5CGJA

Crystal structure of murine keap1 in complex with ra839, a non-covalent small-molecule binder to keap1 and selective activator of nrf2 signalling.
Total Genus 61
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
61
sequence length
290
structure length
290
Chain Sequence
VGRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPC
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Protein binding
molecule keywords Kelch-like ECH-associated protein 1
publication title Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling.
pubmed doi rcsb
source organism Mus musculus
total genus 61
structure length 290
sequence length 290
ec nomenclature
pdb deposition date 2015-07-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 5cgjA00
5FNUA 4ASCA 5CGJA 4L7DA 1X2RA 4L7CA 2VPJA 5F72C 5FNTA 5FNRA 3VNHA 2DYHA 4XMBA 4CH9A 3ADEA 2ZWAA 2ZZKA 3VNGA 4ZGCA 2Z32A 4N1BA 3ZGDA 4IN4A 3WDZA 3WN7A 5FNQA 2FLUX 2WOZA 4ZY3A 4L7BA 4IFNX 4CHBA 1ZGKA 5FZNA 1X2JA 5FNSA 2ZW9A 4IFJA 4IQKA 1U6DX 5FZJA 4YY8A 3II7A 3ZGCA 4IFLX 2XN4A
chains in the Genus database with same CATH superfamily
4FZHA 4FP3A 4SLIA 1N1TA 2VK7A 3CYEA 1F8EA 4D8SA 3LI5A 3H71A 3K38A 4N1BA 4YZ1A 3DR2A 3BYCA 4GNBA 4DGRA 4XMAA 4X47A 3K39A 2FP8A 3JU4A 4UF7A 1NMAN 4FP2A 1V0FA 4KS3A 4M4VA 2HTVA 5H47A 2HTUA 4GJTA 3Q6KA 2QWBA 4M4NA 2VW0A 4FPCA 4AGIA 4YW4A 1W1XA 3CKZA 4HHOA 2F28A 3TI3A 2SIMA 4ZGCA 1V0ZA 1B9SA 3W09A 2QE8A 5FWWA 1EURA 2FPCA 1Q7FA 3DASA 1X2JA 5HX0A 3B7EA 1N1SA 4X49A 2F12A 4FPLA 5GX2A 4WEFA 2F24A 1IVFA 3E5ZA 1E8TA 4MWLA 1SNTA 4HZWA 3SILA 4WA4A 2IARA 3B69A 2W8BA 5EX7A 1N7DA 2VPJA 2IAOA 2DG0A 2C4LA 1L7GA 4QN7A 3TC9A 2QWEA 3SOBB 1SUUA 2HTWA 3T1EA 2P4OA 1NSCA 1W21A 2ISMA 1L7HA 2VK5A 1CQ1A 4YZ5A 4XJ8A 7NN9A 1SLLA 3O4PA 4HHQA 2HTRA 4B7JA 4B7MA 2IAQA 3NO0A 4B7NA 2FP9A 4NN9A 2FPBA 4HW6A 1E1AA 4MJUA 2BERA 1S0JA 3I1CA 1V3CA 4MWJA 2G8SA 2AEPA 3D11A 3OPZA 4XJZA 3CL0A 3TIAA 4KS2A 1IUCA 5FNSA 3S2KA 4GNCA 4GZWA 2IAWA 1MS3A 2YA6A 2XZKA 2YA8A 1H6LA 2AH2A 3ZGCA 4YW5A 3GVJA 1MS5A 1KITA 1W20A 5JYYA 2GVUA 1V04A 4I00A 5CGJA 4K1HA 3KYAA 5F72C 5FNRA 4XMBA 2ZZKA 3V64C 3TI4A 2QWFA 5GX4A 4YW1A 2HT7A 2W38A 3H73A 3A9HA 5FNQA 2QWDA 2HQSA 2DSOA 5GX5A 5D9DA 1S18A 1K32A 4XE9A 2HU0A 3ALXA 2GVXA 3Q6PA 3TI5A 1U6DX 4FPEA 5FZJA 4IFLX 2XN4A 2QWAA 1NCBN 1V2IA 3K37A 2F10A 1CRUA 4XYXA 2ZWAA 1NNAA 5D9CA 4XIOA 5EO8A 1RWLA 4CPOA 3FW0A 3WDZA 1C9UA 3UC1A 4FOYA 4H53A 4XJRA 4B7RA 5GTQA 1IJQA 3V1SA 1Z4WA 2X9MA 1W8OA 3BEQA 4L7DA 4YZ2A 1Z50A 3K36A 2DG1A 4FJ6A 4H52A 1IVDA 1IVEA 1A14N 1MR5A 4WA5A 4C1YB 3AMRA 4KS1A 1MZ5A 4XJQA 4XOGA 2HTQA 1MS0A 4WA3A 4FOVA 1NCDN 4KS5A 2VSKA 2VWDA 1INVA 2IASA 4GNAA 4K1JA 4XJUA 5HUKA 2GVVA 2POOA 4O5SA 4GDIA 5FNTA 2YA4A 2YA7A 5B2CA 4KS4A 2F29A 3NSSA 4AGTA 2CMLA 4PWZA 3WN7A 3CL2A 1MS9A 3SRGA 1N6EA 4MC7A 4GN7A 1S0IA 3TI8A 4B7QA 2QWKA 4NC5A 4GEZA 4FPFA 4K1IA 3P5BL 4DG6A 1NPEA 3WW9A 1VCJA 4CPLA 3FVZA 2F11A 1NMCA 1X2RA 2IAXA 1E8VA 4HZZA 1NNBA 2W20A 2VAQA 1A4GA 3SOQA 4J9TA 2FLUX 1N1YA 3A71A 4CHBA 3HRPA 1B9VA 4GZQA 3U0SA 1CRZA 4JF7A 2BZDA 1V3BA 3IAXA 4IQKA 4XIKA 1XOGA 4YZ3A 3AMSA 4XJAA 4GZSA 3S8ZA 4FPYA 2IATA 2H2NA 3A9GA 4CSDA 5HUGA 2JKBA 2F0ZA 2DYHA 5F9TA 3SLIA 1A4QA 4GN9A 1W0OA 2QWIA 4C1YA 2VVZA 3D12A 4NCSA 1L7FA 2IAVA 2HU4A 3S94A 1IUBA 1V0EA 1W0PA 4A0PA 3L6VA 4IMBA 4D52C 2YDTA 4UOUA 5HUNA 4YW3A 1IVGA 1QBIA 3LI3A 4YZ4A 1CVMA 1DILA 1USXA 2AGSA 4HZVA 2IAPA 3G4EA 1NSDA 1RWIA 3Q6TA 1WCSA 1IVCA 1NSBA 1XOEA 3ZGDA 3HLHA 4IN4A 2QWGA 4AHAA 4ZY3A 2B8HA 2IAUA 2F27A 1NCCN 2HT5A 4GDJA 4IFNX 1INXA 4XMIA 4MWRA 2ZW9A 4CPZA 1WP5A 1S1DA 1SO7A 1SLIA 2V91A 1WCQA 2BATA 3G4HA 3LI4A 4XILA 1INFA 3II7A 4FPJA 4D52B 3A72A 1INWA 1VCUA 3V65B 1MZ6A 4O5TA 4FPGA 5GX1A 4QNPA 1B9TA 1EUTA 3H6JA 3NN9A 4GB1A 2FHRA 1NCAN 2YA5A 1MS1A 3GVKA 2VK6A 2VW1A 4X6KA 4GZXA 5NN9A 4HZXA 1Z4YA 1QLGA 6NN9A 1MS8A 1PJXA 4MX0A 5B2DA 4K1KA 5FNUA 4MWQA 2VW2A 2HT8A 4G3NA 3HLIA 1BJIA 2HTYA 4MWWA 2YDPA 2C4AA 2Z32A 4R40A 4IYGA 1EUSA 4D4UA 2IVZA 4AH4A 1NN2A 3S8VA 3SANA 3O9KA 4XJ9A 1USRA 2H2UA 3ALWA 4GN8A 3TIBA 4IFJA 3H72A 4HZYA 1INHA 1W8NA 4GZTA 4MWUA 4GZPA 4MWVA 4WEGA 1INGA 3GVLA 1N6DA 4HIZA 1F8CA 1IVBA 4MWYA 4CPMA 4FVKA 4L7CA 5EO7A 3VNHA 3SREA 1DIMA 4CH9A 3VNGA 1N6FA 2QWJA 2WOZA 1ZI0A 4FPHA 2SILA 2A75A 1OFZA 4CPYA 2OJHA 4XHXA 4FQ4A 2QWCA 5M1ZA 4D52A 3K3AA 1NMBN 1EUUA 4X4AA 2F25A 2W5NA 2XCYA 3INBA 4YW2A 4ASCA 4QN5A 2W5OA 1Z4ZA 1INYA 2SLIA 3ADEA 2F26A 5D9BA 1MS4A 5GX3A 4MZEA 4MZAA 4FOQA 4FPOB 1F8DA 4M4UA 2VSMA 1ZGKA 1F8BA 3TI6A 4CPNA 2AEQA 1Z4XA 1NNCA 2F13A 4MWXA 4YY8A 4XJWA 4QN6A 3TICA 4FPKA 2RKCA 2BF6A 3PJQA 2XZIA 3O9JA 1C5KA 1N1VA 2W8BB 4BBWA 3WWAA 4ZLRA 4Q1UA 4JMLA 4XHBA 2GHSA 4FOWA 1MWEA 4L7BA 5FZNA 1V3DA 2ZB6A 4K3YA 4Q6KA 3SALA 1E8UA 2QWHA 2ZB5A 3SOVA 4QN3A 4M3MA 4QN4A 2GVWA 1V3EA 1POOA 3KGGA 5HUMA 4GZOA 1Z4VA 2XZJA 4MJVA
chains in the Genus database with same CATH topology
5FNUA 4ASCA 5CGJA 4L7DA 1X2RA 4L7CA 2VPJA 5F72C 5FNTA 5FNRA 3VNHA 2DYHA 4XMBA 4CH9A 3ADEA 2ZWAA 2ZZKA 3VNGA 4ZGCA 2Z32A 4N1BA 3ZGDA 4IN4A 3WDZA 3WN7A 5FNQA 2FLUX 2WOZA 4ZY3A 4L7BA 4IFNX 4CHBA 1ZGKA 5FZNA 1X2JA 5FNSA 2ZW9A 4IFJA 4IQKA 1U6DX 5FZJA 4YY8A 3II7A 3ZGCA 4IFLX 2XN4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5FNU A;  4ASC A;  5CGJ A;  4L7D A;  1X2R A;  4L7C A;  2VPJ A;  5F72 C;  5FNT A;  5FNR A;  3VNH A;  2DYH A;  4XMB A;  4CH9 A;  3ADE A;  2ZWA A;  2ZZK A;  3VNG A;  4ZGC A;  2Z32 A;  4N1B A;  3ZGD A;  4IN4 A;  3WDZ A;  3WN7 A;  5FNQ A;  2FLU X;  2WOZ A;  4ZY3 A;  4L7B A;  4IFN X;  4CHB A;  1ZGK A;  5FZN A;  1X2J A;  5FNS A;  2ZW9 A;  4IFJ A;  4IQK A;  1U6D X;  5FZJ A;  4YY8 A;  3II7 A;  3ZGC A;  4IFL X;  2XN4 A; 
#chains in the Genus database with same CATH topology
 4FZH A;  4FP3 A;  4SLI A;  1N1T A;  2VK7 A;  3CYE A;  1F8E A;  4D8S A;  3LI5 A;  3H71 A;  3K38 A;  4N1B A;  4YZ1 A;  3DR2 A;  3BYC A;  4GNB A;  4DGR A;  4XMA A;  4X47 A;  3K39 A;  2FP8 A;  3JU4 A;  4UF7 A;  1NMA N;  4FP2 A;  1V0F A;  4KS3 A;  4M4V A;  2HTV A;  5H47 A;  2HTU A;  4GJT A;  3Q6K A;  2QWB A;  4M4N A;  2VW0 A;  4FPC A;  4AGI A;  4YW4 A;  1W1X A;  3CKZ A;  4HHO A;  2F28 A;  3TI3 A;  2SIM A;  4ZGC A;  1V0Z A;  1B9S A;  3W09 A;  2QE8 A;  5FWW A;  1EUR A;  2FPC A;  1Q7F A;  3DAS A;  1X2J A;  5HX0 A;  3B7E A;  1N1S A;  4X49 A;  2F12 A;  4FPL A;  5GX2 A;  4WEF A;  2F24 A;  1IVF A;  3E5Z A;  1E8T A;  4MWL A;  1SNT A;  4HZW A;  3SIL A;  4WA4 A;  2IAR A;  3B69 A;  2W8B A;  5EX7 A;  1N7D A;  2VPJ A;  2IAO A;  2DG0 A;  2C4L A;  1L7G A;  4QN7 A;  3TC9 A;  2QWE A;  3SOB B;  1SUU A;  2HTW A;  3T1E A;  2P4O A;  1NSC A;  1W21 A;  2ISM A;  1L7H A;  2VK5 A;  1CQ1 A;  4YZ5 A;  4XJ8 A;  7NN9 A;  1SLL A;  3O4P A;  4HHQ A;  2HTR A;  4B7J A;  4B7M A;  2IAQ A;  3NO0 A;  4B7N A;  2FP9 A;  4NN9 A;  2FPB A;  4HW6 A;  1E1A A;  4MJU A;  2BER A;  1S0J A;  3I1C A;  1V3C A;  4MWJ A;  2G8S A;  2AEP A;  3D11 A;  3OPZ A;  4XJZ A;  3CL0 A;  3TIA A;  4KS2 A;  1IUC A;  5FNS A;  3S2K A;  4GNC A;  4GZW A;  2IAW A;  1MS3 A;  2YA6 A;  2XZK A;  2YA8 A;  1H6L A;  2AH2 A;  3ZGC A;  4YW5 A;  3GVJ A;  1MS5 A;  1KIT A;  1W20 A;  5JYY A;  2GVU A;  1V04 A;  4I00 A;  5CGJ A;  4K1H A;  3KYA A;  5F72 C;  5FNR A;  4XMB A;  2ZZK A;  3V64 C;  3TI4 A;  2QWF A;  5GX4 A;  4YW1 A;  2HT7 A;  2W38 A;  3H73 A;  3A9H A;  5FNQ A;  2QWD A;  2HQS A;  2DSO A;  5GX5 A;  5D9D A;  1S18 A;  1K32 A;  4XE9 A;  2HU0 A;  3ALX A;  2GVX A;  3Q6P A;  3TI5 A;  1U6D X;  4FPE A;  5FZJ A;  4IFL X;  2XN4 A;  2QWA A;  1NCB N;  1V2I A;  3K37 A;  2F10 A;  1CRU A;  4XYX A;  2ZWA A;  1NNA A;  5D9C A;  4XIO A;  5EO8 A;  1RWL A;  4CPO A;  3FW0 A;  3WDZ A;  1C9U A;  3UC1 A;  4FOY A;  4H53 A;  4XJR A;  4B7R A;  5GTQ A;  1IJQ A;  3V1S A;  1Z4W A;  2X9M A;  1W8O A;  3BEQ A;  4L7D A;  4YZ2 A;  1Z50 A;  3K36 A;  2DG1 A;  4FJ6 A;  4H52 A;  1IVD A;  1IVE A;  1A14 N;  1MR5 A;  4WA5 A;  4C1Y B;  3AMR A;  4KS1 A;  1MZ5 A;  4XJQ A;  4XOG A;  2HTQ A;  1MS0 A;  4WA3 A;  4FOV A;  1NCD N;  4KS5 A;  2VSK A;  2VWD A;  1INV A;  2IAS A;  4GNA A;  4K1J A;  4XJU A;  5HUK A;  2GVV A;  2POO A;  4O5S A;  4GDI A;  5FNT A;  2YA4 A;  2YA7 A;  5B2C A;  4KS4 A;  2F29 A;  3NSS A;  4AGT A;  2CML A;  4PWZ A;  3WN7 A;  3CL2 A;  1MS9 A;  3SRG A;  1N6E A;  4MC7 A;  4GN7 A;  1S0I A;  3TI8 A;  4B7Q A;  2QWK A;  4NC5 A;  4GEZ A;  4FPF A;  4K1I A;  3P5B L;  4DG6 A;  1NPE A;  3WW9 A;  1VCJ A;  4CPL A;  3FVZ A;  2F11 A;  1NMC A;  1X2R A;  2IAX A;  1E8V A;  4HZZ A;  1NNB A;  2W20 A;  2VAQ A;  1A4G A;  3SOQ A;  4J9T A;  2FLU X;  1N1Y A;  3A71 A;  4CHB A;  3HRP A;  1B9V A;  4GZQ A;  3U0S A;  1CRZ A;  4JF7 A;  2BZD A;  1V3B A;  3IAX A;  4IQK A;  4XIK A;  1XOG A;  4YZ3 A;  3AMS A;  4XJA A;  4GZS A;  3S8Z A;  4FPY A;  2IAT A;  2H2N A;  3A9G A;  4CSD A;  5HUG A;  2JKB A;  2F0Z A;  2DYH A;  5F9T A;  3SLI A;  1A4Q A;  4GN9 A;  1W0O A;  2QWI A;  4C1Y A;  2VVZ A;  3D12 A;  4NCS A;  1L7F A;  2IAV A;  2HU4 A;  3S94 A;  1IUB A;  1V0E A;  1W0P A;  4A0P A;  3L6V A;  4IMB A;  4D52 C;  2YDT A;  4UOU A;  5HUN A;  4YW3 A;  1IVG A;  1QBI A;  3LI3 A;  4YZ4 A;  1CVM A;  1DIL A;  1USX A;  2AGS A;  4HZV A;  2IAP A;  3G4E A;  1NSD A;  1RWI A;  3Q6T A;  1WCS A;  1IVC A;  1NSB A;  1XOE A;  3ZGD A;  3HLH A;  4IN4 A;  2QWG A;  4AHA A;  4ZY3 A;  2B8H A;  2IAU A;  2F27 A;  1NCC N;  2HT5 A;  4GDJ A;  4IFN X;  1INX A;  4XMI A;  4MWR A;  2ZW9 A;  4CPZ A;  1WP5 A;  1S1D A;  1SO7 A;  1SLI A;  2V91 A;  1WCQ A;  2BAT A;  3G4H A;  3LI4 A;  4XIL A;  1INF A;  3II7 A;  4FPJ A;  4D52 B;  3A72 A;  1INW A;  1VCU A;  3V65 B;  1MZ6 A;  4O5T A;  4FPG A;  5GX1 A;  4QNP A;  1B9T A;  1EUT A;  3H6J A;  3NN9 A;  4GB1 A;  2FHR A;  1NCA N;  2YA5 A;  1MS1 A;  3GVK A;  2VK6 A;  2VW1 A;  4X6K A;  4GZX A;  5NN9 A;  4HZX A;  1Z4Y A;  1QLG A;  6NN9 A;  1MS8 A;  1PJX A;  4MX0 A;  5B2D A;  4K1K A;  5FNU A;  4MWQ A;  2VW2 A;  2HT8 A;  4G3N A;  3HLI A;  1BJI A;  2HTY A;  4MWW A;  2YDP A;  2C4A A;  2Z32 A;  4R40 A;  4IYG A;  1EUS A;  4D4U A;  2IVZ A;  4AH4 A;  1NN2 A;  3S8V A;  3SAN A;  3O9K A;  4XJ9 A;  1USR A;  2H2U A;  3ALW A;  4GN8 A;  3TIB A;  4IFJ A;  3H72 A;  4HZY A;  1INH A;  1W8N A;  4GZT A;  4MWU A;  4GZP A;  4MWV A;  4WEG A;  1ING A;  3GVL A;  1N6D A;  4HIZ A;  1F8C A;  1IVB A;  4MWY A;  4CPM A;  4FVK A;  4L7C A;  5EO7 A;  3VNH A;  3SRE A;  1DIM A;  4CH9 A;  3VNG A;  1N6F A;  2QWJ A;  2WOZ A;  1ZI0 A;  4FPH A;  2SIL A;  2A75 A;  1OFZ A;  4CPY A;  2OJH A;  4XHX A;  4FQ4 A;  2QWC A;  5M1Z A;  4D52 A;  3K3A A;  1NMB N;  1EUU A;  4X4A A;  2F25 A;  2W5N A;  2XCY A;  3INB A;  4YW2 A;  4ASC A;  4QN5 A;  2W5O A;  1Z4Z A;  1INY A;  2SLI A;  3ADE A;  2F26 A;  5D9B A;  1MS4 A;  5GX3 A;  4MZE A;  4MZA A;  4FOQ A;  4FPO B;  1F8D A;  4M4U A;  2VSM A;  1ZGK A;  1F8B A;  3TI6 A;  4CPN A;  2AEQ A;  1Z4X A;  1NNC A;  2F13 A;  4MWX A;  4YY8 A;  4XJW A;  4QN6 A;  3TIC A;  4FPK A;  2RKC A;  2BF6 A;  3PJQ A;  2XZI A;  3O9J A;  1C5K A;  1N1V A;  2W8B B;  4BBW A;  3WWA A;  4ZLR A;  4Q1U A;  4JML A;  4XHB A;  2GHS A;  4FOW A;  1MWE A;  4L7B A;  5FZN A;  1V3D A;  2ZB6 A;  4K3Y A;  4Q6K A;  3SAL A;  1E8U A;  2QWH A;  2ZB5 A;  3SOV A;  4QN3 A;  4M3M A;  4QN4 A;  2GVW A;  1V3E A;  1POO A;  3KGG A;  5HUM A;  4GZO A;  1Z4V A;  2XZJ A;  4MJV A; 
#chains in the Genus database with same CATH homology
 5FNU A;  4ASC A;  5CGJ A;  4L7D A;  1X2R A;  4L7C A;  2VPJ A;  5F72 C;  5FNT A;  5FNR A;  3VNH A;  2DYH A;  4XMB A;  4CH9 A;  3ADE A;  2ZWA A;  2ZZK A;  3VNG A;  4ZGC A;  2Z32 A;  4N1B A;  3ZGD A;  4IN4 A;  3WDZ A;  3WN7 A;  5FNQ A;  2FLU X;  2WOZ A;  4ZY3 A;  4L7B A;  4IFN X;  4CHB A;  1ZGK A;  5FZN A;  1X2J A;  5FNS A;  2ZW9 A;  4IFJ A;  4IQK A;  1U6D X;  5FZJ A;  4YY8 A;  3II7 A;  3ZGC A;  4IFL X;  2XN4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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