2WXZA

Crystal structure of rat angiotensinogen in c2 space group
Total Genus 105
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
105
sequence length
445
structure length
422
Chain Sequence
HPFHLLYYSKSTCAQTLPEPTFEPVPIQAKTSPVDEKTLRDKLVLATEKLEAEDRQRAAQVAMIANFVGFRMYKMLSEARVASGAVLSPPALFGTLVSFYLGSLDPTASQLQVLLGVPVKEGDCTSRLDGHKVLTALQAVQGLLVTPLLQSTVVGLFTAPGLRLKQPFVESLGPFTPAIFPRSLDLSTDPVLAAQKINRFVQAVTGWKMNLPLEGVSTDSTLFFNTYVHFQGKMRGFSQLTGLHEFWVDNSTSVSVPMLSGTGNFQHWSDAQNNFSVTRVPLGESVTLLLIQPQCASDLDRVEVLVFQHDFLTWIKNPPPRAIRLTLPQLEIRGSYNLQDLLAQAKLSTLLGAEANLGKMGDTNPRVGEVLNSILLELQAGEAQQPGSPEVLDVTLSSPFLFAIYERDSGALHFLGRVDNPQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A Redox Switch in Angiotensinogen Modulates Angiotensin Release.
pubmed doi rcsb
molecule keywords ANGIOTENSINOGEN
molecule tags Hormone
source organism Rattus norvegicus
total genus 105
structure length 422
sequence length 445
ec nomenclature
pdb deposition date 2009-11-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 2wxzA01
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 2wxzA02
3UT3A 2ARRA 3LW2A 2VDXA 1DVNA 2BEHI 3NDAA 2ANTI 3PB1I 4DTEA 5CDXA 1C8OA 2XN7A 2XN5A 1E05I 4ZK3A 1D5SA 1DVMA 1IZ2A 1C5GA 8APIA 1HLEA 1E03I 3VVJA 1LJ5A 2B4XI 2PEFA 4C41A 3R4LA 1DZGI 3ZHAA 1JVQI 2PEEA 2WXWA 5C98A 1SEKA 2XN6A 1ATHA 1OC0A 4RO9A 3NDDA 2WXXA 5CE0A 2VH4A 1XU8A 2H4RA 4X30A 1TB6I 1ATTA 3B9FI 1JRRA 1DZGL 5CDZA 5EI0A 2ARQA 2HIJI 3H5CA 1JMJA 5INWA 3F1SA 2D26A 2GD4C 1AS4A 5IO1A 1NQ9I 1XQGA 4PYWA 4BB2A 4P0OA 9APIA 1HP7A 3CWMA 4CAAA 7APIA 1EZXA 3LE2A 1SNGA 3CAAA 1E04I 2RIWA 2BEHL 2HIJL 1M93B 2DUTA 2VDYA 3KCGI 1BR8I 1ANTI 3PZFA 4AJTA 1MTPA 3STOA 4EB1I 2ZV6A 1OYHI 2QUGA 3EVJI 2XN3A 2B4XL 4G8OA 4AJUA 2R9YA 1JJOC 1R1LI 2OAYA 2OL2A 3F5NA 4IC0A 4IF8A 4ROAA 4AFXA 1KCTA 2WY0C 1IMVA 4C49A 1OVAB 4RSQA 1UHGA 4G8RA 3T1PA 1PSIA 3EOXA 3FGQA 1A7CA 2WY1A 1OPHA 4EB1L 4AU3A 4ZK0A 5BRRI 1QLPA 1OYHL 1XQJA 5HGCA 4ROBA 4Y40A 2HI9A 1BY7A 1OVAC 4Y3KA 3NE4A 4GA7A 4R9IA 4YIAA 4AU3B 1B3KA 1OVAA 2H4QA 3F02A 4AU4A 3DRMA 1DB2A 2WXZC 2WXYC 1AZXI 4P0FA 3DRUA 3Q03A 3DY0A 1QMBA 4KDSA 1T1FA 3OZQA 4AU2A 2V95A 3NDFA 1DZHI 9PAIA 4AQHA 3CWLA 1LQ8A 2CEOA 2WXZA 4DY7C 3CVMA 1WZ9A 2ZNHA 1JMOA 2RIVA 1F0CA 1SR5A 1YXAA 2B5TI 1QMNA 3DLWA 1LK6I 1ATUA 1DZHL 4DY0A 3Q02A 2H4PA 1JTIA 1K9OI 2ACHA 1OO8A
chains in the Genus database with same CATH superfamily
3UT3A 2ARRA 3LW2A 2VDXA 1DVNA 2BEHI 3NDAA 2ANTI 3PB1I 4DTEA 5CDXA 1C8OA 2XN7A 2XN5A 1E05I 4ZK3A 1D5SA 1DVMA 1IZ2A 1C5GA 8APIA 1HLEA 1E03I 3VVJA 1LJ5A 2B4XI 2PEFA 4C41A 3R4LA 1DZGI 3ZHAA 1JVQI 2PEEA 2WXWA 5C98A 1SEKA 2XN6A 1ATHA 1OC0A 4RO9A 3NDDA 2WXXA 5CE0A 2VH4A 1XU8A 2H4RA 4X30A 1TB6I 1ATTA 3B9FI 1JRRA 1DZGL 5CDZA 5EI0A 2ARQA 2HIJI 3H5CA 1JMJA 5INWA 3F1SA 2D26A 2GD4C 1AS4A 5IO1A 1NQ9I 1XQGA 4PYWA 4BB2A 4P0OA 9APIA 1HP7A 3CWMA 4CAAA 7APIA 1EZXA 3LE2A 1SNGA 3CAAA 1E04I 2RIWA 2BEHL 2HIJL 1M93B 2DUTA 2VDYA 3KCGI 1BR8I 1ANTI 3PZFA 4AJTA 1MTPA 3STOA 4EB1I 2ZV6A 1OYHI 2QUGA 3EVJI 2XN3A 2B4XL 4G8OA 4AJUA 2R9YA 1JJOC 1R1LI 2OAYA 2OL2A 3F5NA 4IC0A 4IF8A 4ROAA 4AFXA 1KCTA 2WY0C 1IMVA 4C49A 1OVAB 4RSQA 1UHGA 4G8RA 3T1PA 1PSIA 3EOXA 3FGQA 1A7CA 2WY1A 1OPHA 4EB1L 4AU3A 4ZK0A 5BRRI 1QLPA 1OYHL 1XQJA 5HGCA 4ROBA 4Y40A 2HI9A 1BY7A 1OVAC 4Y3KA 3NE4A 4GA7A 4R9IA 4YIAA 4AU3B 1B3KA 1OVAA 2H4QA 3F02A 4AU4A 3DRMA 1DB2A 2WXZC 2WXYC 1AZXI 4P0FA 3DRUA 3Q03A 3DY0A 1QMBA 4KDSA 1T1FA 3OZQA 4AU2A 2V95A 3NDFA 1DZHI 9PAIA 4AQHA 3CWLA 1LQ8A 2CEOA 2WXZA 4DY7C 3CVMA 1WZ9A 2ZNHA 1JMOA 2RIVA 1F0CA 1SR5A 1YXAA 2B5TI 1QMNA 3DLWA 1LK6I 1ATUA 1DZHL 4DY0A 3Q02A 2H4PA 1JTIA 1K9OI 2ACHA 1OO8A
chains in the Genus database with same CATH topology
3UT3A 2ARRA 3LW2A 2VDXA 1DVNA 2BEHI 3NDAA 2ANTI 3PB1I 4DTEA 5CDXA 1C8OA 2XN7A 2XN5A 1E05I 4ZK3A 1D5SA 1DVMA 1IZ2A 1C5GA 8APIA 1HLEA 1E03I 3VVJA 1LJ5A 2B4XI 2PEFA 4C41A 3R4LA 1DZGI 3ZHAA 1JVQI 2PEEA 2WXWA 5C98A 1SEKA 2XN6A 1ATHA 1OC0A 4RO9A 3NDDA 2WXXA 5CE0A 2VH4A 1XU8A 2H4RA 4X30A 1TB6I 1ATTA 3B9FI 1JRRA 1DZGL 5CDZA 5EI0A 2ARQA 2HIJI 3H5CA 1JMJA 5INWA 3F1SA 2D26A 2GD4C 1AS4A 5IO1A 1NQ9I 1XQGA 4PYWA 4BB2A 4P0OA 9APIA 1HP7A 3CWMA 4CAAA 7APIA 1EZXA 3LE2A 1SNGA 3CAAA 1E04I 2RIWA 2BEHL 2HIJL 1M93B 2DUTA 2VDYA 3KCGI 1BR8I 1ANTI 3PZFA 4AJTA 1MTPA 3STOA 4EB1I 2ZV6A 1OYHI 2QUGA 3EVJI 2XN3A 2B4XL 4G8OA 4AJUA 2R9YA 1JJOC 1R1LI 2OAYA 2OL2A 3F5NA 4IC0A 4IF8A 4ROAA 4AFXA 1KCTA 2WY0C 1IMVA 4C49A 1OVAB 4RSQA 1UHGA 4G8RA 3T1PA 1PSIA 3EOXA 3FGQA 1A7CA 2WY1A 1OPHA 4EB1L 4AU3A 4ZK0A 5BRRI 1QLPA 1OYHL 1XQJA 5HGCA 4ROBA 4Y40A 2HI9A 1BY7A 1OVAC 4Y3KA 3NE4A 4GA7A 4R9IA 4YIAA 4AU3B 1B3KA 1OVAA 2H4QA 3F02A 4AU4A 3DRMA 1DB2A 2WXZC 2WXYC 1AZXI 4P0FA 3DRUA 3Q03A 3DY0A 1QMBA 4KDSA 1T1FA 3OZQA 4AU2A 2V95A 3NDFA 1DZHI 9PAIA 4AQHA 3CWLA 1LQ8A 2CEOA 2WXZA 4DY7C 3CVMA 1WZ9A 2ZNHA 1JMOA 2RIVA 1F0CA 1SR5A 1YXAA 2B5TI 1QMNA 3DLWA 1LK6I 1ATUA 1DZHL 4DY0A 3Q02A 2H4PA 1JTIA 1K9OI 2ACHA 1OO8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3UT3 A;  2ARR A;  3LW2 A;  2VDX A;  1DVN A;  2BEH I;  3NDA A;  2ANT I;  3PB1 I;  4DTE A;  5CDX A;  1C8O A;  2XN7 A;  2XN5 A;  1E05 I;  4ZK3 A;  1D5S A;  1DVM A;  1IZ2 A;  1C5G A;  8API A;  1HLE A;  1E03 I;  3VVJ A;  1LJ5 A;  2B4X I;  2PEF A;  4C41 A;  3R4L A;  1DZG I;  3ZHA A;  1JVQ I;  2PEE A;  2WXW A;  5C98 A;  1SEK A;  2XN6 A;  1ATH A;  1OC0 A;  4RO9 A;  3NDD A;  2WXX A;  5CE0 A;  2VH4 A;  1XU8 A;  2H4R A;  4X30 A;  1TB6 I;  1ATT A;  3B9F I;  1JRR A;  1DZG L;  5CDZ A;  5EI0 A;  2ARQ A;  2HIJ I;  3H5C A;  1JMJ A;  5INW A;  3F1S A;  2D26 A;  2GD4 C;  1AS4 A;  5IO1 A;  1NQ9 I;  1XQG A;  4PYW A;  4BB2 A;  4P0O A;  9API A;  1HP7 A;  3CWM A;  4CAA A;  7API A;  1EZX A;  3LE2 A;  1SNG A;  3CAA A;  1E04 I;  2RIW A;  2BEH L;  2HIJ L;  1M93 B;  2DUT A;  2VDY A;  3KCG I;  1BR8 I;  1ANT I;  3PZF A;  4AJT A;  1MTP A;  3STO A;  4EB1 I;  2ZV6 A;  1OYH I;  2QUG A;  3EVJ I;  2XN3 A;  2B4X L;  4G8O A;  4AJU A;  2R9Y A;  1JJO C;  1R1L I;  2OAY A;  2OL2 A;  3F5N A;  4IC0 A;  4IF8 A;  4ROA A;  4AFX A;  1KCT A;  2WY0 C;  1IMV A;  4C49 A;  1OVA B;  4RSQ A;  1UHG A;  4G8R A;  3T1P A;  1PSI A;  3EOX A;  3FGQ A;  1A7C A;  2WY1 A;  1OPH A;  4EB1 L;  4AU3 A;  4ZK0 A;  5BRR I;  1QLP A;  1OYH L;  1XQJ A;  5HGC A;  4ROB A;  4Y40 A;  2HI9 A;  1BY7 A;  1OVA C;  4Y3K A;  3NE4 A;  4GA7 A;  4R9I A;  4YIA A;  4AU3 B;  1B3K A;  1OVA A;  2H4Q A;  3F02 A;  4AU4 A;  3DRM A;  1DB2 A;  2WXZ C;  2WXY C;  1AZX I;  4P0F A;  3DRU A;  3Q03 A;  3DY0 A;  1QMB A;  4KDS A;  1T1F A;  3OZQ A;  4AU2 A;  2V95 A;  3NDF A;  1DZH I;  9PAI A;  4AQH A;  3CWL A;  1LQ8 A;  2CEO A;  2WXZ A;  4DY7 C;  3CVM A;  1WZ9 A;  2ZNH A;  1JMO A;  2RIV A;  1F0C A;  1SR5 A;  1YXA A;  2B5T I;  1QMN A;  3DLW A;  1LK6 I;  1ATU A;  1DZH L;  4DY0 A;  3Q02 A;  2H4P A;  1JTI A;  1K9O I;  2ACH A;  1OO8 A; 
#chains in the Genus database with same CATH topology
 3UT3 A;  2ARR A;  3LW2 A;  2VDX A;  1DVN A;  2BEH I;  3NDA A;  2ANT I;  3PB1 I;  4DTE A;  5CDX A;  1C8O A;  2XN7 A;  2XN5 A;  1E05 I;  4ZK3 A;  1D5S A;  1DVM A;  1IZ2 A;  1C5G A;  8API A;  1HLE A;  1E03 I;  3VVJ A;  1LJ5 A;  2B4X I;  2PEF A;  4C41 A;  3R4L A;  1DZG I;  3ZHA A;  1JVQ I;  2PEE A;  2WXW A;  5C98 A;  1SEK A;  2XN6 A;  1ATH A;  1OC0 A;  4RO9 A;  3NDD A;  2WXX A;  5CE0 A;  2VH4 A;  1XU8 A;  2H4R A;  4X30 A;  1TB6 I;  1ATT A;  3B9F I;  1JRR A;  1DZG L;  5CDZ A;  5EI0 A;  2ARQ A;  2HIJ I;  3H5C A;  1JMJ A;  5INW A;  3F1S A;  2D26 A;  2GD4 C;  1AS4 A;  5IO1 A;  1NQ9 I;  1XQG A;  4PYW A;  4BB2 A;  4P0O A;  9API A;  1HP7 A;  3CWM A;  4CAA A;  7API A;  1EZX A;  3LE2 A;  1SNG A;  3CAA A;  1E04 I;  2RIW A;  2BEH L;  2HIJ L;  1M93 B;  2DUT A;  2VDY A;  3KCG I;  1BR8 I;  1ANT I;  3PZF A;  4AJT A;  1MTP A;  3STO A;  4EB1 I;  2ZV6 A;  1OYH I;  2QUG A;  3EVJ I;  2XN3 A;  2B4X L;  4G8O A;  4AJU A;  2R9Y A;  1JJO C;  1R1L I;  2OAY A;  2OL2 A;  3F5N A;  4IC0 A;  4IF8 A;  4ROA A;  4AFX A;  1KCT A;  2WY0 C;  1IMV A;  4C49 A;  1OVA B;  4RSQ A;  1UHG A;  4G8R A;  3T1P A;  1PSI A;  3EOX A;  3FGQ A;  1A7C A;  2WY1 A;  1OPH A;  4EB1 L;  4AU3 A;  4ZK0 A;  5BRR I;  1QLP A;  1OYH L;  1XQJ A;  5HGC A;  4ROB A;  4Y40 A;  2HI9 A;  1BY7 A;  1OVA C;  4Y3K A;  3NE4 A;  4GA7 A;  4R9I A;  4YIA A;  4AU3 B;  1B3K A;  1OVA A;  2H4Q A;  3F02 A;  4AU4 A;  3DRM A;  1DB2 A;  2WXZ C;  2WXY C;  1AZX I;  4P0F A;  3DRU A;  3Q03 A;  3DY0 A;  1QMB A;  4KDS A;  1T1F A;  3OZQ A;  4AU2 A;  2V95 A;  3NDF A;  1DZH I;  9PAI A;  4AQH A;  3CWL A;  1LQ8 A;  2CEO A;  2WXZ A;  4DY7 C;  3CVM A;  1WZ9 A;  2ZNH A;  1JMO A;  2RIV A;  1F0C A;  1SR5 A;  1YXA A;  2B5T I;  1QMN A;  3DLW A;  1LK6 I;  1ATU A;  1DZH L;  4DY0 A;  3Q02 A;  2H4P A;  1JTI A;  1K9O I;  2ACH A;  1OO8 A; 
#chains in the Genus database with same CATH homology
 3UT3 A;  2ARR A;  3LW2 A;  2VDX A;  1DVN A;  2BEH I;  3NDA A;  2ANT I;  3PB1 I;  4DTE A;  5CDX A;  1C8O A;  2XN7 A;  2XN5 A;  1E05 I;  4ZK3 A;  1D5S A;  1DVM A;  1IZ2 A;  1C5G A;  8API A;  1HLE A;  1E03 I;  3VVJ A;  1LJ5 A;  2B4X I;  2PEF A;  4C41 A;  3R4L A;  1DZG I;  3ZHA A;  1JVQ I;  2PEE A;  2WXW A;  5C98 A;  1SEK A;  2XN6 A;  1ATH A;  1OC0 A;  4RO9 A;  3NDD A;  2WXX A;  5CE0 A;  2VH4 A;  1XU8 A;  2H4R A;  4X30 A;  1TB6 I;  1ATT A;  3B9F I;  1JRR A;  1DZG L;  5CDZ A;  5EI0 A;  2ARQ A;  2HIJ I;  3H5C A;  1JMJ A;  5INW A;  3F1S A;  2D26 A;  2GD4 C;  1AS4 A;  5IO1 A;  1NQ9 I;  1XQG A;  4PYW A;  4BB2 A;  4P0O A;  9API A;  1HP7 A;  3CWM A;  4CAA A;  7API A;  1EZX A;  3LE2 A;  1SNG A;  3CAA A;  1E04 I;  2RIW A;  2BEH L;  2HIJ L;  1M93 B;  2DUT A;  2VDY A;  3KCG I;  1BR8 I;  1ANT I;  3PZF A;  4AJT A;  1MTP A;  3STO A;  4EB1 I;  2ZV6 A;  1OYH I;  2QUG A;  3EVJ I;  2XN3 A;  2B4X L;  4G8O A;  4AJU A;  2R9Y A;  1JJO C;  1R1L I;  2OAY A;  2OL2 A;  3F5N A;  4IC0 A;  4IF8 A;  4ROA A;  4AFX A;  1KCT A;  2WY0 C;  1IMV A;  4C49 A;  1OVA B;  4RSQ A;  1UHG A;  4G8R A;  3T1P A;  1PSI A;  3EOX A;  3FGQ A;  1A7C A;  2WY1 A;  1OPH A;  4EB1 L;  4AU3 A;  4ZK0 A;  5BRR I;  1QLP A;  1OYH L;  1XQJ A;  5HGC A;  4ROB A;  4Y40 A;  2HI9 A;  1BY7 A;  1OVA C;  4Y3K A;  3NE4 A;  4GA7 A;  4R9I A;  4YIA A;  4AU3 B;  1B3K A;  1OVA A;  2H4Q A;  3F02 A;  4AU4 A;  3DRM A;  1DB2 A;  2WXZ C;  2WXY C;  1AZX I;  4P0F A;  3DRU A;  3Q03 A;  3DY0 A;  1QMB A;  4KDS A;  1T1F A;  3OZQ A;  4AU2 A;  2V95 A;  3NDF A;  1DZH I;  9PAI A;  4AQH A;  3CWL A;  1LQ8 A;  2CEO A;  2WXZ A;  4DY7 C;  3CVM A;  1WZ9 A;  2ZNH A;  1JMO A;  2RIV A;  1F0C A;  1SR5 A;  1YXA A;  2B5T I;  1QMN A;  3DLW A;  1LK6 I;  1ATU A;  1DZH L;  4DY0 A;  3Q02 A;  2H4P A;  1JTI A;  1K9O I;  2ACH A;  1OO8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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