2XN7A

Crystal structure of thyroxine-binding globulin complexed with thyroxine-fluoresein (t405-cf)
Total Genus 103
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
103
sequence length
339
structure length
339
Chain Sequence
ATLYKMSSINADFAFNLYRRFTVETPDKNIFFSPVSISAALVMLSFGACCSTQTEIVETLGFNLTDTPMVEIQHGFQHLICSLNFPKKELELQIGNALFIGKHLKPLAKFLNDVKTLYETEVFSTDFSNISAAKQEINSHVEMQTKGKVVGLIQDLKPNTIMVLVNYIHFKAQWANPFDPSKTEDSSSFLIDKTTTVQVPMMHQMEQYYHLVDMELNCTVLQMDYSKNALALFVLPKEGQMESVEAAMSSKTLKKWNRLLQKGWVDLFVPKFSISATYDLGATLLKMGIQHAYSENADFSGLTEDNGLKLSNAAHKAVLHIGEKGTEAAGAMFLEAIPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Allosteric Modulation of Hormone Release from Thyroxine and Corticosteroid Binding-Globulins.
pubmed doi rcsb
molecule keywords THYROXINE-BINDING GLOBULIN
molecule tags Transport
source organism Homo sapiens
total genus 103
structure length 339
sequence length 339
ec nomenclature
pdb deposition date 2010-07-30
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 2xn7A02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 2xn7A01
3NDAA 1JMJA 1QMBA 4P0OA 1A7CA 2BEHI 4AJTA 2QUGA 1T1FA 4EB1I 1SR5A 2RIVA 5CE0A 3FGQA 2H4QA 2WXZA 4IC0A 4Y3KA 1BY7A 1PSIA 1AZXI 4P0FA 4AU3A 2XN7A 4C49A 1LQ8A 3CAAA 1OVAC 4R9IA 9PAIA 2ZNHA 1DB2A 3CVMA 1OYHL 1DZHL 2HIJI 4AU3B 2XN6A 4AFXA 2ANTI 3CWMA 2D26A 4G8OA 5C98A 4YIAA 2ARRA 2V95A 3R4LA 3F5NA 2CEOA 2WY1A 2WXZC 1R1LI 1MTPA 1QLPA 3NDDA 3DY0A 3VVJA 3NDFA 1DVMA 2B4XI 4Y40A 2DUTA 5CDXA 3F02A 4DY7C 9APIA 5IO1A 5BRRI 1JVQI 2PEEA 1XQGA 1XU8A 2ACHA 3ZHAA 1OC0A 3LE2A 1OO8A 2OAYA 1DVNA 1TB6I 4GA7A 1JMOA 1ATUA 3KCGI 2VDXA 2WXWA 2WY0C 4RO9A 4CAAA 1JRRA 1WZ9A 3EVJI 1E05I 5EI0A 5INWA 4BB2A 3DRUA 1OYHI 2ARQA 3PZFA 1DZHI 3LW2A 1C8OA 8APIA 2PEFA 1QMNA 2XN3A 3B9FI 3T1PA 4DY0A 1JJOC 3DLWA 3STOA 2RIWA 3PB1I 5CDZA 5HGCA 4C41A 2ZV6A 1C5GA 2R9YA 1LK6I 2H4RA 1KCTA 3H5CA 1SNGA 2WXXA 4EB1L 3DRMA 2OL2A 4ROBA 4ROAA 4DTEA 4X30A 1D5SA 1EZXA 1OPHA 7APIA 1HP7A 4ZK0A 4ZK3A 1UHGA 2VH4A 1B3KA 1E04I 1SEKA 2VDYA 3OZQA 3F1SA 4RSQA 1BR8I 1AS4A 2H4PA 2WXYC 2GD4C 2HIJL 3UT3A 1JTIA 1F0CA 3EOXA 1M93B 3Q03A 1K9OI 1IMVA 1DZGL 1HLEA 1NQ9I 4AJUA 4AU2A 1ATTA 4IF8A 4KDSA 3Q02A 1LJ5A 1ATHA 2BEHL 4PYWA 2XN5A 1ANTI 1IZ2A 1E03I 4G8RA 1OVAA 1YXAA 3CWLA 2B5TI 4AQHA 2HI9A 4AU4A 3NE4A 1XQJA 2B4XL 1DZGI 1OVAB
chains in the Genus database with same CATH superfamily
3NDAA 1JMJA 1QMBA 4P0OA 1A7CA 2BEHI 4AJTA 2QUGA 1T1FA 4EB1I 1SR5A 2RIVA 5CE0A 3FGQA 2H4QA 2WXZA 4IC0A 4Y3KA 1BY7A 1PSIA 1AZXI 4P0FA 4AU3A 2XN7A 4C49A 1LQ8A 3CAAA 1OVAC 4R9IA 9PAIA 2ZNHA 1DB2A 3CVMA 1OYHL 1DZHL 2HIJI 4AU3B 2XN6A 4AFXA 2ANTI 3CWMA 2D26A 4G8OA 5C98A 4YIAA 2ARRA 2V95A 3R4LA 3F5NA 2CEOA 2WY1A 2WXZC 1R1LI 1MTPA 1QLPA 3NDDA 3DY0A 3VVJA 3NDFA 1DVMA 2B4XI 4Y40A 2DUTA 5CDXA 3F02A 4DY7C 9APIA 5IO1A 5BRRI 1JVQI 2PEEA 1XQGA 1XU8A 2ACHA 3ZHAA 1OC0A 3LE2A 1OO8A 2OAYA 1DVNA 1TB6I 4GA7A 1JMOA 1ATUA 3KCGI 2VDXA 2WXWA 2WY0C 4RO9A 4CAAA 1JRRA 1WZ9A 3EVJI 1E05I 5EI0A 5INWA 4BB2A 3DRUA 1OYHI 2ARQA 3PZFA 1DZHI 3LW2A 1C8OA 8APIA 2PEFA 1QMNA 2XN3A 3B9FI 3T1PA 4DY0A 1JJOC 3DLWA 3STOA 2RIWA 3PB1I 5CDZA 5HGCA 4C41A 2ZV6A 1C5GA 2R9YA 1LK6I 2H4RA 1KCTA 3H5CA 1SNGA 2WXXA 4EB1L 3DRMA 2OL2A 4ROBA 4ROAA 4DTEA 4X30A 1D5SA 1EZXA 1OPHA 7APIA 1HP7A 4ZK0A 4ZK3A 1UHGA 2VH4A 1B3KA 1E04I 1SEKA 2VDYA 3OZQA 3F1SA 4RSQA 1BR8I 1AS4A 2H4PA 2WXYC 2GD4C 2HIJL 3UT3A 1JTIA 1F0CA 3EOXA 1M93B 3Q03A 1K9OI 1IMVA 1DZGL 1HLEA 1NQ9I 4AJUA 4AU2A 1ATTA 4IF8A 4KDSA 3Q02A 1LJ5A 1ATHA 2BEHL 4PYWA 2XN5A 1ANTI 1IZ2A 1E03I 4G8RA 1OVAA 1YXAA 3CWLA 2B5TI 4AQHA 2HI9A 4AU4A 3NE4A 1XQJA 2B4XL 1DZGI 1OVAB
chains in the Genus database with same CATH topology
3NDAA 1JMJA 1QMBA 4P0OA 1A7CA 2BEHI 4AJTA 2QUGA 1T1FA 4EB1I 1SR5A 2RIVA 5CE0A 3FGQA 2H4QA 2WXZA 4IC0A 4Y3KA 1BY7A 1PSIA 1AZXI 4P0FA 4AU3A 2XN7A 4C49A 1LQ8A 3CAAA 1OVAC 4R9IA 9PAIA 2ZNHA 1DB2A 3CVMA 1OYHL 1DZHL 2HIJI 4AU3B 2XN6A 4AFXA 2ANTI 3CWMA 2D26A 4G8OA 5C98A 4YIAA 2ARRA 2V95A 3R4LA 3F5NA 2CEOA 2WY1A 2WXZC 1R1LI 1MTPA 1QLPA 3NDDA 3DY0A 3VVJA 3NDFA 1DVMA 2B4XI 4Y40A 2DUTA 5CDXA 3F02A 4DY7C 9APIA 5IO1A 5BRRI 1JVQI 2PEEA 1XQGA 1XU8A 2ACHA 3ZHAA 1OC0A 3LE2A 1OO8A 2OAYA 1DVNA 1TB6I 4GA7A 1JMOA 1ATUA 3KCGI 2VDXA 2WXWA 2WY0C 4RO9A 4CAAA 1JRRA 1WZ9A 3EVJI 1E05I 5EI0A 5INWA 4BB2A 3DRUA 1OYHI 2ARQA 3PZFA 1DZHI 3LW2A 1C8OA 8APIA 2PEFA 1QMNA 2XN3A 3B9FI 3T1PA 4DY0A 1JJOC 3DLWA 3STOA 2RIWA 3PB1I 5CDZA 5HGCA 4C41A 2ZV6A 1C5GA 2R9YA 1LK6I 2H4RA 1KCTA 3H5CA 1SNGA 2WXXA 4EB1L 3DRMA 2OL2A 4ROBA 4ROAA 4DTEA 4X30A 1D5SA 1EZXA 1OPHA 7APIA 1HP7A 4ZK0A 4ZK3A 1UHGA 2VH4A 1B3KA 1E04I 1SEKA 2VDYA 3OZQA 3F1SA 4RSQA 1BR8I 1AS4A 2H4PA 2WXYC 2GD4C 2HIJL 3UT3A 1JTIA 1F0CA 3EOXA 1M93B 3Q03A 1K9OI 1IMVA 1DZGL 1HLEA 1NQ9I 4AJUA 4AU2A 1ATTA 4IF8A 4KDSA 3Q02A 1LJ5A 1ATHA 2BEHL 4PYWA 2XN5A 1ANTI 1IZ2A 1E03I 4G8RA 1OVAA 1YXAA 3CWLA 2B5TI 4AQHA 2HI9A 4AU4A 3NE4A 1XQJA 2B4XL 1DZGI 1OVAB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3NDA A;  1JMJ A;  1QMB A;  4P0O A;  1A7C A;  2BEH I;  4AJT A;  2QUG A;  1T1F A;  4EB1 I;  1SR5 A;  2RIV A;  5CE0 A;  3FGQ A;  2H4Q A;  2WXZ A;  4IC0 A;  4Y3K A;  1BY7 A;  1PSI A;  1AZX I;  4P0F A;  4AU3 A;  2XN7 A;  4C49 A;  1LQ8 A;  3CAA A;  1OVA C;  4R9I A;  9PAI A;  2ZNH A;  1DB2 A;  3CVM A;  1OYH L;  1DZH L;  2HIJ I;  4AU3 B;  2XN6 A;  4AFX A;  2ANT I;  3CWM A;  2D26 A;  4G8O A;  5C98 A;  4YIA A;  2ARR A;  2V95 A;  3R4L A;  3F5N A;  2CEO A;  2WY1 A;  2WXZ C;  1R1L I;  1MTP A;  1QLP A;  3NDD A;  3DY0 A;  3VVJ A;  3NDF A;  1DVM A;  2B4X I;  4Y40 A;  2DUT A;  5CDX A;  3F02 A;  4DY7 C;  9API A;  5IO1 A;  5BRR I;  1JVQ I;  2PEE A;  1XQG A;  1XU8 A;  2ACH A;  3ZHA A;  1OC0 A;  3LE2 A;  1OO8 A;  2OAY A;  1DVN A;  1TB6 I;  4GA7 A;  1JMO A;  1ATU A;  3KCG I;  2VDX A;  2WXW A;  2WY0 C;  4RO9 A;  4CAA A;  1JRR A;  1WZ9 A;  3EVJ I;  1E05 I;  5EI0 A;  5INW A;  4BB2 A;  3DRU A;  1OYH I;  2ARQ A;  3PZF A;  1DZH I;  3LW2 A;  1C8O A;  8API A;  2PEF A;  1QMN A;  2XN3 A;  3B9F I;  3T1P A;  4DY0 A;  1JJO C;  3DLW A;  3STO A;  2RIW A;  3PB1 I;  5CDZ A;  5HGC A;  4C41 A;  2ZV6 A;  1C5G A;  2R9Y A;  1LK6 I;  2H4R A;  1KCT A;  3H5C A;  1SNG A;  2WXX A;  4EB1 L;  3DRM A;  2OL2 A;  4ROB A;  4ROA A;  4DTE A;  4X30 A;  1D5S A;  1EZX A;  1OPH A;  7API A;  1HP7 A;  4ZK0 A;  4ZK3 A;  1UHG A;  2VH4 A;  1B3K A;  1E04 I;  1SEK A;  2VDY A;  3OZQ A;  3F1S A;  4RSQ A;  1BR8 I;  1AS4 A;  2H4P A;  2WXY C;  2GD4 C;  2HIJ L;  3UT3 A;  1JTI A;  1F0C A;  3EOX A;  1M93 B;  3Q03 A;  1K9O I;  1IMV A;  1DZG L;  1HLE A;  1NQ9 I;  4AJU A;  4AU2 A;  1ATT A;  4IF8 A;  4KDS A;  3Q02 A;  1LJ5 A;  1ATH A;  2BEH L;  4PYW A;  2XN5 A;  1ANT I;  1IZ2 A;  1E03 I;  4G8R A;  1OVA A;  1YXA A;  3CWL A;  2B5T I;  4AQH A;  2HI9 A;  4AU4 A;  3NE4 A;  1XQJ A;  2B4X L;  1DZG I;  1OVA B; 
#chains in the Genus database with same CATH topology
 3NDA A;  1JMJ A;  1QMB A;  4P0O A;  1A7C A;  2BEH I;  4AJT A;  2QUG A;  1T1F A;  4EB1 I;  1SR5 A;  2RIV A;  5CE0 A;  3FGQ A;  2H4Q A;  2WXZ A;  4IC0 A;  4Y3K A;  1BY7 A;  1PSI A;  1AZX I;  4P0F A;  4AU3 A;  2XN7 A;  4C49 A;  1LQ8 A;  3CAA A;  1OVA C;  4R9I A;  9PAI A;  2ZNH A;  1DB2 A;  3CVM A;  1OYH L;  1DZH L;  2HIJ I;  4AU3 B;  2XN6 A;  4AFX A;  2ANT I;  3CWM A;  2D26 A;  4G8O A;  5C98 A;  4YIA A;  2ARR A;  2V95 A;  3R4L A;  3F5N A;  2CEO A;  2WY1 A;  2WXZ C;  1R1L I;  1MTP A;  1QLP A;  3NDD A;  3DY0 A;  3VVJ A;  3NDF A;  1DVM A;  2B4X I;  4Y40 A;  2DUT A;  5CDX A;  3F02 A;  4DY7 C;  9API A;  5IO1 A;  5BRR I;  1JVQ I;  2PEE A;  1XQG A;  1XU8 A;  2ACH A;  3ZHA A;  1OC0 A;  3LE2 A;  1OO8 A;  2OAY A;  1DVN A;  1TB6 I;  4GA7 A;  1JMO A;  1ATU A;  3KCG I;  2VDX A;  2WXW A;  2WY0 C;  4RO9 A;  4CAA A;  1JRR A;  1WZ9 A;  3EVJ I;  1E05 I;  5EI0 A;  5INW A;  4BB2 A;  3DRU A;  1OYH I;  2ARQ A;  3PZF A;  1DZH I;  3LW2 A;  1C8O A;  8API A;  2PEF A;  1QMN A;  2XN3 A;  3B9F I;  3T1P A;  4DY0 A;  1JJO C;  3DLW A;  3STO A;  2RIW A;  3PB1 I;  5CDZ A;  5HGC A;  4C41 A;  2ZV6 A;  1C5G A;  2R9Y A;  1LK6 I;  2H4R A;  1KCT A;  3H5C A;  1SNG A;  2WXX A;  4EB1 L;  3DRM A;  2OL2 A;  4ROB A;  4ROA A;  4DTE A;  4X30 A;  1D5S A;  1EZX A;  1OPH A;  7API A;  1HP7 A;  4ZK0 A;  4ZK3 A;  1UHG A;  2VH4 A;  1B3K A;  1E04 I;  1SEK A;  2VDY A;  3OZQ A;  3F1S A;  4RSQ A;  1BR8 I;  1AS4 A;  2H4P A;  2WXY C;  2GD4 C;  2HIJ L;  3UT3 A;  1JTI A;  1F0C A;  3EOX A;  1M93 B;  3Q03 A;  1K9O I;  1IMV A;  1DZG L;  1HLE A;  1NQ9 I;  4AJU A;  4AU2 A;  1ATT A;  4IF8 A;  4KDS A;  3Q02 A;  1LJ5 A;  1ATH A;  2BEH L;  4PYW A;  2XN5 A;  1ANT I;  1IZ2 A;  1E03 I;  4G8R A;  1OVA A;  1YXA A;  3CWL A;  2B5T I;  4AQH A;  2HI9 A;  4AU4 A;  3NE4 A;  1XQJ A;  2B4X L;  1DZG I;  1OVA B; 
#chains in the Genus database with same CATH homology
 3NDA A;  1JMJ A;  1QMB A;  4P0O A;  1A7C A;  2BEH I;  4AJT A;  2QUG A;  1T1F A;  4EB1 I;  1SR5 A;  2RIV A;  5CE0 A;  3FGQ A;  2H4Q A;  2WXZ A;  4IC0 A;  4Y3K A;  1BY7 A;  1PSI A;  1AZX I;  4P0F A;  4AU3 A;  2XN7 A;  4C49 A;  1LQ8 A;  3CAA A;  1OVA C;  4R9I A;  9PAI A;  2ZNH A;  1DB2 A;  3CVM A;  1OYH L;  1DZH L;  2HIJ I;  4AU3 B;  2XN6 A;  4AFX A;  2ANT I;  3CWM A;  2D26 A;  4G8O A;  5C98 A;  4YIA A;  2ARR A;  2V95 A;  3R4L A;  3F5N A;  2CEO A;  2WY1 A;  2WXZ C;  1R1L I;  1MTP A;  1QLP A;  3NDD A;  3DY0 A;  3VVJ A;  3NDF A;  1DVM A;  2B4X I;  4Y40 A;  2DUT A;  5CDX A;  3F02 A;  4DY7 C;  9API A;  5IO1 A;  5BRR I;  1JVQ I;  2PEE A;  1XQG A;  1XU8 A;  2ACH A;  3ZHA A;  1OC0 A;  3LE2 A;  1OO8 A;  2OAY A;  1DVN A;  1TB6 I;  4GA7 A;  1JMO A;  1ATU A;  3KCG I;  2VDX A;  2WXW A;  2WY0 C;  4RO9 A;  4CAA A;  1JRR A;  1WZ9 A;  3EVJ I;  1E05 I;  5EI0 A;  5INW A;  4BB2 A;  3DRU A;  1OYH I;  2ARQ A;  3PZF A;  1DZH I;  3LW2 A;  1C8O A;  8API A;  2PEF A;  1QMN A;  2XN3 A;  3B9F I;  3T1P A;  4DY0 A;  1JJO C;  3DLW A;  3STO A;  2RIW A;  3PB1 I;  5CDZ A;  5HGC A;  4C41 A;  2ZV6 A;  1C5G A;  2R9Y A;  1LK6 I;  2H4R A;  1KCT A;  3H5C A;  1SNG A;  2WXX A;  4EB1 L;  3DRM A;  2OL2 A;  4ROB A;  4ROA A;  4DTE A;  4X30 A;  1D5S A;  1EZX A;  1OPH A;  7API A;  1HP7 A;  4ZK0 A;  4ZK3 A;  1UHG A;  2VH4 A;  1B3K A;  1E04 I;  1SEK A;  2VDY A;  3OZQ A;  3F1S A;  4RSQ A;  1BR8 I;  1AS4 A;  2H4P A;  2WXY C;  2GD4 C;  2HIJ L;  3UT3 A;  1JTI A;  1F0C A;  3EOX A;  1M93 B;  3Q03 A;  1K9O I;  1IMV A;  1DZG L;  1HLE A;  1NQ9 I;  4AJU A;  4AU2 A;  1ATT A;  4IF8 A;  4KDS A;  3Q02 A;  1LJ5 A;  1ATH A;  2BEH L;  4PYW A;  2XN5 A;  1ANT I;  1IZ2 A;  1E03 I;  4G8R A;  1OVA A;  1YXA A;  3CWL A;  2B5T I;  4AQH A;  2HI9 A;  4AU4 A;  3NE4 A;  1XQJ A;  2B4X L;  1DZG I;  1OVA B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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