3ZHAA

Molecular basis for the action of the collagen-specific chaperone hsp47 serpinh1 and its structure-specific client recognition.
Total Genus 115
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
115
sequence length
386
structure length
380
Chain Sequence
MLSPKAATLAERSAGLAFSLYQAMAKDQAVENILLSPVVVASSLGLVSLGGKATTASQAKAVLSAEQLRDEEVHAGLGELLRSLSVTWKLGSRLYGPSSVSFAEDFVRSSKQHYNCEHSKINFRDKRSALQSINEWAAQTTDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVTMMHRTGLYNYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKIWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFEWDTEGNPFDQDIYGREELRSPKLFYADHPFIFLVRDTQSGSLLFIGRLVRPKGDKMRDELLE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Molecular Basis for the Action of the Collagen-Specific Chaperone Hsp47/Serpinh1 and its Structure-Specific Client Recognition.
pubmed doi rcsb
molecule keywords HSP47
molecule tags Chaperone
source organism Canis lupus familiaris
total genus 115
structure length 380
sequence length 386
chains with identical sequence B, C, D, K, L, P, Q
ec nomenclature
pdb deposition date 2012-12-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 3zhaA02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 3zhaA01
2WXYC 4X30A 3DRMA 1QMBA 3CWLA 1OPHA 4ZK0A 3LE2A 1WZ9A 1ATUA 4R9IA 4YIAA 1JTIA 3LW2A 2BEHL 2PEFA 5CDZA 1DZHI 4RSQA 2WXWA 1HLEA 1R1LI 5HGCA 3UT3A 4RO9A 1XQGA 3EVJI 2ZNHA 2PEEA 2RIVA 1T1FA 2VDYA 4AFXA 4KDSA 3NDFA 3R4LA 3DRUA 1ANTI 1BY7A 1E05I 1JVQI 3FGQA 3OZQA 2BEHI 2XN6A 2ARRA 1DZGL 3EOXA 1JMJA 1SNGA 2ARQA 2B4XL 1LK6I 3F5NA 1IMVA 4AQHA 2WXXA 2VDXA 1SEKA 2XN3A 1M93B 2V95A 2ZV6A 2D26A 1QMNA 1BR8I 4P0OA 5INWA 1QLPA 4PYWA 3STOA 1DZGI 3DY0A 4GA7A 1DVMA 1NQ9I 4IC0A 2RIWA 4ZK3A 3B9FI 2B4XI 2GD4C 1JJOC 1E03I 1HP7A 1TB6I 2DUTA 2QUGA 7APIA 9APIA 3Q03A 4Y40A 1A7CA 4AU3A 5BRRI 5CE0A 4C41A 1XU8A 3NDAA 4AU2A 2OAYA 2VH4A 4C49A 2R9YA 2WY0C 3H5CA 4BB2A 1PSIA 1OO8A 1YXAA 1DB2A 1OVAC 1SR5A 1OC0A 3CVMA 3KCGI 3PZFA 3CAAA 3NDDA 4DY0A 3PB1I 3NE4A 8APIA 1OYHL 1B3KA 3DLWA 9PAIA 3F02A 4Y3KA 2H4RA 1OVAA 1LJ5A 1E04I 2XN7A 4AJUA 4CAAA 5C98A 3VVJA 2CEOA 2WXZC 2B5TI 4AU4A 1ATHA 1JRRA 3ZHAA 4AU3B 1OYHI 1DVNA 2WY1A 4AJTA 4IF8A 2ACHA 2H4QA 4EB1L 3CWMA 5CDXA 2HI9A 1LQ8A 2HIJL 2WXZA 1MTPA 1JMOA 1K9OI 2H4PA 4DY7C 1C8OA 1C5GA 2XN5A 5EI0A 2ANTI 1AS4A 4G8RA 2OL2A 4ROBA 1OVAB 4P0FA 4G8OA 4EB1I 1F0CA 1KCTA 2HIJI 1XQJA 4ROAA 5IO1A 3Q02A 1ATTA 1IZ2A 4DTEA 1DZHL 3F1SA 1D5SA 1EZXA 1AZXI 3T1PA 1UHGA
chains in the Genus database with same CATH superfamily
2WXYC 4X30A 3DRMA 1QMBA 3CWLA 1OPHA 4ZK0A 3LE2A 1WZ9A 1ATUA 4R9IA 4YIAA 1JTIA 3LW2A 2BEHL 2PEFA 5CDZA 1DZHI 4RSQA 2WXWA 1HLEA 1R1LI 5HGCA 3UT3A 4RO9A 1XQGA 3EVJI 2ZNHA 2PEEA 2RIVA 1T1FA 2VDYA 4AFXA 4KDSA 3NDFA 3R4LA 3DRUA 1ANTI 1BY7A 1E05I 1JVQI 3FGQA 3OZQA 2BEHI 2XN6A 2ARRA 1DZGL 3EOXA 1JMJA 1SNGA 2ARQA 2B4XL 1LK6I 3F5NA 1IMVA 4AQHA 2WXXA 2VDXA 1SEKA 2XN3A 1M93B 2V95A 2ZV6A 2D26A 1QMNA 1BR8I 4P0OA 5INWA 1QLPA 4PYWA 3STOA 1DZGI 3DY0A 4GA7A 1DVMA 1NQ9I 4IC0A 2RIWA 4ZK3A 3B9FI 2B4XI 2GD4C 1JJOC 1E03I 1HP7A 1TB6I 2DUTA 2QUGA 7APIA 9APIA 3Q03A 4Y40A 1A7CA 4AU3A 5BRRI 5CE0A 4C41A 1XU8A 3NDAA 4AU2A 2OAYA 2VH4A 4C49A 2R9YA 2WY0C 3H5CA 4BB2A 1PSIA 1OO8A 1YXAA 1DB2A 1OVAC 1SR5A 1OC0A 3CVMA 3KCGI 3PZFA 3CAAA 3NDDA 4DY0A 3PB1I 3NE4A 8APIA 1OYHL 1B3KA 3DLWA 9PAIA 3F02A 4Y3KA 2H4RA 1OVAA 1LJ5A 1E04I 2XN7A 4AJUA 4CAAA 5C98A 3VVJA 2CEOA 2WXZC 2B5TI 4AU4A 1ATHA 1JRRA 3ZHAA 4AU3B 1OYHI 1DVNA 2WY1A 4AJTA 4IF8A 2ACHA 2H4QA 4EB1L 3CWMA 5CDXA 2HI9A 1LQ8A 2HIJL 2WXZA 1MTPA 1JMOA 1K9OI 2H4PA 4DY7C 1C8OA 1C5GA 2XN5A 5EI0A 2ANTI 1AS4A 4G8RA 2OL2A 4ROBA 1OVAB 4P0FA 4G8OA 4EB1I 1F0CA 1KCTA 2HIJI 1XQJA 4ROAA 5IO1A 3Q02A 1ATTA 1IZ2A 4DTEA 1DZHL 3F1SA 1D5SA 1EZXA 1AZXI 3T1PA 1UHGA
chains in the Genus database with same CATH topology
2WXYC 4X30A 3DRMA 1QMBA 3CWLA 1OPHA 4ZK0A 3LE2A 1WZ9A 1ATUA 4R9IA 4YIAA 1JTIA 3LW2A 2BEHL 2PEFA 5CDZA 1DZHI 4RSQA 2WXWA 1HLEA 1R1LI 5HGCA 3UT3A 4RO9A 1XQGA 3EVJI 2ZNHA 2PEEA 2RIVA 1T1FA 2VDYA 4AFXA 4KDSA 3NDFA 3R4LA 3DRUA 1ANTI 1BY7A 1E05I 1JVQI 3FGQA 3OZQA 2BEHI 2XN6A 2ARRA 1DZGL 3EOXA 1JMJA 1SNGA 2ARQA 2B4XL 1LK6I 3F5NA 1IMVA 4AQHA 2WXXA 2VDXA 1SEKA 2XN3A 1M93B 2V95A 2ZV6A 2D26A 1QMNA 1BR8I 4P0OA 5INWA 1QLPA 4PYWA 3STOA 1DZGI 3DY0A 4GA7A 1DVMA 1NQ9I 4IC0A 2RIWA 4ZK3A 3B9FI 2B4XI 2GD4C 1JJOC 1E03I 1HP7A 1TB6I 2DUTA 2QUGA 7APIA 9APIA 3Q03A 4Y40A 1A7CA 4AU3A 5BRRI 5CE0A 4C41A 1XU8A 3NDAA 4AU2A 2OAYA 2VH4A 4C49A 2R9YA 2WY0C 3H5CA 4BB2A 1PSIA 1OO8A 1YXAA 1DB2A 1OVAC 1SR5A 1OC0A 3CVMA 3KCGI 3PZFA 3CAAA 3NDDA 4DY0A 3PB1I 3NE4A 8APIA 1OYHL 1B3KA 3DLWA 9PAIA 3F02A 4Y3KA 2H4RA 1OVAA 1LJ5A 1E04I 2XN7A 4AJUA 4CAAA 5C98A 3VVJA 2CEOA 2WXZC 2B5TI 4AU4A 1ATHA 1JRRA 3ZHAA 4AU3B 1OYHI 1DVNA 2WY1A 4AJTA 4IF8A 2ACHA 2H4QA 4EB1L 3CWMA 5CDXA 2HI9A 1LQ8A 2HIJL 2WXZA 1MTPA 1JMOA 1K9OI 2H4PA 4DY7C 1C8OA 1C5GA 2XN5A 5EI0A 2ANTI 1AS4A 4G8RA 2OL2A 4ROBA 1OVAB 4P0FA 4G8OA 4EB1I 1F0CA 1KCTA 2HIJI 1XQJA 4ROAA 5IO1A 3Q02A 1ATTA 1IZ2A 4DTEA 1DZHL 3F1SA 1D5SA 1EZXA 1AZXI 3T1PA 1UHGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2WXY C;  4X30 A;  3DRM A;  1QMB A;  3CWL A;  1OPH A;  4ZK0 A;  3LE2 A;  1WZ9 A;  1ATU A;  4R9I A;  4YIA A;  1JTI A;  3LW2 A;  2BEH L;  2PEF A;  5CDZ A;  1DZH I;  4RSQ A;  2WXW A;  1HLE A;  1R1L I;  5HGC A;  3UT3 A;  4RO9 A;  1XQG A;  3EVJ I;  2ZNH A;  2PEE A;  2RIV A;  1T1F A;  2VDY A;  4AFX A;  4KDS A;  3NDF A;  3R4L A;  3DRU A;  1ANT I;  1BY7 A;  1E05 I;  1JVQ I;  3FGQ A;  3OZQ A;  2BEH I;  2XN6 A;  2ARR A;  1DZG L;  3EOX A;  1JMJ A;  1SNG A;  2ARQ A;  2B4X L;  1LK6 I;  3F5N A;  1IMV A;  4AQH A;  2WXX A;  2VDX A;  1SEK A;  2XN3 A;  1M93 B;  2V95 A;  2ZV6 A;  2D26 A;  1QMN A;  1BR8 I;  4P0O A;  5INW A;  1QLP A;  4PYW A;  3STO A;  1DZG I;  3DY0 A;  4GA7 A;  1DVM A;  1NQ9 I;  4IC0 A;  2RIW A;  4ZK3 A;  3B9F I;  2B4X I;  2GD4 C;  1JJO C;  1E03 I;  1HP7 A;  1TB6 I;  2DUT A;  2QUG A;  7API A;  9API A;  3Q03 A;  4Y40 A;  1A7C A;  4AU3 A;  5BRR I;  5CE0 A;  4C41 A;  1XU8 A;  3NDA A;  4AU2 A;  2OAY A;  2VH4 A;  4C49 A;  2R9Y A;  2WY0 C;  3H5C A;  4BB2 A;  1PSI A;  1OO8 A;  1YXA A;  1DB2 A;  1OVA C;  1SR5 A;  1OC0 A;  3CVM A;  3KCG I;  3PZF A;  3CAA A;  3NDD A;  4DY0 A;  3PB1 I;  3NE4 A;  8API A;  1OYH L;  1B3K A;  3DLW A;  9PAI A;  3F02 A;  4Y3K A;  2H4R A;  1OVA A;  1LJ5 A;  1E04 I;  2XN7 A;  4AJU A;  4CAA A;  5C98 A;  3VVJ A;  2CEO A;  2WXZ C;  2B5T I;  4AU4 A;  1ATH A;  1JRR A;  3ZHA A;  4AU3 B;  1OYH I;  1DVN A;  2WY1 A;  4AJT A;  4IF8 A;  2ACH A;  2H4Q A;  4EB1 L;  3CWM A;  5CDX A;  2HI9 A;  1LQ8 A;  2HIJ L;  2WXZ A;  1MTP A;  1JMO A;  1K9O I;  2H4P A;  4DY7 C;  1C8O A;  1C5G A;  2XN5 A;  5EI0 A;  2ANT I;  1AS4 A;  4G8R A;  2OL2 A;  4ROB A;  1OVA B;  4P0F A;  4G8O A;  4EB1 I;  1F0C A;  1KCT A;  2HIJ I;  1XQJ A;  4ROA A;  5IO1 A;  3Q02 A;  1ATT A;  1IZ2 A;  4DTE A;  1DZH L;  3F1S A;  1D5S A;  1EZX A;  1AZX I;  3T1P A;  1UHG A; 
#chains in the Genus database with same CATH topology
 2WXY C;  4X30 A;  3DRM A;  1QMB A;  3CWL A;  1OPH A;  4ZK0 A;  3LE2 A;  1WZ9 A;  1ATU A;  4R9I A;  4YIA A;  1JTI A;  3LW2 A;  2BEH L;  2PEF A;  5CDZ A;  1DZH I;  4RSQ A;  2WXW A;  1HLE A;  1R1L I;  5HGC A;  3UT3 A;  4RO9 A;  1XQG A;  3EVJ I;  2ZNH A;  2PEE A;  2RIV A;  1T1F A;  2VDY A;  4AFX A;  4KDS A;  3NDF A;  3R4L A;  3DRU A;  1ANT I;  1BY7 A;  1E05 I;  1JVQ I;  3FGQ A;  3OZQ A;  2BEH I;  2XN6 A;  2ARR A;  1DZG L;  3EOX A;  1JMJ A;  1SNG A;  2ARQ A;  2B4X L;  1LK6 I;  3F5N A;  1IMV A;  4AQH A;  2WXX A;  2VDX A;  1SEK A;  2XN3 A;  1M93 B;  2V95 A;  2ZV6 A;  2D26 A;  1QMN A;  1BR8 I;  4P0O A;  5INW A;  1QLP A;  4PYW A;  3STO A;  1DZG I;  3DY0 A;  4GA7 A;  1DVM A;  1NQ9 I;  4IC0 A;  2RIW A;  4ZK3 A;  3B9F I;  2B4X I;  2GD4 C;  1JJO C;  1E03 I;  1HP7 A;  1TB6 I;  2DUT A;  2QUG A;  7API A;  9API A;  3Q03 A;  4Y40 A;  1A7C A;  4AU3 A;  5BRR I;  5CE0 A;  4C41 A;  1XU8 A;  3NDA A;  4AU2 A;  2OAY A;  2VH4 A;  4C49 A;  2R9Y A;  2WY0 C;  3H5C A;  4BB2 A;  1PSI A;  1OO8 A;  1YXA A;  1DB2 A;  1OVA C;  1SR5 A;  1OC0 A;  3CVM A;  3KCG I;  3PZF A;  3CAA A;  3NDD A;  4DY0 A;  3PB1 I;  3NE4 A;  8API A;  1OYH L;  1B3K A;  3DLW A;  9PAI A;  3F02 A;  4Y3K A;  2H4R A;  1OVA A;  1LJ5 A;  1E04 I;  2XN7 A;  4AJU A;  4CAA A;  5C98 A;  3VVJ A;  2CEO A;  2WXZ C;  2B5T I;  4AU4 A;  1ATH A;  1JRR A;  3ZHA A;  4AU3 B;  1OYH I;  1DVN A;  2WY1 A;  4AJT A;  4IF8 A;  2ACH A;  2H4Q A;  4EB1 L;  3CWM A;  5CDX A;  2HI9 A;  1LQ8 A;  2HIJ L;  2WXZ A;  1MTP A;  1JMO A;  1K9O I;  2H4P A;  4DY7 C;  1C8O A;  1C5G A;  2XN5 A;  5EI0 A;  2ANT I;  1AS4 A;  4G8R A;  2OL2 A;  4ROB A;  1OVA B;  4P0F A;  4G8O A;  4EB1 I;  1F0C A;  1KCT A;  2HIJ I;  1XQJ A;  4ROA A;  5IO1 A;  3Q02 A;  1ATT A;  1IZ2 A;  4DTE A;  1DZH L;  3F1S A;  1D5S A;  1EZX A;  1AZX I;  3T1P A;  1UHG A; 
#chains in the Genus database with same CATH homology
 2WXY C;  4X30 A;  3DRM A;  1QMB A;  3CWL A;  1OPH A;  4ZK0 A;  3LE2 A;  1WZ9 A;  1ATU A;  4R9I A;  4YIA A;  1JTI A;  3LW2 A;  2BEH L;  2PEF A;  5CDZ A;  1DZH I;  4RSQ A;  2WXW A;  1HLE A;  1R1L I;  5HGC A;  3UT3 A;  4RO9 A;  1XQG A;  3EVJ I;  2ZNH A;  2PEE A;  2RIV A;  1T1F A;  2VDY A;  4AFX A;  4KDS A;  3NDF A;  3R4L A;  3DRU A;  1ANT I;  1BY7 A;  1E05 I;  1JVQ I;  3FGQ A;  3OZQ A;  2BEH I;  2XN6 A;  2ARR A;  1DZG L;  3EOX A;  1JMJ A;  1SNG A;  2ARQ A;  2B4X L;  1LK6 I;  3F5N A;  1IMV A;  4AQH A;  2WXX A;  2VDX A;  1SEK A;  2XN3 A;  1M93 B;  2V95 A;  2ZV6 A;  2D26 A;  1QMN A;  1BR8 I;  4P0O A;  5INW A;  1QLP A;  4PYW A;  3STO A;  1DZG I;  3DY0 A;  4GA7 A;  1DVM A;  1NQ9 I;  4IC0 A;  2RIW A;  4ZK3 A;  3B9F I;  2B4X I;  2GD4 C;  1JJO C;  1E03 I;  1HP7 A;  1TB6 I;  2DUT A;  2QUG A;  7API A;  9API A;  3Q03 A;  4Y40 A;  1A7C A;  4AU3 A;  5BRR I;  5CE0 A;  4C41 A;  1XU8 A;  3NDA A;  4AU2 A;  2OAY A;  2VH4 A;  4C49 A;  2R9Y A;  2WY0 C;  3H5C A;  4BB2 A;  1PSI A;  1OO8 A;  1YXA A;  1DB2 A;  1OVA C;  1SR5 A;  1OC0 A;  3CVM A;  3KCG I;  3PZF A;  3CAA A;  3NDD A;  4DY0 A;  3PB1 I;  3NE4 A;  8API A;  1OYH L;  1B3K A;  3DLW A;  9PAI A;  3F02 A;  4Y3K A;  2H4R A;  1OVA A;  1LJ5 A;  1E04 I;  2XN7 A;  4AJU A;  4CAA A;  5C98 A;  3VVJ A;  2CEO A;  2WXZ C;  2B5T I;  4AU4 A;  1ATH A;  1JRR A;  3ZHA A;  4AU3 B;  1OYH I;  1DVN A;  2WY1 A;  4AJT A;  4IF8 A;  2ACH A;  2H4Q A;  4EB1 L;  3CWM A;  5CDX A;  2HI9 A;  1LQ8 A;  2HIJ L;  2WXZ A;  1MTP A;  1JMO A;  1K9O I;  2H4P A;  4DY7 C;  1C8O A;  1C5G A;  2XN5 A;  5EI0 A;  2ANT I;  1AS4 A;  4G8R A;  2OL2 A;  4ROB A;  1OVA B;  4P0F A;  4G8O A;  4EB1 I;  1F0C A;  1KCT A;  2HIJ I;  1XQJ A;  4ROA A;  5IO1 A;  3Q02 A;  1ATT A;  1IZ2 A;  4DTE A;  1DZH L;  3F1S A;  1D5S A;  1EZX A;  1AZX I;  3T1P A;  1UHG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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