4C49A

Reactive loop cleaved human cbg in complex with cortisol
Total Genus 105
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
105
sequence length
368
structure length
367
Chain Sequence
GLASANVDFAFSLYKHLVALSPKKNIFISPVSISMALAMLSLGTCGHTRAQLLQGLGFNLTERSETEIHQGFQHLHQLFAKSDTSLEMTMGNALFLDGSLELLESFSADIKHYYESEVLAMNFQDWATASRQINSYVKNKTQGKIVDLFSGLDSPAILVLVNYIFFKGTWTQPFDLASTREENFYVDETTVVKVPMMLQSSTISYLHDSELPCQLVQMNYVGNGTVFFILPDKGKMNTVIAALSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMGIADLFTNQANFSRITQDAQLKSSKVVHKAVLQLNEEGVDTAGSTGVTLNLRKPIILRFNQPFIIMIFDHFTWSSLFLARVMNPV
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Role of Sa-Hd Loop Movement in Cortisol Release Mechanism of Cbg
rcsb
molecule keywords CORTICOSTEROID-BINDING GLOBULIN
molecule tags Transport protein
source organism Homo sapiens
total genus 105
structure length 367
sequence length 368
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2013-09-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4c49A02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4c49A01
8APIA 3CVMA 1IZ2A 3DY0A 2HIJL 4EB1I 1YXAA 1A7CA 4G8RA 3F02A 4YIAA 5BRRI 1OO8A 1OVAC 2ZNHA 3NDAA 2WXZC 1TB6I 3CAAA 2WXWA 1LJ5A 1AZXI 1E04I 2XN5A 1DZGL 3VVJA 3EVJI 1ATHA 5HGCA 4ZK3A 4AU2A 4P0FA 1LQ8A 4AU4A 1UHGA 2H4PA 2PEFA 9APIA 2ARQA 1ATTA 5IO1A 4G8OA 5CDXA 2ACHA 3NDDA 4AJUA 1IMVA 1AS4A 1OC0A 1XQGA 1OYHI 2B4XL 2ANTI 1OVAA 2GD4C 4ROAA 2XN3A 3Q03A 1MTPA 1T1FA 4Y40A 2RIWA 2BEHI 1XU8A 1JMJA 3Q02A 1ANTI 3PZFA 4DTEA 5INWA 4R9IA 1DVMA 1JJOC 3F5NA 1KCTA 3B9FI 1JRRA 1PSIA 1E03I 1M93B 1R1LI 2HI9A 3H5CA 4DY7C 2H4RA 3PB1I 4AFXA 4IC0A 4ZK0A 2HIJI 3FGQA 5CE0A 3KCGI 1JTIA 3OZQA 2DUTA 9PAIA 2WXZA 4AU3B 1XQJA 1OYHL 4P0OA 1OPHA 2D26A 1D5SA 1DB2A 1DZGI 2H4QA 3LW2A 3CWMA 1DZHI 1SNGA 1LK6I 4DY0A 3DLWA 2ARRA 4C49A 1K9OI 1JMOA 3F1SA 4EB1L 4CAAA 4X30A 1QLPA 2WY0C 1JVQI 1C8OA 2B4XI 1QMBA 2ZV6A 3CWLA 4KDSA 2VDXA 4Y3KA 1F0CA 1EZXA 3DRMA 1SR5A 4AJTA 5EI0A 2OL2A 2OAYA 3NDFA 5CDZA 1ATUA 2XN6A 2R9YA 2V95A 2XN7A 1HLEA 1DVNA 4AU3A 1C5GA 2WXXA 3DRUA 3NE4A 3T1PA 4RO9A 2B5TI 1B3KA 1BY7A 2VDYA 4AQHA 3STOA 1BR8I 3ZHAA 2VH4A 4PYWA 2BEHL 1SEKA 1DZHL 2WXYC 3EOXA 4BB2A 2CEOA 1QMNA 3LE2A 4ROBA 7APIA 4IF8A 4RSQA 5C98A 4GA7A 3R4LA 2WY1A 3UT3A 2RIVA 1NQ9I 1E05I 4C41A 1OVAB 1WZ9A 1HP7A 2PEEA 2QUGA
chains in the Genus database with same CATH superfamily
8APIA 3CVMA 1IZ2A 3DY0A 2HIJL 4EB1I 1YXAA 1A7CA 4G8RA 3F02A 4YIAA 5BRRI 1OO8A 1OVAC 2ZNHA 3NDAA 2WXZC 1TB6I 3CAAA 2WXWA 1LJ5A 1AZXI 1E04I 2XN5A 1DZGL 3VVJA 3EVJI 1ATHA 5HGCA 4ZK3A 4AU2A 4P0FA 1LQ8A 4AU4A 1UHGA 2H4PA 2PEFA 9APIA 2ARQA 1ATTA 5IO1A 4G8OA 5CDXA 2ACHA 3NDDA 4AJUA 1IMVA 1AS4A 1OC0A 1XQGA 1OYHI 2B4XL 2ANTI 1OVAA 2GD4C 4ROAA 2XN3A 3Q03A 1MTPA 1T1FA 4Y40A 2RIWA 2BEHI 1XU8A 1JMJA 3Q02A 1ANTI 3PZFA 4DTEA 5INWA 4R9IA 1DVMA 1JJOC 3F5NA 1KCTA 3B9FI 1JRRA 1PSIA 1E03I 1M93B 1R1LI 2HI9A 3H5CA 4DY7C 2H4RA 3PB1I 4AFXA 4IC0A 4ZK0A 2HIJI 3FGQA 5CE0A 3KCGI 1JTIA 3OZQA 2DUTA 9PAIA 2WXZA 4AU3B 1XQJA 1OYHL 4P0OA 1OPHA 2D26A 1D5SA 1DB2A 1DZGI 2H4QA 3LW2A 3CWMA 1DZHI 1SNGA 1LK6I 4DY0A 3DLWA 2ARRA 4C49A 1K9OI 1JMOA 3F1SA 4EB1L 4CAAA 4X30A 1QLPA 2WY0C 1JVQI 1C8OA 2B4XI 1QMBA 2ZV6A 3CWLA 4KDSA 2VDXA 4Y3KA 1F0CA 1EZXA 3DRMA 1SR5A 4AJTA 5EI0A 2OL2A 2OAYA 3NDFA 5CDZA 1ATUA 2XN6A 2R9YA 2V95A 2XN7A 1HLEA 1DVNA 4AU3A 1C5GA 2WXXA 3DRUA 3NE4A 3T1PA 4RO9A 2B5TI 1B3KA 1BY7A 2VDYA 4AQHA 3STOA 1BR8I 3ZHAA 2VH4A 4PYWA 2BEHL 1SEKA 1DZHL 2WXYC 3EOXA 4BB2A 2CEOA 1QMNA 3LE2A 4ROBA 7APIA 4IF8A 4RSQA 5C98A 4GA7A 3R4LA 2WY1A 3UT3A 2RIVA 1NQ9I 1E05I 4C41A 1OVAB 1WZ9A 1HP7A 2PEEA 2QUGA
chains in the Genus database with same CATH topology
8APIA 3CVMA 1IZ2A 3DY0A 2HIJL 4EB1I 1YXAA 1A7CA 4G8RA 3F02A 4YIAA 5BRRI 1OO8A 1OVAC 2ZNHA 3NDAA 2WXZC 1TB6I 3CAAA 2WXWA 1LJ5A 1AZXI 1E04I 2XN5A 1DZGL 3VVJA 3EVJI 1ATHA 5HGCA 4ZK3A 4AU2A 4P0FA 1LQ8A 4AU4A 1UHGA 2H4PA 2PEFA 9APIA 2ARQA 1ATTA 5IO1A 4G8OA 5CDXA 2ACHA 3NDDA 4AJUA 1IMVA 1AS4A 1OC0A 1XQGA 1OYHI 2B4XL 2ANTI 1OVAA 2GD4C 4ROAA 2XN3A 3Q03A 1MTPA 1T1FA 4Y40A 2RIWA 2BEHI 1XU8A 1JMJA 3Q02A 1ANTI 3PZFA 4DTEA 5INWA 4R9IA 1DVMA 1JJOC 3F5NA 1KCTA 3B9FI 1JRRA 1PSIA 1E03I 1M93B 1R1LI 2HI9A 3H5CA 4DY7C 2H4RA 3PB1I 4AFXA 4IC0A 4ZK0A 2HIJI 3FGQA 5CE0A 3KCGI 1JTIA 3OZQA 2DUTA 9PAIA 2WXZA 4AU3B 1XQJA 1OYHL 4P0OA 1OPHA 2D26A 1D5SA 1DB2A 1DZGI 2H4QA 3LW2A 3CWMA 1DZHI 1SNGA 1LK6I 4DY0A 3DLWA 2ARRA 4C49A 1K9OI 1JMOA 3F1SA 4EB1L 4CAAA 4X30A 1QLPA 2WY0C 1JVQI 1C8OA 2B4XI 1QMBA 2ZV6A 3CWLA 4KDSA 2VDXA 4Y3KA 1F0CA 1EZXA 3DRMA 1SR5A 4AJTA 5EI0A 2OL2A 2OAYA 3NDFA 5CDZA 1ATUA 2XN6A 2R9YA 2V95A 2XN7A 1HLEA 1DVNA 4AU3A 1C5GA 2WXXA 3DRUA 3NE4A 3T1PA 4RO9A 2B5TI 1B3KA 1BY7A 2VDYA 4AQHA 3STOA 1BR8I 3ZHAA 2VH4A 4PYWA 2BEHL 1SEKA 1DZHL 2WXYC 3EOXA 4BB2A 2CEOA 1QMNA 3LE2A 4ROBA 7APIA 4IF8A 4RSQA 5C98A 4GA7A 3R4LA 2WY1A 3UT3A 2RIVA 1NQ9I 1E05I 4C41A 1OVAB 1WZ9A 1HP7A 2PEEA 2QUGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 8API A;  3CVM A;  1IZ2 A;  3DY0 A;  2HIJ L;  4EB1 I;  1YXA A;  1A7C A;  4G8R A;  3F02 A;  4YIA A;  5BRR I;  1OO8 A;  1OVA C;  2ZNH A;  3NDA A;  2WXZ C;  1TB6 I;  3CAA A;  2WXW A;  1LJ5 A;  1AZX I;  1E04 I;  2XN5 A;  1DZG L;  3VVJ A;  3EVJ I;  1ATH A;  5HGC A;  4ZK3 A;  4AU2 A;  4P0F A;  1LQ8 A;  4AU4 A;  1UHG A;  2H4P A;  2PEF A;  9API A;  2ARQ A;  1ATT A;  5IO1 A;  4G8O A;  5CDX A;  2ACH A;  3NDD A;  4AJU A;  1IMV A;  1AS4 A;  1OC0 A;  1XQG A;  1OYH I;  2B4X L;  2ANT I;  1OVA A;  2GD4 C;  4ROA A;  2XN3 A;  3Q03 A;  1MTP A;  1T1F A;  4Y40 A;  2RIW A;  2BEH I;  1XU8 A;  1JMJ A;  3Q02 A;  1ANT I;  3PZF A;  4DTE A;  5INW A;  4R9I A;  1DVM A;  1JJO C;  3F5N A;  1KCT A;  3B9F I;  1JRR A;  1PSI A;  1E03 I;  1M93 B;  1R1L I;  2HI9 A;  3H5C A;  4DY7 C;  2H4R A;  3PB1 I;  4AFX A;  4IC0 A;  4ZK0 A;  2HIJ I;  3FGQ A;  5CE0 A;  3KCG I;  1JTI A;  3OZQ A;  2DUT A;  9PAI A;  2WXZ A;  4AU3 B;  1XQJ A;  1OYH L;  4P0O A;  1OPH A;  2D26 A;  1D5S A;  1DB2 A;  1DZG I;  2H4Q A;  3LW2 A;  3CWM A;  1DZH I;  1SNG A;  1LK6 I;  4DY0 A;  3DLW A;  2ARR A;  4C49 A;  1K9O I;  1JMO A;  3F1S A;  4EB1 L;  4CAA A;  4X30 A;  1QLP A;  2WY0 C;  1JVQ I;  1C8O A;  2B4X I;  1QMB A;  2ZV6 A;  3CWL A;  4KDS A;  2VDX A;  4Y3K A;  1F0C A;  1EZX A;  3DRM A;  1SR5 A;  4AJT A;  5EI0 A;  2OL2 A;  2OAY A;  3NDF A;  5CDZ A;  1ATU A;  2XN6 A;  2R9Y A;  2V95 A;  2XN7 A;  1HLE A;  1DVN A;  4AU3 A;  1C5G A;  2WXX A;  3DRU A;  3NE4 A;  3T1P A;  4RO9 A;  2B5T I;  1B3K A;  1BY7 A;  2VDY A;  4AQH A;  3STO A;  1BR8 I;  3ZHA A;  2VH4 A;  4PYW A;  2BEH L;  1SEK A;  1DZH L;  2WXY C;  3EOX A;  4BB2 A;  2CEO A;  1QMN A;  3LE2 A;  4ROB A;  7API A;  4IF8 A;  4RSQ A;  5C98 A;  4GA7 A;  3R4L A;  2WY1 A;  3UT3 A;  2RIV A;  1NQ9 I;  1E05 I;  4C41 A;  1OVA B;  1WZ9 A;  1HP7 A;  2PEE A;  2QUG A; 
#chains in the Genus database with same CATH topology
 8API A;  3CVM A;  1IZ2 A;  3DY0 A;  2HIJ L;  4EB1 I;  1YXA A;  1A7C A;  4G8R A;  3F02 A;  4YIA A;  5BRR I;  1OO8 A;  1OVA C;  2ZNH A;  3NDA A;  2WXZ C;  1TB6 I;  3CAA A;  2WXW A;  1LJ5 A;  1AZX I;  1E04 I;  2XN5 A;  1DZG L;  3VVJ A;  3EVJ I;  1ATH A;  5HGC A;  4ZK3 A;  4AU2 A;  4P0F A;  1LQ8 A;  4AU4 A;  1UHG A;  2H4P A;  2PEF A;  9API A;  2ARQ A;  1ATT A;  5IO1 A;  4G8O A;  5CDX A;  2ACH A;  3NDD A;  4AJU A;  1IMV A;  1AS4 A;  1OC0 A;  1XQG A;  1OYH I;  2B4X L;  2ANT I;  1OVA A;  2GD4 C;  4ROA A;  2XN3 A;  3Q03 A;  1MTP A;  1T1F A;  4Y40 A;  2RIW A;  2BEH I;  1XU8 A;  1JMJ A;  3Q02 A;  1ANT I;  3PZF A;  4DTE A;  5INW A;  4R9I A;  1DVM A;  1JJO C;  3F5N A;  1KCT A;  3B9F I;  1JRR A;  1PSI A;  1E03 I;  1M93 B;  1R1L I;  2HI9 A;  3H5C A;  4DY7 C;  2H4R A;  3PB1 I;  4AFX A;  4IC0 A;  4ZK0 A;  2HIJ I;  3FGQ A;  5CE0 A;  3KCG I;  1JTI A;  3OZQ A;  2DUT A;  9PAI A;  2WXZ A;  4AU3 B;  1XQJ A;  1OYH L;  4P0O A;  1OPH A;  2D26 A;  1D5S A;  1DB2 A;  1DZG I;  2H4Q A;  3LW2 A;  3CWM A;  1DZH I;  1SNG A;  1LK6 I;  4DY0 A;  3DLW A;  2ARR A;  4C49 A;  1K9O I;  1JMO A;  3F1S A;  4EB1 L;  4CAA A;  4X30 A;  1QLP A;  2WY0 C;  1JVQ I;  1C8O A;  2B4X I;  1QMB A;  2ZV6 A;  3CWL A;  4KDS A;  2VDX A;  4Y3K A;  1F0C A;  1EZX A;  3DRM A;  1SR5 A;  4AJT A;  5EI0 A;  2OL2 A;  2OAY A;  3NDF A;  5CDZ A;  1ATU A;  2XN6 A;  2R9Y A;  2V95 A;  2XN7 A;  1HLE A;  1DVN A;  4AU3 A;  1C5G A;  2WXX A;  3DRU A;  3NE4 A;  3T1P A;  4RO9 A;  2B5T I;  1B3K A;  1BY7 A;  2VDY A;  4AQH A;  3STO A;  1BR8 I;  3ZHA A;  2VH4 A;  4PYW A;  2BEH L;  1SEK A;  1DZH L;  2WXY C;  3EOX A;  4BB2 A;  2CEO A;  1QMN A;  3LE2 A;  4ROB A;  7API A;  4IF8 A;  4RSQ A;  5C98 A;  4GA7 A;  3R4L A;  2WY1 A;  3UT3 A;  2RIV A;  1NQ9 I;  1E05 I;  4C41 A;  1OVA B;  1WZ9 A;  1HP7 A;  2PEE A;  2QUG A; 
#chains in the Genus database with same CATH homology
 8API A;  3CVM A;  1IZ2 A;  3DY0 A;  2HIJ L;  4EB1 I;  1YXA A;  1A7C A;  4G8R A;  3F02 A;  4YIA A;  5BRR I;  1OO8 A;  1OVA C;  2ZNH A;  3NDA A;  2WXZ C;  1TB6 I;  3CAA A;  2WXW A;  1LJ5 A;  1AZX I;  1E04 I;  2XN5 A;  1DZG L;  3VVJ A;  3EVJ I;  1ATH A;  5HGC A;  4ZK3 A;  4AU2 A;  4P0F A;  1LQ8 A;  4AU4 A;  1UHG A;  2H4P A;  2PEF A;  9API A;  2ARQ A;  1ATT A;  5IO1 A;  4G8O A;  5CDX A;  2ACH A;  3NDD A;  4AJU A;  1IMV A;  1AS4 A;  1OC0 A;  1XQG A;  1OYH I;  2B4X L;  2ANT I;  1OVA A;  2GD4 C;  4ROA A;  2XN3 A;  3Q03 A;  1MTP A;  1T1F A;  4Y40 A;  2RIW A;  2BEH I;  1XU8 A;  1JMJ A;  3Q02 A;  1ANT I;  3PZF A;  4DTE A;  5INW A;  4R9I A;  1DVM A;  1JJO C;  3F5N A;  1KCT A;  3B9F I;  1JRR A;  1PSI A;  1E03 I;  1M93 B;  1R1L I;  2HI9 A;  3H5C A;  4DY7 C;  2H4R A;  3PB1 I;  4AFX A;  4IC0 A;  4ZK0 A;  2HIJ I;  3FGQ A;  5CE0 A;  3KCG I;  1JTI A;  3OZQ A;  2DUT A;  9PAI A;  2WXZ A;  4AU3 B;  1XQJ A;  1OYH L;  4P0O A;  1OPH A;  2D26 A;  1D5S A;  1DB2 A;  1DZG I;  2H4Q A;  3LW2 A;  3CWM A;  1DZH I;  1SNG A;  1LK6 I;  4DY0 A;  3DLW A;  2ARR A;  4C49 A;  1K9O I;  1JMO A;  3F1S A;  4EB1 L;  4CAA A;  4X30 A;  1QLP A;  2WY0 C;  1JVQ I;  1C8O A;  2B4X I;  1QMB A;  2ZV6 A;  3CWL A;  4KDS A;  2VDX A;  4Y3K A;  1F0C A;  1EZX A;  3DRM A;  1SR5 A;  4AJT A;  5EI0 A;  2OL2 A;  2OAY A;  3NDF A;  5CDZ A;  1ATU A;  2XN6 A;  2R9Y A;  2V95 A;  2XN7 A;  1HLE A;  1DVN A;  4AU3 A;  1C5G A;  2WXX A;  3DRU A;  3NE4 A;  3T1P A;  4RO9 A;  2B5T I;  1B3K A;  1BY7 A;  2VDY A;  4AQH A;  3STO A;  1BR8 I;  3ZHA A;  2VH4 A;  4PYW A;  2BEH L;  1SEK A;  1DZH L;  2WXY C;  3EOX A;  4BB2 A;  2CEO A;  1QMN A;  3LE2 A;  4ROB A;  7API A;  4IF8 A;  4RSQ A;  5C98 A;  4GA7 A;  3R4L A;  2WY1 A;  3UT3 A;  2RIV A;  1NQ9 I;  1E05 I;  4C41 A;  1OVA B;  1WZ9 A;  1HP7 A;  2PEE A;  2QUG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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