1DVMA

Active form of human pai-1
Total Genus 113
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
113
sequence length
376
structure length
375
Chain Sequence
PPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISHLLGTGAVQQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVALALQKVKIEVNESGTVASSSAVIVSARMAPEEIIIDRPFLFVVRHNPTGTVLFMGQVMEP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of active and latent PAI-1: a possible stabilizing role for chloride ions.
pubmed doi rcsb
molecule keywords PLASMINOGEN ACTIVATOR INHIBITOR-1
molecule tags Blood clotting
source organism Homo sapiens
total genus 113
structure length 375
sequence length 376
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2000-01-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 1dvmA02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 1dvmA01
1DVMA 2VDYA 1R1LI 1ATHA 1DZHL 1KCTA 3LE2A 1YXAA 4AU2A 1LQ8A 4EB1L 2H4RA 1ANTI 4AU4A 4ZK0A 1UHGA 4ROBA 1OC0A 4RO9A 4YIAA 5CDXA 4CAAA 1HP7A 4X30A 3DRMA 1DVNA 3DLWA 1JMJA 3F1SA 5BRRI 1SNGA 2ACHA 2B4XI 2WXZA 1AS4A 5CDZA 4AU3B 2WXYC 4G8OA 1DZGI 3NDAA 3Q03A 3R4LA 8APIA 1C8OA 1SEKA 2XN3A 4C49A 1JTIA 4AFXA 2WXZC 1A7CA 4AU3A 2HIJI 4C41A 2XN5A 1ATTA 2BEHL 1E03I 4Y3KA 2VH4A 1OVAB 1DZHI 1AZXI 1OO8A 1B3KA 2B5TI 3OZQA 1OYHI 1XQGA 2WY0C 2GD4C 2R9YA 4EB1I 3NE4A 2ZNHA 2HI9A 3NDDA 3EVJI 1SR5A 1OVAA 4DY7C 7APIA 4ZK3A 2WY1A 3EOXA 3FGQA 3CWLA 4P0FA 1HLEA 1BR8I 1OPHA 1WZ9A 2ARQA 3VVJA 4AJUA 1OVAC 2DUTA 2QUGA 1XU8A 1DB2A 2ARRA 2D26A 5IO1A 2OL2A 4AQHA 1IMVA 1TB6I 4AJTA 2BEHI 4P0OA 3B9FI 2PEEA 4DTEA 2WXWA 2XN6A 2H4PA 4GA7A 3H5CA 2H4QA 2RIWA 1JVQI 1XQJA 3KCGI 4KDSA 1NQ9I 1QLPA 1JMOA 2RIVA 1LK6I 5C98A 1QMBA 1IZ2A 4R9IA 3NDFA 1DZGL 4IF8A 3ZHAA 3PZFA 2OAYA 1E05I 2PEFA 3CAAA 3LW2A 3F02A 2HIJL 2XN7A 1D5SA 5HGCA 1MTPA 4PYWA 2V95A 3Q02A 3PB1I 2WXXA 1K9OI 1JJOC 1M93B 1LJ5A 1OYHL 1E04I 1EZXA 4Y40A 2ANTI 1ATUA 1JRRA 9PAIA 3T1PA 3CVMA 3CWMA 4G8RA 3DRUA 4BB2A 1PSIA 4RSQA 2B4XL 3DY0A 3UT3A 1BY7A 9APIA 5EI0A 4ROAA 1C5GA 2CEOA 2VDXA 1F0CA 5INWA 1QMNA 2ZV6A 5CE0A 4IC0A 3F5NA 1T1FA 4DY0A 3STOA
chains in the Genus database with same CATH superfamily
1DVMA 2VDYA 1R1LI 1ATHA 1DZHL 1KCTA 3LE2A 1YXAA 4AU2A 1LQ8A 4EB1L 2H4RA 1ANTI 4AU4A 4ZK0A 1UHGA 4ROBA 1OC0A 4RO9A 4YIAA 5CDXA 4CAAA 1HP7A 4X30A 3DRMA 1DVNA 3DLWA 1JMJA 3F1SA 5BRRI 1SNGA 2ACHA 2B4XI 2WXZA 1AS4A 5CDZA 4AU3B 2WXYC 4G8OA 1DZGI 3NDAA 3Q03A 3R4LA 8APIA 1C8OA 1SEKA 2XN3A 4C49A 1JTIA 4AFXA 2WXZC 1A7CA 4AU3A 2HIJI 4C41A 2XN5A 1ATTA 2BEHL 1E03I 4Y3KA 2VH4A 1OVAB 1DZHI 1AZXI 1OO8A 1B3KA 2B5TI 3OZQA 1OYHI 1XQGA 2WY0C 2GD4C 2R9YA 4EB1I 3NE4A 2ZNHA 2HI9A 3NDDA 3EVJI 1SR5A 1OVAA 4DY7C 7APIA 4ZK3A 2WY1A 3EOXA 3FGQA 3CWLA 4P0FA 1HLEA 1BR8I 1OPHA 1WZ9A 2ARQA 3VVJA 4AJUA 1OVAC 2DUTA 2QUGA 1XU8A 1DB2A 2ARRA 2D26A 5IO1A 2OL2A 4AQHA 1IMVA 1TB6I 4AJTA 2BEHI 4P0OA 3B9FI 2PEEA 4DTEA 2WXWA 2XN6A 2H4PA 4GA7A 3H5CA 2H4QA 2RIWA 1JVQI 1XQJA 3KCGI 4KDSA 1NQ9I 1QLPA 1JMOA 2RIVA 1LK6I 5C98A 1QMBA 1IZ2A 4R9IA 3NDFA 1DZGL 4IF8A 3ZHAA 3PZFA 2OAYA 1E05I 2PEFA 3CAAA 3LW2A 3F02A 2HIJL 2XN7A 1D5SA 5HGCA 1MTPA 4PYWA 2V95A 3Q02A 3PB1I 2WXXA 1K9OI 1JJOC 1M93B 1LJ5A 1OYHL 1E04I 1EZXA 4Y40A 2ANTI 1ATUA 1JRRA 9PAIA 3T1PA 3CVMA 3CWMA 4G8RA 3DRUA 4BB2A 1PSIA 4RSQA 2B4XL 3DY0A 3UT3A 1BY7A 9APIA 5EI0A 4ROAA 1C5GA 2CEOA 2VDXA 1F0CA 5INWA 1QMNA 2ZV6A 5CE0A 4IC0A 3F5NA 1T1FA 4DY0A 3STOA
chains in the Genus database with same CATH topology
1DVMA 2VDYA 1R1LI 1ATHA 1DZHL 1KCTA 3LE2A 1YXAA 4AU2A 1LQ8A 4EB1L 2H4RA 1ANTI 4AU4A 4ZK0A 1UHGA 4ROBA 1OC0A 4RO9A 4YIAA 5CDXA 4CAAA 1HP7A 4X30A 3DRMA 1DVNA 3DLWA 1JMJA 3F1SA 5BRRI 1SNGA 2ACHA 2B4XI 2WXZA 1AS4A 5CDZA 4AU3B 2WXYC 4G8OA 1DZGI 3NDAA 3Q03A 3R4LA 8APIA 1C8OA 1SEKA 2XN3A 4C49A 1JTIA 4AFXA 2WXZC 1A7CA 4AU3A 2HIJI 4C41A 2XN5A 1ATTA 2BEHL 1E03I 4Y3KA 2VH4A 1OVAB 1DZHI 1AZXI 1OO8A 1B3KA 2B5TI 3OZQA 1OYHI 1XQGA 2WY0C 2GD4C 2R9YA 4EB1I 3NE4A 2ZNHA 2HI9A 3NDDA 3EVJI 1SR5A 1OVAA 4DY7C 7APIA 4ZK3A 2WY1A 3EOXA 3FGQA 3CWLA 4P0FA 1HLEA 1BR8I 1OPHA 1WZ9A 2ARQA 3VVJA 4AJUA 1OVAC 2DUTA 2QUGA 1XU8A 1DB2A 2ARRA 2D26A 5IO1A 2OL2A 4AQHA 1IMVA 1TB6I 4AJTA 2BEHI 4P0OA 3B9FI 2PEEA 4DTEA 2WXWA 2XN6A 2H4PA 4GA7A 3H5CA 2H4QA 2RIWA 1JVQI 1XQJA 3KCGI 4KDSA 1NQ9I 1QLPA 1JMOA 2RIVA 1LK6I 5C98A 1QMBA 1IZ2A 4R9IA 3NDFA 1DZGL 4IF8A 3ZHAA 3PZFA 2OAYA 1E05I 2PEFA 3CAAA 3LW2A 3F02A 2HIJL 2XN7A 1D5SA 5HGCA 1MTPA 4PYWA 2V95A 3Q02A 3PB1I 2WXXA 1K9OI 1JJOC 1M93B 1LJ5A 1OYHL 1E04I 1EZXA 4Y40A 2ANTI 1ATUA 1JRRA 9PAIA 3T1PA 3CVMA 3CWMA 4G8RA 3DRUA 4BB2A 1PSIA 4RSQA 2B4XL 3DY0A 3UT3A 1BY7A 9APIA 5EI0A 4ROAA 1C5GA 2CEOA 2VDXA 1F0CA 5INWA 1QMNA 2ZV6A 5CE0A 4IC0A 3F5NA 1T1FA 4DY0A 3STOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DVM A;  2VDY A;  1R1L I;  1ATH A;  1DZH L;  1KCT A;  3LE2 A;  1YXA A;  4AU2 A;  1LQ8 A;  4EB1 L;  2H4R A;  1ANT I;  4AU4 A;  4ZK0 A;  1UHG A;  4ROB A;  1OC0 A;  4RO9 A;  4YIA A;  5CDX A;  4CAA A;  1HP7 A;  4X30 A;  3DRM A;  1DVN A;  3DLW A;  1JMJ A;  3F1S A;  5BRR I;  1SNG A;  2ACH A;  2B4X I;  2WXZ A;  1AS4 A;  5CDZ A;  4AU3 B;  2WXY C;  4G8O A;  1DZG I;  3NDA A;  3Q03 A;  3R4L A;  8API A;  1C8O A;  1SEK A;  2XN3 A;  4C49 A;  1JTI A;  4AFX A;  2WXZ C;  1A7C A;  4AU3 A;  2HIJ I;  4C41 A;  2XN5 A;  1ATT A;  2BEH L;  1E03 I;  4Y3K A;  2VH4 A;  1OVA B;  1DZH I;  1AZX I;  1OO8 A;  1B3K A;  2B5T I;  3OZQ A;  1OYH I;  1XQG A;  2WY0 C;  2GD4 C;  2R9Y A;  4EB1 I;  3NE4 A;  2ZNH A;  2HI9 A;  3NDD A;  3EVJ I;  1SR5 A;  1OVA A;  4DY7 C;  7API A;  4ZK3 A;  2WY1 A;  3EOX A;  3FGQ A;  3CWL A;  4P0F A;  1HLE A;  1BR8 I;  1OPH A;  1WZ9 A;  2ARQ A;  3VVJ A;  4AJU A;  1OVA C;  2DUT A;  2QUG A;  1XU8 A;  1DB2 A;  2ARR A;  2D26 A;  5IO1 A;  2OL2 A;  4AQH A;  1IMV A;  1TB6 I;  4AJT A;  2BEH I;  4P0O A;  3B9F I;  2PEE A;  4DTE A;  2WXW A;  2XN6 A;  2H4P A;  4GA7 A;  3H5C A;  2H4Q A;  2RIW A;  1JVQ I;  1XQJ A;  3KCG I;  4KDS A;  1NQ9 I;  1QLP A;  1JMO A;  2RIV A;  1LK6 I;  5C98 A;  1QMB A;  1IZ2 A;  4R9I A;  3NDF A;  1DZG L;  4IF8 A;  3ZHA A;  3PZF A;  2OAY A;  1E05 I;  2PEF A;  3CAA A;  3LW2 A;  3F02 A;  2HIJ L;  2XN7 A;  1D5S A;  5HGC A;  1MTP A;  4PYW A;  2V95 A;  3Q02 A;  3PB1 I;  2WXX A;  1K9O I;  1JJO C;  1M93 B;  1LJ5 A;  1OYH L;  1E04 I;  1EZX A;  4Y40 A;  2ANT I;  1ATU A;  1JRR A;  9PAI A;  3T1P A;  3CVM A;  3CWM A;  4G8R A;  3DRU A;  4BB2 A;  1PSI A;  4RSQ A;  2B4X L;  3DY0 A;  3UT3 A;  1BY7 A;  9API A;  5EI0 A;  4ROA A;  1C5G A;  2CEO A;  2VDX A;  1F0C A;  5INW A;  1QMN A;  2ZV6 A;  5CE0 A;  4IC0 A;  3F5N A;  1T1F A;  4DY0 A;  3STO A; 
#chains in the Genus database with same CATH topology
 1DVM A;  2VDY A;  1R1L I;  1ATH A;  1DZH L;  1KCT A;  3LE2 A;  1YXA A;  4AU2 A;  1LQ8 A;  4EB1 L;  2H4R A;  1ANT I;  4AU4 A;  4ZK0 A;  1UHG A;  4ROB A;  1OC0 A;  4RO9 A;  4YIA A;  5CDX A;  4CAA A;  1HP7 A;  4X30 A;  3DRM A;  1DVN A;  3DLW A;  1JMJ A;  3F1S A;  5BRR I;  1SNG A;  2ACH A;  2B4X I;  2WXZ A;  1AS4 A;  5CDZ A;  4AU3 B;  2WXY C;  4G8O A;  1DZG I;  3NDA A;  3Q03 A;  3R4L A;  8API A;  1C8O A;  1SEK A;  2XN3 A;  4C49 A;  1JTI A;  4AFX A;  2WXZ C;  1A7C A;  4AU3 A;  2HIJ I;  4C41 A;  2XN5 A;  1ATT A;  2BEH L;  1E03 I;  4Y3K A;  2VH4 A;  1OVA B;  1DZH I;  1AZX I;  1OO8 A;  1B3K A;  2B5T I;  3OZQ A;  1OYH I;  1XQG A;  2WY0 C;  2GD4 C;  2R9Y A;  4EB1 I;  3NE4 A;  2ZNH A;  2HI9 A;  3NDD A;  3EVJ I;  1SR5 A;  1OVA A;  4DY7 C;  7API A;  4ZK3 A;  2WY1 A;  3EOX A;  3FGQ A;  3CWL A;  4P0F A;  1HLE A;  1BR8 I;  1OPH A;  1WZ9 A;  2ARQ A;  3VVJ A;  4AJU A;  1OVA C;  2DUT A;  2QUG A;  1XU8 A;  1DB2 A;  2ARR A;  2D26 A;  5IO1 A;  2OL2 A;  4AQH A;  1IMV A;  1TB6 I;  4AJT A;  2BEH I;  4P0O A;  3B9F I;  2PEE A;  4DTE A;  2WXW A;  2XN6 A;  2H4P A;  4GA7 A;  3H5C A;  2H4Q A;  2RIW A;  1JVQ I;  1XQJ A;  3KCG I;  4KDS A;  1NQ9 I;  1QLP A;  1JMO A;  2RIV A;  1LK6 I;  5C98 A;  1QMB A;  1IZ2 A;  4R9I A;  3NDF A;  1DZG L;  4IF8 A;  3ZHA A;  3PZF A;  2OAY A;  1E05 I;  2PEF A;  3CAA A;  3LW2 A;  3F02 A;  2HIJ L;  2XN7 A;  1D5S A;  5HGC A;  1MTP A;  4PYW A;  2V95 A;  3Q02 A;  3PB1 I;  2WXX A;  1K9O I;  1JJO C;  1M93 B;  1LJ5 A;  1OYH L;  1E04 I;  1EZX A;  4Y40 A;  2ANT I;  1ATU A;  1JRR A;  9PAI A;  3T1P A;  3CVM A;  3CWM A;  4G8R A;  3DRU A;  4BB2 A;  1PSI A;  4RSQ A;  2B4X L;  3DY0 A;  3UT3 A;  1BY7 A;  9API A;  5EI0 A;  4ROA A;  1C5G A;  2CEO A;  2VDX A;  1F0C A;  5INW A;  1QMN A;  2ZV6 A;  5CE0 A;  4IC0 A;  3F5N A;  1T1F A;  4DY0 A;  3STO A; 
#chains in the Genus database with same CATH homology
 1DVM A;  2VDY A;  1R1L I;  1ATH A;  1DZH L;  1KCT A;  3LE2 A;  1YXA A;  4AU2 A;  1LQ8 A;  4EB1 L;  2H4R A;  1ANT I;  4AU4 A;  4ZK0 A;  1UHG A;  4ROB A;  1OC0 A;  4RO9 A;  4YIA A;  5CDX A;  4CAA A;  1HP7 A;  4X30 A;  3DRM A;  1DVN A;  3DLW A;  1JMJ A;  3F1S A;  5BRR I;  1SNG A;  2ACH A;  2B4X I;  2WXZ A;  1AS4 A;  5CDZ A;  4AU3 B;  2WXY C;  4G8O A;  1DZG I;  3NDA A;  3Q03 A;  3R4L A;  8API A;  1C8O A;  1SEK A;  2XN3 A;  4C49 A;  1JTI A;  4AFX A;  2WXZ C;  1A7C A;  4AU3 A;  2HIJ I;  4C41 A;  2XN5 A;  1ATT A;  2BEH L;  1E03 I;  4Y3K A;  2VH4 A;  1OVA B;  1DZH I;  1AZX I;  1OO8 A;  1B3K A;  2B5T I;  3OZQ A;  1OYH I;  1XQG A;  2WY0 C;  2GD4 C;  2R9Y A;  4EB1 I;  3NE4 A;  2ZNH A;  2HI9 A;  3NDD A;  3EVJ I;  1SR5 A;  1OVA A;  4DY7 C;  7API A;  4ZK3 A;  2WY1 A;  3EOX A;  3FGQ A;  3CWL A;  4P0F A;  1HLE A;  1BR8 I;  1OPH A;  1WZ9 A;  2ARQ A;  3VVJ A;  4AJU A;  1OVA C;  2DUT A;  2QUG A;  1XU8 A;  1DB2 A;  2ARR A;  2D26 A;  5IO1 A;  2OL2 A;  4AQH A;  1IMV A;  1TB6 I;  4AJT A;  2BEH I;  4P0O A;  3B9F I;  2PEE A;  4DTE A;  2WXW A;  2XN6 A;  2H4P A;  4GA7 A;  3H5C A;  2H4Q A;  2RIW A;  1JVQ I;  1XQJ A;  3KCG I;  4KDS A;  1NQ9 I;  1QLP A;  1JMO A;  2RIV A;  1LK6 I;  5C98 A;  1QMB A;  1IZ2 A;  4R9I A;  3NDF A;  1DZG L;  4IF8 A;  3ZHA A;  3PZF A;  2OAY A;  1E05 I;  2PEF A;  3CAA A;  3LW2 A;  3F02 A;  2HIJ L;  2XN7 A;  1D5S A;  5HGC A;  1MTP A;  4PYW A;  2V95 A;  3Q02 A;  3PB1 I;  2WXX A;  1K9O I;  1JJO C;  1M93 B;  1LJ5 A;  1OYH L;  1E04 I;  1EZX A;  4Y40 A;  2ANT I;  1ATU A;  1JRR A;  9PAI A;  3T1P A;  3CVM A;  3CWM A;  4G8R A;  3DRU A;  4BB2 A;  1PSI A;  4RSQ A;  2B4X L;  3DY0 A;  3UT3 A;  1BY7 A;  9API A;  5EI0 A;  4ROA A;  1C5G A;  2CEO A;  2VDX A;  1F0C A;  5INW A;  1QMN A;  2ZV6 A;  5CE0 A;  4IC0 A;  3F5N A;  1T1F A;  4DY0 A;  3STO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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