4DY0A

Crystal structure of native protease nexin-1 with heparin
Total Genus 110
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
110
sequence length
377
structure length
362
Chain Sequence
FNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITTNLHVSHILQKAKIEVSEDGTRSSPPWFIVDRPFLFFIRHNPTGAVLFMGQINKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism.
pubmed doi rcsb
molecule keywords Glia-derived nexin
molecule tags Hydrolase inhibitor
source organism Homo sapiens
total genus 110
structure length 362
sequence length 377
chains with identical sequence B
ec nomenclature
pdb deposition date 2012-02-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4dy0A02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4dy0A01
2XN7A 4RO9A 2WXXA 2WY1A 2VDXA 1DZGL 1D5SA 3LE2A 1LK6I 2BEHI 3OZQA 1ANTI 1M93B 1AS4A 1EZXA 2WXYC 4GA7A 5IO1A 2ARRA 1HP7A 2OL2A 2HIJI 1JTIA 2R9YA 2WXZA 2XN5A 2ARQA 4IF8A 8APIA 3B9FI 3T1PA 1QMNA 1ATUA 5BRRI 4EB1L 2VDYA 2RIVA 4P0OA 1JMOA 4C49A 1AZXI 4AU2A 3DY0A 3NE4A 4Y3KA 2ACHA 4BB2A 2D26A 2ZV6A 4G8RA 4PYWA 2PEEA 4DY7C 4AU4A 3UT3A 2WXZC 3DLWA 3CVMA 1NQ9I 1OVAB 2B4XI 3Q03A 1WZ9A 1UHGA 4ROBA 1QMBA 5C98A 2HI9A 7APIA 3NDFA 2OAYA 4KDSA 4YIAA 1IZ2A 1DZHI 1OVAC 3CWLA 4C41A 3EOXA 1SEKA 1DVNA 1JVQI 2PEFA 4DTEA 1ATTA 1QLPA 2BEHL 2H4RA 3F02A 1XQJA 2H4QA 2HIJL 4ZK3A 4AJTA 1XQGA 3KCGI 1E03I 5HGCA 1ATHA 5INWA 1T1FA 1XU8A 4R9IA 1YXAA 9APIA 2V95A 3LW2A 1DZGI 1OO8A 3FGQA 4ROAA 4RSQA 3VVJA 3DRMA 2ANTI 1MTPA 3PZFA 4CAAA 9PAIA 4Y40A 1OPHA 5CDZA 2CEOA 3H5CA 1F0CA 1JRRA 3R4LA 1E05I 3F1SA 3F5NA 4EB1I 1IMVA 1TB6I 2B4XL 1OYHI 1K9OI 1JMJA 1DB2A 3PB1I 5CE0A 1LJ5A 3DRUA 2XN6A 5EI0A 3CWMA 5CDXA 4P0FA 3CAAA 3NDDA 4DY0A 1HLEA 1BY7A 1E04I 2B5TI 2H4PA 2VH4A 1JJOC 1OC0A 4ZK0A 4G8OA 1BR8I 4X30A 1DVMA 1DZHL 3Q02A 1A7CA 4AFXA 4AJUA 2QUGA 4AQHA 1LQ8A 1OYHL 1SR5A 3NDAA 2GD4C 4AU3A 2RIWA 2WY0C 3EVJI 1R1LI 1C5GA 2DUTA 1SNGA 1C8OA 2XN3A 1PSIA 3STOA 4AU3B 1B3KA 2ZNHA 4IC0A 2WXWA 1OVAA 3ZHAA 1KCTA
chains in the Genus database with same CATH superfamily
2XN7A 4RO9A 2WXXA 2WY1A 2VDXA 1DZGL 1D5SA 3LE2A 1LK6I 2BEHI 3OZQA 1ANTI 1M93B 1AS4A 1EZXA 2WXYC 4GA7A 5IO1A 2ARRA 1HP7A 2OL2A 2HIJI 1JTIA 2R9YA 2WXZA 2XN5A 2ARQA 4IF8A 8APIA 3B9FI 3T1PA 1QMNA 1ATUA 5BRRI 4EB1L 2VDYA 2RIVA 4P0OA 1JMOA 4C49A 1AZXI 4AU2A 3DY0A 3NE4A 4Y3KA 2ACHA 4BB2A 2D26A 2ZV6A 4G8RA 4PYWA 2PEEA 4DY7C 4AU4A 3UT3A 2WXZC 3DLWA 3CVMA 1NQ9I 1OVAB 2B4XI 3Q03A 1WZ9A 1UHGA 4ROBA 1QMBA 5C98A 2HI9A 7APIA 3NDFA 2OAYA 4KDSA 4YIAA 1IZ2A 1DZHI 1OVAC 3CWLA 4C41A 3EOXA 1SEKA 1DVNA 1JVQI 2PEFA 4DTEA 1ATTA 1QLPA 2BEHL 2H4RA 3F02A 1XQJA 2H4QA 2HIJL 4ZK3A 4AJTA 1XQGA 3KCGI 1E03I 5HGCA 1ATHA 5INWA 1T1FA 1XU8A 4R9IA 1YXAA 9APIA 2V95A 3LW2A 1DZGI 1OO8A 3FGQA 4ROAA 4RSQA 3VVJA 3DRMA 2ANTI 1MTPA 3PZFA 4CAAA 9PAIA 4Y40A 1OPHA 5CDZA 2CEOA 3H5CA 1F0CA 1JRRA 3R4LA 1E05I 3F1SA 3F5NA 4EB1I 1IMVA 1TB6I 2B4XL 1OYHI 1K9OI 1JMJA 1DB2A 3PB1I 5CE0A 1LJ5A 3DRUA 2XN6A 5EI0A 3CWMA 5CDXA 4P0FA 3CAAA 3NDDA 4DY0A 1HLEA 1BY7A 1E04I 2B5TI 2H4PA 2VH4A 1JJOC 1OC0A 4ZK0A 4G8OA 1BR8I 4X30A 1DVMA 1DZHL 3Q02A 1A7CA 4AFXA 4AJUA 2QUGA 4AQHA 1LQ8A 1OYHL 1SR5A 3NDAA 2GD4C 4AU3A 2RIWA 2WY0C 3EVJI 1R1LI 1C5GA 2DUTA 1SNGA 1C8OA 2XN3A 1PSIA 3STOA 4AU3B 1B3KA 2ZNHA 4IC0A 2WXWA 1OVAA 3ZHAA 1KCTA
chains in the Genus database with same CATH topology
2XN7A 4RO9A 2WXXA 2WY1A 2VDXA 1DZGL 1D5SA 3LE2A 1LK6I 2BEHI 3OZQA 1ANTI 1M93B 1AS4A 1EZXA 2WXYC 4GA7A 5IO1A 2ARRA 1HP7A 2OL2A 2HIJI 1JTIA 2R9YA 2WXZA 2XN5A 2ARQA 4IF8A 8APIA 3B9FI 3T1PA 1QMNA 1ATUA 5BRRI 4EB1L 2VDYA 2RIVA 4P0OA 1JMOA 4C49A 1AZXI 4AU2A 3DY0A 3NE4A 4Y3KA 2ACHA 4BB2A 2D26A 2ZV6A 4G8RA 4PYWA 2PEEA 4DY7C 4AU4A 3UT3A 2WXZC 3DLWA 3CVMA 1NQ9I 1OVAB 2B4XI 3Q03A 1WZ9A 1UHGA 4ROBA 1QMBA 5C98A 2HI9A 7APIA 3NDFA 2OAYA 4KDSA 4YIAA 1IZ2A 1DZHI 1OVAC 3CWLA 4C41A 3EOXA 1SEKA 1DVNA 1JVQI 2PEFA 4DTEA 1ATTA 1QLPA 2BEHL 2H4RA 3F02A 1XQJA 2H4QA 2HIJL 4ZK3A 4AJTA 1XQGA 3KCGI 1E03I 5HGCA 1ATHA 5INWA 1T1FA 1XU8A 4R9IA 1YXAA 9APIA 2V95A 3LW2A 1DZGI 1OO8A 3FGQA 4ROAA 4RSQA 3VVJA 3DRMA 2ANTI 1MTPA 3PZFA 4CAAA 9PAIA 4Y40A 1OPHA 5CDZA 2CEOA 3H5CA 1F0CA 1JRRA 3R4LA 1E05I 3F1SA 3F5NA 4EB1I 1IMVA 1TB6I 2B4XL 1OYHI 1K9OI 1JMJA 1DB2A 3PB1I 5CE0A 1LJ5A 3DRUA 2XN6A 5EI0A 3CWMA 5CDXA 4P0FA 3CAAA 3NDDA 4DY0A 1HLEA 1BY7A 1E04I 2B5TI 2H4PA 2VH4A 1JJOC 1OC0A 4ZK0A 4G8OA 1BR8I 4X30A 1DVMA 1DZHL 3Q02A 1A7CA 4AFXA 4AJUA 2QUGA 4AQHA 1LQ8A 1OYHL 1SR5A 3NDAA 2GD4C 4AU3A 2RIWA 2WY0C 3EVJI 1R1LI 1C5GA 2DUTA 1SNGA 1C8OA 2XN3A 1PSIA 3STOA 4AU3B 1B3KA 2ZNHA 4IC0A 2WXWA 1OVAA 3ZHAA 1KCTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XN7 A;  4RO9 A;  2WXX A;  2WY1 A;  2VDX A;  1DZG L;  1D5S A;  3LE2 A;  1LK6 I;  2BEH I;  3OZQ A;  1ANT I;  1M93 B;  1AS4 A;  1EZX A;  2WXY C;  4GA7 A;  5IO1 A;  2ARR A;  1HP7 A;  2OL2 A;  2HIJ I;  1JTI A;  2R9Y A;  2WXZ A;  2XN5 A;  2ARQ A;  4IF8 A;  8API A;  3B9F I;  3T1P A;  1QMN A;  1ATU A;  5BRR I;  4EB1 L;  2VDY A;  2RIV A;  4P0O A;  1JMO A;  4C49 A;  1AZX I;  4AU2 A;  3DY0 A;  3NE4 A;  4Y3K A;  2ACH A;  4BB2 A;  2D26 A;  2ZV6 A;  4G8R A;  4PYW A;  2PEE A;  4DY7 C;  4AU4 A;  3UT3 A;  2WXZ C;  3DLW A;  3CVM A;  1NQ9 I;  1OVA B;  2B4X I;  3Q03 A;  1WZ9 A;  1UHG A;  4ROB A;  1QMB A;  5C98 A;  2HI9 A;  7API A;  3NDF A;  2OAY A;  4KDS A;  4YIA A;  1IZ2 A;  1DZH I;  1OVA C;  3CWL A;  4C41 A;  3EOX A;  1SEK A;  1DVN A;  1JVQ I;  2PEF A;  4DTE A;  1ATT A;  1QLP A;  2BEH L;  2H4R A;  3F02 A;  1XQJ A;  2H4Q A;  2HIJ L;  4ZK3 A;  4AJT A;  1XQG A;  3KCG I;  1E03 I;  5HGC A;  1ATH A;  5INW A;  1T1F A;  1XU8 A;  4R9I A;  1YXA A;  9API A;  2V95 A;  3LW2 A;  1DZG I;  1OO8 A;  3FGQ A;  4ROA A;  4RSQ A;  3VVJ A;  3DRM A;  2ANT I;  1MTP A;  3PZF A;  4CAA A;  9PAI A;  4Y40 A;  1OPH A;  5CDZ A;  2CEO A;  3H5C A;  1F0C A;  1JRR A;  3R4L A;  1E05 I;  3F1S A;  3F5N A;  4EB1 I;  1IMV A;  1TB6 I;  2B4X L;  1OYH I;  1K9O I;  1JMJ A;  1DB2 A;  3PB1 I;  5CE0 A;  1LJ5 A;  3DRU A;  2XN6 A;  5EI0 A;  3CWM A;  5CDX A;  4P0F A;  3CAA A;  3NDD A;  4DY0 A;  1HLE A;  1BY7 A;  1E04 I;  2B5T I;  2H4P A;  2VH4 A;  1JJO C;  1OC0 A;  4ZK0 A;  4G8O A;  1BR8 I;  4X30 A;  1DVM A;  1DZH L;  3Q02 A;  1A7C A;  4AFX A;  4AJU A;  2QUG A;  4AQH A;  1LQ8 A;  1OYH L;  1SR5 A;  3NDA A;  2GD4 C;  4AU3 A;  2RIW A;  2WY0 C;  3EVJ I;  1R1L I;  1C5G A;  2DUT A;  1SNG A;  1C8O A;  2XN3 A;  1PSI A;  3STO A;  4AU3 B;  1B3K A;  2ZNH A;  4IC0 A;  2WXW A;  1OVA A;  3ZHA A;  1KCT A; 
#chains in the Genus database with same CATH topology
 2XN7 A;  4RO9 A;  2WXX A;  2WY1 A;  2VDX A;  1DZG L;  1D5S A;  3LE2 A;  1LK6 I;  2BEH I;  3OZQ A;  1ANT I;  1M93 B;  1AS4 A;  1EZX A;  2WXY C;  4GA7 A;  5IO1 A;  2ARR A;  1HP7 A;  2OL2 A;  2HIJ I;  1JTI A;  2R9Y A;  2WXZ A;  2XN5 A;  2ARQ A;  4IF8 A;  8API A;  3B9F I;  3T1P A;  1QMN A;  1ATU A;  5BRR I;  4EB1 L;  2VDY A;  2RIV A;  4P0O A;  1JMO A;  4C49 A;  1AZX I;  4AU2 A;  3DY0 A;  3NE4 A;  4Y3K A;  2ACH A;  4BB2 A;  2D26 A;  2ZV6 A;  4G8R A;  4PYW A;  2PEE A;  4DY7 C;  4AU4 A;  3UT3 A;  2WXZ C;  3DLW A;  3CVM A;  1NQ9 I;  1OVA B;  2B4X I;  3Q03 A;  1WZ9 A;  1UHG A;  4ROB A;  1QMB A;  5C98 A;  2HI9 A;  7API A;  3NDF A;  2OAY A;  4KDS A;  4YIA A;  1IZ2 A;  1DZH I;  1OVA C;  3CWL A;  4C41 A;  3EOX A;  1SEK A;  1DVN A;  1JVQ I;  2PEF A;  4DTE A;  1ATT A;  1QLP A;  2BEH L;  2H4R A;  3F02 A;  1XQJ A;  2H4Q A;  2HIJ L;  4ZK3 A;  4AJT A;  1XQG A;  3KCG I;  1E03 I;  5HGC A;  1ATH A;  5INW A;  1T1F A;  1XU8 A;  4R9I A;  1YXA A;  9API A;  2V95 A;  3LW2 A;  1DZG I;  1OO8 A;  3FGQ A;  4ROA A;  4RSQ A;  3VVJ A;  3DRM A;  2ANT I;  1MTP A;  3PZF A;  4CAA A;  9PAI A;  4Y40 A;  1OPH A;  5CDZ A;  2CEO A;  3H5C A;  1F0C A;  1JRR A;  3R4L A;  1E05 I;  3F1S A;  3F5N A;  4EB1 I;  1IMV A;  1TB6 I;  2B4X L;  1OYH I;  1K9O I;  1JMJ A;  1DB2 A;  3PB1 I;  5CE0 A;  1LJ5 A;  3DRU A;  2XN6 A;  5EI0 A;  3CWM A;  5CDX A;  4P0F A;  3CAA A;  3NDD A;  4DY0 A;  1HLE A;  1BY7 A;  1E04 I;  2B5T I;  2H4P A;  2VH4 A;  1JJO C;  1OC0 A;  4ZK0 A;  4G8O A;  1BR8 I;  4X30 A;  1DVM A;  1DZH L;  3Q02 A;  1A7C A;  4AFX A;  4AJU A;  2QUG A;  4AQH A;  1LQ8 A;  1OYH L;  1SR5 A;  3NDA A;  2GD4 C;  4AU3 A;  2RIW A;  2WY0 C;  3EVJ I;  1R1L I;  1C5G A;  2DUT A;  1SNG A;  1C8O A;  2XN3 A;  1PSI A;  3STO A;  4AU3 B;  1B3K A;  2ZNH A;  4IC0 A;  2WXW A;  1OVA A;  3ZHA A;  1KCT A; 
#chains in the Genus database with same CATH homology
 2XN7 A;  4RO9 A;  2WXX A;  2WY1 A;  2VDX A;  1DZG L;  1D5S A;  3LE2 A;  1LK6 I;  2BEH I;  3OZQ A;  1ANT I;  1M93 B;  1AS4 A;  1EZX A;  2WXY C;  4GA7 A;  5IO1 A;  2ARR A;  1HP7 A;  2OL2 A;  2HIJ I;  1JTI A;  2R9Y A;  2WXZ A;  2XN5 A;  2ARQ A;  4IF8 A;  8API A;  3B9F I;  3T1P A;  1QMN A;  1ATU A;  5BRR I;  4EB1 L;  2VDY A;  2RIV A;  4P0O A;  1JMO A;  4C49 A;  1AZX I;  4AU2 A;  3DY0 A;  3NE4 A;  4Y3K A;  2ACH A;  4BB2 A;  2D26 A;  2ZV6 A;  4G8R A;  4PYW A;  2PEE A;  4DY7 C;  4AU4 A;  3UT3 A;  2WXZ C;  3DLW A;  3CVM A;  1NQ9 I;  1OVA B;  2B4X I;  3Q03 A;  1WZ9 A;  1UHG A;  4ROB A;  1QMB A;  5C98 A;  2HI9 A;  7API A;  3NDF A;  2OAY A;  4KDS A;  4YIA A;  1IZ2 A;  1DZH I;  1OVA C;  3CWL A;  4C41 A;  3EOX A;  1SEK A;  1DVN A;  1JVQ I;  2PEF A;  4DTE A;  1ATT A;  1QLP A;  2BEH L;  2H4R A;  3F02 A;  1XQJ A;  2H4Q A;  2HIJ L;  4ZK3 A;  4AJT A;  1XQG A;  3KCG I;  1E03 I;  5HGC A;  1ATH A;  5INW A;  1T1F A;  1XU8 A;  4R9I A;  1YXA A;  9API A;  2V95 A;  3LW2 A;  1DZG I;  1OO8 A;  3FGQ A;  4ROA A;  4RSQ A;  3VVJ A;  3DRM A;  2ANT I;  1MTP A;  3PZF A;  4CAA A;  9PAI A;  4Y40 A;  1OPH A;  5CDZ A;  2CEO A;  3H5C A;  1F0C A;  1JRR A;  3R4L A;  1E05 I;  3F1S A;  3F5N A;  4EB1 I;  1IMV A;  1TB6 I;  2B4X L;  1OYH I;  1K9O I;  1JMJ A;  1DB2 A;  3PB1 I;  5CE0 A;  1LJ5 A;  3DRU A;  2XN6 A;  5EI0 A;  3CWM A;  5CDX A;  4P0F A;  3CAA A;  3NDD A;  4DY0 A;  1HLE A;  1BY7 A;  1E04 I;  2B5T I;  2H4P A;  2VH4 A;  1JJO C;  1OC0 A;  4ZK0 A;  4G8O A;  1BR8 I;  4X30 A;  1DVM A;  1DZH L;  3Q02 A;  1A7C A;  4AFX A;  4AJU A;  2QUG A;  4AQH A;  1LQ8 A;  1OYH L;  1SR5 A;  3NDA A;  2GD4 C;  4AU3 A;  2RIW A;  2WY0 C;  3EVJ I;  1R1L I;  1C5G A;  2DUT A;  1SNG A;  1C8O A;  2XN3 A;  1PSI A;  3STO A;  4AU3 B;  1B3K A;  2ZNH A;  4IC0 A;  2WXW A;  1OVA A;  3ZHA A;  1KCT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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