3ZUS | Genus

Total Genus 275

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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	275
sequence length	913
structure length	851
Chain Sequence	MEFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLFEFYKLLCVDEMALALQCIKVNNWDLFFSPSEDNFTNDLNKGEEITSDTNIEAAEENISLDLIQQYYLTFNFDNEPENISIENLSSDIIGQLELMPNIERFPNGKKYELDKYTMFHYLRAQEFEHGKSRIALTNSVNEALLNPSRVYTFFSSDYVKKVNKATEAAMFLGWVEQLVYDFTDETSEVSTTDKIADITIIIPYIGPALNIGNMLYKDDFVGALIFSGAVILLEFIPEIAIPVLGTFALVSYIANKVLTVQTIDNALSKRNEKWDEVYKYIVTNWLAKVNTQIDLIRKKMKEALENQAEATKAIINYQYNQYTEEEKNNINFNIDDLSSKLNESINKAMININKFLNQCSVSYLMNSMIPYGVKRLEDFDASLKDALLKYIYDNRGTLIGQVDRLKDKVNNTLSTDIPFQLSKYVDNQRLLST

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Hydrolase/signaling protein
source organism	Clostridium botulinum
publication title	Structures of Engineered Clostridium Botulinum Neurotoxin Derivatives pubmed doi rcsb
molecule keywords	BOTULINUM NEUROTOXIN TYPE A, SYNAPTOSOMAL-ASSOCIATED PROTEIN
total genus	275
structure length	851
sequence length	913
chains with identical sequence	B, C, D
ec nomenclature	ec 3.4.24.69: Bontoxilysin.
pdb deposition date	2011-07-19

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.20.1120.10	Mainly Alpha	Up-down Bundle	Clostridium botulinum neurotoxin B, "coiled-coil" domain	Clostridium botulinum neurotoxin b, "coiled-coil" domain	3zusA02
3.90.1240.10	Alpha Beta	Alpha-Beta Complex	Zincin-like	Metalloproteases ("zincins"), catalytic domain like	3zusA01

1ZB7A 3ZUSA 1ZKXA 2QN0A 2G7KA 2ISHA 3QW5A 3VUOA 1S0FA 3C89A 3FFZA 3DSEA 3C8AA 4ZKTB 3NF3A 1S0EA 3C8BA 2IMBA 2G7QA 1EPWA 3DDBA 2NYYA 4KUFA 2ETFA 2A97A 1S0CA 4J1LA 2IMCA 1S0BA 2NP0A 4KS6A 3ZURA 2FPQA 2ISGA 1G9AA 1T3AA 1G9BA 1ZKWA 3BOOA 3DEBA 1XTFA 3QIZA 3BTAA 1YVGA 1G9DA 1G9CA 3DDAA 4KTXA 3V0AA 1ZN3A 3K3QB 5BQMA 1ZL5A 3V0AB 1Z7HA 1S0DA 2G7NA 5BQMB 3V0BA 1F31A 3QW7A 2NZ9A 3QIYA 3QW8A 2IMAA 3V0BB 3FIEA 2ILPA 4EL4A 1XTGA 2W2DB 3QJ0A 2ISEA 2A8AA 1E1HA 3DS9A 1T3CA 1I1EA 4HEVA 3D3XA 2G7PA 1S0GA 3C88A 3QIXA 5BQNA 3BWIA 4ELCA 4EJ5A 2XHLA 3ZUQA 3QW6A 2XHLB 1F82A 3FIIA 2W2DA 4ZJXA 1ZL6A 3BONA 3BOKA
chains in the Genus database with same CATH superfamily

1ZB7A 3ZUSA 1ZKXA 2QN0A 2G7KA 2ISHA 3QW5A 3VUOA 1S0FA 3C89A 3FFZA 3DSEA 3C8AA 4ZKTB 3NF3A 1S0EA 3C8BA 3CQBA 2IMBA 2G7QA 1EPWA 3DDBA 2NYYA 4KUFA 2ETFA 2A97A 1S0CA 4J1LA 2IMCA 2EJQA 1S0BA 2NP0A 4KS6A 3ZURA 2FPQA 2ISGA 1G9AA 1T3AA 1G9BA 1ZKWA 3BOOA 3DEBA 1XTFA 3QIZA 3BTAA 1YVGA 1G9DA 1G9CA 3DDAA 4KTXA 3V0AA 4AW6A 1ZN3A 4QHFA 3K3QB 5BQMA 1ZL5A 3V0AB 1Z7HA 1S0DA 2G7NA 5BQMB 3V0BA 1F31A 3E11A 3QW7A 2NZ9A 3QIYA 3QW8A 2IMAA 3V0BB 3FIEA 2ILPA 4EL4A 1XTGA 2W2DB 3QJ0A 4IL3A 2ISEA 2A8AA 1E1HA 3DS9A 1T3CA 4JIUA 1I1EA 4HEVA 3D3XA 2G7PA 1S0GA 3C88A 3QIXA 5BQNA 3BWIA 4ELCA 4EJ5A 2XHLA 3ZUQA 3QW6A 2XHLB 1F82A 3FIIA 4JIXA 2YPTA 2W2DA 4ZJXA 1ZL6A 3BONA 3BOKA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 1ZB7 A;  3ZUS A;  1ZKX A;  2QN0 A;  2G7K A;  2ISH A;  3QW5 A;  3VUO A;  1S0F A;  3C89 A;  3FFZ A;  3DSE A;  3C8A A;  4ZKT B;  3NF3 A;  1S0E A;  3C8B A;  2IMB A;  2G7Q A;  1EPW A;  3DDB A;  2NYY A;  4KUF A;  2ETF A;  2A97 A;  1S0C A;  4J1L A;  2IMC A;  1S0B A;  2NP0 A;  4KS6 A;  3ZUR A;  2FPQ A;  2ISG A;  1G9A A;  1T3A A;  1G9B A;  1ZKW A;  3BOO A;  3DEB A;  1XTF A;  3QIZ A;  3BTA A;  1YVG A;  1G9D A;  1G9C A;  3DDA A;  4KTX A;  3V0A A;  1ZN3 A;  3K3Q B;  5BQM A;  1ZL5 A;  3V0A B;  1Z7H A;  1S0D A;  2G7N A;  5BQM B;  3V0B A;  1F31 A;  3QW7 A;  2NZ9 A;  3QIY A;  3QW8 A;  2IMA A;  3V0B B;  3FIE A;  2ILP A;  4EL4 A;  1XTG A;  2W2D B;  3QJ0 A;  2ISE A;  2A8A A;  1E1H A;  3DS9 A;  1T3C A;  1I1E A;  4HEV A;  3D3X A;  2G7P A;  1S0G A;  3C88 A;  3QIX A;  5BQN A;  3BWI A;  4ELC A;  4EJ5 A;  2XHL A;  3ZUQ A;  3QW6 A;  2XHL B;  1F82 A;  3FII A;  2W2D A;  4ZJX A;  1ZL6 A;  3BON A;  3BOK A; 
#chains in the Genus database with same CATH topology
 1ZB7 A;  3ZUS A;  1ZKX A;  2QN0 A;  2G7K A;  2ISH A;  3QW5 A;  3VUO A;  1S0F A;  3C89 A;  3FFZ A;  3DSE A;  3C8A A;  4ZKT B;  3NF3 A;  1S0E A;  3C8B A;  3CQB A;  2IMB A;  2G7Q A;  1EPW A;  3DDB A;  2NYY A;  4KUF A;  2ETF A;  2A97 A;  1S0C A;  4J1L A;  2IMC A;  2EJQ A;  1S0B A;  2NP0 A;  4KS6 A;  3ZUR A;  2FPQ A;  2ISG A;  1G9A A;  1T3A A;  1G9B A;  1ZKW A;  3BOO A;  3DEB A;  1XTF A;  3QIZ A;  3BTA A;  1YVG A;  1G9D A;  1G9C A;  3DDA A;  4KTX A;  3V0A A;  4AW6 A;  1ZN3 A;  4QHF A;  3K3Q B;  5BQM A;  1ZL5 A;  3V0A B;  1Z7H A;  1S0D A;  2G7N A;  5BQM B;  3V0B A;  1F31 A;  3E11 A;  3QW7 A;  2NZ9 A;  3QIY A;  3QW8 A;  2IMA A;  3V0B B;  3FIE A;  2ILP A;  4EL4 A;  1XTG A;  2W2D B;  3QJ0 A;  4IL3 A;  2ISE A;  2A8A A;  1E1H A;  3DS9 A;  1T3C A;  4JIU A;  1I1E A;  4HEV A;  3D3X A;  2G7P A;  1S0G A;  3C88 A;  3QIX A;  5BQN A;  3BWI A;  4ELC A;  4EJ5 A;  2XHL A;  3ZUQ A;  3QW6 A;  2XHL B;  1F82 A;  3FII A;  4JIX A;  2YPT A;  2W2D A;  4ZJX A;  1ZL6 A;  3BON A;  3BOK A; 
#chains in the Genus database with same CATH homology
 1ZB7 A;  3ZUS A;  1ZKX A;  2QN0 A;  2G7K A;  2ISH A;  3QW5 A;  3VUO A;  1S0F A;  3C89 A;  3FFZ A;  3DSE A;  3C8A A;  4ZKT B;  3NF3 A;  1S0E A;  3C8B A;  2IMB A;  2G7Q A;  1EPW A;  3DDB A;  2NYY A;  4KUF A;  2ETF A;  2A97 A;  1S0C A;  4J1L A;  2IMC A;  1S0B A;  2NP0 A;  4KS6 A;  3ZUR A;  2FPQ A;  2ISG A;  1G9A A;  1T3A A;  1G9B A;  1ZKW A;  3BOO A;  3DEB A;  1XTF A;  3QIZ A;  3BTA A;  1YVG A;  1G9D A;  1G9C A;  3DDA A;  4KTX A;  3V0A A;  1ZN3 A;  3K3Q B;  5BQM A;  1ZL5 A;  3V0A B;  1Z7H A;  1S0D A;  2G7N A;  5BQM B;  3V0B A;  1F31 A;  3QW7 A;  2NZ9 A;  3QIY A;  3QW8 A;  2IMA A;  3V0B B;  3FIE A;  2ILP A;  4EL4 A;  1XTG A;  2W2D B;  3QJ0 A;  2ISE A;  2A8A A;  1E1H A;  3DS9 A;  1T3C A;  1I1E A;  4HEV A;  3D3X A;  2G7P A;  1S0G A;  3C88 A;  3QIX A;  5BQN A;  3BWI A;  4ELC A;  4EJ5 A;  2XHL A;  3ZUQ A;  3QW6 A;  2XHL B;  1F82 A;  3FII A;  2W2D A;  4ZJX A;  1ZL6 A;  3BON A;  3BOK A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

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#similar chains, but unknotted
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3ZUSA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization