8APIA

The s variant of human alpha1-antitrypsin, structure and implications for function and metabolism
Total Genus 95
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
95
sequence length
340
structure length
340
Chain Sequence
DHPTFNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLEAIPM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Proteinase inhibitor
molecule keywords ALPHA-1 ANTITRYPSIN (CHAIN A)
publication title The S variant of human alpha 1-antitrypsin, structure and implications for function and metabolism.
pubmed doi rcsb
total genus 95
structure length 340
sequence length 340
ec nomenclature
pdb deposition date 1988-09-08
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 8apiA01
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 8apiA02
5CDXA 2B4XL 2B4XI 2V95A 5EI0A 1JVQI 2D26A 5CE0A 1JTIA 8APIA 2WXZC 4DY0A 1DVMA 3PB1I 1AS4A 4AQHA 4ROAA 1PSIA 4ZK0A 2VDYA 3Q02A 3NDDA 1OPHA 1ATUA 1YXAA 1SEKA 3F02A 4AFXA 5C98A 1EZXA 3B9FI 1OVAB 4C41A 4GA7A 1ATTA 1B3KA 1LK6I 2H4QA 4Y3KA 2WY0C 3CWLA 3NDFA 4G8OA 5BRRI 2CEOA 1DZHI 4RO9A 3NE4A 1JJOC 1WZ9A 1K9OI 5IO1A 2WXZA 4EB1L 4EB1I 3DRMA 2DUTA 3DY0A 2XN5A 4X30A 1OVAC 3NDAA 2ACHA 1D5SA 1BY7A 3H5CA 2H4RA 2RIWA 4RSQA 5CDZA 1HLEA 1A7CA 2XN3A 2WXWA 4P0FA 1SR5A 1OO8A 3LE2A 1LJ5A 4YIAA 5INWA 1XQGA 2ZV6A 1HP7A 2B5TI 1E03I 1QMNA 4R9IA 2ARQA 3Q03A 2PEEA 1C8OA 2BEHI 2BEHL 1QMBA 2XN6A 3FGQA 1KCTA 4ROBA 4AU3B 1JMJA 1ATHA 1IMVA 2HI9A 2PEFA 2WXXA 2HIJI 1SNGA 2HIJL 4Y40A 2WXYC 4AJUA 1F0CA 1DB2A 3EVJI 1OVAA 9PAIA 3DLWA 1DVNA 2VH4A 2RIVA 4ZK3A 1AZXI 4G8RA 1ANTI 2VDXA 4AU4A 1E05I 1C5GA 2R9YA 3OZQA 4AU2A 4C49A 3CWMA 4CAAA 1LQ8A 3VVJA 3ZHAA 3F5NA 1E04I 9APIA 1UHGA 2XN7A 3PZFA 1TB6I 2OAYA 3LW2A 3STOA 4DY7C 1M93B 1IZ2A 4KDSA 2OL2A 2WY1A 1JMOA 2ZNHA 1MTPA 3CAAA 4IC0A 3EOXA 3R4LA 1OC0A 1JRRA 1R1LI 1XQJA 1DZGI 2H4PA 3T1PA 4BB2A 4PYWA 1OYHI 1OYHL 1BR8I 4IF8A 7APIA 1QLPA 3DRUA 2ARRA 2GD4C 4DTEA 4AU3A 3CVMA 4AJTA 3KCGI 2QUGA 4P0OA 5HGCA 3F1SA 2ANTI 3UT3A 1T1FA 1DZGL 1XU8A 1NQ9I 1DZHL
chains in the Genus database with same CATH superfamily
5CDXA 2B4XL 2B4XI 2V95A 5EI0A 1JVQI 2D26A 5CE0A 1JTIA 8APIA 2WXZC 4DY0A 1DVMA 3PB1I 1AS4A 4AQHA 4ROAA 1PSIA 4ZK0A 2VDYA 3Q02A 3NDDA 1OPHA 1ATUA 1YXAA 1SEKA 3F02A 4AFXA 5C98A 1EZXA 3B9FI 1OVAB 4C41A 4GA7A 1ATTA 1B3KA 1LK6I 2H4QA 4Y3KA 2WY0C 3CWLA 3NDFA 4G8OA 5BRRI 2CEOA 1DZHI 4RO9A 3NE4A 1JJOC 1WZ9A 1K9OI 5IO1A 2WXZA 4EB1L 4EB1I 3DRMA 2DUTA 3DY0A 2XN5A 4X30A 1OVAC 3NDAA 2ACHA 1D5SA 1BY7A 3H5CA 2H4RA 2RIWA 4RSQA 5CDZA 1HLEA 1A7CA 2XN3A 2WXWA 4P0FA 1SR5A 1OO8A 3LE2A 1LJ5A 4YIAA 5INWA 1XQGA 2ZV6A 1HP7A 2B5TI 1E03I 1QMNA 4R9IA 2ARQA 3Q03A 2PEEA 1C8OA 2BEHI 2BEHL 1QMBA 2XN6A 3FGQA 1KCTA 4ROBA 4AU3B 1JMJA 1ATHA 1IMVA 2HI9A 2PEFA 2WXXA 2HIJI 1SNGA 2HIJL 4Y40A 2WXYC 4AJUA 1F0CA 1DB2A 3EVJI 1OVAA 9PAIA 3DLWA 1DVNA 2VH4A 2RIVA 4ZK3A 1AZXI 4G8RA 1ANTI 2VDXA 4AU4A 1E05I 1C5GA 2R9YA 3OZQA 4AU2A 4C49A 3CWMA 4CAAA 1LQ8A 3VVJA 3ZHAA 3F5NA 1E04I 9APIA 1UHGA 2XN7A 3PZFA 1TB6I 2OAYA 3LW2A 3STOA 4DY7C 1M93B 1IZ2A 4KDSA 2OL2A 2WY1A 1JMOA 2ZNHA 1MTPA 3CAAA 4IC0A 3EOXA 3R4LA 1OC0A 1JRRA 1R1LI 1XQJA 1DZGI 2H4PA 3T1PA 4BB2A 4PYWA 1OYHI 1OYHL 1BR8I 4IF8A 7APIA 1QLPA 3DRUA 2ARRA 2GD4C 4DTEA 4AU3A 3CVMA 4AJTA 3KCGI 2QUGA 4P0OA 5HGCA 3F1SA 2ANTI 3UT3A 1T1FA 1DZGL 1XU8A 1NQ9I 1DZHL
chains in the Genus database with same CATH topology
5CDXA 2B4XL 2B4XI 2V95A 5EI0A 1JVQI 2D26A 5CE0A 1JTIA 8APIA 2WXZC 4DY0A 1DVMA 3PB1I 1AS4A 4AQHA 4ROAA 1PSIA 4ZK0A 2VDYA 3Q02A 3NDDA 1OPHA 1ATUA 1YXAA 1SEKA 3F02A 4AFXA 5C98A 1EZXA 3B9FI 1OVAB 4C41A 4GA7A 1ATTA 1B3KA 1LK6I 2H4QA 4Y3KA 2WY0C 3CWLA 3NDFA 4G8OA 5BRRI 2CEOA 1DZHI 4RO9A 3NE4A 1JJOC 1WZ9A 1K9OI 5IO1A 2WXZA 4EB1L 4EB1I 3DRMA 2DUTA 3DY0A 2XN5A 4X30A 1OVAC 3NDAA 2ACHA 1D5SA 1BY7A 3H5CA 2H4RA 2RIWA 4RSQA 5CDZA 1HLEA 1A7CA 2XN3A 2WXWA 4P0FA 1SR5A 1OO8A 3LE2A 1LJ5A 4YIAA 5INWA 1XQGA 2ZV6A 1HP7A 2B5TI 1E03I 1QMNA 4R9IA 2ARQA 3Q03A 2PEEA 1C8OA 2BEHI 2BEHL 1QMBA 2XN6A 3FGQA 1KCTA 4ROBA 4AU3B 1JMJA 1ATHA 1IMVA 2HI9A 2PEFA 2WXXA 2HIJI 1SNGA 2HIJL 4Y40A 2WXYC 4AJUA 1F0CA 1DB2A 3EVJI 1OVAA 9PAIA 3DLWA 1DVNA 2VH4A 2RIVA 4ZK3A 1AZXI 4G8RA 1ANTI 2VDXA 4AU4A 1E05I 1C5GA 2R9YA 3OZQA 4AU2A 4C49A 3CWMA 4CAAA 1LQ8A 3VVJA 3ZHAA 3F5NA 1E04I 9APIA 1UHGA 2XN7A 3PZFA 1TB6I 2OAYA 3LW2A 3STOA 4DY7C 1M93B 1IZ2A 4KDSA 2OL2A 2WY1A 1JMOA 2ZNHA 1MTPA 3CAAA 4IC0A 3EOXA 3R4LA 1OC0A 1JRRA 1R1LI 1XQJA 1DZGI 2H4PA 3T1PA 4BB2A 4PYWA 1OYHI 1OYHL 1BR8I 4IF8A 7APIA 1QLPA 3DRUA 2ARRA 2GD4C 4DTEA 4AU3A 3CVMA 4AJTA 3KCGI 2QUGA 4P0OA 5HGCA 3F1SA 2ANTI 3UT3A 1T1FA 1DZGL 1XU8A 1NQ9I 1DZHL
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5CDX A;  2B4X L;  2B4X I;  2V95 A;  5EI0 A;  1JVQ I;  2D26 A;  5CE0 A;  1JTI A;  8API A;  2WXZ C;  4DY0 A;  1DVM A;  3PB1 I;  1AS4 A;  4AQH A;  4ROA A;  1PSI A;  4ZK0 A;  2VDY A;  3Q02 A;  3NDD A;  1OPH A;  1ATU A;  1YXA A;  1SEK A;  3F02 A;  4AFX A;  5C98 A;  1EZX A;  3B9F I;  1OVA B;  4C41 A;  4GA7 A;  1ATT A;  1B3K A;  1LK6 I;  2H4Q A;  4Y3K A;  2WY0 C;  3CWL A;  3NDF A;  4G8O A;  5BRR I;  2CEO A;  1DZH I;  4RO9 A;  3NE4 A;  1JJO C;  1WZ9 A;  1K9O I;  5IO1 A;  2WXZ A;  4EB1 L;  4EB1 I;  3DRM A;  2DUT A;  3DY0 A;  2XN5 A;  4X30 A;  1OVA C;  3NDA A;  2ACH A;  1D5S A;  1BY7 A;  3H5C A;  2H4R A;  2RIW A;  4RSQ A;  5CDZ A;  1HLE A;  1A7C A;  2XN3 A;  2WXW A;  4P0F A;  1SR5 A;  1OO8 A;  3LE2 A;  1LJ5 A;  4YIA A;  5INW A;  1XQG A;  2ZV6 A;  1HP7 A;  2B5T I;  1E03 I;  1QMN A;  4R9I A;  2ARQ A;  3Q03 A;  2PEE A;  1C8O A;  2BEH I;  2BEH L;  1QMB A;  2XN6 A;  3FGQ A;  1KCT A;  4ROB A;  4AU3 B;  1JMJ A;  1ATH A;  1IMV A;  2HI9 A;  2PEF A;  2WXX A;  2HIJ I;  1SNG A;  2HIJ L;  4Y40 A;  2WXY C;  4AJU A;  1F0C A;  1DB2 A;  3EVJ I;  1OVA A;  9PAI A;  3DLW A;  1DVN A;  2VH4 A;  2RIV A;  4ZK3 A;  1AZX I;  4G8R A;  1ANT I;  2VDX A;  4AU4 A;  1E05 I;  1C5G A;  2R9Y A;  3OZQ A;  4AU2 A;  4C49 A;  3CWM A;  4CAA A;  1LQ8 A;  3VVJ A;  3ZHA A;  3F5N A;  1E04 I;  9API A;  1UHG A;  2XN7 A;  3PZF A;  1TB6 I;  2OAY A;  3LW2 A;  3STO A;  4DY7 C;  1M93 B;  1IZ2 A;  4KDS A;  2OL2 A;  2WY1 A;  1JMO A;  2ZNH A;  1MTP A;  3CAA A;  4IC0 A;  3EOX A;  3R4L A;  1OC0 A;  1JRR A;  1R1L I;  1XQJ A;  1DZG I;  2H4P A;  3T1P A;  4BB2 A;  4PYW A;  1OYH I;  1OYH L;  1BR8 I;  4IF8 A;  7API A;  1QLP A;  3DRU A;  2ARR A;  2GD4 C;  4DTE A;  4AU3 A;  3CVM A;  4AJT A;  3KCG I;  2QUG A;  4P0O A;  5HGC A;  3F1S A;  2ANT I;  3UT3 A;  1T1F A;  1DZG L;  1XU8 A;  1NQ9 I;  1DZH L; 
#chains in the Genus database with same CATH topology
 5CDX A;  2B4X L;  2B4X I;  2V95 A;  5EI0 A;  1JVQ I;  2D26 A;  5CE0 A;  1JTI A;  8API A;  2WXZ C;  4DY0 A;  1DVM A;  3PB1 I;  1AS4 A;  4AQH A;  4ROA A;  1PSI A;  4ZK0 A;  2VDY A;  3Q02 A;  3NDD A;  1OPH A;  1ATU A;  1YXA A;  1SEK A;  3F02 A;  4AFX A;  5C98 A;  1EZX A;  3B9F I;  1OVA B;  4C41 A;  4GA7 A;  1ATT A;  1B3K A;  1LK6 I;  2H4Q A;  4Y3K A;  2WY0 C;  3CWL A;  3NDF A;  4G8O A;  5BRR I;  2CEO A;  1DZH I;  4RO9 A;  3NE4 A;  1JJO C;  1WZ9 A;  1K9O I;  5IO1 A;  2WXZ A;  4EB1 L;  4EB1 I;  3DRM A;  2DUT A;  3DY0 A;  2XN5 A;  4X30 A;  1OVA C;  3NDA A;  2ACH A;  1D5S A;  1BY7 A;  3H5C A;  2H4R A;  2RIW A;  4RSQ A;  5CDZ A;  1HLE A;  1A7C A;  2XN3 A;  2WXW A;  4P0F A;  1SR5 A;  1OO8 A;  3LE2 A;  1LJ5 A;  4YIA A;  5INW A;  1XQG A;  2ZV6 A;  1HP7 A;  2B5T I;  1E03 I;  1QMN A;  4R9I A;  2ARQ A;  3Q03 A;  2PEE A;  1C8O A;  2BEH I;  2BEH L;  1QMB A;  2XN6 A;  3FGQ A;  1KCT A;  4ROB A;  4AU3 B;  1JMJ A;  1ATH A;  1IMV A;  2HI9 A;  2PEF A;  2WXX A;  2HIJ I;  1SNG A;  2HIJ L;  4Y40 A;  2WXY C;  4AJU A;  1F0C A;  1DB2 A;  3EVJ I;  1OVA A;  9PAI A;  3DLW A;  1DVN A;  2VH4 A;  2RIV A;  4ZK3 A;  1AZX I;  4G8R A;  1ANT I;  2VDX A;  4AU4 A;  1E05 I;  1C5G A;  2R9Y A;  3OZQ A;  4AU2 A;  4C49 A;  3CWM A;  4CAA A;  1LQ8 A;  3VVJ A;  3ZHA A;  3F5N A;  1E04 I;  9API A;  1UHG A;  2XN7 A;  3PZF A;  1TB6 I;  2OAY A;  3LW2 A;  3STO A;  4DY7 C;  1M93 B;  1IZ2 A;  4KDS A;  2OL2 A;  2WY1 A;  1JMO A;  2ZNH A;  1MTP A;  3CAA A;  4IC0 A;  3EOX A;  3R4L A;  1OC0 A;  1JRR A;  1R1L I;  1XQJ A;  1DZG I;  2H4P A;  3T1P A;  4BB2 A;  4PYW A;  1OYH I;  1OYH L;  1BR8 I;  4IF8 A;  7API A;  1QLP A;  3DRU A;  2ARR A;  2GD4 C;  4DTE A;  4AU3 A;  3CVM A;  4AJT A;  3KCG I;  2QUG A;  4P0O A;  5HGC A;  3F1S A;  2ANT I;  3UT3 A;  1T1F A;  1DZG L;  1XU8 A;  1NQ9 I;  1DZH L; 
#chains in the Genus database with same CATH homology
 5CDX A;  2B4X L;  2B4X I;  2V95 A;  5EI0 A;  1JVQ I;  2D26 A;  5CE0 A;  1JTI A;  8API A;  2WXZ C;  4DY0 A;  1DVM A;  3PB1 I;  1AS4 A;  4AQH A;  4ROA A;  1PSI A;  4ZK0 A;  2VDY A;  3Q02 A;  3NDD A;  1OPH A;  1ATU A;  1YXA A;  1SEK A;  3F02 A;  4AFX A;  5C98 A;  1EZX A;  3B9F I;  1OVA B;  4C41 A;  4GA7 A;  1ATT A;  1B3K A;  1LK6 I;  2H4Q A;  4Y3K A;  2WY0 C;  3CWL A;  3NDF A;  4G8O A;  5BRR I;  2CEO A;  1DZH I;  4RO9 A;  3NE4 A;  1JJO C;  1WZ9 A;  1K9O I;  5IO1 A;  2WXZ A;  4EB1 L;  4EB1 I;  3DRM A;  2DUT A;  3DY0 A;  2XN5 A;  4X30 A;  1OVA C;  3NDA A;  2ACH A;  1D5S A;  1BY7 A;  3H5C A;  2H4R A;  2RIW A;  4RSQ A;  5CDZ A;  1HLE A;  1A7C A;  2XN3 A;  2WXW A;  4P0F A;  1SR5 A;  1OO8 A;  3LE2 A;  1LJ5 A;  4YIA A;  5INW A;  1XQG A;  2ZV6 A;  1HP7 A;  2B5T I;  1E03 I;  1QMN A;  4R9I A;  2ARQ A;  3Q03 A;  2PEE A;  1C8O A;  2BEH I;  2BEH L;  1QMB A;  2XN6 A;  3FGQ A;  1KCT A;  4ROB A;  4AU3 B;  1JMJ A;  1ATH A;  1IMV A;  2HI9 A;  2PEF A;  2WXX A;  2HIJ I;  1SNG A;  2HIJ L;  4Y40 A;  2WXY C;  4AJU A;  1F0C A;  1DB2 A;  3EVJ I;  1OVA A;  9PAI A;  3DLW A;  1DVN A;  2VH4 A;  2RIV A;  4ZK3 A;  1AZX I;  4G8R A;  1ANT I;  2VDX A;  4AU4 A;  1E05 I;  1C5G A;  2R9Y A;  3OZQ A;  4AU2 A;  4C49 A;  3CWM A;  4CAA A;  1LQ8 A;  3VVJ A;  3ZHA A;  3F5N A;  1E04 I;  9API A;  1UHG A;  2XN7 A;  3PZF A;  1TB6 I;  2OAY A;  3LW2 A;  3STO A;  4DY7 C;  1M93 B;  1IZ2 A;  4KDS A;  2OL2 A;  2WY1 A;  1JMO A;  2ZNH A;  1MTP A;  3CAA A;  4IC0 A;  3EOX A;  3R4L A;  1OC0 A;  1JRR A;  1R1L I;  1XQJ A;  1DZG I;  2H4P A;  3T1P A;  4BB2 A;  4PYW A;  1OYH I;  1OYH L;  1BR8 I;  4IF8 A;  7API A;  1QLP A;  3DRU A;  2ARR A;  2GD4 C;  4DTE A;  4AU3 A;  3CVM A;  4AJT A;  3KCG I;  2QUG A;  4P0O A;  5HGC A;  3F1S A;  2ANT I;  3UT3 A;  1T1F A;  1DZG L;  1XU8 A;  1NQ9 I;  1DZH L; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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