1R1LI

Structure of dimeric antithrombin complexed with a p14-p9 reactive loop peptide and an exogenous tripeptide (formyl-norleucine-lf)
Total Genus 117
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
117
sequence length
427
structure length
416
Chain Sequence
VDICTAKPRDIPMNPMCIYRSPEKKPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCV
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Serpins and the design of peptides to block intermolecular beta-linkages
rcsb
molecule keywords Antithrombin-III
molecule tags Hydrolase/hydrolase inhibitor
total genus 117
structure length 416
sequence length 427
chains with identical sequence L
ec nomenclature
pdb deposition date 2003-09-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 1r1lI01
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 1r1lI02
3CWLA 2WXYC 3DRUA 5CE0A 1T1FA 2XN7A 2H4PA 9PAIA 1HP7A 1KCTA 2WY1A 1OC0A 4G8OA 2H4RA 1LQ8A 1NQ9I 3OZQA 5IO1A 3NDDA 2PEFA 1JVQI 1F0CA 1SR5A 2ZNHA 1E03I 4ROBA 1ATHA 4Y3KA 2GD4C 4AJUA 4ZK0A 2ZV6A 1QLPA 4P0OA 1WZ9A 1PSIA 4EB1I 4G8RA 2WXXA 4CAAA 1OVAA 1JMJA 4DTEA 1JRRA 3CWMA 2WXZC 3F5NA 5HGCA 4ROAA 1B3KA 1DZHI 2CEOA 3LW2A 4DY0A 3DLWA 4AU3B 1LJ5A 4IC0A 4RSQA 4AFXA 1EZXA 4EB1L 3FGQA 1E05I 1R1LI 2DUTA 4AQHA 4DY7C 5CDXA 3VVJA 1DZGI 4IF8A 2XN6A 2OAYA 1OPHA 4PYWA 1C8OA 3H5CA 3KCGI 2QUGA 2BEHL 4AJTA 1DZHL 3DRMA 1E04I 5C98A 2ARQA 2B4XI 3PB1I 3Q03A 3STOA 1XQGA 2R9YA 1AZXI 1K9OI 1IZ2A 3LE2A 2B5TI 2BEHI 3Q02A 3UT3A 2V95A 8APIA 1QMBA 2OL2A 1XU8A 2HIJI 4Y40A 1DZGL 3F1SA 4AU3A 7APIA 1ATUA 3R4LA 4BB2A 3B9FI 1ATTA 3F02A 1D5SA 2ARRA 2VDYA 2ANTI 4P0FA 1C5GA 1JJOC 4C41A 9APIA 1SNGA 5CDZA 2WXZA 2B4XL 1BR8I 3CVMA 4GA7A 1IMVA 3T1PA 1JMOA 1LK6I 1OVAB 1YXAA 1AS4A 4YIAA 1DB2A 5INWA 1UHGA 4ZK3A 2H4QA 5EI0A 2ACHA 2HIJL 2XN3A 4X30A 3EOXA 1ANTI 2D26A 1JTIA 1OVAC 3PZFA 2WXWA 3NE4A 2VH4A 2RIWA 3CAAA 1OYHI 1OO8A 5BRRI 2WY0C 1QMNA 4KDSA 1A7CA 4R9IA 4C49A 1DVMA 1BY7A 3EVJI 2HI9A 2VDXA 1DVNA 1SEKA 2XN5A 2RIVA 3DY0A 1HLEA 1TB6I 1XQJA 1MTPA 3ZHAA 4RO9A 3NDAA 4AU4A 3NDFA 4AU2A 1M93B 2PEEA 1OYHL
chains in the Genus database with same CATH superfamily
3CWLA 2WXYC 3DRUA 5CE0A 1T1FA 2XN7A 2H4PA 9PAIA 1HP7A 1KCTA 2WY1A 1OC0A 4G8OA 2H4RA 1LQ8A 1NQ9I 3OZQA 5IO1A 3NDDA 2PEFA 1JVQI 1F0CA 1SR5A 2ZNHA 1E03I 4ROBA 1ATHA 4Y3KA 2GD4C 4AJUA 4ZK0A 2ZV6A 1QLPA 4P0OA 1WZ9A 1PSIA 4EB1I 4G8RA 2WXXA 4CAAA 1OVAA 1JMJA 4DTEA 1JRRA 3CWMA 2WXZC 3F5NA 5HGCA 4ROAA 1B3KA 1DZHI 2CEOA 3LW2A 4DY0A 3DLWA 4AU3B 1LJ5A 4IC0A 4RSQA 4AFXA 1EZXA 4EB1L 3FGQA 1E05I 1R1LI 2DUTA 4AQHA 4DY7C 5CDXA 3VVJA 1DZGI 4IF8A 2XN6A 2OAYA 1OPHA 4PYWA 1C8OA 3H5CA 3KCGI 2QUGA 2BEHL 4AJTA 1DZHL 3DRMA 1E04I 5C98A 2ARQA 2B4XI 3PB1I 3Q03A 3STOA 1XQGA 2R9YA 1AZXI 1K9OI 1IZ2A 3LE2A 2B5TI 2BEHI 3Q02A 3UT3A 2V95A 8APIA 1QMBA 2OL2A 1XU8A 2HIJI 4Y40A 1DZGL 3F1SA 4AU3A 7APIA 1ATUA 3R4LA 4BB2A 3B9FI 1ATTA 3F02A 1D5SA 2ARRA 2VDYA 2ANTI 4P0FA 1C5GA 1JJOC 4C41A 9APIA 1SNGA 5CDZA 2WXZA 2B4XL 1BR8I 3CVMA 4GA7A 1IMVA 3T1PA 1JMOA 1LK6I 1OVAB 1YXAA 1AS4A 4YIAA 1DB2A 5INWA 1UHGA 4ZK3A 2H4QA 5EI0A 2ACHA 2HIJL 2XN3A 4X30A 3EOXA 1ANTI 2D26A 1JTIA 1OVAC 3PZFA 2WXWA 3NE4A 2VH4A 2RIWA 3CAAA 1OYHI 1OO8A 5BRRI 2WY0C 1QMNA 4KDSA 1A7CA 4R9IA 4C49A 1DVMA 1BY7A 3EVJI 2HI9A 2VDXA 1DVNA 1SEKA 2XN5A 2RIVA 3DY0A 1HLEA 1TB6I 1XQJA 1MTPA 3ZHAA 4RO9A 3NDAA 4AU4A 3NDFA 4AU2A 1M93B 2PEEA 1OYHL
chains in the Genus database with same CATH topology
3CWLA 2WXYC 3DRUA 5CE0A 1T1FA 2XN7A 2H4PA 9PAIA 1HP7A 1KCTA 2WY1A 1OC0A 4G8OA 2H4RA 1LQ8A 1NQ9I 3OZQA 5IO1A 3NDDA 2PEFA 1JVQI 1F0CA 1SR5A 2ZNHA 1E03I 4ROBA 1ATHA 4Y3KA 2GD4C 4AJUA 4ZK0A 2ZV6A 1QLPA 4P0OA 1WZ9A 1PSIA 4EB1I 4G8RA 2WXXA 4CAAA 1OVAA 1JMJA 4DTEA 1JRRA 3CWMA 2WXZC 3F5NA 5HGCA 4ROAA 1B3KA 1DZHI 2CEOA 3LW2A 4DY0A 3DLWA 4AU3B 1LJ5A 4IC0A 4RSQA 4AFXA 1EZXA 4EB1L 3FGQA 1E05I 1R1LI 2DUTA 4AQHA 4DY7C 5CDXA 3VVJA 1DZGI 4IF8A 2XN6A 2OAYA 1OPHA 4PYWA 1C8OA 3H5CA 3KCGI 2QUGA 2BEHL 4AJTA 1DZHL 3DRMA 1E04I 5C98A 2ARQA 2B4XI 3PB1I 3Q03A 3STOA 1XQGA 2R9YA 1AZXI 1K9OI 1IZ2A 3LE2A 2B5TI 2BEHI 3Q02A 3UT3A 2V95A 8APIA 1QMBA 2OL2A 1XU8A 2HIJI 4Y40A 1DZGL 3F1SA 4AU3A 7APIA 1ATUA 3R4LA 4BB2A 3B9FI 1ATTA 3F02A 1D5SA 2ARRA 2VDYA 2ANTI 4P0FA 1C5GA 1JJOC 4C41A 9APIA 1SNGA 5CDZA 2WXZA 2B4XL 1BR8I 3CVMA 4GA7A 1IMVA 3T1PA 1JMOA 1LK6I 1OVAB 1YXAA 1AS4A 4YIAA 1DB2A 5INWA 1UHGA 4ZK3A 2H4QA 5EI0A 2ACHA 2HIJL 2XN3A 4X30A 3EOXA 1ANTI 2D26A 1JTIA 1OVAC 3PZFA 2WXWA 3NE4A 2VH4A 2RIWA 3CAAA 1OYHI 1OO8A 5BRRI 2WY0C 1QMNA 4KDSA 1A7CA 4R9IA 4C49A 1DVMA 1BY7A 3EVJI 2HI9A 2VDXA 1DVNA 1SEKA 2XN5A 2RIVA 3DY0A 1HLEA 1TB6I 1XQJA 1MTPA 3ZHAA 4RO9A 3NDAA 4AU4A 3NDFA 4AU2A 1M93B 2PEEA 1OYHL
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3CWL A;  2WXY C;  3DRU A;  5CE0 A;  1T1F A;  2XN7 A;  2H4P A;  9PAI A;  1HP7 A;  1KCT A;  2WY1 A;  1OC0 A;  4G8O A;  2H4R A;  1LQ8 A;  1NQ9 I;  3OZQ A;  5IO1 A;  3NDD A;  2PEF A;  1JVQ I;  1F0C A;  1SR5 A;  2ZNH A;  1E03 I;  4ROB A;  1ATH A;  4Y3K A;  2GD4 C;  4AJU A;  4ZK0 A;  2ZV6 A;  1QLP A;  4P0O A;  1WZ9 A;  1PSI A;  4EB1 I;  4G8R A;  2WXX A;  4CAA A;  1OVA A;  1JMJ A;  4DTE A;  1JRR A;  3CWM A;  2WXZ C;  3F5N A;  5HGC A;  4ROA A;  1B3K A;  1DZH I;  2CEO A;  3LW2 A;  4DY0 A;  3DLW A;  4AU3 B;  1LJ5 A;  4IC0 A;  4RSQ A;  4AFX A;  1EZX A;  4EB1 L;  3FGQ A;  1E05 I;  1R1L I;  2DUT A;  4AQH A;  4DY7 C;  5CDX A;  3VVJ A;  1DZG I;  4IF8 A;  2XN6 A;  2OAY A;  1OPH A;  4PYW A;  1C8O A;  3H5C A;  3KCG I;  2QUG A;  2BEH L;  4AJT A;  1DZH L;  3DRM A;  1E04 I;  5C98 A;  2ARQ A;  2B4X I;  3PB1 I;  3Q03 A;  3STO A;  1XQG A;  2R9Y A;  1AZX I;  1K9O I;  1IZ2 A;  3LE2 A;  2B5T I;  2BEH I;  3Q02 A;  3UT3 A;  2V95 A;  8API A;  1QMB A;  2OL2 A;  1XU8 A;  2HIJ I;  4Y40 A;  1DZG L;  3F1S A;  4AU3 A;  7API A;  1ATU A;  3R4L A;  4BB2 A;  3B9F I;  1ATT A;  3F02 A;  1D5S A;  2ARR A;  2VDY A;  2ANT I;  4P0F A;  1C5G A;  1JJO C;  4C41 A;  9API A;  1SNG A;  5CDZ A;  2WXZ A;  2B4X L;  1BR8 I;  3CVM A;  4GA7 A;  1IMV A;  3T1P A;  1JMO A;  1LK6 I;  1OVA B;  1YXA A;  1AS4 A;  4YIA A;  1DB2 A;  5INW A;  1UHG A;  4ZK3 A;  2H4Q A;  5EI0 A;  2ACH A;  2HIJ L;  2XN3 A;  4X30 A;  3EOX A;  1ANT I;  2D26 A;  1JTI A;  1OVA C;  3PZF A;  2WXW A;  3NE4 A;  2VH4 A;  2RIW A;  3CAA A;  1OYH I;  1OO8 A;  5BRR I;  2WY0 C;  1QMN A;  4KDS A;  1A7C A;  4R9I A;  4C49 A;  1DVM A;  1BY7 A;  3EVJ I;  2HI9 A;  2VDX A;  1DVN A;  1SEK A;  2XN5 A;  2RIV A;  3DY0 A;  1HLE A;  1TB6 I;  1XQJ A;  1MTP A;  3ZHA A;  4RO9 A;  3NDA A;  4AU4 A;  3NDF A;  4AU2 A;  1M93 B;  2PEE A;  1OYH L; 
#chains in the Genus database with same CATH topology
 3CWL A;  2WXY C;  3DRU A;  5CE0 A;  1T1F A;  2XN7 A;  2H4P A;  9PAI A;  1HP7 A;  1KCT A;  2WY1 A;  1OC0 A;  4G8O A;  2H4R A;  1LQ8 A;  1NQ9 I;  3OZQ A;  5IO1 A;  3NDD A;  2PEF A;  1JVQ I;  1F0C A;  1SR5 A;  2ZNH A;  1E03 I;  4ROB A;  1ATH A;  4Y3K A;  2GD4 C;  4AJU A;  4ZK0 A;  2ZV6 A;  1QLP A;  4P0O A;  1WZ9 A;  1PSI A;  4EB1 I;  4G8R A;  2WXX A;  4CAA A;  1OVA A;  1JMJ A;  4DTE A;  1JRR A;  3CWM A;  2WXZ C;  3F5N A;  5HGC A;  4ROA A;  1B3K A;  1DZH I;  2CEO A;  3LW2 A;  4DY0 A;  3DLW A;  4AU3 B;  1LJ5 A;  4IC0 A;  4RSQ A;  4AFX A;  1EZX A;  4EB1 L;  3FGQ A;  1E05 I;  1R1L I;  2DUT A;  4AQH A;  4DY7 C;  5CDX A;  3VVJ A;  1DZG I;  4IF8 A;  2XN6 A;  2OAY A;  1OPH A;  4PYW A;  1C8O A;  3H5C A;  3KCG I;  2QUG A;  2BEH L;  4AJT A;  1DZH L;  3DRM A;  1E04 I;  5C98 A;  2ARQ A;  2B4X I;  3PB1 I;  3Q03 A;  3STO A;  1XQG A;  2R9Y A;  1AZX I;  1K9O I;  1IZ2 A;  3LE2 A;  2B5T I;  2BEH I;  3Q02 A;  3UT3 A;  2V95 A;  8API A;  1QMB A;  2OL2 A;  1XU8 A;  2HIJ I;  4Y40 A;  1DZG L;  3F1S A;  4AU3 A;  7API A;  1ATU A;  3R4L A;  4BB2 A;  3B9F I;  1ATT A;  3F02 A;  1D5S A;  2ARR A;  2VDY A;  2ANT I;  4P0F A;  1C5G A;  1JJO C;  4C41 A;  9API A;  1SNG A;  5CDZ A;  2WXZ A;  2B4X L;  1BR8 I;  3CVM A;  4GA7 A;  1IMV A;  3T1P A;  1JMO A;  1LK6 I;  1OVA B;  1YXA A;  1AS4 A;  4YIA A;  1DB2 A;  5INW A;  1UHG A;  4ZK3 A;  2H4Q A;  5EI0 A;  2ACH A;  2HIJ L;  2XN3 A;  4X30 A;  3EOX A;  1ANT I;  2D26 A;  1JTI A;  1OVA C;  3PZF A;  2WXW A;  3NE4 A;  2VH4 A;  2RIW A;  3CAA A;  1OYH I;  1OO8 A;  5BRR I;  2WY0 C;  1QMN A;  4KDS A;  1A7C A;  4R9I A;  4C49 A;  1DVM A;  1BY7 A;  3EVJ I;  2HI9 A;  2VDX A;  1DVN A;  1SEK A;  2XN5 A;  2RIV A;  3DY0 A;  1HLE A;  1TB6 I;  1XQJ A;  1MTP A;  3ZHA A;  4RO9 A;  3NDA A;  4AU4 A;  3NDF A;  4AU2 A;  1M93 B;  2PEE A;  1OYH L; 
#chains in the Genus database with same CATH homology
 3CWL A;  2WXY C;  3DRU A;  5CE0 A;  1T1F A;  2XN7 A;  2H4P A;  9PAI A;  1HP7 A;  1KCT A;  2WY1 A;  1OC0 A;  4G8O A;  2H4R A;  1LQ8 A;  1NQ9 I;  3OZQ A;  5IO1 A;  3NDD A;  2PEF A;  1JVQ I;  1F0C A;  1SR5 A;  2ZNH A;  1E03 I;  4ROB A;  1ATH A;  4Y3K A;  2GD4 C;  4AJU A;  4ZK0 A;  2ZV6 A;  1QLP A;  4P0O A;  1WZ9 A;  1PSI A;  4EB1 I;  4G8R A;  2WXX A;  4CAA A;  1OVA A;  1JMJ A;  4DTE A;  1JRR A;  3CWM A;  2WXZ C;  3F5N A;  5HGC A;  4ROA A;  1B3K A;  1DZH I;  2CEO A;  3LW2 A;  4DY0 A;  3DLW A;  4AU3 B;  1LJ5 A;  4IC0 A;  4RSQ A;  4AFX A;  1EZX A;  4EB1 L;  3FGQ A;  1E05 I;  1R1L I;  2DUT A;  4AQH A;  4DY7 C;  5CDX A;  3VVJ A;  1DZG I;  4IF8 A;  2XN6 A;  2OAY A;  1OPH A;  4PYW A;  1C8O A;  3H5C A;  3KCG I;  2QUG A;  2BEH L;  4AJT A;  1DZH L;  3DRM A;  1E04 I;  5C98 A;  2ARQ A;  2B4X I;  3PB1 I;  3Q03 A;  3STO A;  1XQG A;  2R9Y A;  1AZX I;  1K9O I;  1IZ2 A;  3LE2 A;  2B5T I;  2BEH I;  3Q02 A;  3UT3 A;  2V95 A;  8API A;  1QMB A;  2OL2 A;  1XU8 A;  2HIJ I;  4Y40 A;  1DZG L;  3F1S A;  4AU3 A;  7API A;  1ATU A;  3R4L A;  4BB2 A;  3B9F I;  1ATT A;  3F02 A;  1D5S A;  2ARR A;  2VDY A;  2ANT I;  4P0F A;  1C5G A;  1JJO C;  4C41 A;  9API A;  1SNG A;  5CDZ A;  2WXZ A;  2B4X L;  1BR8 I;  3CVM A;  4GA7 A;  1IMV A;  3T1P A;  1JMO A;  1LK6 I;  1OVA B;  1YXA A;  1AS4 A;  4YIA A;  1DB2 A;  5INW A;  1UHG A;  4ZK3 A;  2H4Q A;  5EI0 A;  2ACH A;  2HIJ L;  2XN3 A;  4X30 A;  3EOX A;  1ANT I;  2D26 A;  1JTI A;  1OVA C;  3PZF A;  2WXW A;  3NE4 A;  2VH4 A;  2RIW A;  3CAA A;  1OYH I;  1OO8 A;  5BRR I;  2WY0 C;  1QMN A;  4KDS A;  1A7C A;  4R9I A;  4C49 A;  1DVM A;  1BY7 A;  3EVJ I;  2HI9 A;  2VDX A;  1DVN A;  1SEK A;  2XN5 A;  2RIV A;  3DY0 A;  1HLE A;  1TB6 I;  1XQJ A;  1MTP A;  3ZHA A;  4RO9 A;  3NDA A;  4AU4 A;  3NDF A;  4AU2 A;  1M93 B;  2PEE A;  1OYH L; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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