4XMBA

Crystal structure of 2,2'-(naphthalene-1,4-diylbis(((4-methoxyphenyl)sulfonyl)azanediyl))diacetamide bound to human keap1 kelch domain
Total Genus 64
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
64
sequence length
286
structure length
286
Chain Sequence
VGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVT
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Protein binding
molecule keywords Kelch-like ECH-associated protein 1
publication title Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators.
pubmed doi rcsb
source organism Homo sapiens
total genus 64
structure length 286
sequence length 286
ec nomenclature
pdb deposition date 2015-01-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 4xmbA00
2ZWAA 2WOZA 2XN4A 3ZGDA 1ZGKA 4ZY3A 4IN4A 2DYHA 5FZNA 3ZGCA 4YY8A 3VNGA 4ASCA 2VPJA 4L7BA 3WDZA 1U6DX 2ZW9A 4IQKA 3VNHA 4CH9A 1X2RA 1X2JA 4IFJA 2Z32A 5FNRA 3WN7A 2ZZKA 5FNUA 5FZJA 5F72C 4N1BA 5FNSA 4IFLX 4XMBA 3ADEA 4L7CA 4IFNX 5FNQA 4L7DA 4CHBA 4ZGCA 5FNTA 3II7A 5CGJA 2FLUX
chains in the Genus database with same CATH superfamily
3CL0A 4H52A 2W8BB 2W5OA 4WA5A 1L7HA 4QNPA 4M4NA 4XJQA 3Q6TA 3PJQA 3KYAA 2QWBA 2DG1A 2QWAA 1C5KA 3ALXA 2Z32A 1Z50A 2HU0A 4B7NA 4CPLA 4A0PA 5F72C 1E8UA 1V2IA 1VCUA 2ZB6A 4GZSA 1CQ1A 5FWWA 1USXA 5GTQA 4FOWA 2A75A 3WW9A 3HLHA 1N1TA 3V1SA 3DASA 1SO7A 1V04A 1F8BA 3SALA 1B9SA 3NO0A 4AGTA 4IQKA 1X2RA 1DIMA 4GZOA 4YW3A 1VCJA 4XJZA 4XYXA 4GZTA 5FNSA 5H47A 1QBIA 3IAXA 2SIMA 4FPCA 2HQSA 4UF7A 4WA3A 1V0EA 1F8DA 2QWHA 2HTVA 4XJUA 1V3EA 2GVUA 2C4LA 2HTUA 5HUKA 4FPFA 3TIAA 2IAVA 2VW1A 3TI6A 3H6JA 2SILA 5NN9A 4MWUA 4DG6A 1IJQA 3UC1A 1A4GA 2QWIA 3D12A 2YA5A 5GX4A 4AHAA 2AH2A 4XOGA 4YW5A 3V65B 4H53A 4CHBA 2FPBA 4AGIA 2FLUX 4FPYA 1EURA 3TI8A 3T1EA 2YDPA 4HIZA 1RWLA 2F28A 3ZGCA 4ASCA 4FOVA 2VK7A 1F8CA 4YW1A 4FP3A 2HTWA 2FP8A 1W21A 4YZ4A 3S94A 3SANA 3SLIA 5FNUA 1IVEA 5HUNA 1L7GA 2VAQA 1POOA 4IFLX 4XJAA 2YA4A 4FPKA 6NN9A 2QWCA 5D9CA 3WWAA 5JYYA 4ZGCA 3II7A 4XJWA 2F25A 2QWDA 3LI4A 1INYA 4IYGA 4KS5A 2HTYA 4FOQA 3TICA 1U6DX 1E8VA 4YZ2A 4BBWA 4KS2A 2HT7A 2RKCA 1EUUA 2W8BA 4DGRA 1W0PA 2F11A 4XHXA 5FZJA 2F10A 1EUSA 2HU4A 3ALWA 4WEGA 4XMBA 4CPYA 4YZ1A 3CL2A 2QWJA 4B7RA 1S18A 5EX7A 1IVCA 5FNTA 2W38A 5HUGA 5GX5A 1MS3A 2VVZA 3GVKA 1N1YA 5HUMA 4IN4A 1MWEA 2C4AA 3O9KA 3K36A 1N1SA 4GN9A 1MS0A 5FNRA 1NNBA 4IMBA 3LI3A 2IASA 2IAUA 4FVKA 5GX1A 2VSKA 3NSSA 4QN5A 2F24A 2AGSA 2ZWAA 1QLGA 2HTRA 4MWLA 2WOZA 3A9GA 4X49A 1CRZA 2H2UA 1F8EA 5FZNA 4MWQA 4X6KA 4CPZA 1XOGA 2H2NA 2YA6A 3AMSA 1INHA 4WA4A 4D52B 2QWFA 4MJUA 1EUTA 2F27A 1W8NA 1IVFA 4GEZA 4QN7A 4HW6A 4GDJA 4GB1A 3V64C 1INGA 4MX0A 1Z4YA 4M3MA 2XZJA 4MWXA 1INVA 3GVLA 3TI4A 1WCQA 4HZWA 1ZI0A 4I00A 2POOA 3D11A 2F29A 3B69A 1INXA 3O4PA 4GZWA 2P4OA 1MR5A 4GN7A 1KITA 2FP9A 2HT8A 5GX2A 1NSCA 4O5TA 4CPMA 4J9TA 2XZIA 4D4UA 4B7MA 3S8VA 5HX0A 1N6EA 4FPGA 1C9UA 2BZDA 3NN9A 5EO8A 1S0IA 4B7QA 5M1ZA 4L7BA 4MWVA 4M4VA 2VW0A 4HHOA 3B7EA 1WCSA 4KS4A 3SOVA 4K1HA 4G3NA 3S2KA 4ZLRA 1A14N 2VW2A 1MS8A 1MS4A 2GVXA 1NCDN 1MZ5A 3TI3A 1IVGA 1Z4ZA 3KGGA 4QN3A 4YW4A 2DYHA 2ZB5A 1XOEA 3LI5A 5B2DA 5D9BA 4C1YB 1NMBN 4Q6KA 4D52C 3FW0A 2F12A 2ISMA 4NC5A 4HZZA 3GVJA 1E1AA 4IFJA 1N6DA 4GZPA 4K1KA 4NN9A 1K32A 2CMLA 2GHSA 2V91A 2VK6A 4JF7A 4L7CA 5B2CA 4YW2A 3HRPA 1BJIA 3G4EA 3K39A 2W20A 4FJ6A 4FPJA 4PWZA 1V3BA 2XN4A 1V0FA 4MWWA 1A4QA 2DG0A 4KS1A 4ZY3A 4XMIA 4HZVA 2XZKA 4MC7A 2F13A 2BF6A 4GNBA 3FVZA 4FPOB 4GZXA 3WDZA 3K38A 1IUCA 1NSDA 3AMRA 4SLIA 3K3AA 2VSMA 1SLIA 3L6VA 4N1BA 2HT5A 4HZYA 4XHBA 5GX3A 4XJRA 1IVDA 1PJXA 4IFNX 2IAPA 4XILA 4L7DA 4D52A 4GDIA 2YDTA 1Z4VA 2QE8A 3H72A 4JMLA 2AEPA 4YZ3A 1ZGKA 4KS3A 3SREA 4GN8A 1B9TA 3TI5A 4QN6A 2VPJA 3Q6KA 3BYCA 1NCBN 2XCYA 2IAWA 4R40A 3U0SA 1MZ6A 1W20A 2GVWA 4GNCA 4QN4A 2AEQA 3OPZA 1Q7FA 1IUBA 1IVBA 1RWIA 4K1JA 3H73A 4NCSA 3ADEA 2DSOA 1NMAN 4FZHA 3TIBA 5FNQA 1B9VA 2IAOA 3A9HA 2OJHA 4B7JA 1W0OA 2FPCA 2IARA 3SOQA 2W5NA 2VWDA 4MWJA 3K37A 3W09A 2VK5A 1W1XA 4CH9A 2IATA 4MJVA 4X4AA 4MWRA 4CPOA 1N6FA 2ZZKA 1WP5A 3A72A 2BERA 4FP2A 3CYEA 4XIOA 3HLIA 1V3CA 2GVVA 4M4UA 1SNTA 2HTQA 1SLLA 1OFZA 4O5SA 2F26A 3SOBB 5CGJA 3ZGDA 3O9JA 1MS9A 1V3DA 1E8TA 1NMCA 2YA8A 4XIKA 3TC9A 3VNGA 2QWKA 1W8OA 1MS1A 4FPEA 4Q1UA 4GJTA 1NSBA 2QWEA 2BATA 2IVZA 1INFA 2B8HA 4C1YA 1N7DA 4FQ4A 4FOYA 2G8SA 2X9MA 4XJ8A 1NCAN 1L7FA 2IAXA 4AH4A 4HHQA 1NNAA 1SUUA 1Z4XA 1DILA 3E5ZA 4YZ5A 4XMAA 5F9TA 3DR2A 1NN2A 1NPEA 3S8ZA 4K3YA 1USRA 3JU4A 3I1CA 3P5BL 4MZAA 3BEQA 3H71A 2YA7A 5D9DA 7NN9A 1CVMA 3WN7A 3INBA 4MZEA 4CPNA 1H6LA 1MS5A 3Q6PA 4K1IA 1INWA 1NCCN 1NNCA 1N1VA 4CSDA 4MWYA 2QWGA 3SRGA 4HZXA 1V0ZA 1S1DA 4FPHA 4YY8A 4XJ9A 3A71A 4FPLA 2ZW9A 3VNHA 1Z4WA 4X47A 2F0ZA 4GNAA 4GZQA 1X2JA 3G4HA 1CRUA 5EO7A 4D8SA 2JKBA 2SLIA 4UOUA 3SILA 4WEFA 2IAQA 2FHRA 3CKZA 1S0JA 4XE9A
chains in the Genus database with same CATH topology
2ZWAA 2WOZA 2XN4A 3ZGDA 1ZGKA 4ZY3A 4IN4A 2DYHA 5FZNA 3ZGCA 4YY8A 3VNGA 4ASCA 2VPJA 4L7BA 3WDZA 1U6DX 2ZW9A 4IQKA 3VNHA 4CH9A 1X2RA 1X2JA 4IFJA 2Z32A 5FNRA 3WN7A 2ZZKA 5FNUA 5FZJA 5F72C 4N1BA 5FNSA 4IFLX 4XMBA 3ADEA 4L7CA 4IFNX 5FNQA 4L7DA 4CHBA 4ZGCA 5FNTA 3II7A 5CGJA 2FLUX
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ZWA A;  2WOZ A;  2XN4 A;  3ZGD A;  1ZGK A;  4ZY3 A;  4IN4 A;  2DYH A;  5FZN A;  3ZGC A;  4YY8 A;  3VNG A;  4ASC A;  2VPJ A;  4L7B A;  3WDZ A;  1U6D X;  2ZW9 A;  4IQK A;  3VNH A;  4CH9 A;  1X2R A;  1X2J A;  4IFJ A;  2Z32 A;  5FNR A;  3WN7 A;  2ZZK A;  5FNU A;  5FZJ A;  5F72 C;  4N1B A;  5FNS A;  4IFL X;  4XMB A;  3ADE A;  4L7C A;  4IFN X;  5FNQ A;  4L7D A;  4CHB A;  4ZGC A;  5FNT A;  3II7 A;  5CGJ A;  2FLU X; 
#chains in the Genus database with same CATH topology
 3CL0 A;  4H52 A;  2W8B B;  2W5O A;  4WA5 A;  1L7H A;  4QNP A;  4M4N A;  4XJQ A;  3Q6T A;  3PJQ A;  3KYA A;  2QWB A;  2DG1 A;  2QWA A;  1C5K A;  3ALX A;  2Z32 A;  1Z50 A;  2HU0 A;  4B7N A;  4CPL A;  4A0P A;  5F72 C;  1E8U A;  1V2I A;  1VCU A;  2ZB6 A;  4GZS A;  1CQ1 A;  5FWW A;  1USX A;  5GTQ A;  4FOW A;  2A75 A;  3WW9 A;  3HLH A;  1N1T A;  3V1S A;  3DAS A;  1SO7 A;  1V04 A;  1F8B A;  3SAL A;  1B9S A;  3NO0 A;  4AGT A;  4IQK A;  1X2R A;  1DIM A;  4GZO A;  4YW3 A;  1VCJ A;  4XJZ A;  4XYX A;  4GZT A;  5FNS A;  5H47 A;  1QBI A;  3IAX A;  2SIM A;  4FPC A;  2HQS A;  4UF7 A;  4WA3 A;  1V0E A;  1F8D A;  2QWH A;  2HTV A;  4XJU A;  1V3E A;  2GVU A;  2C4L A;  2HTU A;  5HUK A;  4FPF A;  3TIA A;  2IAV A;  2VW1 A;  3TI6 A;  3H6J A;  2SIL A;  5NN9 A;  4MWU A;  4DG6 A;  1IJQ A;  3UC1 A;  1A4G A;  2QWI A;  3D12 A;  2YA5 A;  5GX4 A;  4AHA A;  2AH2 A;  4XOG A;  4YW5 A;  3V65 B;  4H53 A;  4CHB A;  2FPB A;  4AGI A;  2FLU X;  4FPY A;  1EUR A;  3TI8 A;  3T1E A;  2YDP A;  4HIZ A;  1RWL A;  2F28 A;  3ZGC A;  4ASC A;  4FOV A;  2VK7 A;  1F8C A;  4YW1 A;  4FP3 A;  2HTW A;  2FP8 A;  1W21 A;  4YZ4 A;  3S94 A;  3SAN A;  3SLI A;  5FNU A;  1IVE A;  5HUN A;  1L7G A;  2VAQ A;  1POO A;  4IFL X;  4XJA A;  2YA4 A;  4FPK A;  6NN9 A;  2QWC A;  5D9C A;  3WWA A;  5JYY A;  4ZGC A;  3II7 A;  4XJW A;  2F25 A;  2QWD A;  3LI4 A;  1INY A;  4IYG A;  4KS5 A;  2HTY A;  4FOQ A;  3TIC A;  1U6D X;  1E8V A;  4YZ2 A;  4BBW A;  4KS2 A;  2HT7 A;  2RKC A;  1EUU A;  2W8B A;  4DGR A;  1W0P A;  2F11 A;  4XHX A;  5FZJ A;  2F10 A;  1EUS A;  2HU4 A;  3ALW A;  4WEG A;  4XMB A;  4CPY A;  4YZ1 A;  3CL2 A;  2QWJ A;  4B7R A;  1S18 A;  5EX7 A;  1IVC A;  5FNT A;  2W38 A;  5HUG A;  5GX5 A;  1MS3 A;  2VVZ A;  3GVK A;  1N1Y A;  5HUM A;  4IN4 A;  1MWE A;  2C4A A;  3O9K A;  3K36 A;  1N1S A;  4GN9 A;  1MS0 A;  5FNR A;  1NNB A;  4IMB A;  3LI3 A;  2IAS A;  2IAU A;  4FVK A;  5GX1 A;  2VSK A;  3NSS A;  4QN5 A;  2F24 A;  2AGS A;  2ZWA A;  1QLG A;  2HTR A;  4MWL A;  2WOZ A;  3A9G A;  4X49 A;  1CRZ A;  2H2U A;  1F8E A;  5FZN A;  4MWQ A;  4X6K A;  4CPZ A;  1XOG A;  2H2N A;  2YA6 A;  3AMS A;  1INH A;  4WA4 A;  4D52 B;  2QWF A;  4MJU A;  1EUT A;  2F27 A;  1W8N A;  1IVF A;  4GEZ A;  4QN7 A;  4HW6 A;  4GDJ A;  4GB1 A;  3V64 C;  1ING A;  4MX0 A;  1Z4Y A;  4M3M A;  2XZJ A;  4MWX A;  1INV A;  3GVL A;  3TI4 A;  1WCQ A;  4HZW A;  1ZI0 A;  4I00 A;  2POO A;  3D11 A;  2F29 A;  3B69 A;  1INX A;  3O4P A;  4GZW A;  2P4O A;  1MR5 A;  4GN7 A;  1KIT A;  2FP9 A;  2HT8 A;  5GX2 A;  1NSC A;  4O5T A;  4CPM A;  4J9T A;  2XZI A;  4D4U A;  4B7M A;  3S8V A;  5HX0 A;  1N6E A;  4FPG A;  1C9U A;  2BZD A;  3NN9 A;  5EO8 A;  1S0I A;  4B7Q A;  5M1Z A;  4L7B A;  4MWV A;  4M4V A;  2VW0 A;  4HHO A;  3B7E A;  1WCS A;  4KS4 A;  3SOV A;  4K1H A;  4G3N A;  3S2K A;  4ZLR A;  1A14 N;  2VW2 A;  1MS8 A;  1MS4 A;  2GVX A;  1NCD N;  1MZ5 A;  3TI3 A;  1IVG A;  1Z4Z A;  3KGG A;  4QN3 A;  4YW4 A;  2DYH A;  2ZB5 A;  1XOE A;  3LI5 A;  5B2D A;  5D9B A;  4C1Y B;  1NMB N;  4Q6K A;  4D52 C;  3FW0 A;  2F12 A;  2ISM A;  4NC5 A;  4HZZ A;  3GVJ A;  1E1A A;  4IFJ A;  1N6D A;  4GZP A;  4K1K A;  4NN9 A;  1K32 A;  2CML A;  2GHS A;  2V91 A;  2VK6 A;  4JF7 A;  4L7C A;  5B2C A;  4YW2 A;  3HRP A;  1BJI A;  3G4E A;  3K39 A;  2W20 A;  4FJ6 A;  4FPJ A;  4PWZ A;  1V3B A;  2XN4 A;  1V0F A;  4MWW A;  1A4Q A;  2DG0 A;  4KS1 A;  4ZY3 A;  4XMI A;  4HZV A;  2XZK A;  4MC7 A;  2F13 A;  2BF6 A;  4GNB A;  3FVZ A;  4FPO B;  4GZX A;  3WDZ A;  3K38 A;  1IUC A;  1NSD A;  3AMR A;  4SLI A;  3K3A A;  2VSM A;  1SLI A;  3L6V A;  4N1B A;  2HT5 A;  4HZY A;  4XHB A;  5GX3 A;  4XJR A;  1IVD A;  1PJX A;  4IFN X;  2IAP A;  4XIL A;  4L7D A;  4D52 A;  4GDI A;  2YDT A;  1Z4V A;  2QE8 A;  3H72 A;  4JML A;  2AEP A;  4YZ3 A;  1ZGK A;  4KS3 A;  3SRE A;  4GN8 A;  1B9T A;  3TI5 A;  4QN6 A;  2VPJ A;  3Q6K A;  3BYC A;  1NCB N;  2XCY A;  2IAW A;  4R40 A;  3U0S A;  1MZ6 A;  1W20 A;  2GVW A;  4GNC A;  4QN4 A;  2AEQ A;  3OPZ A;  1Q7F A;  1IUB A;  1IVB A;  1RWI A;  4K1J A;  3H73 A;  4NCS A;  3ADE A;  2DSO A;  1NMA N;  4FZH A;  3TIB A;  5FNQ A;  1B9V A;  2IAO A;  3A9H A;  2OJH A;  4B7J A;  1W0O A;  2FPC A;  2IAR A;  3SOQ A;  2W5N A;  2VWD A;  4MWJ A;  3K37 A;  3W09 A;  2VK5 A;  1W1X A;  4CH9 A;  2IAT A;  4MJV A;  4X4A A;  4MWR A;  4CPO A;  1N6F A;  2ZZK A;  1WP5 A;  3A72 A;  2BER A;  4FP2 A;  3CYE A;  4XIO A;  3HLI A;  1V3C A;  2GVV A;  4M4U A;  1SNT A;  2HTQ A;  1SLL A;  1OFZ A;  4O5S A;  2F26 A;  3SOB B;  5CGJ A;  3ZGD A;  3O9J A;  1MS9 A;  1V3D A;  1E8T A;  1NMC A;  2YA8 A;  4XIK A;  3TC9 A;  3VNG A;  2QWK A;  1W8O A;  1MS1 A;  4FPE A;  4Q1U A;  4GJT A;  1NSB A;  2QWE A;  2BAT A;  2IVZ A;  1INF A;  2B8H A;  4C1Y A;  1N7D A;  4FQ4 A;  4FOY A;  2G8S A;  2X9M A;  4XJ8 A;  1NCA N;  1L7F A;  2IAX A;  4AH4 A;  4HHQ A;  1NNA A;  1SUU A;  1Z4X A;  1DIL A;  3E5Z A;  4YZ5 A;  4XMA A;  5F9T A;  3DR2 A;  1NN2 A;  1NPE A;  3S8Z A;  4K3Y A;  1USR A;  3JU4 A;  3I1C A;  3P5B L;  4MZA A;  3BEQ A;  3H71 A;  2YA7 A;  5D9D A;  7NN9 A;  1CVM A;  3WN7 A;  3INB A;  4MZE A;  4CPN A;  1H6L A;  1MS5 A;  3Q6P A;  4K1I A;  1INW A;  1NCC N;  1NNC A;  1N1V A;  4CSD A;  4MWY A;  2QWG A;  3SRG A;  4HZX A;  1V0Z A;  1S1D A;  4FPH A;  4YY8 A;  4XJ9 A;  3A71 A;  4FPL A;  2ZW9 A;  3VNH A;  1Z4W A;  4X47 A;  2F0Z A;  4GNA A;  4GZQ A;  1X2J A;  3G4H A;  1CRU A;  5EO7 A;  4D8S A;  2JKB A;  2SLI A;  4UOU A;  3SIL A;  4WEF A;  2IAQ A;  2FHR A;  3CKZ A;  1S0J A;  4XE9 A; 
#chains in the Genus database with same CATH homology
 2ZWA A;  2WOZ A;  2XN4 A;  3ZGD A;  1ZGK A;  4ZY3 A;  4IN4 A;  2DYH A;  5FZN A;  3ZGC A;  4YY8 A;  3VNG A;  4ASC A;  2VPJ A;  4L7B A;  3WDZ A;  1U6D X;  2ZW9 A;  4IQK A;  3VNH A;  4CH9 A;  1X2R A;  1X2J A;  4IFJ A;  2Z32 A;  5FNR A;  3WN7 A;  2ZZK A;  5FNU A;  5FZJ A;  5F72 C;  4N1B A;  5FNS A;  4IFL X;  4XMB A;  3ADE A;  4L7C A;  4IFN X;  5FNQ A;  4L7D A;  4CHB A;  4ZGC A;  5FNT A;  3II7 A;  5CGJ A;  2FLU X; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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