1X2JA

Structural basis for the defects of human lung cancer somatic mutations in the repression activity of keap1 on nrf2
Total Genus 69
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
69
sequence length
290
structure length
290
Chain Sequence
VGRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPC
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transcription
molecule keywords Kelch-like ECH-associated protein 1
publication title Structural basis for defects of keap1 activity provoked by its point mutations in lung cancer
pubmed doi rcsb
source organism Mus musculus
total genus 69
structure length 290
sequence length 290
ec nomenclature
pdb deposition date 2005-04-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 1x2jA00
4L7BA 2VPJA 3WDZA 1X2JA 5F72C 5FNQA 4L7CA 2XN4A 4L7DA 3ZGCA 2FLUX 4CHBA 2DYHA 2ZW9A 2ZZKA 4IFLX 4IQKA 3VNGA 4ASCA 1ZGKA 3WN7A 5FNUA 4IN4A 3ZGDA 5FNRA 4CH9A 3ADEA 1U6DX 2ZWAA 4YY8A 5FNTA 5FZJA 4N1BA 5FZNA 2WOZA 4XMBA 4IFNX 3II7A 4ZGCA 3VNHA 4ZY3A 5CGJA 4IFJA 5FNSA 1X2RA 2Z32A
chains in the Genus database with same CATH superfamily
4GEZA 4GN9A 2QE8A 2VPJA 1V04A 3ALXA 2SLIA 1N7DA 3AMSA 4FPYA 3I1CA 4M4UA 4YW3A 3VNGA 1Z50A 1V0ZA 1W20A 5FNUA 3TI8A 1Q7FA 1DILA 4YZ5A 5GX1A 4AH4A 3WW9A 4NCSA 4QNPA 1SO7A 1CVMA 2YA5A 4YZ1A 4IFNX 3TI4A 3NO0A 2AGSA 3DR2A 2JKBA 4CPMA 4YW4A 1X2RA 4O5TA 4XJ9A 4X47A 4GZTA 3V64C 5B2CA 1NN2A 2XZKA 1IVGA 3ZGCA 4MWVA 2IVZA 4FJ6A 2POOA 2GVUA 4H53A 1A4QA 2F12A 4D52A 4FPHA 4SLIA 3K36A 4K1IA 1MS8A 2QWBA 4DGRA 4NN9A 1WCQA 2IAQA 4ZGCA 2YA8A 2YA7A 4ZY3A 5FNSA 3UC1A 4XJ8A 5HUGA 4MWQA 3H73A 4FOYA 4CSDA 5F72C 2VK7A 4AHAA 2VK6A 4FPEA 4FPJA 4FPKA 1N1TA 1NPEA 3H71A 3SRGA 1V3DA 1EUUA 3KYAA 1V3CA 4A0PA 3CKZA 2H2NA 4R40A 4B7RA 4WEGA 3PJQA 3IAXA 2YDPA 1INGA 4CPOA 1N1SA 1RWIA 4HHQA 4D52B 2FPCA 1MZ5A 2F29A 4MWXA 3TI6A 3GVKA 4XJRA 1XOGA 1NMBN 1INVA 4Q1UA 4YW2A 1S1DA 4DG6A 1B9SA 2AEPA 2P4OA 3K37A 4GZPA 1INWA 2B8HA 5B2DA 1E8VA 5EO8A 1Z4VA 5FZJA 4B7MA 4YW5A 2IAOA 1SNTA 2QWCA 3TIAA 4KS4A 2QWGA 3O9JA 2F11A 4FOQA 4XJAA 1QLGA 4GJTA 4CPLA 3TI5A 2HQSA 4XE9A 1F8DA 3SANA 3NN9A 2F25A 2FP9A 2ZW9A 1MZ6A 5H47A 4GN7A 4XYXA 2VVZA 2FP8A 4KS3A 2IAUA 4QN6A 3SOQA 2VWDA 4QN4A 1L7FA 4GDIA 1V2IA 2HT5A 4YZ3A 1L7GA 1INHA 2ZB6A 1MS3A 1NCBN 2IARA 4L7CA 4ZLRA 3TI3A 4XJWA 4G3NA 4GZWA 4KS1A 4FPOB 5D9BA 3Q6TA 3GVLA 4FP3A 1INXA 3NSSA 3Q6KA 3W09A 4FPLA 4UF7A 1MS0A 3SOVA 3SALA 2ZWAA 4M3MA 4FP2A 5HUNA 3A71A 2GHSA 1N1YA 3GVJA 1QBIA 4KS2A 2HT7A 1INYA 1V3BA 5GX2A 2HTQA 2DG0A 2QWHA 4XHBA 2F13A 1A14N 3L6VA 4YZ2A 4FPFA 4CPYA 1MWEA 4X6KA 3FVZA 4GB1A 3KGGA 4FOWA 4FZHA 2F28A 3ZGDA 1V0FA 4D52C 3SILA 3TIBA 1SLIA 1IVDA 2QWEA 2H2UA 4AGTA 4CPNA 1NNBA 1SLLA 4MJVA 5NN9A 4WA5A 1XOEA 2QWJA 1NSCA 2QWDA 5FNQA 2ZB5A 3FW0A 3S2KA 5GX3A 1KITA 2QWAA 6NN9A 3E5ZA 1NCDN 2DYHA 4HZVA 1PJXA 4K1KA 1Z4XA 2FHRA 4UOUA 1F8BA 2HTYA 4XJZA 4H52A 2X9MA 4GZXA 4QN5A 4MWJA 5D9DA 3TC9A 3D12A 3G4HA 1W0OA 3HLHA 3HRPA 2HU4A 1IVBA 2VSMA 3S94A 5JYYA 4XILA 1A4GA 1USRA 4JMLA 1H6LA 1MS9A 3AMRA 4XJUA 4O5SA 1Z4ZA 2HTVA 1BJIA 4C1YA 2YA4A 4FVKA 1DIMA 2IASA 4IN4A 4MWYA 4HIZA 1W0PA 4M4NA 4HZWA 2C4AA 1E8UA 3D11A 5FZNA 4FPGA 2HU0A 3A9HA 4YZ4A 1L7HA 2BERA 2GVXA 3SLIA 4XIKA 1MR5A 1N1VA 4YY8A 1IVEA 1ZI0A 4MX0A 4B7NA 4MZEA 1S18A 1NSDA 2F26A 4M4VA 2SILA 1Z4YA 2ZZKA 3WWAA 1N6DA 1WP5A 4IFLX 1W8NA 4GZSA 1V3EA 2YDTA 4C1YB 4J9TA 2YA6A 4GNBA 4MWLA 4D4UA 4AGIA 4JF7A 1NNCA 2V91A 1W8OA 2W20A 3II7A 4HHOA 2F10A 4L7BA 2FPBA 3K38A 5M1ZA 1CRUA 1IVFA 5HUMA 4X4AA 4XMAA 1C9UA 4B7JA 3CYEA 2DSOA 4IMBA 2RKCA 4XIOA 3HLIA 1B9VA 4MWWA 1MS1A 5HUKA 5D9CA 3B69A 1MS5A 1W1XA 4GDJA 4XJQA 2HTWA 2HTUA 3VNHA 4IYGA 4XOGA 4B7QA 4K1HA 1S0JA 1K32A 2A75A 3T1EA 2HTRA 1NCAN 1NSBA 4CHBA 1OFZA 2C4LA 4Q6KA 2F27A 2GVVA 3A72A 1IVCA 1VCJA 4CH9A 3TICA 5FNTA 5FWWA 4MWUA 2VW0A 2WOZA 4GZOA 3INBA 3A9GA 2DG1A 5CGJA 1EUSA 2VK5A 1EURA 1IUCA 2IATA 1W21A 2XCYA 3LI5A 3OPZA 1WCSA 2W5OA 3BEQA 3LI4A 2BZDA 3O9KA 2FLUX 1F8CA 3H6JA 1F8EA 1SUUA 2IAVA 3SREA 3DASA 4WEFA 1ZGKA 2VSKA 3ALWA 2F0ZA 4GNAA 3WN7A 1Z4WA 1INFA 4MWRA 5FNRA 3K3AA 3ADEA 5F9TA 3O4PA 2IAWA 2QWKA 1NCCN 3H72A 3S8ZA 1RWLA 2QWFA 3S8VA 4HW6A 2XN4A 1USXA 1CRZA 4HZXA 1MS4A 4K3YA 4IQKA 4FPCA 4QN3A 4MZAA 2SIMA 1IJQA 2IAXA 1S0IA 2OJHA 2VW2A 2W38A 1IUBA 5GX4A 5GX5A 1POOA 3JU4A 1NMCA 4PWZA 4GNCA 2AH2A 4MC7A 4WA4A 2QWIA 2GVWA 3CL2A 1C5KA 3LI3A 4IFJA 2HT8A 4GZQA 3K39A 1CQ1A 3WDZA 1B9TA 7NN9A 3Q6PA 4NC5A 2ISMA 2BATA 2W5NA 4L7DA 3SOBB 2W8BA 4X49A 4I00A 4MJUA 1E8TA 4CPZA 4GN8A 3P5BL 4QN7A 2AEQA 2XZJA 5GTQA 4WA3A 4YW1A 4N1BA 3V1SA 4BBWA 4XMBA 4K1JA 1N6EA 2G8SA 2VAQA 4XHXA 2Z32A 3B7EA 1VCUA 2VW1A 4FOVA 1N6FA 1X2JA 5EO7A 4XMIA 1V0EA 3G4EA 3BYCA 1NNAA 2F24A 4KS5A 3V65B 5HX0A 4ASCA 1EUTA 3U0SA 2W8BB 2BF6A 2CMLA 3CL0A 4HZZA 1NMAN 1U6DX 4HZYA 4FQ4A 5EX7A 2XZIA 4D8SA 1E1AA 2IAPA
chains in the Genus database with same CATH topology
4L7BA 2VPJA 3WDZA 1X2JA 5F72C 5FNQA 4L7CA 2XN4A 4L7DA 3ZGCA 2FLUX 4CHBA 2DYHA 2ZW9A 2ZZKA 4IFLX 4IQKA 3VNGA 4ASCA 1ZGKA 3WN7A 5FNUA 4IN4A 3ZGDA 5FNRA 4CH9A 3ADEA 1U6DX 2ZWAA 4YY8A 5FNTA 5FZJA 4N1BA 5FZNA 2WOZA 4XMBA 4IFNX 3II7A 4ZGCA 3VNHA 4ZY3A 5CGJA 4IFJA 5FNSA 1X2RA 2Z32A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4L7B A;  2VPJ A;  3WDZ A;  1X2J A;  5F72 C;  5FNQ A;  4L7C A;  2XN4 A;  4L7D A;  3ZGC A;  2FLU X;  4CHB A;  2DYH A;  2ZW9 A;  2ZZK A;  4IFL X;  4IQK A;  3VNG A;  4ASC A;  1ZGK A;  3WN7 A;  5FNU A;  4IN4 A;  3ZGD A;  5FNR A;  4CH9 A;  3ADE A;  1U6D X;  2ZWA A;  4YY8 A;  5FNT A;  5FZJ A;  4N1B A;  5FZN A;  2WOZ A;  4XMB A;  4IFN X;  3II7 A;  4ZGC A;  3VNH A;  4ZY3 A;  5CGJ A;  4IFJ A;  5FNS A;  1X2R A;  2Z32 A; 
#chains in the Genus database with same CATH topology
 4GEZ A;  4GN9 A;  2QE8 A;  2VPJ A;  1V04 A;  3ALX A;  2SLI A;  1N7D A;  3AMS A;  4FPY A;  3I1C A;  4M4U A;  4YW3 A;  3VNG A;  1Z50 A;  1V0Z A;  1W20 A;  5FNU A;  3TI8 A;  1Q7F A;  1DIL A;  4YZ5 A;  5GX1 A;  4AH4 A;  3WW9 A;  4NCS A;  4QNP A;  1SO7 A;  1CVM A;  2YA5 A;  4YZ1 A;  4IFN X;  3TI4 A;  3NO0 A;  2AGS A;  3DR2 A;  2JKB A;  4CPM A;  4YW4 A;  1X2R A;  4O5T A;  4XJ9 A;  4X47 A;  4GZT A;  3V64 C;  5B2C A;  1NN2 A;  2XZK A;  1IVG A;  3ZGC A;  4MWV A;  2IVZ A;  4FJ6 A;  2POO A;  2GVU A;  4H53 A;  1A4Q A;  2F12 A;  4D52 A;  4FPH A;  4SLI A;  3K36 A;  4K1I A;  1MS8 A;  2QWB A;  4DGR A;  4NN9 A;  1WCQ A;  2IAQ A;  4ZGC A;  2YA8 A;  2YA7 A;  4ZY3 A;  5FNS A;  3UC1 A;  4XJ8 A;  5HUG A;  4MWQ A;  3H73 A;  4FOY A;  4CSD A;  5F72 C;  2VK7 A;  4AHA A;  2VK6 A;  4FPE A;  4FPJ A;  4FPK A;  1N1T A;  1NPE A;  3H71 A;  3SRG A;  1V3D A;  1EUU A;  3KYA A;  1V3C A;  4A0P A;  3CKZ A;  2H2N A;  4R40 A;  4B7R A;  4WEG A;  3PJQ A;  3IAX A;  2YDP A;  1ING A;  4CPO A;  1N1S A;  1RWI A;  4HHQ A;  4D52 B;  2FPC A;  1MZ5 A;  2F29 A;  4MWX A;  3TI6 A;  3GVK A;  4XJR A;  1XOG A;  1NMB N;  1INV A;  4Q1U A;  4YW2 A;  1S1D A;  4DG6 A;  1B9S A;  2AEP A;  2P4O A;  3K37 A;  4GZP A;  1INW A;  2B8H A;  5B2D A;  1E8V A;  5EO8 A;  1Z4V A;  5FZJ A;  4B7M A;  4YW5 A;  2IAO A;  1SNT A;  2QWC A;  3TIA A;  4KS4 A;  2QWG A;  3O9J A;  2F11 A;  4FOQ A;  4XJA A;  1QLG A;  4GJT A;  4CPL A;  3TI5 A;  2HQS A;  4XE9 A;  1F8D A;  3SAN A;  3NN9 A;  2F25 A;  2FP9 A;  2ZW9 A;  1MZ6 A;  5H47 A;  4GN7 A;  4XYX A;  2VVZ A;  2FP8 A;  4KS3 A;  2IAU A;  4QN6 A;  3SOQ A;  2VWD A;  4QN4 A;  1L7F A;  4GDI A;  1V2I A;  2HT5 A;  4YZ3 A;  1L7G A;  1INH A;  2ZB6 A;  1MS3 A;  1NCB N;  2IAR A;  4L7C A;  4ZLR A;  3TI3 A;  4XJW A;  4G3N A;  4GZW A;  4KS1 A;  4FPO B;  5D9B A;  3Q6T A;  3GVL A;  4FP3 A;  1INX A;  3NSS A;  3Q6K A;  3W09 A;  4FPL A;  4UF7 A;  1MS0 A;  3SOV A;  3SAL A;  2ZWA A;  4M3M A;  4FP2 A;  5HUN A;  3A71 A;  2GHS A;  1N1Y A;  3GVJ A;  1QBI A;  4KS2 A;  2HT7 A;  1INY A;  1V3B A;  5GX2 A;  2HTQ A;  2DG0 A;  2QWH A;  4XHB A;  2F13 A;  1A14 N;  3L6V A;  4YZ2 A;  4FPF A;  4CPY A;  1MWE A;  4X6K A;  3FVZ A;  4GB1 A;  3KGG A;  4FOW A;  4FZH A;  2F28 A;  3ZGD A;  1V0F A;  4D52 C;  3SIL A;  3TIB A;  1SLI A;  1IVD A;  2QWE A;  2H2U A;  4AGT A;  4CPN A;  1NNB A;  1SLL A;  4MJV A;  5NN9 A;  4WA5 A;  1XOE A;  2QWJ A;  1NSC A;  2QWD A;  5FNQ A;  2ZB5 A;  3FW0 A;  3S2K A;  5GX3 A;  1KIT A;  2QWA A;  6NN9 A;  3E5Z A;  1NCD N;  2DYH A;  4HZV A;  1PJX A;  4K1K A;  1Z4X A;  2FHR A;  4UOU A;  1F8B A;  2HTY A;  4XJZ A;  4H52 A;  2X9M A;  4GZX A;  4QN5 A;  4MWJ A;  5D9D A;  3TC9 A;  3D12 A;  3G4H A;  1W0O A;  3HLH A;  3HRP A;  2HU4 A;  1IVB A;  2VSM A;  3S94 A;  5JYY A;  4XIL A;  1A4G A;  1USR A;  4JML A;  1H6L A;  1MS9 A;  3AMR A;  4XJU A;  4O5S A;  1Z4Z A;  2HTV A;  1BJI A;  4C1Y A;  2YA4 A;  4FVK A;  1DIM A;  2IAS A;  4IN4 A;  4MWY A;  4HIZ A;  1W0P A;  4M4N A;  4HZW A;  2C4A A;  1E8U A;  3D11 A;  5FZN A;  4FPG A;  2HU0 A;  3A9H A;  4YZ4 A;  1L7H A;  2BER A;  2GVX A;  3SLI A;  4XIK A;  1MR5 A;  1N1V A;  4YY8 A;  1IVE A;  1ZI0 A;  4MX0 A;  4B7N A;  4MZE A;  1S18 A;  1NSD A;  2F26 A;  4M4V A;  2SIL A;  1Z4Y A;  2ZZK A;  3WWA A;  1N6D A;  1WP5 A;  4IFL X;  1W8N A;  4GZS A;  1V3E A;  2YDT A;  4C1Y B;  4J9T A;  2YA6 A;  4GNB A;  4MWL A;  4D4U A;  4AGI A;  4JF7 A;  1NNC A;  2V91 A;  1W8O A;  2W20 A;  3II7 A;  4HHO A;  2F10 A;  4L7B A;  2FPB A;  3K38 A;  5M1Z A;  1CRU A;  1IVF A;  5HUM A;  4X4A A;  4XMA A;  1C9U A;  4B7J A;  3CYE A;  2DSO A;  4IMB A;  2RKC A;  4XIO A;  3HLI A;  1B9V A;  4MWW A;  1MS1 A;  5HUK A;  5D9C A;  3B69 A;  1MS5 A;  1W1X A;  4GDJ A;  4XJQ A;  2HTW A;  2HTU A;  3VNH A;  4IYG A;  4XOG A;  4B7Q A;  4K1H A;  1S0J A;  1K32 A;  2A75 A;  3T1E A;  2HTR A;  1NCA N;  1NSB A;  4CHB A;  1OFZ A;  2C4L A;  4Q6K A;  2F27 A;  2GVV A;  3A72 A;  1IVC A;  1VCJ A;  4CH9 A;  3TIC A;  5FNT A;  5FWW A;  4MWU A;  2VW0 A;  2WOZ A;  4GZO A;  3INB A;  3A9G A;  2DG1 A;  5CGJ A;  1EUS A;  2VK5 A;  1EUR A;  1IUC A;  2IAT A;  1W21 A;  2XCY A;  3LI5 A;  3OPZ A;  1WCS A;  2W5O A;  3BEQ A;  3LI4 A;  2BZD A;  3O9K A;  2FLU X;  1F8C A;  3H6J A;  1F8E A;  1SUU A;  2IAV A;  3SRE A;  3DAS A;  4WEF A;  1ZGK A;  2VSK A;  3ALW A;  2F0Z A;  4GNA A;  3WN7 A;  1Z4W A;  1INF A;  4MWR A;  5FNR A;  3K3A A;  3ADE A;  5F9T A;  3O4P A;  2IAW A;  2QWK A;  1NCC N;  3H72 A;  3S8Z A;  1RWL A;  2QWF A;  3S8V A;  4HW6 A;  2XN4 A;  1USX A;  1CRZ A;  4HZX A;  1MS4 A;  4K3Y A;  4IQK A;  4FPC A;  4QN3 A;  4MZA A;  2SIM A;  1IJQ A;  2IAX A;  1S0I A;  2OJH A;  2VW2 A;  2W38 A;  1IUB A;  5GX4 A;  5GX5 A;  1POO A;  3JU4 A;  1NMC A;  4PWZ A;  4GNC A;  2AH2 A;  4MC7 A;  4WA4 A;  2QWI A;  2GVW A;  3CL2 A;  1C5K A;  3LI3 A;  4IFJ A;  2HT8 A;  4GZQ A;  3K39 A;  1CQ1 A;  3WDZ A;  1B9T A;  7NN9 A;  3Q6P A;  4NC5 A;  2ISM A;  2BAT A;  2W5N A;  4L7D A;  3SOB B;  2W8B A;  4X49 A;  4I00 A;  4MJU A;  1E8T A;  4CPZ A;  4GN8 A;  3P5B L;  4QN7 A;  2AEQ A;  2XZJ A;  5GTQ A;  4WA3 A;  4YW1 A;  4N1B A;  3V1S A;  4BBW A;  4XMB A;  4K1J A;  1N6E A;  2G8S A;  2VAQ A;  4XHX A;  2Z32 A;  3B7E A;  1VCU A;  2VW1 A;  4FOV A;  1N6F A;  1X2J A;  5EO7 A;  4XMI A;  1V0E A;  3G4E A;  3BYC A;  1NNA A;  2F24 A;  4KS5 A;  3V65 B;  5HX0 A;  4ASC A;  1EUT A;  3U0S A;  2W8B B;  2BF6 A;  2CML A;  3CL0 A;  4HZZ A;  1NMA N;  1U6D X;  4HZY A;  4FQ4 A;  5EX7 A;  2XZI A;  4D8S A;  1E1A A;  2IAP A; 
#chains in the Genus database with same CATH homology
 4L7B A;  2VPJ A;  3WDZ A;  1X2J A;  5F72 C;  5FNQ A;  4L7C A;  2XN4 A;  4L7D A;  3ZGC A;  2FLU X;  4CHB A;  2DYH A;  2ZW9 A;  2ZZK A;  4IFL X;  4IQK A;  3VNG A;  4ASC A;  1ZGK A;  3WN7 A;  5FNU A;  4IN4 A;  3ZGD A;  5FNR A;  4CH9 A;  3ADE A;  1U6D X;  2ZWA A;  4YY8 A;  5FNT A;  5FZJ A;  4N1B A;  5FZN A;  2WOZ A;  4XMB A;  4IFN X;  3II7 A;  4ZGC A;  3VNH A;  4ZY3 A;  5CGJ A;  4IFJ A;  5FNS A;  1X2R A;  2Z32 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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