7APIA

The s variant of human alpha1-antitrypsin, structure and implications for function and metabolism
Total Genus 89
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
89
sequence length
339
structure length
339
Chain Sequence
HPTFNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLEAIPM
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Proteinase inhibitor
molecule keywords ALPHA 1-ANTITRYPSIN
publication title The S variant of human alpha 1-antitrypsin, structure and implications for function and metabolism.
pubmed doi rcsb
source organism Homo sapiens
total genus 89
structure length 339
sequence length 339
ec nomenclature
pdb deposition date 1988-09-08
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 7apiA01
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 7apiA02
1DVNA 1E03I 1ATUA 4PYWA 1DZGI 1JRRA 4RSQA 3NDAA 1MTPA 8APIA 1AS4A 1DVMA 1OVAC 1R1LI 3F02A 1ATTA 1OPHA 1QLPA 2OL2A 4G8RA 4AU2A 1XQJA 4AJUA 1E04I 1QMNA 3H5CA 2R9YA 3PZFA 2PEFA 2ARQA 2WXXA 4DY7C 4AU3B 1OVAB 3T1PA 1KCTA 1PSIA 3R4LA 2ZNHA 1T1FA 2VDXA 3CWMA 3EOXA 2ACHA 2WXWA 3STOA 1JVQI 5CDZA 2XN7A 2OAYA 2XN3A 2WXYC 4EB1I 2PEEA 1DZHI 1DZGL 1DB2A 2B5TI 4C49A 2H4PA 2V95A 2B4XI 1A7CA 5EI0A 1AZXI 3CVMA 3LW2A 3LE2A 2VDYA 4CAAA 1C8OA 1F0CA 4BB2A 1OVAA 1LJ5A 1TB6I 4R9IA 1JMJA 1IZ2A 4AFXA 1E05I 3NDFA 2WXZC 2CEOA 4ROAA 4DY0A 1WZ9A 5BRRI 4IC0A 1OYHL 2BEHL 4EB1L 1SNGA 1DZHL 4IF8A 4RO9A 5IO1A 1ANTI 2RIVA 1JJOC 2ARRA 2B4XL 3DRMA 3NDDA 5HGCA 1HP7A 1BY7A 1IMVA 1BR8I 1EZXA 1JMOA 2HI9A 3DLWA 2RIWA 4AQHA 2XN6A 1YXAA 3CWLA 2XN5A 4P0FA 1LK6I 3FGQA 2ZV6A 1D5SA 1K9OI 1M93B 3EVJI 4AU3A 2WY0C 5CDXA 2H4QA 1HLEA 4G8OA 3F1SA 9PAIA 4X30A 3UT3A 3CAAA 2WY1A 2HIJI 4ZK3A 4Y40A 7APIA 4YIAA 4ROBA 1OC0A 2WXZA 1UHGA 1OO8A 1QMBA 4ZK0A 3VVJA 4AJTA 5CE0A 3NE4A 1JTIA 1ATHA 3OZQA 4P0OA 4KDSA 4GA7A 3B9FI 3DY0A 3ZHAA 1NQ9I 9APIA 3Q02A 5C98A 2QUGA 3DRUA 1B3KA 4Y3KA 2DUTA 1XQGA 5INWA 2GD4C 4AU4A 2BEHI 3KCGI 4DTEA 1LQ8A 3F5NA 2D26A 3Q03A 3PB1I 1C5GA 2ANTI 4C41A 2H4RA 1XU8A 2VH4A 2HIJL 1OYHI 1SR5A 1SEKA
chains in the Genus database with same CATH superfamily
1DVNA 1E03I 1ATUA 4PYWA 1DZGI 1JRRA 4RSQA 3NDAA 1MTPA 8APIA 1AS4A 1DVMA 1OVAC 1R1LI 3F02A 1ATTA 1OPHA 1QLPA 2OL2A 4G8RA 4AU2A 1XQJA 4AJUA 1E04I 1QMNA 3H5CA 2R9YA 3PZFA 2PEFA 2ARQA 2WXXA 4DY7C 4AU3B 1OVAB 3T1PA 1KCTA 1PSIA 3R4LA 2ZNHA 1T1FA 2VDXA 3CWMA 3EOXA 2ACHA 2WXWA 3STOA 1JVQI 5CDZA 2XN7A 2OAYA 2XN3A 2WXYC 4EB1I 2PEEA 1DZHI 1DZGL 1DB2A 2B5TI 4C49A 2H4PA 2V95A 2B4XI 1A7CA 5EI0A 1AZXI 3CVMA 3LW2A 3LE2A 2VDYA 4CAAA 1C8OA 1F0CA 4BB2A 1OVAA 1LJ5A 1TB6I 4R9IA 1JMJA 1IZ2A 4AFXA 1E05I 3NDFA 2WXZC 2CEOA 4ROAA 4DY0A 1WZ9A 5BRRI 4IC0A 1OYHL 2BEHL 4EB1L 1SNGA 1DZHL 4IF8A 4RO9A 5IO1A 1ANTI 2RIVA 1JJOC 2ARRA 2B4XL 3DRMA 3NDDA 5HGCA 1HP7A 1BY7A 1IMVA 1BR8I 1EZXA 1JMOA 2HI9A 3DLWA 2RIWA 4AQHA 2XN6A 1YXAA 3CWLA 2XN5A 4P0FA 1LK6I 3FGQA 2ZV6A 1D5SA 1K9OI 1M93B 3EVJI 4AU3A 2WY0C 5CDXA 2H4QA 1HLEA 4G8OA 3F1SA 9PAIA 4X30A 3UT3A 3CAAA 2WY1A 2HIJI 4ZK3A 4Y40A 7APIA 4YIAA 4ROBA 1OC0A 2WXZA 1UHGA 1OO8A 1QMBA 4ZK0A 3VVJA 4AJTA 5CE0A 3NE4A 1JTIA 1ATHA 3OZQA 4P0OA 4KDSA 4GA7A 3B9FI 3DY0A 3ZHAA 1NQ9I 9APIA 3Q02A 5C98A 2QUGA 3DRUA 1B3KA 4Y3KA 2DUTA 1XQGA 5INWA 2GD4C 4AU4A 2BEHI 3KCGI 4DTEA 1LQ8A 3F5NA 2D26A 3Q03A 3PB1I 1C5GA 2ANTI 4C41A 2H4RA 1XU8A 2VH4A 2HIJL 1OYHI 1SR5A 1SEKA
chains in the Genus database with same CATH topology
1DVNA 1E03I 1ATUA 4PYWA 1DZGI 1JRRA 4RSQA 3NDAA 1MTPA 8APIA 1AS4A 1DVMA 1OVAC 1R1LI 3F02A 1ATTA 1OPHA 1QLPA 2OL2A 4G8RA 4AU2A 1XQJA 4AJUA 1E04I 1QMNA 3H5CA 2R9YA 3PZFA 2PEFA 2ARQA 2WXXA 4DY7C 4AU3B 1OVAB 3T1PA 1KCTA 1PSIA 3R4LA 2ZNHA 1T1FA 2VDXA 3CWMA 3EOXA 2ACHA 2WXWA 3STOA 1JVQI 5CDZA 2XN7A 2OAYA 2XN3A 2WXYC 4EB1I 2PEEA 1DZHI 1DZGL 1DB2A 2B5TI 4C49A 2H4PA 2V95A 2B4XI 1A7CA 5EI0A 1AZXI 3CVMA 3LW2A 3LE2A 2VDYA 4CAAA 1C8OA 1F0CA 4BB2A 1OVAA 1LJ5A 1TB6I 4R9IA 1JMJA 1IZ2A 4AFXA 1E05I 3NDFA 2WXZC 2CEOA 4ROAA 4DY0A 1WZ9A 5BRRI 4IC0A 1OYHL 2BEHL 4EB1L 1SNGA 1DZHL 4IF8A 4RO9A 5IO1A 1ANTI 2RIVA 1JJOC 2ARRA 2B4XL 3DRMA 3NDDA 5HGCA 1HP7A 1BY7A 1IMVA 1BR8I 1EZXA 1JMOA 2HI9A 3DLWA 2RIWA 4AQHA 2XN6A 1YXAA 3CWLA 2XN5A 4P0FA 1LK6I 3FGQA 2ZV6A 1D5SA 1K9OI 1M93B 3EVJI 4AU3A 2WY0C 5CDXA 2H4QA 1HLEA 4G8OA 3F1SA 9PAIA 4X30A 3UT3A 3CAAA 2WY1A 2HIJI 4ZK3A 4Y40A 7APIA 4YIAA 4ROBA 1OC0A 2WXZA 1UHGA 1OO8A 1QMBA 4ZK0A 3VVJA 4AJTA 5CE0A 3NE4A 1JTIA 1ATHA 3OZQA 4P0OA 4KDSA 4GA7A 3B9FI 3DY0A 3ZHAA 1NQ9I 9APIA 3Q02A 5C98A 2QUGA 3DRUA 1B3KA 4Y3KA 2DUTA 1XQGA 5INWA 2GD4C 4AU4A 2BEHI 3KCGI 4DTEA 1LQ8A 3F5NA 2D26A 3Q03A 3PB1I 1C5GA 2ANTI 4C41A 2H4RA 1XU8A 2VH4A 2HIJL 1OYHI 1SR5A 1SEKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DVN A;  1E03 I;  1ATU A;  4PYW A;  1DZG I;  1JRR A;  4RSQ A;  3NDA A;  1MTP A;  8API A;  1AS4 A;  1DVM A;  1OVA C;  1R1L I;  3F02 A;  1ATT A;  1OPH A;  1QLP A;  2OL2 A;  4G8R A;  4AU2 A;  1XQJ A;  4AJU A;  1E04 I;  1QMN A;  3H5C A;  2R9Y A;  3PZF A;  2PEF A;  2ARQ A;  2WXX A;  4DY7 C;  4AU3 B;  1OVA B;  3T1P A;  1KCT A;  1PSI A;  3R4L A;  2ZNH A;  1T1F A;  2VDX A;  3CWM A;  3EOX A;  2ACH A;  2WXW A;  3STO A;  1JVQ I;  5CDZ A;  2XN7 A;  2OAY A;  2XN3 A;  2WXY C;  4EB1 I;  2PEE A;  1DZH I;  1DZG L;  1DB2 A;  2B5T I;  4C49 A;  2H4P A;  2V95 A;  2B4X I;  1A7C A;  5EI0 A;  1AZX I;  3CVM A;  3LW2 A;  3LE2 A;  2VDY A;  4CAA A;  1C8O A;  1F0C A;  4BB2 A;  1OVA A;  1LJ5 A;  1TB6 I;  4R9I A;  1JMJ A;  1IZ2 A;  4AFX A;  1E05 I;  3NDF A;  2WXZ C;  2CEO A;  4ROA A;  4DY0 A;  1WZ9 A;  5BRR I;  4IC0 A;  1OYH L;  2BEH L;  4EB1 L;  1SNG A;  1DZH L;  4IF8 A;  4RO9 A;  5IO1 A;  1ANT I;  2RIV A;  1JJO C;  2ARR A;  2B4X L;  3DRM A;  3NDD A;  5HGC A;  1HP7 A;  1BY7 A;  1IMV A;  1BR8 I;  1EZX A;  1JMO A;  2HI9 A;  3DLW A;  2RIW A;  4AQH A;  2XN6 A;  1YXA A;  3CWL A;  2XN5 A;  4P0F A;  1LK6 I;  3FGQ A;  2ZV6 A;  1D5S A;  1K9O I;  1M93 B;  3EVJ I;  4AU3 A;  2WY0 C;  5CDX A;  2H4Q A;  1HLE A;  4G8O A;  3F1S A;  9PAI A;  4X30 A;  3UT3 A;  3CAA A;  2WY1 A;  2HIJ I;  4ZK3 A;  4Y40 A;  7API A;  4YIA A;  4ROB A;  1OC0 A;  2WXZ A;  1UHG A;  1OO8 A;  1QMB A;  4ZK0 A;  3VVJ A;  4AJT A;  5CE0 A;  3NE4 A;  1JTI A;  1ATH A;  3OZQ A;  4P0O A;  4KDS A;  4GA7 A;  3B9F I;  3DY0 A;  3ZHA A;  1NQ9 I;  9API A;  3Q02 A;  5C98 A;  2QUG A;  3DRU A;  1B3K A;  4Y3K A;  2DUT A;  1XQG A;  5INW A;  2GD4 C;  4AU4 A;  2BEH I;  3KCG I;  4DTE A;  1LQ8 A;  3F5N A;  2D26 A;  3Q03 A;  3PB1 I;  1C5G A;  2ANT I;  4C41 A;  2H4R A;  1XU8 A;  2VH4 A;  2HIJ L;  1OYH I;  1SR5 A;  1SEK A; 
#chains in the Genus database with same CATH topology
 1DVN A;  1E03 I;  1ATU A;  4PYW A;  1DZG I;  1JRR A;  4RSQ A;  3NDA A;  1MTP A;  8API A;  1AS4 A;  1DVM A;  1OVA C;  1R1L I;  3F02 A;  1ATT A;  1OPH A;  1QLP A;  2OL2 A;  4G8R A;  4AU2 A;  1XQJ A;  4AJU A;  1E04 I;  1QMN A;  3H5C A;  2R9Y A;  3PZF A;  2PEF A;  2ARQ A;  2WXX A;  4DY7 C;  4AU3 B;  1OVA B;  3T1P A;  1KCT A;  1PSI A;  3R4L A;  2ZNH A;  1T1F A;  2VDX A;  3CWM A;  3EOX A;  2ACH A;  2WXW A;  3STO A;  1JVQ I;  5CDZ A;  2XN7 A;  2OAY A;  2XN3 A;  2WXY C;  4EB1 I;  2PEE A;  1DZH I;  1DZG L;  1DB2 A;  2B5T I;  4C49 A;  2H4P A;  2V95 A;  2B4X I;  1A7C A;  5EI0 A;  1AZX I;  3CVM A;  3LW2 A;  3LE2 A;  2VDY A;  4CAA A;  1C8O A;  1F0C A;  4BB2 A;  1OVA A;  1LJ5 A;  1TB6 I;  4R9I A;  1JMJ A;  1IZ2 A;  4AFX A;  1E05 I;  3NDF A;  2WXZ C;  2CEO A;  4ROA A;  4DY0 A;  1WZ9 A;  5BRR I;  4IC0 A;  1OYH L;  2BEH L;  4EB1 L;  1SNG A;  1DZH L;  4IF8 A;  4RO9 A;  5IO1 A;  1ANT I;  2RIV A;  1JJO C;  2ARR A;  2B4X L;  3DRM A;  3NDD A;  5HGC A;  1HP7 A;  1BY7 A;  1IMV A;  1BR8 I;  1EZX A;  1JMO A;  2HI9 A;  3DLW A;  2RIW A;  4AQH A;  2XN6 A;  1YXA A;  3CWL A;  2XN5 A;  4P0F A;  1LK6 I;  3FGQ A;  2ZV6 A;  1D5S A;  1K9O I;  1M93 B;  3EVJ I;  4AU3 A;  2WY0 C;  5CDX A;  2H4Q A;  1HLE A;  4G8O A;  3F1S A;  9PAI A;  4X30 A;  3UT3 A;  3CAA A;  2WY1 A;  2HIJ I;  4ZK3 A;  4Y40 A;  7API A;  4YIA A;  4ROB A;  1OC0 A;  2WXZ A;  1UHG A;  1OO8 A;  1QMB A;  4ZK0 A;  3VVJ A;  4AJT A;  5CE0 A;  3NE4 A;  1JTI A;  1ATH A;  3OZQ A;  4P0O A;  4KDS A;  4GA7 A;  3B9F I;  3DY0 A;  3ZHA A;  1NQ9 I;  9API A;  3Q02 A;  5C98 A;  2QUG A;  3DRU A;  1B3K A;  4Y3K A;  2DUT A;  1XQG A;  5INW A;  2GD4 C;  4AU4 A;  2BEH I;  3KCG I;  4DTE A;  1LQ8 A;  3F5N A;  2D26 A;  3Q03 A;  3PB1 I;  1C5G A;  2ANT I;  4C41 A;  2H4R A;  1XU8 A;  2VH4 A;  2HIJ L;  1OYH I;  1SR5 A;  1SEK A; 
#chains in the Genus database with same CATH homology
 1DVN A;  1E03 I;  1ATU A;  4PYW A;  1DZG I;  1JRR A;  4RSQ A;  3NDA A;  1MTP A;  8API A;  1AS4 A;  1DVM A;  1OVA C;  1R1L I;  3F02 A;  1ATT A;  1OPH A;  1QLP A;  2OL2 A;  4G8R A;  4AU2 A;  1XQJ A;  4AJU A;  1E04 I;  1QMN A;  3H5C A;  2R9Y A;  3PZF A;  2PEF A;  2ARQ A;  2WXX A;  4DY7 C;  4AU3 B;  1OVA B;  3T1P A;  1KCT A;  1PSI A;  3R4L A;  2ZNH A;  1T1F A;  2VDX A;  3CWM A;  3EOX A;  2ACH A;  2WXW A;  3STO A;  1JVQ I;  5CDZ A;  2XN7 A;  2OAY A;  2XN3 A;  2WXY C;  4EB1 I;  2PEE A;  1DZH I;  1DZG L;  1DB2 A;  2B5T I;  4C49 A;  2H4P A;  2V95 A;  2B4X I;  1A7C A;  5EI0 A;  1AZX I;  3CVM A;  3LW2 A;  3LE2 A;  2VDY A;  4CAA A;  1C8O A;  1F0C A;  4BB2 A;  1OVA A;  1LJ5 A;  1TB6 I;  4R9I A;  1JMJ A;  1IZ2 A;  4AFX A;  1E05 I;  3NDF A;  2WXZ C;  2CEO A;  4ROA A;  4DY0 A;  1WZ9 A;  5BRR I;  4IC0 A;  1OYH L;  2BEH L;  4EB1 L;  1SNG A;  1DZH L;  4IF8 A;  4RO9 A;  5IO1 A;  1ANT I;  2RIV A;  1JJO C;  2ARR A;  2B4X L;  3DRM A;  3NDD A;  5HGC A;  1HP7 A;  1BY7 A;  1IMV A;  1BR8 I;  1EZX A;  1JMO A;  2HI9 A;  3DLW A;  2RIW A;  4AQH A;  2XN6 A;  1YXA A;  3CWL A;  2XN5 A;  4P0F A;  1LK6 I;  3FGQ A;  2ZV6 A;  1D5S A;  1K9O I;  1M93 B;  3EVJ I;  4AU3 A;  2WY0 C;  5CDX A;  2H4Q A;  1HLE A;  4G8O A;  3F1S A;  9PAI A;  4X30 A;  3UT3 A;  3CAA A;  2WY1 A;  2HIJ I;  4ZK3 A;  4Y40 A;  7API A;  4YIA A;  4ROB A;  1OC0 A;  2WXZ A;  1UHG A;  1OO8 A;  1QMB A;  4ZK0 A;  3VVJ A;  4AJT A;  5CE0 A;  3NE4 A;  1JTI A;  1ATH A;  3OZQ A;  4P0O A;  4KDS A;  4GA7 A;  3B9F I;  3DY0 A;  3ZHA A;  1NQ9 I;  9API A;  3Q02 A;  5C98 A;  2QUG A;  3DRU A;  1B3K A;  4Y3K A;  2DUT A;  1XQG A;  5INW A;  2GD4 C;  4AU4 A;  2BEH I;  3KCG I;  4DTE A;  1LQ8 A;  3F5N A;  2D26 A;  3Q03 A;  3PB1 I;  1C5G A;  2ANT I;  4C41 A;  2H4R A;  1XU8 A;  2VH4 A;  2HIJ L;  1OYH I;  1SR5 A;  1SEK A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...