 3QW7A 1ZL5A 2A8AA 2IMCA 2YPTA 1EPWA 3QW6A 2XHLA 2ETFA 4KTXA 3C8AA 1G9AA 2XHLB 2IMBA 1G9CA 4KUFA 1S0CA 3E11A 4KS6A 3BTAA 4J1LA 3ZUQA 1I1EA 1S0EA 4HEVA 1G9DA 1S0FA 3V0BA 1S0BA 3V0BB 3VUOA 5BQMA 2G7QA 4EJ5A 5BQMB 1S0DA 4ZKTB 2IMAA 3QJ0A 1XTGA 4IL3A 1G9BA 2G7NA 1ZKWA 3QIYA 3BOOA 1YVGA 1ZB7A 3ZURA 2FPQA 1T3AA 3QW8A 2NP0A 2EJQA 1E1HA 3NF3A 3FFZA 3FIIA 1T3CA 1ZL6A 3DEBA 2G7KA 3ZUSA 2ISHA 1XTFA 3K3QB 1S0GA 2QN0A
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 3DS9 A;  3DSE A;  1ZKX A;  1ZN3 A;  4EL4 A;  2ILP A;  3V0A B;  3BON A;  4ZJX A;  3C89 A;  3QW5 A;  3FIE A;  2G7P A;  3C8B A;  1F31 A;  1F82 A;  3D3X A;  2W2D A;  5BQN A;  3BOK A;  3C88 A;  2NZ9 A;  4ELC A;  2W2D B;  3BWI A;  2A97 A;  2ISE A;  3DDB A;  1Z7H A;  3V0A A;  3QIZ A;  2NYY A;  3DDA A;  2ISG A;  3QIX A;  3QW7 A;  1ZL5 A;  2A8A A;  2IMC A;  1EPW A;  3QW6 A;  2XHL A;  2ETF A;  4KTX A;  3C8A A;  1G9A A;  2XHL B;  2IMB A;  1G9C A;  4KUF A;  1S0C A;  4KS6 A;  3BTA A;  4J1L A;  3ZUQ A;  1I1E A;  1S0E A;  4HEV A;  1G9D A;  1S0F A;  3V0B A;  1S0B A;  3V0B B;  3VUO A;  5BQM A;  2G7Q A;  4EJ5 A;  5BQM B;  1S0D A;  4ZKT B;  2IMA A;  3QJ0 A;  1XTG A;  1G9B A;  2G7N A;  1ZKW A;  3QIY A;  3BOO A;  1YVG A;  1ZB7 A;  3ZUR A;  2FPQ A;  1T3A A;  3QW8 A;  2NP0 A;  1E1H A;  3NF3 A;  3FFZ A;  3FII A;  1T3C A;  1ZL6 A;  3DEB A;  2G7K A;  3ZUS A;  2ISH A;  1XTF A;  3K3Q B;  1S0G A;  2QN0 A; 
#chains in the Genus database with same CATH topology
 3DS9 A;  3DSE A;  1ZKX A;  1ZN3 A;  4EL4 A;  2ILP A;  3V0A B;  3BON A;  4ZJX A;  3C89 A;  3QW5 A;  4JIX A;  3FIE A;  4JIU A;  2G7P A;  3C8B A;  1F31 A;  1F82 A;  3D3X A;  2W2D A;  5BQN A;  3BOK A;  3C88 A;  4QHF A;  2NZ9 A;  4ELC A;  3CQB A;  2W2D B;  4AW6 A;  3BWI A;  2A97 A;  2ISE A;  3DDB A;  1Z7H A;  3V0A A;  3QIZ A;  2NYY A;  3DDA A;  2ISG A;  3QIX A;  3QW7 A;  1ZL5 A;  2A8A A;  2IMC A;  2YPT A;  1EPW A;  3QW6 A;  2XHL A;  2ETF A;  4KTX A;  3C8A A;  1G9A A;  2XHL B;  2IMB A;  1G9C A;  4KUF A;  1S0C A;  3E11 A;  4KS6 A;  3BTA A;  4J1L A;  3ZUQ A;  1I1E A;  1S0E A;  4HEV A;  1G9D A;  1S0F A;  3V0B A;  1S0B A;  3V0B B;  3VUO A;  5BQM A;  2G7Q A;  4EJ5 A;  5BQM B;  1S0D A;  4ZKT B;  2IMA A;  3QJ0 A;  1XTG A;  4IL3 A;  1G9B A;  2G7N A;  1ZKW A;  3QIY A;  3BOO A;  1YVG A;  1ZB7 A;  3ZUR A;  2FPQ A;  1T3A A;  3QW8 A;  2NP0 A;  2EJQ A;  1E1H A;  3NF3 A;  3FFZ A;  3FII A;  1T3C A;  1ZL6 A;  3DEB A;  2G7K A;  3ZUS A;  2ISH A;  1XTF A;  3K3Q B;  1S0G A;  2QN0 A; 
#chains in the Genus database with same CATH homology
 3DS9 A;  3DSE A;  1ZKX A;  1ZN3 A;  4EL4 A;  2ILP A;  3V0A B;  3BON A;  4ZJX A;  3C89 A;  3QW5 A;  3FIE A;  2G7P A;  3C8B A;  1F31 A;  1F82 A;  3D3X A;  2W2D A;  5BQN A;  3BOK A;  3C88 A;  2NZ9 A;  4ELC A;  2W2D B;  3BWI A;  2A97 A;  2ISE A;  3DDB A;  1Z7H A;  3V0A A;  3QIZ A;  2NYY A;  3DDA A;  2ISG A;  3QIX A;  3QW7 A;  1ZL5 A;  2A8A A;  2IMC A;  1EPW A;  3QW6 A;  2XHL A;  2ETF A;  4KTX A;  3C8A A;  1G9A A;  2XHL B;  2IMB A;  1G9C A;  4KUF A;  1S0C A;  4KS6 A;  3BTA A;  4J1L A;  3ZUQ A;  1I1E A;  1S0E A;  4HEV A;  1G9D A;  1S0F A;  3V0B A;  1S0B A;  3V0B B;  3VUO A;  5BQM A;  2G7Q A;  4EJ5 A;  5BQM B;  1S0D A;  4ZKT B;  2IMA A;  3QJ0 A;  1XTG A;  1G9B A;  2G7N A;  1ZKW A;  3QIY A;  3BOO A;  1YVG A;  1ZB7 A;  3ZUR A;  2FPQ A;  1T3A A;  3QW8 A;  2NP0 A;  1E1H A;  3NF3 A;  3FFZ A;  3FII A;  1T3C A;  1ZL6 A;  3DEB A;  2G7K A;  3ZUS A;  2ISH A;  1XTF A;  3K3Q B;  1S0G A;  2QN0 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

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#similar chains, but unknotted
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3ZUQA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

pfam database annotations