5BQN | Genus

Total Genus 271

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	271
sequence length	871
structure length	838
Chain Sequence	MTWPVKDFNYSDPVNDNDILYLRIPQNKLITTPVKAFMITQNIWVIPERFSSDTNPSLSKPPRPTSKYQSYYDPSYLSTDEQKDTFLKGIIKLFKRINERDIGKKLINYLVVGSPFMGDSSTPEDTFDFTRHTTNIAVEKFENGSWKVTNIITPSVLIFGPLPNILDYTASLTLQGQQSNPSFEGFGTLSILKVAPEFLLTFSDVTSNQSSAVLGKSIFCMDPVIALMHQLTYSLHQLYGINIPSDKRIRPQVSEGFFSQDGPNVQFEELYTFGGLDVEIIPQIERSQLREKALGHYKDIAKRLNNINKTIPSSWISNIDKYKKIFSEKYNFDKDNTGNFVVNIDKFNSLYSDLTNVMSEVVYSSQYNVKNRTHYFSRHYLPVFANILDDNIYTIRDGFNLTNKGFNIENSGQNIERNPALQKLSSESVVDLFTKVCVDKSLQCIKVKNNRLPYVADKDSISQEIFENKIITDETNVVPINPEIVDPLLPNVNMEPLNLPGEEIVFYDDITKYVDYLNSYYYLESQKLSNNVENITLTTSVEEALGYSNKIYTFLPSLAEKVNKGVQAGLFLNWANEVVEDFTTNIMKKDTLDKISDVSVIIPYIGPALNIGNSALRGNFNQAFATAGVAFLLEGFPEFTIPALGVFTFYSSIQEREKIIKTIENCLEQRVKRWKDSYQWMVSNWLSRITTQFNHINYQMYDSLSYQADAIKAKIDLEYKKYSGSDKENIKSQVENLKNSLDVKISEAMNNINKFIRECSVTYLFKNMLPKVIDELNKFDLRTKTELINLIDSHNIILVGEVDRLKAKVNESFENTMPFNIFSYTNNSLLKDIINEYF

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Hydrolase
source organism	Clostridium botulinum
publication title	Structural analysis of Clostridium botulinum neurotoxin type D as a platform for the development of targeted secretion inhibitors. pubmed doi rcsb
molecule keywords	Botulinum neurotoxin type D,Botulinum neurotoxin type D
total genus	271
structure length	838
sequence length	871
ec nomenclature	ec 3.4.24.69: Bontoxilysin.
pdb deposition date	2015-05-29

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF01742	Peptidase_M27	Clostridial neurotoxin zinc protease
A	PF07952	Toxin_trans	Clostridium neurotoxin, Translocation domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.20.1120.10	Mainly Alpha	Up-down Bundle	Clostridium botulinum neurotoxin B, "coiled-coil" domain	Clostridium botulinum neurotoxin b, "coiled-coil" domain	5bqnA02
3.90.1240.10	Alpha Beta	Alpha-Beta Complex	Zincin-like	Metalloproteases ("zincins"), catalytic domain like	5bqnA01

3DS9A 4KS6A 4HEVA 2XHLA 5BQNA 3ZURA 1EPWA 2FPQA 3DEBA 1T3CA 4ZJXA 2G7QA 1XTFA 1YVGA 2NYYA 2W2DB 3NF3A 3FIEA 3FIIA 2G7KA 3C8BA 1ZL5A 1G9CA 4EL4A 1ZKWA 4J1LA 3QIYA 2IMCA 3BTAA 3FFZA 1S0EA 2W2DA 3QW6A 3BONA 1Z7HA 2NZ9A 1G9BA 1XTGA 3DDBA 3QIXA 3K3QB 2QN0A 3BWIA 3QIZA 1ZN3A 1G9DA 3C89A 3DDAA 3C8AA 1S0BA 3V0AB 1S0DA 3ZUQA 3VUOA 1ZKXA 1S0GA 1G9AA 3QW5A 3BOOA 1T3AA 2ILPA 3QW7A 2A8AA 3QJ0A 1ZL6A 1S0CA 3D3XA 3C88A 2G7PA 2A97A 1F82A 3ZUSA 3V0BB 3BOKA 1ZB7A 2ISHA 3DSEA 5BQMB 2ISEA 1I1EA 2NP0A 4ELCA 1E1HA 1S0FA 3QW8A 2ISGA 4KTXA 3V0BA 2XHLB 5BQMA 4KUFA 4EJ5A 3V0AA 2G7NA 4ZKTB 2IMAA 1F31A 2IMBA 2ETFA
chains in the Genus database with same CATH superfamily

3DS9A 4KS6A 4HEVA 2XHLA 5BQNA 3ZURA 1EPWA 2FPQA 3DEBA 1T3CA 4ZJXA 2G7QA 1XTFA 1YVGA 2NYYA 2W2DB 3NF3A 4QHFA 3FIEA 3FIIA 2G7KA 3C8BA 1ZL5A 1G9CA 4EL4A 1ZKWA 4J1LA 3QIYA 2IMCA 3BTAA 3FFZA 1S0EA 2W2DA 3QW6A 3BONA 4IL3A 2YPTA 1Z7HA 2NZ9A 1G9BA 1XTGA 3DDBA 3QIXA 3CQBA 3K3QB 2QN0A 3BWIA 3QIZA 4AW6A 3E11A 1ZN3A 1G9DA 3C89A 3DDAA 3C8AA 1S0BA 3V0AB 1S0DA 3ZUQA 3VUOA 1ZKXA 4JIUA 1S0GA 1G9AA 3QW5A 3BOOA 1T3AA 2ILPA 3QW7A 2A8AA 3QJ0A 1ZL6A 1S0CA 3D3XA 3C88A 2G7PA 2A97A 4JIXA 1F82A 3ZUSA 3V0BB 3BOKA 1ZB7A 2ISHA 3DSEA 5BQMB 2ISEA 1I1EA 2NP0A 4ELCA 1E1HA 1S0FA 3QW8A 2ISGA 4KTXA 2EJQA 3V0BA 2XHLB 5BQMA 4KUFA 4EJ5A 3V0AA 2G7NA 4ZKTB 2IMAA 1F31A 2IMBA 2ETFA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 3DS9 A;  4KS6 A;  4HEV A;  2XHL A;  5BQN A;  3ZUR A;  1EPW A;  2FPQ A;  3DEB A;  1T3C A;  4ZJX A;  2G7Q A;  1XTF A;  1YVG A;  2NYY A;  2W2D B;  3NF3 A;  3FIE A;  3FII A;  2G7K A;  3C8B A;  1ZL5 A;  1G9C A;  4EL4 A;  1ZKW A;  4J1L A;  3QIY A;  2IMC A;  3BTA A;  3FFZ A;  1S0E A;  2W2D A;  3QW6 A;  3BON A;  1Z7H A;  2NZ9 A;  1G9B A;  1XTG A;  3DDB A;  3QIX A;  3K3Q B;  2QN0 A;  3BWI A;  3QIZ A;  1ZN3 A;  1G9D A;  3C89 A;  3DDA A;  3C8A A;  1S0B A;  3V0A B;  1S0D A;  3ZUQ A;  3VUO A;  1ZKX A;  1S0G A;  1G9A A;  3QW5 A;  3BOO A;  1T3A A;  2ILP A;  3QW7 A;  2A8A A;  3QJ0 A;  1ZL6 A;  1S0C A;  3D3X A;  3C88 A;  2G7P A;  2A97 A;  1F82 A;  3ZUS A;  3V0B B;  3BOK A;  1ZB7 A;  2ISH A;  3DSE A;  5BQM B;  2ISE A;  1I1E A;  2NP0 A;  4ELC A;  1E1H A;  1S0F A;  3QW8 A;  2ISG A;  4KTX A;  3V0B A;  2XHL B;  5BQM A;  4KUF A;  4EJ5 A;  3V0A A;  2G7N A;  4ZKT B;  2IMA A;  1F31 A;  2IMB A;  2ETF A; 
#chains in the Genus database with same CATH topology
 3DS9 A;  4KS6 A;  4HEV A;  2XHL A;  5BQN A;  3ZUR A;  1EPW A;  2FPQ A;  3DEB A;  1T3C A;  4ZJX A;  2G7Q A;  1XTF A;  1YVG A;  2NYY A;  2W2D B;  3NF3 A;  4QHF A;  3FIE A;  3FII A;  2G7K A;  3C8B A;  1ZL5 A;  1G9C A;  4EL4 A;  1ZKW A;  4J1L A;  3QIY A;  2IMC A;  3BTA A;  3FFZ A;  1S0E A;  2W2D A;  3QW6 A;  3BON A;  4IL3 A;  2YPT A;  1Z7H A;  2NZ9 A;  1G9B A;  1XTG A;  3DDB A;  3QIX A;  3CQB A;  3K3Q B;  2QN0 A;  3BWI A;  3QIZ A;  4AW6 A;  3E11 A;  1ZN3 A;  1G9D A;  3C89 A;  3DDA A;  3C8A A;  1S0B A;  3V0A B;  1S0D A;  3ZUQ A;  3VUO A;  1ZKX A;  4JIU A;  1S0G A;  1G9A A;  3QW5 A;  3BOO A;  1T3A A;  2ILP A;  3QW7 A;  2A8A A;  3QJ0 A;  1ZL6 A;  1S0C A;  3D3X A;  3C88 A;  2G7P A;  2A97 A;  4JIX A;  1F82 A;  3ZUS A;  3V0B B;  3BOK A;  1ZB7 A;  2ISH A;  3DSE A;  5BQM B;  2ISE A;  1I1E A;  2NP0 A;  4ELC A;  1E1H A;  1S0F A;  3QW8 A;  2ISG A;  4KTX A;  2EJQ A;  3V0B A;  2XHL B;  5BQM A;  4KUF A;  4EJ5 A;  3V0A A;  2G7N A;  4ZKT B;  2IMA A;  1F31 A;  2IMB A;  2ETF A; 
#chains in the Genus database with same CATH homology
 3DS9 A;  4KS6 A;  4HEV A;  2XHL A;  5BQN A;  3ZUR A;  1EPW A;  2FPQ A;  3DEB A;  1T3C A;  4ZJX A;  2G7Q A;  1XTF A;  1YVG A;  2NYY A;  2W2D B;  3NF3 A;  3FIE A;  3FII A;  2G7K A;  3C8B A;  1ZL5 A;  1G9C A;  4EL4 A;  1ZKW A;  4J1L A;  3QIY A;  2IMC A;  3BTA A;  3FFZ A;  1S0E A;  2W2D A;  3QW6 A;  3BON A;  1Z7H A;  2NZ9 A;  1G9B A;  1XTG A;  3DDB A;  3QIX A;  3K3Q B;  2QN0 A;  3BWI A;  3QIZ A;  1ZN3 A;  1G9D A;  3C89 A;  3DDA A;  3C8A A;  1S0B A;  3V0A B;  1S0D A;  3ZUQ A;  3VUO A;  1ZKX A;  1S0G A;  1G9A A;  3QW5 A;  3BOO A;  1T3A A;  2ILP A;  3QW7 A;  2A8A A;  3QJ0 A;  1ZL6 A;  1S0C A;  3D3X A;  3C88 A;  2G7P A;  2A97 A;  1F82 A;  3ZUS A;  3V0B B;  3BOK A;  1ZB7 A;  2ISH A;  3DSE A;  5BQM B;  2ISE A;  1I1E A;  2NP0 A;  4ELC A;  1E1H A;  1S0F A;  3QW8 A;  2ISG A;  4KTX A;  3V0B A;  2XHL B;  5BQM A;  4KUF A;  4EJ5 A;  3V0A A;  2G7N A;  4ZKT B;  2IMA A;  1F31 A;  2IMB A;  2ETF A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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5BQNA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

pfam database annotations