4GA7A

Crystal structure of human serpinb1 mutant
Total Genus 113
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
113
sequence length
379
structure length
369
Chain Sequence
MEQLSSANTRFALDLFLALSENNPAGNIFISPFSISSAMAMVFLGTRGNTAAQLSKTFHFNTVEEVHSRFQSLNADINKRGASYILKLANRLYGEKTYNFLPEFLVSTQKTYGADLASVDFQHASEDARKTINQWVKGQTEGKIPELLASGMVDNMTKLVLVNAIYFKGNWKDKFMKEATTNAPFRLNKKDRKTVKMMYQKKKFAYGYIEDLKCRVLELPYQGEELSMVILLPDDIEDESTGLKKIEEQLTLEKLHEWTKPENLDFIEVNVSLPRFKLEESYTLNSDLARLGVQDLFNSSKADLSGMSGARDIFISKIVHKSFVEVNEEGTTFCMDDPEENFTADHPFLFFIRHNSSGSILFLGRFSSP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Identification of SERPINB1 as a physiological inhibitor of human granzyme H
pubmed doi rcsb
molecule keywords Leukocyte elastase inhibitor
molecule tags Hydrolase inhibitor
source organism Homo sapiens
total genus 113
structure length 369
sequence length 379
chains with identical sequence B
ec nomenclature
pdb deposition date 2012-07-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4ga7A02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4ga7A01
4RO9A 1T1FA 3FGQA 1OC0A 3H5CA 3CVMA 2WXYC 2WY0C 4IF8A 4ROAA 8APIA 2B4XL 1E05I 1OVAA 5IO1A 3R4LA 1ATHA 5C98A 4IC0A 9APIA 3KCGI 1DZGI 1DVNA 2ANTI 2BEHL 3Q02A 2OAYA 4DTEA 4Y40A 1OPHA 2XN7A 1HP7A 3Q03A 1A7CA 1R1LI 1ATTA 2HIJI 1SEKA 1JVQI 3DLWA 4AJUA 1ATUA 4P0OA 1EZXA 3CAAA 1YXAA 4ZK0A 5CE0A 1E03I 1DVMA 1F0CA 5HGCA 2H4PA 1TB6I 4RSQA 2XN6A 2VDYA 1K9OI 4PYWA 2VDXA 1DB2A 4AU2A 3DRUA 4BB2A 1NQ9I 1MTPA 3EVJI 3PB1I 5CDZA 2WY1A 4GA7A 2B4XI 3UT3A 2ZV6A 4DY0A 1LK6I 4R9IA 1PSIA 5BRRI 4EB1L 1UHGA 4AU4A 2BEHI 5INWA 4KDSA 1IMVA 2DUTA 9PAIA 2CEOA 1DZHL 2ACHA 1OYHI 3OZQA 2H4RA 4G8OA 3F1SA 4AQHA 2B5TI 1XQGA 1SNGA 4AU3B 1M93B 2D26A 2RIVA 5CDXA 1JJOC 4ROBA 3EOXA 1LJ5A 2HI9A 1C8OA 1B3KA 3STOA 2ZNHA 4CAAA 3LW2A 1KCTA 2PEFA 2XN5A 1LQ8A 1OO8A 1AS4A 1BR8I 5EI0A 2GD4C 1ANTI 4AU3A 4YIAA 2R9YA 1JMJA 2XN3A 2ARQA 7APIA 1DZHI 1QMNA 1D5SA 3B9FI 3LE2A 1AZXI 3PZFA 4G8RA 2RIWA 3NDFA 2V95A 3CWLA 3NDAA 3T1PA 1HLEA 2PEEA 3DY0A 2VH4A 1DZGL 2WXXA 3DRMA 3VVJA 1XU8A 3F5NA 4Y3KA 2WXZC 2OL2A 4C49A 1BY7A 2HIJL 1SR5A 1JRRA 4AFXA 1C5GA 1OYHL 2H4QA 2ARRA 1OVAB 4EB1I 3NDDA 3NE4A 1QLPA 1JMOA 4DY7C 1IZ2A 2WXZA 4P0FA 4X30A 4C41A 2QUGA 3ZHAA 1E04I 3F02A 1JTIA 1QMBA 1XQJA 4AJTA 4ZK3A 3CWMA 1WZ9A 2WXWA 1OVAC
chains in the Genus database with same CATH superfamily
4RO9A 1T1FA 3FGQA 1OC0A 3H5CA 3CVMA 2WXYC 2WY0C 4IF8A 4ROAA 8APIA 2B4XL 1E05I 1OVAA 5IO1A 3R4LA 1ATHA 5C98A 4IC0A 9APIA 3KCGI 1DZGI 1DVNA 2ANTI 2BEHL 3Q02A 2OAYA 4DTEA 4Y40A 1OPHA 2XN7A 1HP7A 3Q03A 1A7CA 1R1LI 1ATTA 2HIJI 1SEKA 1JVQI 3DLWA 4AJUA 1ATUA 4P0OA 1EZXA 3CAAA 1YXAA 4ZK0A 5CE0A 1E03I 1DVMA 1F0CA 5HGCA 2H4PA 1TB6I 4RSQA 2XN6A 2VDYA 1K9OI 4PYWA 2VDXA 1DB2A 4AU2A 3DRUA 4BB2A 1NQ9I 1MTPA 3EVJI 3PB1I 5CDZA 2WY1A 4GA7A 2B4XI 3UT3A 2ZV6A 4DY0A 1LK6I 4R9IA 1PSIA 5BRRI 4EB1L 1UHGA 4AU4A 2BEHI 5INWA 4KDSA 1IMVA 2DUTA 9PAIA 2CEOA 1DZHL 2ACHA 1OYHI 3OZQA 2H4RA 4G8OA 3F1SA 4AQHA 2B5TI 1XQGA 1SNGA 4AU3B 1M93B 2D26A 2RIVA 5CDXA 1JJOC 4ROBA 3EOXA 1LJ5A 2HI9A 1C8OA 1B3KA 3STOA 2ZNHA 4CAAA 3LW2A 1KCTA 2PEFA 2XN5A 1LQ8A 1OO8A 1AS4A 1BR8I 5EI0A 2GD4C 1ANTI 4AU3A 4YIAA 2R9YA 1JMJA 2XN3A 2ARQA 7APIA 1DZHI 1QMNA 1D5SA 3B9FI 3LE2A 1AZXI 3PZFA 4G8RA 2RIWA 3NDFA 2V95A 3CWLA 3NDAA 3T1PA 1HLEA 2PEEA 3DY0A 2VH4A 1DZGL 2WXXA 3DRMA 3VVJA 1XU8A 3F5NA 4Y3KA 2WXZC 2OL2A 4C49A 1BY7A 2HIJL 1SR5A 1JRRA 4AFXA 1C5GA 1OYHL 2H4QA 2ARRA 1OVAB 4EB1I 3NDDA 3NE4A 1QLPA 1JMOA 4DY7C 1IZ2A 2WXZA 4P0FA 4X30A 4C41A 2QUGA 3ZHAA 1E04I 3F02A 1JTIA 1QMBA 1XQJA 4AJTA 4ZK3A 3CWMA 1WZ9A 2WXWA 1OVAC
chains in the Genus database with same CATH topology
4RO9A 1T1FA 3FGQA 1OC0A 3H5CA 3CVMA 2WXYC 2WY0C 4IF8A 4ROAA 8APIA 2B4XL 1E05I 1OVAA 5IO1A 3R4LA 1ATHA 5C98A 4IC0A 9APIA 3KCGI 1DZGI 1DVNA 2ANTI 2BEHL 3Q02A 2OAYA 4DTEA 4Y40A 1OPHA 2XN7A 1HP7A 3Q03A 1A7CA 1R1LI 1ATTA 2HIJI 1SEKA 1JVQI 3DLWA 4AJUA 1ATUA 4P0OA 1EZXA 3CAAA 1YXAA 4ZK0A 5CE0A 1E03I 1DVMA 1F0CA 5HGCA 2H4PA 1TB6I 4RSQA 2XN6A 2VDYA 1K9OI 4PYWA 2VDXA 1DB2A 4AU2A 3DRUA 4BB2A 1NQ9I 1MTPA 3EVJI 3PB1I 5CDZA 2WY1A 4GA7A 2B4XI 3UT3A 2ZV6A 4DY0A 1LK6I 4R9IA 1PSIA 5BRRI 4EB1L 1UHGA 4AU4A 2BEHI 5INWA 4KDSA 1IMVA 2DUTA 9PAIA 2CEOA 1DZHL 2ACHA 1OYHI 3OZQA 2H4RA 4G8OA 3F1SA 4AQHA 2B5TI 1XQGA 1SNGA 4AU3B 1M93B 2D26A 2RIVA 5CDXA 1JJOC 4ROBA 3EOXA 1LJ5A 2HI9A 1C8OA 1B3KA 3STOA 2ZNHA 4CAAA 3LW2A 1KCTA 2PEFA 2XN5A 1LQ8A 1OO8A 1AS4A 1BR8I 5EI0A 2GD4C 1ANTI 4AU3A 4YIAA 2R9YA 1JMJA 2XN3A 2ARQA 7APIA 1DZHI 1QMNA 1D5SA 3B9FI 3LE2A 1AZXI 3PZFA 4G8RA 2RIWA 3NDFA 2V95A 3CWLA 3NDAA 3T1PA 1HLEA 2PEEA 3DY0A 2VH4A 1DZGL 2WXXA 3DRMA 3VVJA 1XU8A 3F5NA 4Y3KA 2WXZC 2OL2A 4C49A 1BY7A 2HIJL 1SR5A 1JRRA 4AFXA 1C5GA 1OYHL 2H4QA 2ARRA 1OVAB 4EB1I 3NDDA 3NE4A 1QLPA 1JMOA 4DY7C 1IZ2A 2WXZA 4P0FA 4X30A 4C41A 2QUGA 3ZHAA 1E04I 3F02A 1JTIA 1QMBA 1XQJA 4AJTA 4ZK3A 3CWMA 1WZ9A 2WXWA 1OVAC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4RO9 A;  1T1F A;  3FGQ A;  1OC0 A;  3H5C A;  3CVM A;  2WXY C;  2WY0 C;  4IF8 A;  4ROA A;  8API A;  2B4X L;  1E05 I;  1OVA A;  5IO1 A;  3R4L A;  1ATH A;  5C98 A;  4IC0 A;  9API A;  3KCG I;  1DZG I;  1DVN A;  2ANT I;  2BEH L;  3Q02 A;  2OAY A;  4DTE A;  4Y40 A;  1OPH A;  2XN7 A;  1HP7 A;  3Q03 A;  1A7C A;  1R1L I;  1ATT A;  2HIJ I;  1SEK A;  1JVQ I;  3DLW A;  4AJU A;  1ATU A;  4P0O A;  1EZX A;  3CAA A;  1YXA A;  4ZK0 A;  5CE0 A;  1E03 I;  1DVM A;  1F0C A;  5HGC A;  2H4P A;  1TB6 I;  4RSQ A;  2XN6 A;  2VDY A;  1K9O I;  4PYW A;  2VDX A;  1DB2 A;  4AU2 A;  3DRU A;  4BB2 A;  1NQ9 I;  1MTP A;  3EVJ I;  3PB1 I;  5CDZ A;  2WY1 A;  4GA7 A;  2B4X I;  3UT3 A;  2ZV6 A;  4DY0 A;  1LK6 I;  4R9I A;  1PSI A;  5BRR I;  4EB1 L;  1UHG A;  4AU4 A;  2BEH I;  5INW A;  4KDS A;  1IMV A;  2DUT A;  9PAI A;  2CEO A;  1DZH L;  2ACH A;  1OYH I;  3OZQ A;  2H4R A;  4G8O A;  3F1S A;  4AQH A;  2B5T I;  1XQG A;  1SNG A;  4AU3 B;  1M93 B;  2D26 A;  2RIV A;  5CDX A;  1JJO C;  4ROB A;  3EOX A;  1LJ5 A;  2HI9 A;  1C8O A;  1B3K A;  3STO A;  2ZNH A;  4CAA A;  3LW2 A;  1KCT A;  2PEF A;  2XN5 A;  1LQ8 A;  1OO8 A;  1AS4 A;  1BR8 I;  5EI0 A;  2GD4 C;  1ANT I;  4AU3 A;  4YIA A;  2R9Y A;  1JMJ A;  2XN3 A;  2ARQ A;  7API A;  1DZH I;  1QMN A;  1D5S A;  3B9F I;  3LE2 A;  1AZX I;  3PZF A;  4G8R A;  2RIW A;  3NDF A;  2V95 A;  3CWL A;  3NDA A;  3T1P A;  1HLE A;  2PEE A;  3DY0 A;  2VH4 A;  1DZG L;  2WXX A;  3DRM A;  3VVJ A;  1XU8 A;  3F5N A;  4Y3K A;  2WXZ C;  2OL2 A;  4C49 A;  1BY7 A;  2HIJ L;  1SR5 A;  1JRR A;  4AFX A;  1C5G A;  1OYH L;  2H4Q A;  2ARR A;  1OVA B;  4EB1 I;  3NDD A;  3NE4 A;  1QLP A;  1JMO A;  4DY7 C;  1IZ2 A;  2WXZ A;  4P0F A;  4X30 A;  4C41 A;  2QUG A;  3ZHA A;  1E04 I;  3F02 A;  1JTI A;  1QMB A;  1XQJ A;  4AJT A;  4ZK3 A;  3CWM A;  1WZ9 A;  2WXW A;  1OVA C; 
#chains in the Genus database with same CATH topology
 4RO9 A;  1T1F A;  3FGQ A;  1OC0 A;  3H5C A;  3CVM A;  2WXY C;  2WY0 C;  4IF8 A;  4ROA A;  8API A;  2B4X L;  1E05 I;  1OVA A;  5IO1 A;  3R4L A;  1ATH A;  5C98 A;  4IC0 A;  9API A;  3KCG I;  1DZG I;  1DVN A;  2ANT I;  2BEH L;  3Q02 A;  2OAY A;  4DTE A;  4Y40 A;  1OPH A;  2XN7 A;  1HP7 A;  3Q03 A;  1A7C A;  1R1L I;  1ATT A;  2HIJ I;  1SEK A;  1JVQ I;  3DLW A;  4AJU A;  1ATU A;  4P0O A;  1EZX A;  3CAA A;  1YXA A;  4ZK0 A;  5CE0 A;  1E03 I;  1DVM A;  1F0C A;  5HGC A;  2H4P A;  1TB6 I;  4RSQ A;  2XN6 A;  2VDY A;  1K9O I;  4PYW A;  2VDX A;  1DB2 A;  4AU2 A;  3DRU A;  4BB2 A;  1NQ9 I;  1MTP A;  3EVJ I;  3PB1 I;  5CDZ A;  2WY1 A;  4GA7 A;  2B4X I;  3UT3 A;  2ZV6 A;  4DY0 A;  1LK6 I;  4R9I A;  1PSI A;  5BRR I;  4EB1 L;  1UHG A;  4AU4 A;  2BEH I;  5INW A;  4KDS A;  1IMV A;  2DUT A;  9PAI A;  2CEO A;  1DZH L;  2ACH A;  1OYH I;  3OZQ A;  2H4R A;  4G8O A;  3F1S A;  4AQH A;  2B5T I;  1XQG A;  1SNG A;  4AU3 B;  1M93 B;  2D26 A;  2RIV A;  5CDX A;  1JJO C;  4ROB A;  3EOX A;  1LJ5 A;  2HI9 A;  1C8O A;  1B3K A;  3STO A;  2ZNH A;  4CAA A;  3LW2 A;  1KCT A;  2PEF A;  2XN5 A;  1LQ8 A;  1OO8 A;  1AS4 A;  1BR8 I;  5EI0 A;  2GD4 C;  1ANT I;  4AU3 A;  4YIA A;  2R9Y A;  1JMJ A;  2XN3 A;  2ARQ A;  7API A;  1DZH I;  1QMN A;  1D5S A;  3B9F I;  3LE2 A;  1AZX I;  3PZF A;  4G8R A;  2RIW A;  3NDF A;  2V95 A;  3CWL A;  3NDA A;  3T1P A;  1HLE A;  2PEE A;  3DY0 A;  2VH4 A;  1DZG L;  2WXX A;  3DRM A;  3VVJ A;  1XU8 A;  3F5N A;  4Y3K A;  2WXZ C;  2OL2 A;  4C49 A;  1BY7 A;  2HIJ L;  1SR5 A;  1JRR A;  4AFX A;  1C5G A;  1OYH L;  2H4Q A;  2ARR A;  1OVA B;  4EB1 I;  3NDD A;  3NE4 A;  1QLP A;  1JMO A;  4DY7 C;  1IZ2 A;  2WXZ A;  4P0F A;  4X30 A;  4C41 A;  2QUG A;  3ZHA A;  1E04 I;  3F02 A;  1JTI A;  1QMB A;  1XQJ A;  4AJT A;  4ZK3 A;  3CWM A;  1WZ9 A;  2WXW A;  1OVA C; 
#chains in the Genus database with same CATH homology
 4RO9 A;  1T1F A;  3FGQ A;  1OC0 A;  3H5C A;  3CVM A;  2WXY C;  2WY0 C;  4IF8 A;  4ROA A;  8API A;  2B4X L;  1E05 I;  1OVA A;  5IO1 A;  3R4L A;  1ATH A;  5C98 A;  4IC0 A;  9API A;  3KCG I;  1DZG I;  1DVN A;  2ANT I;  2BEH L;  3Q02 A;  2OAY A;  4DTE A;  4Y40 A;  1OPH A;  2XN7 A;  1HP7 A;  3Q03 A;  1A7C A;  1R1L I;  1ATT A;  2HIJ I;  1SEK A;  1JVQ I;  3DLW A;  4AJU A;  1ATU A;  4P0O A;  1EZX A;  3CAA A;  1YXA A;  4ZK0 A;  5CE0 A;  1E03 I;  1DVM A;  1F0C A;  5HGC A;  2H4P A;  1TB6 I;  4RSQ A;  2XN6 A;  2VDY A;  1K9O I;  4PYW A;  2VDX A;  1DB2 A;  4AU2 A;  3DRU A;  4BB2 A;  1NQ9 I;  1MTP A;  3EVJ I;  3PB1 I;  5CDZ A;  2WY1 A;  4GA7 A;  2B4X I;  3UT3 A;  2ZV6 A;  4DY0 A;  1LK6 I;  4R9I A;  1PSI A;  5BRR I;  4EB1 L;  1UHG A;  4AU4 A;  2BEH I;  5INW A;  4KDS A;  1IMV A;  2DUT A;  9PAI A;  2CEO A;  1DZH L;  2ACH A;  1OYH I;  3OZQ A;  2H4R A;  4G8O A;  3F1S A;  4AQH A;  2B5T I;  1XQG A;  1SNG A;  4AU3 B;  1M93 B;  2D26 A;  2RIV A;  5CDX A;  1JJO C;  4ROB A;  3EOX A;  1LJ5 A;  2HI9 A;  1C8O A;  1B3K A;  3STO A;  2ZNH A;  4CAA A;  3LW2 A;  1KCT A;  2PEF A;  2XN5 A;  1LQ8 A;  1OO8 A;  1AS4 A;  1BR8 I;  5EI0 A;  2GD4 C;  1ANT I;  4AU3 A;  4YIA A;  2R9Y A;  1JMJ A;  2XN3 A;  2ARQ A;  7API A;  1DZH I;  1QMN A;  1D5S A;  3B9F I;  3LE2 A;  1AZX I;  3PZF A;  4G8R A;  2RIW A;  3NDF A;  2V95 A;  3CWL A;  3NDA A;  3T1P A;  1HLE A;  2PEE A;  3DY0 A;  2VH4 A;  1DZG L;  2WXX A;  3DRM A;  3VVJ A;  1XU8 A;  3F5N A;  4Y3K A;  2WXZ C;  2OL2 A;  4C49 A;  1BY7 A;  2HIJ L;  1SR5 A;  1JRR A;  4AFX A;  1C5G A;  1OYH L;  2H4Q A;  2ARR A;  1OVA B;  4EB1 I;  3NDD A;  3NE4 A;  1QLP A;  1JMO A;  4DY7 C;  1IZ2 A;  2WXZ A;  4P0F A;  4X30 A;  4C41 A;  2QUG A;  3ZHA A;  1E04 I;  3F02 A;  1JTI A;  1QMB A;  1XQJ A;  4AJT A;  4ZK3 A;  3CWM A;  1WZ9 A;  2WXW A;  1OVA C; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...