3LW2A

Mouse plasminogen activator inhibitor-1 (pai-1)
Total Genus 114
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
114
sequence length
373
structure length
365
Chain Sequence
HTAHQATDFGVKVFQQVVQASKDRNVVFSPYGVSSVLAMLQMTTAGKTRRQIQDAMGFKVNEKGTAHALRQLSKELMGPWNKNEISTADAIFVQRDLELVQGFMPHFFKLFQTMVKQVDFSEVERARFIINDWVERHTKGMINDLLAKGAVDELTRLVLVNALYFSGQWKTPFLEASTHQRLVSVPMMAQSNKFNYTEFTTPDGLEYDVVELPYQGDTLSMFIAAPFEKDVHLSALTNILDAELIRQWKGNMTRLPRLLILPKFSLETEVDLRGPLEKLGMPDMFSATLADFTSLSDQEQLSVAQALQKVRIEVNESGTVASSSTAFVISARMAPTEMVIDRSFLFVVRHNPTETILFMGQVMEP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Subtle structural differences between human and mouse PAI-1 reveal the basis for biochemical differences.
pubmed doi rcsb
molecule keywords Plasminogen activator inhibitor 1
molecule tags Hydrolase inhibitor
source organism Mus musculus
total genus 114
structure length 365
sequence length 373
ec nomenclature
pdb deposition date 2010-02-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 3lw2A02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 3lw2A01
2OL2A 5CDZA 1JTIA 4AJUA 5CE0A 2CEOA 2V95A 1QLPA 2DUTA 2H4QA 2BEHL 4DY7C 4Y3KA 3T1PA 3B9FI 4AFXA 4YIAA 3F5NA 1A7CA 1YXAA 4C49A 2PEEA 4GA7A 5IO1A 2R9YA 2ARRA 2VDXA 3NDFA 3DLWA 3CWLA 1MTPA 3NE4A 4PYWA 4RSQA 3PZFA 1PSIA 4R9IA 1JMOA 3DRMA 3EVJI 3F02A 2WXWA 1F0CA 2PEFA 2WXZC 2HI9A 3CWMA 4DTEA 4X30A 3Q02A 1DVNA 4AU3B 2WXZA 1JRRA 1KCTA 5CDXA 4EB1L 8APIA 3DY0A 3EOXA 1SEKA 4AU3A 4AQHA 1DZHI 1EZXA 1OYHL 1DVMA 1ATTA 2RIVA 4IC0A 2B4XI 1B3KA 1LQ8A 1ATHA 1UHGA 3UT3A 4Y40A 4BB2A 1XU8A 4P0FA 3R4LA 2XN5A 3VVJA 1JJOC 1QMNA 5INWA 3LW2A 1BY7A 1SR5A 3KCGI 2HIJL 1BR8I 1DZGI 7APIA 3Q03A 1JMJA 2B5TI 3DRUA 4IF8A 3CAAA 4AU2A 2BEHI 5BRRI 1NQ9I 1AS4A 2WXXA 2WY1A 1XQJA 1XQGA 1LJ5A 1AZXI 1WZ9A 4ROAA 2H4RA 1IMVA 1C5GA 1K9OI 1OPHA 4ZK3A 1IZ2A 2H4PA 2ZNHA 1M93B 1SNGA 4AU4A 9PAIA 4ZK0A 4C41A 9APIA 3NDAA 2XN6A 3OZQA 1JVQI 3FGQA 2VH4A 1OC0A 2OAYA 1OVAC 1HP7A 5HGCA 2QUGA 4ROBA 3CVMA 1OVAA 2WY0C 2D26A 1QMBA 1R1LI 1TB6I 3STOA 1E03I 2VDYA 2RIWA 4EB1I 4DY0A 1LK6I 1DB2A 4AJTA 3F1SA 1DZHL 2GD4C 5C98A 3PB1I 4CAAA 1OYHI 1ANTI 2B4XL 3LE2A 3ZHAA 5EI0A 4P0OA 2ACHA 1OO8A 3NDDA 1E05I 2XN3A 4G8RA 2XN7A 3H5CA 4G8OA 4KDSA 1C8OA 1HLEA 1D5SA 2ANTI 1ATUA 1E04I 2WXYC 4RO9A 2ARQA 2ZV6A 1T1FA 1OVAB 1DZGL 2HIJI
chains in the Genus database with same CATH superfamily
2OL2A 5CDZA 1JTIA 4AJUA 5CE0A 2CEOA 2V95A 1QLPA 2DUTA 2H4QA 2BEHL 4DY7C 4Y3KA 3T1PA 3B9FI 4AFXA 4YIAA 3F5NA 1A7CA 1YXAA 4C49A 2PEEA 4GA7A 5IO1A 2R9YA 2ARRA 2VDXA 3NDFA 3DLWA 3CWLA 1MTPA 3NE4A 4PYWA 4RSQA 3PZFA 1PSIA 4R9IA 1JMOA 3DRMA 3EVJI 3F02A 2WXWA 1F0CA 2PEFA 2WXZC 2HI9A 3CWMA 4DTEA 4X30A 3Q02A 1DVNA 4AU3B 2WXZA 1JRRA 1KCTA 5CDXA 4EB1L 8APIA 3DY0A 3EOXA 1SEKA 4AU3A 4AQHA 1DZHI 1EZXA 1OYHL 1DVMA 1ATTA 2RIVA 4IC0A 2B4XI 1B3KA 1LQ8A 1ATHA 1UHGA 3UT3A 4Y40A 4BB2A 1XU8A 4P0FA 3R4LA 2XN5A 3VVJA 1JJOC 1QMNA 5INWA 3LW2A 1BY7A 1SR5A 3KCGI 2HIJL 1BR8I 1DZGI 7APIA 3Q03A 1JMJA 2B5TI 3DRUA 4IF8A 3CAAA 4AU2A 2BEHI 5BRRI 1NQ9I 1AS4A 2WXXA 2WY1A 1XQJA 1XQGA 1LJ5A 1AZXI 1WZ9A 4ROAA 2H4RA 1IMVA 1C5GA 1K9OI 1OPHA 4ZK3A 1IZ2A 2H4PA 2ZNHA 1M93B 1SNGA 4AU4A 9PAIA 4ZK0A 4C41A 9APIA 3NDAA 2XN6A 3OZQA 1JVQI 3FGQA 2VH4A 1OC0A 2OAYA 1OVAC 1HP7A 5HGCA 2QUGA 4ROBA 3CVMA 1OVAA 2WY0C 2D26A 1QMBA 1R1LI 1TB6I 3STOA 1E03I 2VDYA 2RIWA 4EB1I 4DY0A 1LK6I 1DB2A 4AJTA 3F1SA 1DZHL 2GD4C 5C98A 3PB1I 4CAAA 1OYHI 1ANTI 2B4XL 3LE2A 3ZHAA 5EI0A 4P0OA 2ACHA 1OO8A 3NDDA 1E05I 2XN3A 4G8RA 2XN7A 3H5CA 4G8OA 4KDSA 1C8OA 1HLEA 1D5SA 2ANTI 1ATUA 1E04I 2WXYC 4RO9A 2ARQA 2ZV6A 1T1FA 1OVAB 1DZGL 2HIJI
chains in the Genus database with same CATH topology
2OL2A 5CDZA 1JTIA 4AJUA 5CE0A 2CEOA 2V95A 1QLPA 2DUTA 2H4QA 2BEHL 4DY7C 4Y3KA 3T1PA 3B9FI 4AFXA 4YIAA 3F5NA 1A7CA 1YXAA 4C49A 2PEEA 4GA7A 5IO1A 2R9YA 2ARRA 2VDXA 3NDFA 3DLWA 3CWLA 1MTPA 3NE4A 4PYWA 4RSQA 3PZFA 1PSIA 4R9IA 1JMOA 3DRMA 3EVJI 3F02A 2WXWA 1F0CA 2PEFA 2WXZC 2HI9A 3CWMA 4DTEA 4X30A 3Q02A 1DVNA 4AU3B 2WXZA 1JRRA 1KCTA 5CDXA 4EB1L 8APIA 3DY0A 3EOXA 1SEKA 4AU3A 4AQHA 1DZHI 1EZXA 1OYHL 1DVMA 1ATTA 2RIVA 4IC0A 2B4XI 1B3KA 1LQ8A 1ATHA 1UHGA 3UT3A 4Y40A 4BB2A 1XU8A 4P0FA 3R4LA 2XN5A 3VVJA 1JJOC 1QMNA 5INWA 3LW2A 1BY7A 1SR5A 3KCGI 2HIJL 1BR8I 1DZGI 7APIA 3Q03A 1JMJA 2B5TI 3DRUA 4IF8A 3CAAA 4AU2A 2BEHI 5BRRI 1NQ9I 1AS4A 2WXXA 2WY1A 1XQJA 1XQGA 1LJ5A 1AZXI 1WZ9A 4ROAA 2H4RA 1IMVA 1C5GA 1K9OI 1OPHA 4ZK3A 1IZ2A 2H4PA 2ZNHA 1M93B 1SNGA 4AU4A 9PAIA 4ZK0A 4C41A 9APIA 3NDAA 2XN6A 3OZQA 1JVQI 3FGQA 2VH4A 1OC0A 2OAYA 1OVAC 1HP7A 5HGCA 2QUGA 4ROBA 3CVMA 1OVAA 2WY0C 2D26A 1QMBA 1R1LI 1TB6I 3STOA 1E03I 2VDYA 2RIWA 4EB1I 4DY0A 1LK6I 1DB2A 4AJTA 3F1SA 1DZHL 2GD4C 5C98A 3PB1I 4CAAA 1OYHI 1ANTI 2B4XL 3LE2A 3ZHAA 5EI0A 4P0OA 2ACHA 1OO8A 3NDDA 1E05I 2XN3A 4G8RA 2XN7A 3H5CA 4G8OA 4KDSA 1C8OA 1HLEA 1D5SA 2ANTI 1ATUA 1E04I 2WXYC 4RO9A 2ARQA 2ZV6A 1T1FA 1OVAB 1DZGL 2HIJI
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2OL2 A;  5CDZ A;  1JTI A;  4AJU A;  5CE0 A;  2CEO A;  2V95 A;  1QLP A;  2DUT A;  2H4Q A;  2BEH L;  4DY7 C;  4Y3K A;  3T1P A;  3B9F I;  4AFX A;  4YIA A;  3F5N A;  1A7C A;  1YXA A;  4C49 A;  2PEE A;  4GA7 A;  5IO1 A;  2R9Y A;  2ARR A;  2VDX A;  3NDF A;  3DLW A;  3CWL A;  1MTP A;  3NE4 A;  4PYW A;  4RSQ A;  3PZF A;  1PSI A;  4R9I A;  1JMO A;  3DRM A;  3EVJ I;  3F02 A;  2WXW A;  1F0C A;  2PEF A;  2WXZ C;  2HI9 A;  3CWM A;  4DTE A;  4X30 A;  3Q02 A;  1DVN A;  4AU3 B;  2WXZ A;  1JRR A;  1KCT A;  5CDX A;  4EB1 L;  8API A;  3DY0 A;  3EOX A;  1SEK A;  4AU3 A;  4AQH A;  1DZH I;  1EZX A;  1OYH L;  1DVM A;  1ATT A;  2RIV A;  4IC0 A;  2B4X I;  1B3K A;  1LQ8 A;  1ATH A;  1UHG A;  3UT3 A;  4Y40 A;  4BB2 A;  1XU8 A;  4P0F A;  3R4L A;  2XN5 A;  3VVJ A;  1JJO C;  1QMN A;  5INW A;  3LW2 A;  1BY7 A;  1SR5 A;  3KCG I;  2HIJ L;  1BR8 I;  1DZG I;  7API A;  3Q03 A;  1JMJ A;  2B5T I;  3DRU A;  4IF8 A;  3CAA A;  4AU2 A;  2BEH I;  5BRR I;  1NQ9 I;  1AS4 A;  2WXX A;  2WY1 A;  1XQJ A;  1XQG A;  1LJ5 A;  1AZX I;  1WZ9 A;  4ROA A;  2H4R A;  1IMV A;  1C5G A;  1K9O I;  1OPH A;  4ZK3 A;  1IZ2 A;  2H4P A;  2ZNH A;  1M93 B;  1SNG A;  4AU4 A;  9PAI A;  4ZK0 A;  4C41 A;  9API A;  3NDA A;  2XN6 A;  3OZQ A;  1JVQ I;  3FGQ A;  2VH4 A;  1OC0 A;  2OAY A;  1OVA C;  1HP7 A;  5HGC A;  2QUG A;  4ROB A;  3CVM A;  1OVA A;  2WY0 C;  2D26 A;  1QMB A;  1R1L I;  1TB6 I;  3STO A;  1E03 I;  2VDY A;  2RIW A;  4EB1 I;  4DY0 A;  1LK6 I;  1DB2 A;  4AJT A;  3F1S A;  1DZH L;  2GD4 C;  5C98 A;  3PB1 I;  4CAA A;  1OYH I;  1ANT I;  2B4X L;  3LE2 A;  3ZHA A;  5EI0 A;  4P0O A;  2ACH A;  1OO8 A;  3NDD A;  1E05 I;  2XN3 A;  4G8R A;  2XN7 A;  3H5C A;  4G8O A;  4KDS A;  1C8O A;  1HLE A;  1D5S A;  2ANT I;  1ATU A;  1E04 I;  2WXY C;  4RO9 A;  2ARQ A;  2ZV6 A;  1T1F A;  1OVA B;  1DZG L;  2HIJ I; 
#chains in the Genus database with same CATH topology
 2OL2 A;  5CDZ A;  1JTI A;  4AJU A;  5CE0 A;  2CEO A;  2V95 A;  1QLP A;  2DUT A;  2H4Q A;  2BEH L;  4DY7 C;  4Y3K A;  3T1P A;  3B9F I;  4AFX A;  4YIA A;  3F5N A;  1A7C A;  1YXA A;  4C49 A;  2PEE A;  4GA7 A;  5IO1 A;  2R9Y A;  2ARR A;  2VDX A;  3NDF A;  3DLW A;  3CWL A;  1MTP A;  3NE4 A;  4PYW A;  4RSQ A;  3PZF A;  1PSI A;  4R9I A;  1JMO A;  3DRM A;  3EVJ I;  3F02 A;  2WXW A;  1F0C A;  2PEF A;  2WXZ C;  2HI9 A;  3CWM A;  4DTE A;  4X30 A;  3Q02 A;  1DVN A;  4AU3 B;  2WXZ A;  1JRR A;  1KCT A;  5CDX A;  4EB1 L;  8API A;  3DY0 A;  3EOX A;  1SEK A;  4AU3 A;  4AQH A;  1DZH I;  1EZX A;  1OYH L;  1DVM A;  1ATT A;  2RIV A;  4IC0 A;  2B4X I;  1B3K A;  1LQ8 A;  1ATH A;  1UHG A;  3UT3 A;  4Y40 A;  4BB2 A;  1XU8 A;  4P0F A;  3R4L A;  2XN5 A;  3VVJ A;  1JJO C;  1QMN A;  5INW A;  3LW2 A;  1BY7 A;  1SR5 A;  3KCG I;  2HIJ L;  1BR8 I;  1DZG I;  7API A;  3Q03 A;  1JMJ A;  2B5T I;  3DRU A;  4IF8 A;  3CAA A;  4AU2 A;  2BEH I;  5BRR I;  1NQ9 I;  1AS4 A;  2WXX A;  2WY1 A;  1XQJ A;  1XQG A;  1LJ5 A;  1AZX I;  1WZ9 A;  4ROA A;  2H4R A;  1IMV A;  1C5G A;  1K9O I;  1OPH A;  4ZK3 A;  1IZ2 A;  2H4P A;  2ZNH A;  1M93 B;  1SNG A;  4AU4 A;  9PAI A;  4ZK0 A;  4C41 A;  9API A;  3NDA A;  2XN6 A;  3OZQ A;  1JVQ I;  3FGQ A;  2VH4 A;  1OC0 A;  2OAY A;  1OVA C;  1HP7 A;  5HGC A;  2QUG A;  4ROB A;  3CVM A;  1OVA A;  2WY0 C;  2D26 A;  1QMB A;  1R1L I;  1TB6 I;  3STO A;  1E03 I;  2VDY A;  2RIW A;  4EB1 I;  4DY0 A;  1LK6 I;  1DB2 A;  4AJT A;  3F1S A;  1DZH L;  2GD4 C;  5C98 A;  3PB1 I;  4CAA A;  1OYH I;  1ANT I;  2B4X L;  3LE2 A;  3ZHA A;  5EI0 A;  4P0O A;  2ACH A;  1OO8 A;  3NDD A;  1E05 I;  2XN3 A;  4G8R A;  2XN7 A;  3H5C A;  4G8O A;  4KDS A;  1C8O A;  1HLE A;  1D5S A;  2ANT I;  1ATU A;  1E04 I;  2WXY C;  4RO9 A;  2ARQ A;  2ZV6 A;  1T1F A;  1OVA B;  1DZG L;  2HIJ I; 
#chains in the Genus database with same CATH homology
 2OL2 A;  5CDZ A;  1JTI A;  4AJU A;  5CE0 A;  2CEO A;  2V95 A;  1QLP A;  2DUT A;  2H4Q A;  2BEH L;  4DY7 C;  4Y3K A;  3T1P A;  3B9F I;  4AFX A;  4YIA A;  3F5N A;  1A7C A;  1YXA A;  4C49 A;  2PEE A;  4GA7 A;  5IO1 A;  2R9Y A;  2ARR A;  2VDX A;  3NDF A;  3DLW A;  3CWL A;  1MTP A;  3NE4 A;  4PYW A;  4RSQ A;  3PZF A;  1PSI A;  4R9I A;  1JMO A;  3DRM A;  3EVJ I;  3F02 A;  2WXW A;  1F0C A;  2PEF A;  2WXZ C;  2HI9 A;  3CWM A;  4DTE A;  4X30 A;  3Q02 A;  1DVN A;  4AU3 B;  2WXZ A;  1JRR A;  1KCT A;  5CDX A;  4EB1 L;  8API A;  3DY0 A;  3EOX A;  1SEK A;  4AU3 A;  4AQH A;  1DZH I;  1EZX A;  1OYH L;  1DVM A;  1ATT A;  2RIV A;  4IC0 A;  2B4X I;  1B3K A;  1LQ8 A;  1ATH A;  1UHG A;  3UT3 A;  4Y40 A;  4BB2 A;  1XU8 A;  4P0F A;  3R4L A;  2XN5 A;  3VVJ A;  1JJO C;  1QMN A;  5INW A;  3LW2 A;  1BY7 A;  1SR5 A;  3KCG I;  2HIJ L;  1BR8 I;  1DZG I;  7API A;  3Q03 A;  1JMJ A;  2B5T I;  3DRU A;  4IF8 A;  3CAA A;  4AU2 A;  2BEH I;  5BRR I;  1NQ9 I;  1AS4 A;  2WXX A;  2WY1 A;  1XQJ A;  1XQG A;  1LJ5 A;  1AZX I;  1WZ9 A;  4ROA A;  2H4R A;  1IMV A;  1C5G A;  1K9O I;  1OPH A;  4ZK3 A;  1IZ2 A;  2H4P A;  2ZNH A;  1M93 B;  1SNG A;  4AU4 A;  9PAI A;  4ZK0 A;  4C41 A;  9API A;  3NDA A;  2XN6 A;  3OZQ A;  1JVQ I;  3FGQ A;  2VH4 A;  1OC0 A;  2OAY A;  1OVA C;  1HP7 A;  5HGC A;  2QUG A;  4ROB A;  3CVM A;  1OVA A;  2WY0 C;  2D26 A;  1QMB A;  1R1L I;  1TB6 I;  3STO A;  1E03 I;  2VDY A;  2RIW A;  4EB1 I;  4DY0 A;  1LK6 I;  1DB2 A;  4AJT A;  3F1S A;  1DZH L;  2GD4 C;  5C98 A;  3PB1 I;  4CAA A;  1OYH I;  1ANT I;  2B4X L;  3LE2 A;  3ZHA A;  5EI0 A;  4P0O A;  2ACH A;  1OO8 A;  3NDD A;  1E05 I;  2XN3 A;  4G8R A;  2XN7 A;  3H5C A;  4G8O A;  4KDS A;  1C8O A;  1HLE A;  1D5S A;  2ANT I;  1ATU A;  1E04 I;  2WXY C;  4RO9 A;  2ARQ A;  2ZV6 A;  1T1F A;  1OVA B;  1DZG L;  2HIJ I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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