3CVMA

High resolution structure of a stable plasminogen activator inhibitor type-1 in its protease cleaved form
Total Genus 121
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
121
sequence length
380
structure length
377
Chain Sequence
AVHHPPSYVARLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISHLLGTGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVALALQKVKIEVNESGTVASSSTAVIVSAREEIIIDRPFLFVVRHNPTGTVLFMGQVMEP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title High-resolution structure of the stable plasminogen activator inhibitor type-1 variant 14-1B in its proteinase-cleaved form: a new tool for detailed interaction studies and modeling.
pubmed doi rcsb
molecule keywords Plasminogen activator inhibitor 1
molecule tags Blood clotting
source organism Homo sapiens
total genus 121
structure length 377
sequence length 380
chains with identical sequence B
ec nomenclature
pdb deposition date 2008-04-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 3cvmA02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 3cvmA01
4EB1I 4C49A 1JMOA 1XQJA 2H4QA 1ATHA 1OVAB 1WZ9A 5INWA 2WY0C 1T1FA 3Q03A 2BEHL 4GA7A 2XN6A 5EI0A 3F1SA 4AQHA 4ROAA 4DY7C 4Y40A 4AU4A 1AS4A 3R4LA 5CE0A 4G8RA 1QMNA 1D5SA 3PZFA 2WXXA 3NDFA 3Q02A 5CDZA 1ATUA 7APIA 1BY7A 1IZ2A 2OAYA 3DRUA 4G8OA 4CAAA 1DZHI 2GD4C 1OYHL 3ZHAA 1MTPA 5HGCA 2HIJI 1OO8A 1EZXA 3CWMA 3DLWA 3CAAA 2ZNHA 3LW2A 2CEOA 4X30A 2ACHA 4P0OA 1DZGI 1QLPA 2WXWA 2QUGA 1M93B 1B3KA 1OC0A 1TB6I 3NE4A 4Y3KA 3NDAA 8APIA 1DB2A 2ZV6A 4IC0A 1ATTA 3NDDA 5IO1A 9APIA 3CWLA 2BEHI 4ZK3A 4DY0A 2VDXA 4EB1L 5BRRI 1LQ8A 1LJ5A 1HLEA 4KDSA 1IMVA 1XQGA 2VH4A 5C98A 2ARQA 1NQ9I 4BB2A 1OVAA 4DTEA 4AJTA 3LE2A 3B9FI 3EVJI 1DVMA 1LK6I 1K9OI 3UT3A 2XN5A 1F0CA 2XN3A 4ZK0A 2B5TI 4AFXA 4C41A 2B4XL 4ROBA 1JRRA 1E05I 2DUTA 4IF8A 2PEFA 1DZHL 4AU3A 1QMBA 3F5NA 2HIJL 1E03I 1OVAC 2HI9A 3PB1I 1R1LI 2WY1A 2WXZA 2ARRA 2V95A 2VDYA 3CVMA 4YIAA 4AU2A 1E04I 1XU8A 1DZGL 3KCGI 1C8OA 5CDXA 1SNGA 1PSIA 2PEEA 1OPHA 1YXAA 3DY0A 1SEKA 2ANTI 1UHGA 1HP7A 2RIVA 2D26A 1JMJA 4RSQA 2R9YA 1C5GA 3DRMA 1JTIA 3H5CA 4R9IA 1OYHI 2WXYC 2RIWA 4PYWA 2WXZC 3STOA 4P0FA 3OZQA 1JVQI 1KCTA 2H4RA 3VVJA 3FGQA 1A7CA 1AZXI 1SR5A 2XN7A 3T1PA 3F02A 1JJOC 4AU3B 9PAIA 4RO9A 1ANTI 2B4XI 1DVNA 2OL2A 3EOXA 2H4PA 4AJUA 1BR8I
chains in the Genus database with same CATH superfamily
4EB1I 4C49A 1JMOA 1XQJA 2H4QA 1ATHA 1OVAB 1WZ9A 5INWA 2WY0C 1T1FA 3Q03A 2BEHL 4GA7A 2XN6A 5EI0A 3F1SA 4AQHA 4ROAA 4DY7C 4Y40A 4AU4A 1AS4A 3R4LA 5CE0A 4G8RA 1QMNA 1D5SA 3PZFA 2WXXA 3NDFA 3Q02A 5CDZA 1ATUA 7APIA 1BY7A 1IZ2A 2OAYA 3DRUA 4G8OA 4CAAA 1DZHI 2GD4C 1OYHL 3ZHAA 1MTPA 5HGCA 2HIJI 1OO8A 1EZXA 3CWMA 3DLWA 3CAAA 2ZNHA 3LW2A 2CEOA 4X30A 2ACHA 4P0OA 1DZGI 1QLPA 2WXWA 2QUGA 1M93B 1B3KA 1OC0A 1TB6I 3NE4A 4Y3KA 3NDAA 8APIA 1DB2A 2ZV6A 4IC0A 1ATTA 3NDDA 5IO1A 9APIA 3CWLA 2BEHI 4ZK3A 4DY0A 2VDXA 4EB1L 5BRRI 1LQ8A 1LJ5A 1HLEA 4KDSA 1IMVA 1XQGA 2VH4A 5C98A 2ARQA 1NQ9I 4BB2A 1OVAA 4DTEA 4AJTA 3LE2A 3B9FI 3EVJI 1DVMA 1LK6I 1K9OI 3UT3A 2XN5A 1F0CA 2XN3A 4ZK0A 2B5TI 4AFXA 4C41A 2B4XL 4ROBA 1JRRA 1E05I 2DUTA 4IF8A 2PEFA 1DZHL 4AU3A 1QMBA 3F5NA 2HIJL 1E03I 1OVAC 2HI9A 3PB1I 1R1LI 2WY1A 2WXZA 2ARRA 2V95A 2VDYA 3CVMA 4YIAA 4AU2A 1E04I 1XU8A 1DZGL 3KCGI 1C8OA 5CDXA 1SNGA 1PSIA 2PEEA 1OPHA 1YXAA 3DY0A 1SEKA 2ANTI 1UHGA 1HP7A 2RIVA 2D26A 1JMJA 4RSQA 2R9YA 1C5GA 3DRMA 1JTIA 3H5CA 4R9IA 1OYHI 2WXYC 2RIWA 4PYWA 2WXZC 3STOA 4P0FA 3OZQA 1JVQI 1KCTA 2H4RA 3VVJA 3FGQA 1A7CA 1AZXI 1SR5A 2XN7A 3T1PA 3F02A 1JJOC 4AU3B 9PAIA 4RO9A 1ANTI 2B4XI 1DVNA 2OL2A 3EOXA 2H4PA 4AJUA 1BR8I
chains in the Genus database with same CATH topology
4EB1I 4C49A 1JMOA 1XQJA 2H4QA 1ATHA 1OVAB 1WZ9A 5INWA 2WY0C 1T1FA 3Q03A 2BEHL 4GA7A 2XN6A 5EI0A 3F1SA 4AQHA 4ROAA 4DY7C 4Y40A 4AU4A 1AS4A 3R4LA 5CE0A 4G8RA 1QMNA 1D5SA 3PZFA 2WXXA 3NDFA 3Q02A 5CDZA 1ATUA 7APIA 1BY7A 1IZ2A 2OAYA 3DRUA 4G8OA 4CAAA 1DZHI 2GD4C 1OYHL 3ZHAA 1MTPA 5HGCA 2HIJI 1OO8A 1EZXA 3CWMA 3DLWA 3CAAA 2ZNHA 3LW2A 2CEOA 4X30A 2ACHA 4P0OA 1DZGI 1QLPA 2WXWA 2QUGA 1M93B 1B3KA 1OC0A 1TB6I 3NE4A 4Y3KA 3NDAA 8APIA 1DB2A 2ZV6A 4IC0A 1ATTA 3NDDA 5IO1A 9APIA 3CWLA 2BEHI 4ZK3A 4DY0A 2VDXA 4EB1L 5BRRI 1LQ8A 1LJ5A 1HLEA 4KDSA 1IMVA 1XQGA 2VH4A 5C98A 2ARQA 1NQ9I 4BB2A 1OVAA 4DTEA 4AJTA 3LE2A 3B9FI 3EVJI 1DVMA 1LK6I 1K9OI 3UT3A 2XN5A 1F0CA 2XN3A 4ZK0A 2B5TI 4AFXA 4C41A 2B4XL 4ROBA 1JRRA 1E05I 2DUTA 4IF8A 2PEFA 1DZHL 4AU3A 1QMBA 3F5NA 2HIJL 1E03I 1OVAC 2HI9A 3PB1I 1R1LI 2WY1A 2WXZA 2ARRA 2V95A 2VDYA 3CVMA 4YIAA 4AU2A 1E04I 1XU8A 1DZGL 3KCGI 1C8OA 5CDXA 1SNGA 1PSIA 2PEEA 1OPHA 1YXAA 3DY0A 1SEKA 2ANTI 1UHGA 1HP7A 2RIVA 2D26A 1JMJA 4RSQA 2R9YA 1C5GA 3DRMA 1JTIA 3H5CA 4R9IA 1OYHI 2WXYC 2RIWA 4PYWA 2WXZC 3STOA 4P0FA 3OZQA 1JVQI 1KCTA 2H4RA 3VVJA 3FGQA 1A7CA 1AZXI 1SR5A 2XN7A 3T1PA 3F02A 1JJOC 4AU3B 9PAIA 4RO9A 1ANTI 2B4XI 1DVNA 2OL2A 3EOXA 2H4PA 4AJUA 1BR8I
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4EB1 I;  4C49 A;  1JMO A;  1XQJ A;  2H4Q A;  1ATH A;  1OVA B;  1WZ9 A;  5INW A;  2WY0 C;  1T1F A;  3Q03 A;  2BEH L;  4GA7 A;  2XN6 A;  5EI0 A;  3F1S A;  4AQH A;  4ROA A;  4DY7 C;  4Y40 A;  4AU4 A;  1AS4 A;  3R4L A;  5CE0 A;  4G8R A;  1QMN A;  1D5S A;  3PZF A;  2WXX A;  3NDF A;  3Q02 A;  5CDZ A;  1ATU A;  7API A;  1BY7 A;  1IZ2 A;  2OAY A;  3DRU A;  4G8O A;  4CAA A;  1DZH I;  2GD4 C;  1OYH L;  3ZHA A;  1MTP A;  5HGC A;  2HIJ I;  1OO8 A;  1EZX A;  3CWM A;  3DLW A;  3CAA A;  2ZNH A;  3LW2 A;  2CEO A;  4X30 A;  2ACH A;  4P0O A;  1DZG I;  1QLP A;  2WXW A;  2QUG A;  1M93 B;  1B3K A;  1OC0 A;  1TB6 I;  3NE4 A;  4Y3K A;  3NDA A;  8API A;  1DB2 A;  2ZV6 A;  4IC0 A;  1ATT A;  3NDD A;  5IO1 A;  9API A;  3CWL A;  2BEH I;  4ZK3 A;  4DY0 A;  2VDX A;  4EB1 L;  5BRR I;  1LQ8 A;  1LJ5 A;  1HLE A;  4KDS A;  1IMV A;  1XQG A;  2VH4 A;  5C98 A;  2ARQ A;  1NQ9 I;  4BB2 A;  1OVA A;  4DTE A;  4AJT A;  3LE2 A;  3B9F I;  3EVJ I;  1DVM A;  1LK6 I;  1K9O I;  3UT3 A;  2XN5 A;  1F0C A;  2XN3 A;  4ZK0 A;  2B5T I;  4AFX A;  4C41 A;  2B4X L;  4ROB A;  1JRR A;  1E05 I;  2DUT A;  4IF8 A;  2PEF A;  1DZH L;  4AU3 A;  1QMB A;  3F5N A;  2HIJ L;  1E03 I;  1OVA C;  2HI9 A;  3PB1 I;  1R1L I;  2WY1 A;  2WXZ A;  2ARR A;  2V95 A;  2VDY A;  3CVM A;  4YIA A;  4AU2 A;  1E04 I;  1XU8 A;  1DZG L;  3KCG I;  1C8O A;  5CDX A;  1SNG A;  1PSI A;  2PEE A;  1OPH A;  1YXA A;  3DY0 A;  1SEK A;  2ANT I;  1UHG A;  1HP7 A;  2RIV A;  2D26 A;  1JMJ A;  4RSQ A;  2R9Y A;  1C5G A;  3DRM A;  1JTI A;  3H5C A;  4R9I A;  1OYH I;  2WXY C;  2RIW A;  4PYW A;  2WXZ C;  3STO A;  4P0F A;  3OZQ A;  1JVQ I;  1KCT A;  2H4R A;  3VVJ A;  3FGQ A;  1A7C A;  1AZX I;  1SR5 A;  2XN7 A;  3T1P A;  3F02 A;  1JJO C;  4AU3 B;  9PAI A;  4RO9 A;  1ANT I;  2B4X I;  1DVN A;  2OL2 A;  3EOX A;  2H4P A;  4AJU A;  1BR8 I; 
#chains in the Genus database with same CATH topology
 4EB1 I;  4C49 A;  1JMO A;  1XQJ A;  2H4Q A;  1ATH A;  1OVA B;  1WZ9 A;  5INW A;  2WY0 C;  1T1F A;  3Q03 A;  2BEH L;  4GA7 A;  2XN6 A;  5EI0 A;  3F1S A;  4AQH A;  4ROA A;  4DY7 C;  4Y40 A;  4AU4 A;  1AS4 A;  3R4L A;  5CE0 A;  4G8R A;  1QMN A;  1D5S A;  3PZF A;  2WXX A;  3NDF A;  3Q02 A;  5CDZ A;  1ATU A;  7API A;  1BY7 A;  1IZ2 A;  2OAY A;  3DRU A;  4G8O A;  4CAA A;  1DZH I;  2GD4 C;  1OYH L;  3ZHA A;  1MTP A;  5HGC A;  2HIJ I;  1OO8 A;  1EZX A;  3CWM A;  3DLW A;  3CAA A;  2ZNH A;  3LW2 A;  2CEO A;  4X30 A;  2ACH A;  4P0O A;  1DZG I;  1QLP A;  2WXW A;  2QUG A;  1M93 B;  1B3K A;  1OC0 A;  1TB6 I;  3NE4 A;  4Y3K A;  3NDA A;  8API A;  1DB2 A;  2ZV6 A;  4IC0 A;  1ATT A;  3NDD A;  5IO1 A;  9API A;  3CWL A;  2BEH I;  4ZK3 A;  4DY0 A;  2VDX A;  4EB1 L;  5BRR I;  1LQ8 A;  1LJ5 A;  1HLE A;  4KDS A;  1IMV A;  1XQG A;  2VH4 A;  5C98 A;  2ARQ A;  1NQ9 I;  4BB2 A;  1OVA A;  4DTE A;  4AJT A;  3LE2 A;  3B9F I;  3EVJ I;  1DVM A;  1LK6 I;  1K9O I;  3UT3 A;  2XN5 A;  1F0C A;  2XN3 A;  4ZK0 A;  2B5T I;  4AFX A;  4C41 A;  2B4X L;  4ROB A;  1JRR A;  1E05 I;  2DUT A;  4IF8 A;  2PEF A;  1DZH L;  4AU3 A;  1QMB A;  3F5N A;  2HIJ L;  1E03 I;  1OVA C;  2HI9 A;  3PB1 I;  1R1L I;  2WY1 A;  2WXZ A;  2ARR A;  2V95 A;  2VDY A;  3CVM A;  4YIA A;  4AU2 A;  1E04 I;  1XU8 A;  1DZG L;  3KCG I;  1C8O A;  5CDX A;  1SNG A;  1PSI A;  2PEE A;  1OPH A;  1YXA A;  3DY0 A;  1SEK A;  2ANT I;  1UHG A;  1HP7 A;  2RIV A;  2D26 A;  1JMJ A;  4RSQ A;  2R9Y A;  1C5G A;  3DRM A;  1JTI A;  3H5C A;  4R9I A;  1OYH I;  2WXY C;  2RIW A;  4PYW A;  2WXZ C;  3STO A;  4P0F A;  3OZQ A;  1JVQ I;  1KCT A;  2H4R A;  3VVJ A;  3FGQ A;  1A7C A;  1AZX I;  1SR5 A;  2XN7 A;  3T1P A;  3F02 A;  1JJO C;  4AU3 B;  9PAI A;  4RO9 A;  1ANT I;  2B4X I;  1DVN A;  2OL2 A;  3EOX A;  2H4P A;  4AJU A;  1BR8 I; 
#chains in the Genus database with same CATH homology
 4EB1 I;  4C49 A;  1JMO A;  1XQJ A;  2H4Q A;  1ATH A;  1OVA B;  1WZ9 A;  5INW A;  2WY0 C;  1T1F A;  3Q03 A;  2BEH L;  4GA7 A;  2XN6 A;  5EI0 A;  3F1S A;  4AQH A;  4ROA A;  4DY7 C;  4Y40 A;  4AU4 A;  1AS4 A;  3R4L A;  5CE0 A;  4G8R A;  1QMN A;  1D5S A;  3PZF A;  2WXX A;  3NDF A;  3Q02 A;  5CDZ A;  1ATU A;  7API A;  1BY7 A;  1IZ2 A;  2OAY A;  3DRU A;  4G8O A;  4CAA A;  1DZH I;  2GD4 C;  1OYH L;  3ZHA A;  1MTP A;  5HGC A;  2HIJ I;  1OO8 A;  1EZX A;  3CWM A;  3DLW A;  3CAA A;  2ZNH A;  3LW2 A;  2CEO A;  4X30 A;  2ACH A;  4P0O A;  1DZG I;  1QLP A;  2WXW A;  2QUG A;  1M93 B;  1B3K A;  1OC0 A;  1TB6 I;  3NE4 A;  4Y3K A;  3NDA A;  8API A;  1DB2 A;  2ZV6 A;  4IC0 A;  1ATT A;  3NDD A;  5IO1 A;  9API A;  3CWL A;  2BEH I;  4ZK3 A;  4DY0 A;  2VDX A;  4EB1 L;  5BRR I;  1LQ8 A;  1LJ5 A;  1HLE A;  4KDS A;  1IMV A;  1XQG A;  2VH4 A;  5C98 A;  2ARQ A;  1NQ9 I;  4BB2 A;  1OVA A;  4DTE A;  4AJT A;  3LE2 A;  3B9F I;  3EVJ I;  1DVM A;  1LK6 I;  1K9O I;  3UT3 A;  2XN5 A;  1F0C A;  2XN3 A;  4ZK0 A;  2B5T I;  4AFX A;  4C41 A;  2B4X L;  4ROB A;  1JRR A;  1E05 I;  2DUT A;  4IF8 A;  2PEF A;  1DZH L;  4AU3 A;  1QMB A;  3F5N A;  2HIJ L;  1E03 I;  1OVA C;  2HI9 A;  3PB1 I;  1R1L I;  2WY1 A;  2WXZ A;  2ARR A;  2V95 A;  2VDY A;  3CVM A;  4YIA A;  4AU2 A;  1E04 I;  1XU8 A;  1DZG L;  3KCG I;  1C8O A;  5CDX A;  1SNG A;  1PSI A;  2PEE A;  1OPH A;  1YXA A;  3DY0 A;  1SEK A;  2ANT I;  1UHG A;  1HP7 A;  2RIV A;  2D26 A;  1JMJ A;  4RSQ A;  2R9Y A;  1C5G A;  3DRM A;  1JTI A;  3H5C A;  4R9I A;  1OYH I;  2WXY C;  2RIW A;  4PYW A;  2WXZ C;  3STO A;  4P0F A;  3OZQ A;  1JVQ I;  1KCT A;  2H4R A;  3VVJ A;  3FGQ A;  1A7C A;  1AZX I;  1SR5 A;  2XN7 A;  3T1P A;  3F02 A;  1JJO C;  4AU3 B;  9PAI A;  4RO9 A;  1ANT I;  2B4X I;  1DVN A;  2OL2 A;  3EOX A;  2H4P A;  4AJU A;  1BR8 I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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