3UT3A

A novel pai-i inhibitor and its structural mechanism
Total Genus 108
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
108
sequence length
373
structure length
367
Chain Sequence
YVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISHLLGTGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVALALQKVKIEVNESGTAVIVSARMAPEEIIIDRPFLFVVRHNPTGTVLFMGQVMEP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A novel PAI-I inhibitor and its structural mechanism
rcsb
molecule keywords Plasminogen activator inhibitor 1
molecule tags Hydrolase inhibitor
source organism Homo sapiens
total genus 108
structure length 367
sequence length 373
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2011-11-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 3ut3A02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 3ut3A01
1OVAC 1HLEA 4AJUA 2HIJL 3Q03A 1T1FA 4C49A 1ATTA 1DZHI 2PEEA 3LE2A 2H4PA 4BB2A 2R9YA 3H5CA 2DUTA 4DY7C 5C98A 3VVJA 1TB6I 2ZV6A 4P0OA 4EB1L 3STOA 4AU4A 4PYWA 1ATUA 1OC0A 3NE4A 2BEHI 1ATHA 1HP7A 2ZNHA 1SNGA 1OO8A 1JMJA 2PEFA 4ZK3A 1AZXI 2B4XL 1EZXA 1XU8A 4P0FA 1ANTI 1OYHI 8APIA 4AU3A 1LK6I 4ROBA 1DZGL 1E03I 1E04I 3DLWA 1QMNA 1KCTA 1OVAB 1YXAA 2VH4A 4GA7A 7APIA 1B3KA 4C41A 1D5SA 4Y3KA 1LQ8A 3Q02A 3DY0A 1JTIA 2CEOA 3FGQA 1QMBA 4AU2A 3EVJI 3CVMA 4AFXA 1OPHA 2VDXA 2HIJI 1WZ9A 4AQHA 3B9FI 5BRRI 2ARRA 2H4QA 1JVQI 5CDXA 2D26A 3PZFA 4RSQA 4IF8A 2ARQA 1UHGA 1DVNA 9PAIA 1R1LI 2B5TI 5INWA 1JMOA 4KDSA 1DZHL 4RO9A 2VDYA 4CAAA 4G8OA 4EB1I 5CDZA 3CWLA 1XQGA 5EI0A 2H4RA 1M93B 3ZHAA 1C8OA 1C5GA 2WXXA 3F1SA 4R9IA 2WXYC 3CAAA 1JRRA 2WY1A 4DTEA 3R4LA 2HI9A 1E05I 3KCGI 1XQJA 2B4XI 2WXWA 1NQ9I 4G8RA 4X30A 2BEHL 4ROAA 4YIAA 4AU3B 3UT3A 5CE0A 1IMVA 3PB1I 2WXZC 2XN7A 4ZK0A 1MTPA 1IZ2A 1DZGI 1JJOC 2GD4C 2ACHA 2V95A 1QLPA 1OYHL 1BR8I 3T1PA 2WY0C 3F02A 2ANTI 2XN6A 1PSIA 3EOXA 9APIA 3CWMA 3LW2A 4Y40A 2OL2A 1SEKA 1A7CA 2RIWA 1DB2A 1SR5A 3OZQA 2QUGA 1LJ5A 1OVAA 3DRMA 3NDAA 3NDFA 5HGCA 2WXZA 4AJTA 3NDDA 1F0CA 4IC0A 1DVMA 2RIVA 2OAYA 1AS4A 2XN3A 3DRUA 5IO1A 1K9OI 2XN5A 4DY0A 3F5NA 1BY7A
chains in the Genus database with same CATH superfamily
1OVAC 1HLEA 4AJUA 2HIJL 3Q03A 1T1FA 4C49A 1ATTA 1DZHI 2PEEA 3LE2A 2H4PA 4BB2A 2R9YA 3H5CA 2DUTA 4DY7C 5C98A 3VVJA 1TB6I 2ZV6A 4P0OA 4EB1L 3STOA 4AU4A 4PYWA 1ATUA 1OC0A 3NE4A 2BEHI 1ATHA 1HP7A 2ZNHA 1SNGA 1OO8A 1JMJA 2PEFA 4ZK3A 1AZXI 2B4XL 1EZXA 1XU8A 4P0FA 1ANTI 1OYHI 8APIA 4AU3A 1LK6I 4ROBA 1DZGL 1E03I 1E04I 3DLWA 1QMNA 1KCTA 1OVAB 1YXAA 2VH4A 4GA7A 7APIA 1B3KA 4C41A 1D5SA 4Y3KA 1LQ8A 3Q02A 3DY0A 1JTIA 2CEOA 3FGQA 1QMBA 4AU2A 3EVJI 3CVMA 4AFXA 1OPHA 2VDXA 2HIJI 1WZ9A 4AQHA 3B9FI 5BRRI 2ARRA 2H4QA 1JVQI 5CDXA 2D26A 3PZFA 4RSQA 4IF8A 2ARQA 1UHGA 1DVNA 9PAIA 1R1LI 2B5TI 5INWA 1JMOA 4KDSA 1DZHL 4RO9A 2VDYA 4CAAA 4G8OA 4EB1I 5CDZA 3CWLA 1XQGA 5EI0A 2H4RA 1M93B 3ZHAA 1C8OA 1C5GA 2WXXA 3F1SA 4R9IA 2WXYC 3CAAA 1JRRA 2WY1A 4DTEA 3R4LA 2HI9A 1E05I 3KCGI 1XQJA 2B4XI 2WXWA 1NQ9I 4G8RA 4X30A 2BEHL 4ROAA 4YIAA 4AU3B 3UT3A 5CE0A 1IMVA 3PB1I 2WXZC 2XN7A 4ZK0A 1MTPA 1IZ2A 1DZGI 1JJOC 2GD4C 2ACHA 2V95A 1QLPA 1OYHL 1BR8I 3T1PA 2WY0C 3F02A 2ANTI 2XN6A 1PSIA 3EOXA 9APIA 3CWMA 3LW2A 4Y40A 2OL2A 1SEKA 1A7CA 2RIWA 1DB2A 1SR5A 3OZQA 2QUGA 1LJ5A 1OVAA 3DRMA 3NDAA 3NDFA 5HGCA 2WXZA 4AJTA 3NDDA 1F0CA 4IC0A 1DVMA 2RIVA 2OAYA 1AS4A 2XN3A 3DRUA 5IO1A 1K9OI 2XN5A 4DY0A 3F5NA 1BY7A
chains in the Genus database with same CATH topology
1OVAC 1HLEA 4AJUA 2HIJL 3Q03A 1T1FA 4C49A 1ATTA 1DZHI 2PEEA 3LE2A 2H4PA 4BB2A 2R9YA 3H5CA 2DUTA 4DY7C 5C98A 3VVJA 1TB6I 2ZV6A 4P0OA 4EB1L 3STOA 4AU4A 4PYWA 1ATUA 1OC0A 3NE4A 2BEHI 1ATHA 1HP7A 2ZNHA 1SNGA 1OO8A 1JMJA 2PEFA 4ZK3A 1AZXI 2B4XL 1EZXA 1XU8A 4P0FA 1ANTI 1OYHI 8APIA 4AU3A 1LK6I 4ROBA 1DZGL 1E03I 1E04I 3DLWA 1QMNA 1KCTA 1OVAB 1YXAA 2VH4A 4GA7A 7APIA 1B3KA 4C41A 1D5SA 4Y3KA 1LQ8A 3Q02A 3DY0A 1JTIA 2CEOA 3FGQA 1QMBA 4AU2A 3EVJI 3CVMA 4AFXA 1OPHA 2VDXA 2HIJI 1WZ9A 4AQHA 3B9FI 5BRRI 2ARRA 2H4QA 1JVQI 5CDXA 2D26A 3PZFA 4RSQA 4IF8A 2ARQA 1UHGA 1DVNA 9PAIA 1R1LI 2B5TI 5INWA 1JMOA 4KDSA 1DZHL 4RO9A 2VDYA 4CAAA 4G8OA 4EB1I 5CDZA 3CWLA 1XQGA 5EI0A 2H4RA 1M93B 3ZHAA 1C8OA 1C5GA 2WXXA 3F1SA 4R9IA 2WXYC 3CAAA 1JRRA 2WY1A 4DTEA 3R4LA 2HI9A 1E05I 3KCGI 1XQJA 2B4XI 2WXWA 1NQ9I 4G8RA 4X30A 2BEHL 4ROAA 4YIAA 4AU3B 3UT3A 5CE0A 1IMVA 3PB1I 2WXZC 2XN7A 4ZK0A 1MTPA 1IZ2A 1DZGI 1JJOC 2GD4C 2ACHA 2V95A 1QLPA 1OYHL 1BR8I 3T1PA 2WY0C 3F02A 2ANTI 2XN6A 1PSIA 3EOXA 9APIA 3CWMA 3LW2A 4Y40A 2OL2A 1SEKA 1A7CA 2RIWA 1DB2A 1SR5A 3OZQA 2QUGA 1LJ5A 1OVAA 3DRMA 3NDAA 3NDFA 5HGCA 2WXZA 4AJTA 3NDDA 1F0CA 4IC0A 1DVMA 2RIVA 2OAYA 1AS4A 2XN3A 3DRUA 5IO1A 1K9OI 2XN5A 4DY0A 3F5NA 1BY7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1OVA C;  1HLE A;  4AJU A;  2HIJ L;  3Q03 A;  1T1F A;  4C49 A;  1ATT A;  1DZH I;  2PEE A;  3LE2 A;  2H4P A;  4BB2 A;  2R9Y A;  3H5C A;  2DUT A;  4DY7 C;  5C98 A;  3VVJ A;  1TB6 I;  2ZV6 A;  4P0O A;  4EB1 L;  3STO A;  4AU4 A;  4PYW A;  1ATU A;  1OC0 A;  3NE4 A;  2BEH I;  1ATH A;  1HP7 A;  2ZNH A;  1SNG A;  1OO8 A;  1JMJ A;  2PEF A;  4ZK3 A;  1AZX I;  2B4X L;  1EZX A;  1XU8 A;  4P0F A;  1ANT I;  1OYH I;  8API A;  4AU3 A;  1LK6 I;  4ROB A;  1DZG L;  1E03 I;  1E04 I;  3DLW A;  1QMN A;  1KCT A;  1OVA B;  1YXA A;  2VH4 A;  4GA7 A;  7API A;  1B3K A;  4C41 A;  1D5S A;  4Y3K A;  1LQ8 A;  3Q02 A;  3DY0 A;  1JTI A;  2CEO A;  3FGQ A;  1QMB A;  4AU2 A;  3EVJ I;  3CVM A;  4AFX A;  1OPH A;  2VDX A;  2HIJ I;  1WZ9 A;  4AQH A;  3B9F I;  5BRR I;  2ARR A;  2H4Q A;  1JVQ I;  5CDX A;  2D26 A;  3PZF A;  4RSQ A;  4IF8 A;  2ARQ A;  1UHG A;  1DVN A;  9PAI A;  1R1L I;  2B5T I;  5INW A;  1JMO A;  4KDS A;  1DZH L;  4RO9 A;  2VDY A;  4CAA A;  4G8O A;  4EB1 I;  5CDZ A;  3CWL A;  1XQG A;  5EI0 A;  2H4R A;  1M93 B;  3ZHA A;  1C8O A;  1C5G A;  2WXX A;  3F1S A;  4R9I A;  2WXY C;  3CAA A;  1JRR A;  2WY1 A;  4DTE A;  3R4L A;  2HI9 A;  1E05 I;  3KCG I;  1XQJ A;  2B4X I;  2WXW A;  1NQ9 I;  4G8R A;  4X30 A;  2BEH L;  4ROA A;  4YIA A;  4AU3 B;  3UT3 A;  5CE0 A;  1IMV A;  3PB1 I;  2WXZ C;  2XN7 A;  4ZK0 A;  1MTP A;  1IZ2 A;  1DZG I;  1JJO C;  2GD4 C;  2ACH A;  2V95 A;  1QLP A;  1OYH L;  1BR8 I;  3T1P A;  2WY0 C;  3F02 A;  2ANT I;  2XN6 A;  1PSI A;  3EOX A;  9API A;  3CWM A;  3LW2 A;  4Y40 A;  2OL2 A;  1SEK A;  1A7C A;  2RIW A;  1DB2 A;  1SR5 A;  3OZQ A;  2QUG A;  1LJ5 A;  1OVA A;  3DRM A;  3NDA A;  3NDF A;  5HGC A;  2WXZ A;  4AJT A;  3NDD A;  1F0C A;  4IC0 A;  1DVM A;  2RIV A;  2OAY A;  1AS4 A;  2XN3 A;  3DRU A;  5IO1 A;  1K9O I;  2XN5 A;  4DY0 A;  3F5N A;  1BY7 A; 
#chains in the Genus database with same CATH topology
 1OVA C;  1HLE A;  4AJU A;  2HIJ L;  3Q03 A;  1T1F A;  4C49 A;  1ATT A;  1DZH I;  2PEE A;  3LE2 A;  2H4P A;  4BB2 A;  2R9Y A;  3H5C A;  2DUT A;  4DY7 C;  5C98 A;  3VVJ A;  1TB6 I;  2ZV6 A;  4P0O A;  4EB1 L;  3STO A;  4AU4 A;  4PYW A;  1ATU A;  1OC0 A;  3NE4 A;  2BEH I;  1ATH A;  1HP7 A;  2ZNH A;  1SNG A;  1OO8 A;  1JMJ A;  2PEF A;  4ZK3 A;  1AZX I;  2B4X L;  1EZX A;  1XU8 A;  4P0F A;  1ANT I;  1OYH I;  8API A;  4AU3 A;  1LK6 I;  4ROB A;  1DZG L;  1E03 I;  1E04 I;  3DLW A;  1QMN A;  1KCT A;  1OVA B;  1YXA A;  2VH4 A;  4GA7 A;  7API A;  1B3K A;  4C41 A;  1D5S A;  4Y3K A;  1LQ8 A;  3Q02 A;  3DY0 A;  1JTI A;  2CEO A;  3FGQ A;  1QMB A;  4AU2 A;  3EVJ I;  3CVM A;  4AFX A;  1OPH A;  2VDX A;  2HIJ I;  1WZ9 A;  4AQH A;  3B9F I;  5BRR I;  2ARR A;  2H4Q A;  1JVQ I;  5CDX A;  2D26 A;  3PZF A;  4RSQ A;  4IF8 A;  2ARQ A;  1UHG A;  1DVN A;  9PAI A;  1R1L I;  2B5T I;  5INW A;  1JMO A;  4KDS A;  1DZH L;  4RO9 A;  2VDY A;  4CAA A;  4G8O A;  4EB1 I;  5CDZ A;  3CWL A;  1XQG A;  5EI0 A;  2H4R A;  1M93 B;  3ZHA A;  1C8O A;  1C5G A;  2WXX A;  3F1S A;  4R9I A;  2WXY C;  3CAA A;  1JRR A;  2WY1 A;  4DTE A;  3R4L A;  2HI9 A;  1E05 I;  3KCG I;  1XQJ A;  2B4X I;  2WXW A;  1NQ9 I;  4G8R A;  4X30 A;  2BEH L;  4ROA A;  4YIA A;  4AU3 B;  3UT3 A;  5CE0 A;  1IMV A;  3PB1 I;  2WXZ C;  2XN7 A;  4ZK0 A;  1MTP A;  1IZ2 A;  1DZG I;  1JJO C;  2GD4 C;  2ACH A;  2V95 A;  1QLP A;  1OYH L;  1BR8 I;  3T1P A;  2WY0 C;  3F02 A;  2ANT I;  2XN6 A;  1PSI A;  3EOX A;  9API A;  3CWM A;  3LW2 A;  4Y40 A;  2OL2 A;  1SEK A;  1A7C A;  2RIW A;  1DB2 A;  1SR5 A;  3OZQ A;  2QUG A;  1LJ5 A;  1OVA A;  3DRM A;  3NDA A;  3NDF A;  5HGC A;  2WXZ A;  4AJT A;  3NDD A;  1F0C A;  4IC0 A;  1DVM A;  2RIV A;  2OAY A;  1AS4 A;  2XN3 A;  3DRU A;  5IO1 A;  1K9O I;  2XN5 A;  4DY0 A;  3F5N A;  1BY7 A; 
#chains in the Genus database with same CATH homology
 1OVA C;  1HLE A;  4AJU A;  2HIJ L;  3Q03 A;  1T1F A;  4C49 A;  1ATT A;  1DZH I;  2PEE A;  3LE2 A;  2H4P A;  4BB2 A;  2R9Y A;  3H5C A;  2DUT A;  4DY7 C;  5C98 A;  3VVJ A;  1TB6 I;  2ZV6 A;  4P0O A;  4EB1 L;  3STO A;  4AU4 A;  4PYW A;  1ATU A;  1OC0 A;  3NE4 A;  2BEH I;  1ATH A;  1HP7 A;  2ZNH A;  1SNG A;  1OO8 A;  1JMJ A;  2PEF A;  4ZK3 A;  1AZX I;  2B4X L;  1EZX A;  1XU8 A;  4P0F A;  1ANT I;  1OYH I;  8API A;  4AU3 A;  1LK6 I;  4ROB A;  1DZG L;  1E03 I;  1E04 I;  3DLW A;  1QMN A;  1KCT A;  1OVA B;  1YXA A;  2VH4 A;  4GA7 A;  7API A;  1B3K A;  4C41 A;  1D5S A;  4Y3K A;  1LQ8 A;  3Q02 A;  3DY0 A;  1JTI A;  2CEO A;  3FGQ A;  1QMB A;  4AU2 A;  3EVJ I;  3CVM A;  4AFX A;  1OPH A;  2VDX A;  2HIJ I;  1WZ9 A;  4AQH A;  3B9F I;  5BRR I;  2ARR A;  2H4Q A;  1JVQ I;  5CDX A;  2D26 A;  3PZF A;  4RSQ A;  4IF8 A;  2ARQ A;  1UHG A;  1DVN A;  9PAI A;  1R1L I;  2B5T I;  5INW A;  1JMO A;  4KDS A;  1DZH L;  4RO9 A;  2VDY A;  4CAA A;  4G8O A;  4EB1 I;  5CDZ A;  3CWL A;  1XQG A;  5EI0 A;  2H4R A;  1M93 B;  3ZHA A;  1C8O A;  1C5G A;  2WXX A;  3F1S A;  4R9I A;  2WXY C;  3CAA A;  1JRR A;  2WY1 A;  4DTE A;  3R4L A;  2HI9 A;  1E05 I;  3KCG I;  1XQJ A;  2B4X I;  2WXW A;  1NQ9 I;  4G8R A;  4X30 A;  2BEH L;  4ROA A;  4YIA A;  4AU3 B;  3UT3 A;  5CE0 A;  1IMV A;  3PB1 I;  2WXZ C;  2XN7 A;  4ZK0 A;  1MTP A;  1IZ2 A;  1DZG I;  1JJO C;  2GD4 C;  2ACH A;  2V95 A;  1QLP A;  1OYH L;  1BR8 I;  3T1P A;  2WY0 C;  3F02 A;  2ANT I;  2XN6 A;  1PSI A;  3EOX A;  9API A;  3CWM A;  3LW2 A;  4Y40 A;  2OL2 A;  1SEK A;  1A7C A;  2RIW A;  1DB2 A;  1SR5 A;  3OZQ A;  2QUG A;  1LJ5 A;  1OVA A;  3DRM A;  3NDA A;  3NDF A;  5HGC A;  2WXZ A;  4AJT A;  3NDD A;  1F0C A;  4IC0 A;  1DVM A;  2RIV A;  2OAY A;  1AS4 A;  2XN3 A;  3DRU A;  5IO1 A;  1K9O I;  2XN5 A;  4DY0 A;  3F5N A;  1BY7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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