4AW6 | Genus

Total Genus 166

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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	166
sequence length	471
structure length	427
Chain Sequence	GMWASLDALWEMPAEKRIFGAVLLFSWTVYLWETFLAQRQRRIYKTTTHVPPELGQIMDSETFEKSRLYQLDKSTFSFWSGLYSETEGTLILLFGGIPYLWRLSGRPEYEITQSLVFLLLATLFSALAGLPWSLYNTFVIEEKHGFNQQTLGFFMKDAIKKFVVTQCILLPVSSLLLYIIKIGGDYFFIYAWLFTLVVSLVLVTIYADYIAPLFDKFTPLPEGKLKEEIEVMAKSIDFPLTKVYVVEGSKRSSHSNAYFYGFFKNKRIVLFDTLLEQGCKNEEVLAVLGHELGHWKLGHTVKNIIISQMNSFLCFFLFAVLIGRKELFAAFGFYDSQPTLIGLLIIFQFIFSPYNEVLSFCLTVLSRRFEFQADAFAKKLGKAKDLYSALIKLNKDNLGFPVSDWLFSMWHYSHPPLLERLQALKTM

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Hydrolase
source organism	Homo sapiens
publication title	The Structural Basis of Zmpste24-Dependent Laminopathies. pubmed doi rcsb
molecule keywords	CAAX PRENYL PROTEASE 1 HOMOLOG
total genus	166
structure length	427
sequence length	471
chains with identical sequence	B, D, E
ec nomenclature	ec 3.4.24.84: Ste24 endopeptidase.
pdb deposition date	2012-05-31

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF01435	Peptidase_M48	Peptidase family M48
A	PF16491	Peptidase_M48_N	CAAX prenyl protease N-terminal, five membrane helices

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.30.2010.10	Alpha Beta	2-Layer Sandwich	Zincin-like	Metalloproteases ("zincins"), catalytic domain	4aw6A02

3CQBA 4JIUA 4AW6A 2YPTA 4IL3A 4JIXA 4QHFA
chains in the Genus database with same CATH superfamily

3CQBA 3NF3A 5BQMA 5BQNA 3DEBA 1S0BA 3E11A 4JIXA 2G7KA 3C89A 1ZKXA 2G7NA 2XHLA 3BONA 1G9BA 3V0BB 1ZB7A 4J1LA 2ETFA 4EL4A 3BOKA 2IMCA 2IMAA 4KS6A 4IL3A 2ISHA 2ILPA 2W2DA 1S0DA 4EJ5A 3ZUSA 1YVGA 4ZKTB 1ZL6A 3C88A 3QW8A 3QIXA 1Z7HA 1XTFA 3V0BA 2NP0A 1XTGA 3K3QB 3C8BA 3DSEA 4ZJXA 1F82A 3QJ0A 4JIUA 3BOOA 3DS9A 3QIZA 2G7PA 3QW6A 1I1EA 1EPWA 1G9AA 2QN0A 3FFZA 2EJQA 1ZKWA 1E1HA 1S0GA 3QW7A 3QIYA 1S0CA 1ZL5A 2ISEA 4KUFA 4HEVA 2A8AA 3FIIA 3BWIA 2G7QA 3V0AB 3C8AA 1T3AA 3ZUQA 2A97A 2NYYA 4AW6A 2YPTA 3BTAA 1G9DA 3DDAA 3ZURA 1T3CA 3D3XA 1F31A 2IMBA 3FIEA 3DDBA 2ISGA 1ZN3A 3V0AA 4ELCA 1S0EA 2NZ9A 1G9CA 2FPQA 1S0FA 3QW5A 4KTXA 4QHFA 3VUOA
chains in the Genus database with same CATH topology

1OZ9A 1TVIA 1XAXA 3CQBA 4JIUA 1XM5A 4AW6A 2YPTA 4IL3A 4JIXA 4QHFA
chains in the Genus database with same CATH homology

#chains in the Genus database with same CATH superfamily
 3CQB A;  4JIU A;  4AW6 A;  2YPT A;  4IL3 A;  4JIX A;  4QHF A; 
#chains in the Genus database with same CATH topology
 3CQB A;  3NF3 A;  5BQM A;  5BQN A;  3DEB A;  1S0B A;  3E11 A;  4JIX A;  2G7K A;  3C89 A;  1ZKX A;  2G7N A;  2XHL A;  3BON A;  1G9B A;  3V0B B;  1ZB7 A;  4J1L A;  2ETF A;  4EL4 A;  3BOK A;  2IMC A;  2IMA A;  4KS6 A;  4IL3 A;  2ISH A;  2ILP A;  2W2D A;  1S0D A;  4EJ5 A;  3ZUS A;  1YVG A;  4ZKT B;  1ZL6 A;  3C88 A;  3QW8 A;  3QIX A;  1Z7H A;  1XTF A;  3V0B A;  2NP0 A;  1XTG A;  3K3Q B;  3C8B A;  3DSE A;  4ZJX A;  1F82 A;  3QJ0 A;  4JIU A;  3BOO A;  3DS9 A;  3QIZ A;  2G7P A;  3QW6 A;  1I1E A;  1EPW A;  1G9A A;  2QN0 A;  3FFZ A;  2EJQ A;  1ZKW A;  1E1H A;  1S0G A;  3QW7 A;  3QIY A;  1S0C A;  1ZL5 A;  2ISE A;  4KUF A;  4HEV A;  2A8A A;  3FII A;  3BWI A;  2G7Q A;  3V0A B;  3C8A A;  1T3A A;  3ZUQ A;  2A97 A;  2NYY A;  4AW6 A;  2YPT A;  3BTA A;  1G9D A;  3DDA A;  3ZUR A;  1T3C A;  3D3X A;  1F31 A;  2IMB A;  3FIE A;  3DDB A;  2ISG A;  1ZN3 A;  3V0A A;  4ELC A;  1S0E A;  2NZ9 A;  1G9C A;  2FPQ A;  1S0F A;  3QW5 A;  4KTX A;  4QHF A;  3VUO A; 
#chains in the Genus database with same CATH homology
 1OZ9 A;  1TVI A;  1XAX A;  3CQB A;  4JIU A;  1XM5 A;  4AW6 A;  2YPT A;  4IL3 A;  4JIX A;  4QHF A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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4AW6A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations