5CGJA

Crystal structure of murine keap1 in complex with ra839, a non-covalent small-molecule binder to keap1 and selective activator of nrf2 signalling.
Total Genus 61
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
61
sequence length
290
structure length
290
Chain Sequence
VGRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPC
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Protein binding
molecule keywords Kelch-like ECH-associated protein 1
publication title Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling.
pubmed doi rcsb
source organism Mus musculus
total genus 61
structure length 290
sequence length 290
ec nomenclature
pdb deposition date 2015-07-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 5cgjA00
2Z32A 5FZNA 2FLUX 4L7DA 2ZWAA 5FNQA 5FZJA 4IFNX 4IN4A 3WN7A 1X2JA 4ZGCA 4ZY3A 2DYHA 3VNGA 4IQKA 4XMBA 3ZGCA 4L7BA 4ASCA 1X2RA 3II7A 5FNUA 4YY8A 4N1BA 2XN4A 5FNSA 3VNHA 4IFJA 3ZGDA 4L7CA 2VPJA 2WOZA 5CGJA 1U6DX 4IFLX 2ZW9A 3WDZA 4CHBA 2ZZKA 5FNTA 5F72C 5FNRA 3ADEA 4CH9A 1ZGKA
chains in the Genus database with same CATH superfamily
4CSDA 3V1SA 2VW2A 4K1HA 5GX3A 1H6LA 4MC7A 1MWEA 3VNGA 5D9CA 1F8EA 4PWZA 2YA6A 4M4NA 1X2RA 4FVKA 1IVGA 4B7JA 2DG1A 5FNSA 1RWLA 4JF7A 4M4UA 5CGJA 4GNCA 4O5TA 4FP3A 2OJHA 4FPGA 3O9JA 3SLIA 1NMCA 2GVUA 1BJIA 3G4HA 4FPCA 2QWHA 1L7GA 3ALWA 4D52A 2HTWA 4MWLA 4FP2A 2F11A 1DIMA 4ASCA 1CRUA 3GVLA 2IATA 2SILA 3WW9A 4D4UA 4QN6A 5D9DA 4CPLA 4GZOA 4GEZA 5GX5A 4B7RA 3SRGA 1N6DA 1Z4WA 1L7HA 2F24A 5FNTA 3ADEA 2AEQA 2SLIA 1F8CA 4FOVA 3TI6A 1INYA 3CL0A 2ZWAA 5FZJA 2IAQA 1SUUA 3FVZA 2BATA 4AGTA 3S8ZA 4XE9A 2HTYA 2HTVA 5B2CA 4XOGA 1A4GA 1W8OA 2FP8A 4IYGA 4MZEA 4CPNA 2XZJA 2F26A 3GVKA 3AMSA 3SANA 1QBIA 1E8TA 4HW6A 3H72A 1DILA 1PJXA 3S8VA 5M1ZA 4YW3A 2XCYA 4NCSA 5FZNA 2FP9A 2F25A 4X4AA 4KS1A 4XJUA 4FPJA 1IVBA 1Z4ZA 4J9TA 1KITA 2CMLA 1Q7FA 1EUTA 1SNTA 3CYEA 4WA5A 7NN9A 4G3NA 1W20A 3K36A 4N1BA 2IAPA 2QE8A 4FOYA 4FZHA 2W5OA 4GZQA 4MWXA 2QWCA 4MJVA 3JU4A 1CVMA 4QN4A 2WOZA 3DR2A 3IAXA 4H52A 2X9MA 2ZW9A 4HHOA 4DG6A 1N1TA 2QWDA 4X47A 4H53A 2GVXA 2VAQA 1MS5A 3TIAA 3SOBB 1EUSA 1USRA 1V3CA 1NPEA 2XZIA 3V64C 1VCJA 3K38A 4MWJA 4KS5A 4B7QA 2H2UA 2IASA 1NCDN 1N1SA 4K3YA 2ISMA 3FW0A 4WA4A 5GX2A 4IFJA 4QNPA 3ALXA 4KS2A 2FPCA 1N6FA 4BBWA 3K3AA 2W8BA 4CHBA 5F9TA 2HU0A 3A71A 4GDJA 2GVVA 3O9KA 1W1XA 2QWJA 4XHXA 1A14N 4B7MA 2ZB5A 1WP5A 2HTQA 1NSBA 3S2KA 4ZY3A 1C9UA 2YDPA 1SLLA 4NN9A 4XIKA 1V3DA 2IAOA 4HZZA 2FHRA 4ZLRA 2QWIA 1RWIA 2F28A 2HU4A 1NNCA 2ZZKA 3Q6PA 2GHSA 5F72C 5GX4A 2W20A 1INGA 2FLUX 1INVA 4L7DA 4FPOB 2F0ZA 1NNAA 4M3MA 3W09A 2DG0A 1NCBN 1VCUA 1X2JA 4IQKA 2XZKA 1S0JA 3ZGCA 4YY8A 4GJTA 2XN4A 1S1DA 3OPZA 4CPMA 1SO7A 1Z4VA 4MWWA 5FWWA 2G8SA 1MS9A 1NCAN 4YZ4A 1USXA 2AH2A 2A75A 4X6KA 3D11A 2HT8A 3CKZA 4UOUA 4MWVA 4YZ3A 4YW4A 2IAVA 2QWBA 4MWRA 2HT7A 3H73A 3KYAA 4GZSA 2JKBA 4XMBA 4C1YA 4Q1UA 4YW5A 1IVCA 1B9SA 2VWDA 3TI5A 2VK7A 1F8BA 4QN3A 2BERA 1B9VA 1INWA 5EX7A 4YZ5A 4GZTA 4IFLX 2IAXA 2QWGA 4XJZA 4KS3A 2QWAA 4XILA 3D12A 2F27A 3GVJA 1E8UA 4GN9A 4A0PA 4WEGA 2VK6A 1V3EA 4FPKA 1K32A 4NC5A 3HLHA 2B8HA 2GVWA 1N6EA 1V0FA 6NN9A 4GNBA 4CPZA 1V0EA 1CQ1A 2ZB6A 5H47A 3G4EA 3TI4A 2W5NA 2F12A 4XIOA 4GNAA 1W21A 4XJ9A 1V2IA 1U6DX 5NN9A 2BZDA 3L6VA 4WEFA 1F8DA 4CH9A 4K1IA 1V04A 2Z32A 2POOA 2YA5A 3A72A 4IN4A 4QN7A 4GN7A 3NO0A 3P5BL 3SALA 2HT5A 4HHQA 1IVDA 3LI3A 3A9HA 2F10A 3II7A 4FPYA 1INFA 4R40A 4HZYA 4MZAA 1EURA 1NSCA 1N7DA 4XMAA 1S0IA 3PJQA 2HTUA 3WWAA 1W8NA 2C4AA 2V91A 4XJQA 4FQ4A 2SIMA 3HLIA 1W0OA 2FPBA 2YA7A 3Q6TA 1MZ6A 4YW2A 4X49A 1MR5A 1ZGKA 4AH4A 3UC1A 4D52B 2VW0A 2IAUA 5FNUA 2BF6A 1B9TA 4XJWA 2HTRA 4O5SA 4KS4A 5EO7A 4D52C 4Q6KA 1CRZA 4SLIA 1XOEA 4FOQA 4CPYA 4D8SA 3LI4A 1Z4XA 4FPEA 4CPOA 2VW1A 1IUBA 5D9BA 4XHBA 1INXA 2IAWA 4HIZA 4GZPA 3KGGA 5HUMA 1Z4YA 4C1YB 1IUCA 1IVFA 2RKCA 3TI8A 3BYCA 1V0ZA 5EO8A 1Z50A 4HZVA 3SILA 3SOVA 4FPFA 1OFZA 4XJAA 1L7FA 4FJ6A 5FNRA 3TC9A 3U0SA 4GDIA 2QWEA 4IFNX 4M4VA 4FOWA 2QWFA 4ZGCA 3B69A 4YZ2A 1NMAN 1SLIA 4MWUA 3HRPA 1EUUA 4L7BA 4HZXA 3DASA 4XJ8A 2YA4A 1MS0A 3VNHA 1MS8A 1WCSA 4WA3A 4XYXA 4GN8A 1IVEA 1INHA 2F29A 4IMBA 3WDZA 4K1JA 4XJRA 4YW1A 4MWQA 4GB1A 1POOA 2HQSA 3A9GA 5JYYA 2P4OA 3TI3A 1NNBA 3B7EA 1N1YA 4UF7A 4MX0A 2QWKA 3TIBA 3WN7A 2VK5A 3AMRA 3H6JA 3CL2A 4FPHA 3Q6KA 2VSMA 5HUKA 4AHAA 1A4QA 1E1AA 1MS3A 2IARA 5HUNA 3V65B 2AGSA 3SOQA 5GTQA 2YA8A 1V3BA 1NCCN 2VSKA 2W8BB 4YZ1A 3K37A 5HUGA 2C4LA 4AGIA 1MS1A 3LI5A 3NSSA 2DYHA 4DGRA 3INBA 1S18A 4MJUA 2H2NA 1E8VA 1QLGA 4QN5A 5B2DA 1XOGA 2VPJA 2AEPA 1N1VA 3SREA 3H71A 1IJQA 1NMBN 1NSDA 4GZWA 2VVZA 4HZWA 4MWYA 1NN2A 1MS4A 3S94A 2DSOA 4FPLA 3I1CA 5FNQA 4GZXA 1MZ5A 1C5KA 2F13A 4XMIA 3K39A 3BEQA 3T1EA 3NN9A 2W38A 2IVZA 5HX0A 5GX1A 4K1KA 4I00A 4B7NA 1W0PA 3ZGDA 4L7CA 3O4PA 3TICA 4JMLA 3E5ZA 1WCQA 1ZI0A 2YDTA
chains in the Genus database with same CATH topology
2Z32A 5FZNA 2FLUX 4L7DA 2ZWAA 5FNQA 5FZJA 4IFNX 4IN4A 3WN7A 1X2JA 4ZGCA 4ZY3A 2DYHA 3VNGA 4IQKA 4XMBA 3ZGCA 4L7BA 4ASCA 1X2RA 3II7A 5FNUA 4YY8A 4N1BA 2XN4A 5FNSA 3VNHA 4IFJA 3ZGDA 4L7CA 2VPJA 2WOZA 5CGJA 1U6DX 4IFLX 2ZW9A 3WDZA 4CHBA 2ZZKA 5FNTA 5F72C 5FNRA 3ADEA 4CH9A 1ZGKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2Z32 A;  5FZN A;  2FLU X;  4L7D A;  2ZWA A;  5FNQ A;  5FZJ A;  4IFN X;  4IN4 A;  3WN7 A;  1X2J A;  4ZGC A;  4ZY3 A;  2DYH A;  3VNG A;  4IQK A;  4XMB A;  3ZGC A;  4L7B A;  4ASC A;  1X2R A;  3II7 A;  5FNU A;  4YY8 A;  4N1B A;  2XN4 A;  5FNS A;  3VNH A;  4IFJ A;  3ZGD A;  4L7C A;  2VPJ A;  2WOZ A;  5CGJ A;  1U6D X;  4IFL X;  2ZW9 A;  3WDZ A;  4CHB A;  2ZZK A;  5FNT A;  5F72 C;  5FNR A;  3ADE A;  4CH9 A;  1ZGK A; 
#chains in the Genus database with same CATH topology
 4CSD A;  3V1S A;  2VW2 A;  4K1H A;  5GX3 A;  1H6L A;  4MC7 A;  1MWE A;  3VNG A;  5D9C A;  1F8E A;  4PWZ A;  2YA6 A;  4M4N A;  1X2R A;  4FVK A;  1IVG A;  4B7J A;  2DG1 A;  5FNS A;  1RWL A;  4JF7 A;  4M4U A;  5CGJ A;  4GNC A;  4O5T A;  4FP3 A;  2OJH A;  4FPG A;  3O9J A;  3SLI A;  1NMC A;  2GVU A;  1BJI A;  3G4H A;  4FPC A;  2QWH A;  1L7G A;  3ALW A;  4D52 A;  2HTW A;  4MWL A;  4FP2 A;  2F11 A;  1DIM A;  4ASC A;  1CRU A;  3GVL A;  2IAT A;  2SIL A;  3WW9 A;  4D4U A;  4QN6 A;  5D9D A;  4CPL A;  4GZO A;  4GEZ A;  5GX5 A;  4B7R A;  3SRG A;  1N6D A;  1Z4W A;  1L7H A;  2F24 A;  5FNT A;  3ADE A;  2AEQ A;  2SLI A;  1F8C A;  4FOV A;  3TI6 A;  1INY A;  3CL0 A;  2ZWA A;  5FZJ A;  2IAQ A;  1SUU A;  3FVZ A;  2BAT A;  4AGT A;  3S8Z A;  4XE9 A;  2HTY A;  2HTV A;  5B2C A;  4XOG A;  1A4G A;  1W8O A;  2FP8 A;  4IYG A;  4MZE A;  4CPN A;  2XZJ A;  2F26 A;  3GVK A;  3AMS A;  3SAN A;  1QBI A;  1E8T A;  4HW6 A;  3H72 A;  1DIL A;  1PJX A;  3S8V A;  5M1Z A;  4YW3 A;  2XCY A;  4NCS A;  5FZN A;  2FP9 A;  2F25 A;  4X4A A;  4KS1 A;  4XJU A;  4FPJ A;  1IVB A;  1Z4Z A;  4J9T A;  1KIT A;  2CML A;  1Q7F A;  1EUT A;  1SNT A;  3CYE A;  4WA5 A;  7NN9 A;  4G3N A;  1W20 A;  3K36 A;  4N1B A;  2IAP A;  2QE8 A;  4FOY A;  4FZH A;  2W5O A;  4GZQ A;  4MWX A;  2QWC A;  4MJV A;  3JU4 A;  1CVM A;  4QN4 A;  2WOZ A;  3DR2 A;  3IAX A;  4H52 A;  2X9M A;  2ZW9 A;  4HHO A;  4DG6 A;  1N1T A;  2QWD A;  4X47 A;  4H53 A;  2GVX A;  2VAQ A;  1MS5 A;  3TIA A;  3SOB B;  1EUS A;  1USR A;  1V3C A;  1NPE A;  2XZI A;  3V64 C;  1VCJ A;  3K38 A;  4MWJ A;  4KS5 A;  4B7Q A;  2H2U A;  2IAS A;  1NCD N;  1N1S A;  4K3Y A;  2ISM A;  3FW0 A;  4WA4 A;  5GX2 A;  4IFJ A;  4QNP A;  3ALX A;  4KS2 A;  2FPC A;  1N6F A;  4BBW A;  3K3A A;  2W8B A;  4CHB A;  5F9T A;  2HU0 A;  3A71 A;  4GDJ A;  2GVV A;  3O9K A;  1W1X A;  2QWJ A;  4XHX A;  1A14 N;  4B7M A;  2ZB5 A;  1WP5 A;  2HTQ A;  1NSB A;  3S2K A;  4ZY3 A;  1C9U A;  2YDP A;  1SLL A;  4NN9 A;  4XIK A;  1V3D A;  2IAO A;  4HZZ A;  2FHR A;  4ZLR A;  2QWI A;  1RWI A;  2F28 A;  2HU4 A;  1NNC A;  2ZZK A;  3Q6P A;  2GHS A;  5F72 C;  5GX4 A;  2W20 A;  1ING A;  2FLU X;  1INV A;  4L7D A;  4FPO B;  2F0Z A;  1NNA A;  4M3M A;  3W09 A;  2DG0 A;  1NCB N;  1VCU A;  1X2J A;  4IQK A;  2XZK A;  1S0J A;  3ZGC A;  4YY8 A;  4GJT A;  2XN4 A;  1S1D A;  3OPZ A;  4CPM A;  1SO7 A;  1Z4V A;  4MWW A;  5FWW A;  2G8S A;  1MS9 A;  1NCA N;  4YZ4 A;  1USX A;  2AH2 A;  2A75 A;  4X6K A;  3D11 A;  2HT8 A;  3CKZ A;  4UOU A;  4MWV A;  4YZ3 A;  4YW4 A;  2IAV A;  2QWB A;  4MWR A;  2HT7 A;  3H73 A;  3KYA A;  4GZS A;  2JKB A;  4XMB A;  4C1Y A;  4Q1U A;  4YW5 A;  1IVC A;  1B9S A;  2VWD A;  3TI5 A;  2VK7 A;  1F8B A;  4QN3 A;  2BER A;  1B9V A;  1INW A;  5EX7 A;  4YZ5 A;  4GZT A;  4IFL X;  2IAX A;  2QWG A;  4XJZ A;  4KS3 A;  2QWA A;  4XIL A;  3D12 A;  2F27 A;  3GVJ A;  1E8U A;  4GN9 A;  4A0P A;  4WEG A;  2VK6 A;  1V3E A;  4FPK A;  1K32 A;  4NC5 A;  3HLH A;  2B8H A;  2GVW A;  1N6E A;  1V0F A;  6NN9 A;  4GNB A;  4CPZ A;  1V0E A;  1CQ1 A;  2ZB6 A;  5H47 A;  3G4E A;  3TI4 A;  2W5N A;  2F12 A;  4XIO A;  4GNA A;  1W21 A;  4XJ9 A;  1V2I A;  1U6D X;  5NN9 A;  2BZD A;  3L6V A;  4WEF A;  1F8D A;  4CH9 A;  4K1I A;  1V04 A;  2Z32 A;  2POO A;  2YA5 A;  3A72 A;  4IN4 A;  4QN7 A;  4GN7 A;  3NO0 A;  3P5B L;  3SAL A;  2HT5 A;  4HHQ A;  1IVD A;  3LI3 A;  3A9H A;  2F10 A;  3II7 A;  4FPY A;  1INF A;  4R40 A;  4HZY A;  4MZA A;  1EUR A;  1NSC A;  1N7D A;  4XMA A;  1S0I A;  3PJQ A;  2HTU A;  3WWA A;  1W8N A;  2C4A A;  2V91 A;  4XJQ A;  4FQ4 A;  2SIM A;  3HLI A;  1W0O A;  2FPB A;  2YA7 A;  3Q6T A;  1MZ6 A;  4YW2 A;  4X49 A;  1MR5 A;  1ZGK A;  4AH4 A;  3UC1 A;  4D52 B;  2VW0 A;  2IAU A;  5FNU A;  2BF6 A;  1B9T A;  4XJW A;  2HTR A;  4O5S A;  4KS4 A;  5EO7 A;  4D52 C;  4Q6K A;  1CRZ A;  4SLI A;  1XOE A;  4FOQ A;  4CPY A;  4D8S A;  3LI4 A;  1Z4X A;  4FPE A;  4CPO A;  2VW1 A;  1IUB A;  5D9B A;  4XHB A;  1INX A;  2IAW A;  4HIZ A;  4GZP A;  3KGG A;  5HUM A;  1Z4Y A;  4C1Y B;  1IUC A;  1IVF A;  2RKC A;  3TI8 A;  3BYC A;  1V0Z A;  5EO8 A;  1Z50 A;  4HZV A;  3SIL A;  3SOV A;  4FPF A;  1OFZ A;  4XJA A;  1L7F A;  4FJ6 A;  5FNR A;  3TC9 A;  3U0S A;  4GDI A;  2QWE A;  4IFN X;  4M4V A;  4FOW A;  2QWF A;  4ZGC A;  3B69 A;  4YZ2 A;  1NMA N;  1SLI A;  4MWU A;  3HRP A;  1EUU A;  4L7B A;  4HZX A;  3DAS A;  4XJ8 A;  2YA4 A;  1MS0 A;  3VNH A;  1MS8 A;  1WCS A;  4WA3 A;  4XYX A;  4GN8 A;  1IVE A;  1INH A;  2F29 A;  4IMB A;  3WDZ A;  4K1J A;  4XJR A;  4YW1 A;  4MWQ A;  4GB1 A;  1POO A;  2HQS A;  3A9G A;  5JYY A;  2P4O A;  3TI3 A;  1NNB A;  3B7E A;  1N1Y A;  4UF7 A;  4MX0 A;  2QWK A;  3TIB A;  3WN7 A;  2VK5 A;  3AMR A;  3H6J A;  3CL2 A;  4FPH A;  3Q6K A;  2VSM A;  5HUK A;  4AHA A;  1A4Q A;  1E1A A;  1MS3 A;  2IAR A;  5HUN A;  3V65 B;  2AGS A;  3SOQ A;  5GTQ A;  2YA8 A;  1V3B A;  1NCC N;  2VSK A;  2W8B B;  4YZ1 A;  3K37 A;  5HUG A;  2C4L A;  4AGI A;  1MS1 A;  3LI5 A;  3NSS A;  2DYH A;  4DGR A;  3INB A;  1S18 A;  4MJU A;  2H2N A;  1E8V A;  1QLG A;  4QN5 A;  5B2D A;  1XOG A;  2VPJ A;  2AEP A;  1N1V A;  3SRE A;  3H71 A;  1IJQ A;  1NMB N;  1NSD A;  4GZW A;  2VVZ A;  4HZW A;  4MWY A;  1NN2 A;  1MS4 A;  3S94 A;  2DSO A;  4FPL A;  3I1C A;  5FNQ A;  4GZX A;  1MZ5 A;  1C5K A;  2F13 A;  4XMI A;  3K39 A;  3BEQ A;  3T1E A;  3NN9 A;  2W38 A;  2IVZ A;  5HX0 A;  5GX1 A;  4K1K A;  4I00 A;  4B7N A;  1W0P A;  3ZGD A;  4L7C A;  3O4P A;  3TIC A;  4JML A;  3E5Z A;  1WCQ A;  1ZI0 A;  2YDT A; 
#chains in the Genus database with same CATH homology
 2Z32 A;  5FZN A;  2FLU X;  4L7D A;  2ZWA A;  5FNQ A;  5FZJ A;  4IFN X;  4IN4 A;  3WN7 A;  1X2J A;  4ZGC A;  4ZY3 A;  2DYH A;  3VNG A;  4IQK A;  4XMB A;  3ZGC A;  4L7B A;  4ASC A;  1X2R A;  3II7 A;  5FNU A;  4YY8 A;  4N1B A;  2XN4 A;  5FNS A;  3VNH A;  4IFJ A;  3ZGD A;  4L7C A;  2VPJ A;  2WOZ A;  5CGJ A;  1U6D X;  4IFL X;  2ZW9 A;  3WDZ A;  4CHB A;  2ZZK A;  5FNT A;  5F72 C;  5FNR A;  3ADE A;  4CH9 A;  1ZGK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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