2BEHL

Crystal structure of antithrombin variant s137a/v317c/t401c with plasma latent antithrombin
Total Genus 117
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
117
sequence length
426
structure length
403
Chain Sequence
VDICTAKPRDIPMNPMCIYRATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISETSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNKANRPFLVFIREVPLNTIIFMGRVANPC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of monomeric native antithrombin reveals a novel reactive center loop conformation.
pubmed doi rcsb
molecule keywords Antithrombin-III
molecule tags Blood clotting
source organism Homo sapiens
total genus 117
structure length 403
sequence length 426
ec nomenclature
pdb deposition date 2005-10-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
L PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 2behL02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 2behL01
1R1LI 4P0FA 1DVMA 1EZXA 4AU3A 7APIA 2VDYA 3CAAA 4AFXA 1DZHI 8APIA 9PAIA 3EVJI 2RIVA 2WXWA 1XU8A 2HIJL 1OC0A 2B5TI 4AU2A 1SNGA 1PSIA 1SEKA 2XN3A 2RIWA 2OAYA 3CWMA 2ZNHA 3EOXA 4P0OA 4Y40A 1DZHL 3F5NA 1DZGI 1K9OI 1MTPA 5C98A 1NQ9I 1LQ8A 2H4RA 1E03I 2WY1A 4ZK3A 2V95A 2OL2A 2WXZC 1C8OA 2H4QA 5BRRI 1E05I 1LK6I 3CVMA 2XN7A 1XQJA 4ROBA 1ATHA 2HIJI 5CE0A 1JMOA 3STOA 2HI9A 4KDSA 1IZ2A 4DTEA 1JJOC 3PB1I 1C5GA 2ACHA 1IMVA 3DRMA 4BB2A 1E04I 5HGCA 3R4LA 1QMBA 4G8OA 2WXYC 3T1PA 1WZ9A 1QMNA 1JRRA 2VDXA 2XN5A 4ZK0A 3F1SA 2D26A 2WY0C 4IC0A 1AS4A 1B3KA 1SR5A 1KCTA 4AJUA 1M93B 5INWA 1DVNA 3OZQA 2WXZA 5CDZA 1JTIA 3NE4A 1OO8A 3Q03A 2R9YA 1DB2A 2WXXA 5EI0A 2BEHL 2H4PA 3KCGI 4IF8A 1XQGA 4C41A 4AQHA 1JVQI 2QUGA 2GD4C 4YIAA 1OVAC 3H5CA 1TB6I 1ATUA 1ANTI 1AZXI 2DUTA 2ARQA 3NDAA 3LE2A 4CAAA 1T1FA 4X30A 1OYHL 4DY7C 1ATTA 4Y3KA 3DRUA 2BEHI 4R9IA 3DLWA 3ZHAA 1LJ5A 2ZV6A 1D5SA 1UHGA 9APIA 2ARRA 3FGQA 2B4XI 4RSQA 3B9FI 3NDFA 4PYWA 1F0CA 3VVJA 2PEEA 1BR8I 3NDDA 3Q02A 3UT3A 4C49A 1HLEA 1OPHA 1YXAA 2VH4A 1JMJA 2PEFA 4GA7A 4AU4A 4EB1I 3CWLA 2B4XL 1OYHI 2CEOA 5CDXA 4G8RA 4ROAA 3DY0A 1OVAB 4RO9A 2ANTI 1QLPA 1A7CA 3PZFA 5IO1A 4AJTA 3F02A 4DY0A 4EB1L 1BY7A 1DZGL 1HP7A 3LW2A 4AU3B 2XN6A 1OVAA
chains in the Genus database with same CATH superfamily
1R1LI 4P0FA 1DVMA 1EZXA 4AU3A 7APIA 2VDYA 3CAAA 4AFXA 1DZHI 8APIA 9PAIA 3EVJI 2RIVA 2WXWA 1XU8A 2HIJL 1OC0A 2B5TI 4AU2A 1SNGA 1PSIA 1SEKA 2XN3A 2RIWA 2OAYA 3CWMA 2ZNHA 3EOXA 4P0OA 4Y40A 1DZHL 3F5NA 1DZGI 1K9OI 1MTPA 5C98A 1NQ9I 1LQ8A 2H4RA 1E03I 2WY1A 4ZK3A 2V95A 2OL2A 2WXZC 1C8OA 2H4QA 5BRRI 1E05I 1LK6I 3CVMA 2XN7A 1XQJA 4ROBA 1ATHA 2HIJI 5CE0A 1JMOA 3STOA 2HI9A 4KDSA 1IZ2A 4DTEA 1JJOC 3PB1I 1C5GA 2ACHA 1IMVA 3DRMA 4BB2A 1E04I 5HGCA 3R4LA 1QMBA 4G8OA 2WXYC 3T1PA 1WZ9A 1QMNA 1JRRA 2VDXA 2XN5A 4ZK0A 3F1SA 2D26A 2WY0C 4IC0A 1AS4A 1B3KA 1SR5A 1KCTA 4AJUA 1M93B 5INWA 1DVNA 3OZQA 2WXZA 5CDZA 1JTIA 3NE4A 1OO8A 3Q03A 2R9YA 1DB2A 2WXXA 5EI0A 2BEHL 2H4PA 3KCGI 4IF8A 1XQGA 4C41A 4AQHA 1JVQI 2QUGA 2GD4C 4YIAA 1OVAC 3H5CA 1TB6I 1ATUA 1ANTI 1AZXI 2DUTA 2ARQA 3NDAA 3LE2A 4CAAA 1T1FA 4X30A 1OYHL 4DY7C 1ATTA 4Y3KA 3DRUA 2BEHI 4R9IA 3DLWA 3ZHAA 1LJ5A 2ZV6A 1D5SA 1UHGA 9APIA 2ARRA 3FGQA 2B4XI 4RSQA 3B9FI 3NDFA 4PYWA 1F0CA 3VVJA 2PEEA 1BR8I 3NDDA 3Q02A 3UT3A 4C49A 1HLEA 1OPHA 1YXAA 2VH4A 1JMJA 2PEFA 4GA7A 4AU4A 4EB1I 3CWLA 2B4XL 1OYHI 2CEOA 5CDXA 4G8RA 4ROAA 3DY0A 1OVAB 4RO9A 2ANTI 1QLPA 1A7CA 3PZFA 5IO1A 4AJTA 3F02A 4DY0A 4EB1L 1BY7A 1DZGL 1HP7A 3LW2A 4AU3B 2XN6A 1OVAA
chains in the Genus database with same CATH topology
1R1LI 4P0FA 1DVMA 1EZXA 4AU3A 7APIA 2VDYA 3CAAA 4AFXA 1DZHI 8APIA 9PAIA 3EVJI 2RIVA 2WXWA 1XU8A 2HIJL 1OC0A 2B5TI 4AU2A 1SNGA 1PSIA 1SEKA 2XN3A 2RIWA 2OAYA 3CWMA 2ZNHA 3EOXA 4P0OA 4Y40A 1DZHL 3F5NA 1DZGI 1K9OI 1MTPA 5C98A 1NQ9I 1LQ8A 2H4RA 1E03I 2WY1A 4ZK3A 2V95A 2OL2A 2WXZC 1C8OA 2H4QA 5BRRI 1E05I 1LK6I 3CVMA 2XN7A 1XQJA 4ROBA 1ATHA 2HIJI 5CE0A 1JMOA 3STOA 2HI9A 4KDSA 1IZ2A 4DTEA 1JJOC 3PB1I 1C5GA 2ACHA 1IMVA 3DRMA 4BB2A 1E04I 5HGCA 3R4LA 1QMBA 4G8OA 2WXYC 3T1PA 1WZ9A 1QMNA 1JRRA 2VDXA 2XN5A 4ZK0A 3F1SA 2D26A 2WY0C 4IC0A 1AS4A 1B3KA 1SR5A 1KCTA 4AJUA 1M93B 5INWA 1DVNA 3OZQA 2WXZA 5CDZA 1JTIA 3NE4A 1OO8A 3Q03A 2R9YA 1DB2A 2WXXA 5EI0A 2BEHL 2H4PA 3KCGI 4IF8A 1XQGA 4C41A 4AQHA 1JVQI 2QUGA 2GD4C 4YIAA 1OVAC 3H5CA 1TB6I 1ATUA 1ANTI 1AZXI 2DUTA 2ARQA 3NDAA 3LE2A 4CAAA 1T1FA 4X30A 1OYHL 4DY7C 1ATTA 4Y3KA 3DRUA 2BEHI 4R9IA 3DLWA 3ZHAA 1LJ5A 2ZV6A 1D5SA 1UHGA 9APIA 2ARRA 3FGQA 2B4XI 4RSQA 3B9FI 3NDFA 4PYWA 1F0CA 3VVJA 2PEEA 1BR8I 3NDDA 3Q02A 3UT3A 4C49A 1HLEA 1OPHA 1YXAA 2VH4A 1JMJA 2PEFA 4GA7A 4AU4A 4EB1I 3CWLA 2B4XL 1OYHI 2CEOA 5CDXA 4G8RA 4ROAA 3DY0A 1OVAB 4RO9A 2ANTI 1QLPA 1A7CA 3PZFA 5IO1A 4AJTA 3F02A 4DY0A 4EB1L 1BY7A 1DZGL 1HP7A 3LW2A 4AU3B 2XN6A 1OVAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1R1L I;  4P0F A;  1DVM A;  1EZX A;  4AU3 A;  7API A;  2VDY A;  3CAA A;  4AFX A;  1DZH I;  8API A;  9PAI A;  3EVJ I;  2RIV A;  2WXW A;  1XU8 A;  2HIJ L;  1OC0 A;  2B5T I;  4AU2 A;  1SNG A;  1PSI A;  1SEK A;  2XN3 A;  2RIW A;  2OAY A;  3CWM A;  2ZNH A;  3EOX A;  4P0O A;  4Y40 A;  1DZH L;  3F5N A;  1DZG I;  1K9O I;  1MTP A;  5C98 A;  1NQ9 I;  1LQ8 A;  2H4R A;  1E03 I;  2WY1 A;  4ZK3 A;  2V95 A;  2OL2 A;  2WXZ C;  1C8O A;  2H4Q A;  5BRR I;  1E05 I;  1LK6 I;  3CVM A;  2XN7 A;  1XQJ A;  4ROB A;  1ATH A;  2HIJ I;  5CE0 A;  1JMO A;  3STO A;  2HI9 A;  4KDS A;  1IZ2 A;  4DTE A;  1JJO C;  3PB1 I;  1C5G A;  2ACH A;  1IMV A;  3DRM A;  4BB2 A;  1E04 I;  5HGC A;  3R4L A;  1QMB A;  4G8O A;  2WXY C;  3T1P A;  1WZ9 A;  1QMN A;  1JRR A;  2VDX A;  2XN5 A;  4ZK0 A;  3F1S A;  2D26 A;  2WY0 C;  4IC0 A;  1AS4 A;  1B3K A;  1SR5 A;  1KCT A;  4AJU A;  1M93 B;  5INW A;  1DVN A;  3OZQ A;  2WXZ A;  5CDZ A;  1JTI A;  3NE4 A;  1OO8 A;  3Q03 A;  2R9Y A;  1DB2 A;  2WXX A;  5EI0 A;  2BEH L;  2H4P A;  3KCG I;  4IF8 A;  1XQG A;  4C41 A;  4AQH A;  1JVQ I;  2QUG A;  2GD4 C;  4YIA A;  1OVA C;  3H5C A;  1TB6 I;  1ATU A;  1ANT I;  1AZX I;  2DUT A;  2ARQ A;  3NDA A;  3LE2 A;  4CAA A;  1T1F A;  4X30 A;  1OYH L;  4DY7 C;  1ATT A;  4Y3K A;  3DRU A;  2BEH I;  4R9I A;  3DLW A;  3ZHA A;  1LJ5 A;  2ZV6 A;  1D5S A;  1UHG A;  9API A;  2ARR A;  3FGQ A;  2B4X I;  4RSQ A;  3B9F I;  3NDF A;  4PYW A;  1F0C A;  3VVJ A;  2PEE A;  1BR8 I;  3NDD A;  3Q02 A;  3UT3 A;  4C49 A;  1HLE A;  1OPH A;  1YXA A;  2VH4 A;  1JMJ A;  2PEF A;  4GA7 A;  4AU4 A;  4EB1 I;  3CWL A;  2B4X L;  1OYH I;  2CEO A;  5CDX A;  4G8R A;  4ROA A;  3DY0 A;  1OVA B;  4RO9 A;  2ANT I;  1QLP A;  1A7C A;  3PZF A;  5IO1 A;  4AJT A;  3F02 A;  4DY0 A;  4EB1 L;  1BY7 A;  1DZG L;  1HP7 A;  3LW2 A;  4AU3 B;  2XN6 A;  1OVA A; 
#chains in the Genus database with same CATH topology
 1R1L I;  4P0F A;  1DVM A;  1EZX A;  4AU3 A;  7API A;  2VDY A;  3CAA A;  4AFX A;  1DZH I;  8API A;  9PAI A;  3EVJ I;  2RIV A;  2WXW A;  1XU8 A;  2HIJ L;  1OC0 A;  2B5T I;  4AU2 A;  1SNG A;  1PSI A;  1SEK A;  2XN3 A;  2RIW A;  2OAY A;  3CWM A;  2ZNH A;  3EOX A;  4P0O A;  4Y40 A;  1DZH L;  3F5N A;  1DZG I;  1K9O I;  1MTP A;  5C98 A;  1NQ9 I;  1LQ8 A;  2H4R A;  1E03 I;  2WY1 A;  4ZK3 A;  2V95 A;  2OL2 A;  2WXZ C;  1C8O A;  2H4Q A;  5BRR I;  1E05 I;  1LK6 I;  3CVM A;  2XN7 A;  1XQJ A;  4ROB A;  1ATH A;  2HIJ I;  5CE0 A;  1JMO A;  3STO A;  2HI9 A;  4KDS A;  1IZ2 A;  4DTE A;  1JJO C;  3PB1 I;  1C5G A;  2ACH A;  1IMV A;  3DRM A;  4BB2 A;  1E04 I;  5HGC A;  3R4L A;  1QMB A;  4G8O A;  2WXY C;  3T1P A;  1WZ9 A;  1QMN A;  1JRR A;  2VDX A;  2XN5 A;  4ZK0 A;  3F1S A;  2D26 A;  2WY0 C;  4IC0 A;  1AS4 A;  1B3K A;  1SR5 A;  1KCT A;  4AJU A;  1M93 B;  5INW A;  1DVN A;  3OZQ A;  2WXZ A;  5CDZ A;  1JTI A;  3NE4 A;  1OO8 A;  3Q03 A;  2R9Y A;  1DB2 A;  2WXX A;  5EI0 A;  2BEH L;  2H4P A;  3KCG I;  4IF8 A;  1XQG A;  4C41 A;  4AQH A;  1JVQ I;  2QUG A;  2GD4 C;  4YIA A;  1OVA C;  3H5C A;  1TB6 I;  1ATU A;  1ANT I;  1AZX I;  2DUT A;  2ARQ A;  3NDA A;  3LE2 A;  4CAA A;  1T1F A;  4X30 A;  1OYH L;  4DY7 C;  1ATT A;  4Y3K A;  3DRU A;  2BEH I;  4R9I A;  3DLW A;  3ZHA A;  1LJ5 A;  2ZV6 A;  1D5S A;  1UHG A;  9API A;  2ARR A;  3FGQ A;  2B4X I;  4RSQ A;  3B9F I;  3NDF A;  4PYW A;  1F0C A;  3VVJ A;  2PEE A;  1BR8 I;  3NDD A;  3Q02 A;  3UT3 A;  4C49 A;  1HLE A;  1OPH A;  1YXA A;  2VH4 A;  1JMJ A;  2PEF A;  4GA7 A;  4AU4 A;  4EB1 I;  3CWL A;  2B4X L;  1OYH I;  2CEO A;  5CDX A;  4G8R A;  4ROA A;  3DY0 A;  1OVA B;  4RO9 A;  2ANT I;  1QLP A;  1A7C A;  3PZF A;  5IO1 A;  4AJT A;  3F02 A;  4DY0 A;  4EB1 L;  1BY7 A;  1DZG L;  1HP7 A;  3LW2 A;  4AU3 B;  2XN6 A;  1OVA A; 
#chains in the Genus database with same CATH homology
 1R1L I;  4P0F A;  1DVM A;  1EZX A;  4AU3 A;  7API A;  2VDY A;  3CAA A;  4AFX A;  1DZH I;  8API A;  9PAI A;  3EVJ I;  2RIV A;  2WXW A;  1XU8 A;  2HIJ L;  1OC0 A;  2B5T I;  4AU2 A;  1SNG A;  1PSI A;  1SEK A;  2XN3 A;  2RIW A;  2OAY A;  3CWM A;  2ZNH A;  3EOX A;  4P0O A;  4Y40 A;  1DZH L;  3F5N A;  1DZG I;  1K9O I;  1MTP A;  5C98 A;  1NQ9 I;  1LQ8 A;  2H4R A;  1E03 I;  2WY1 A;  4ZK3 A;  2V95 A;  2OL2 A;  2WXZ C;  1C8O A;  2H4Q A;  5BRR I;  1E05 I;  1LK6 I;  3CVM A;  2XN7 A;  1XQJ A;  4ROB A;  1ATH A;  2HIJ I;  5CE0 A;  1JMO A;  3STO A;  2HI9 A;  4KDS A;  1IZ2 A;  4DTE A;  1JJO C;  3PB1 I;  1C5G A;  2ACH A;  1IMV A;  3DRM A;  4BB2 A;  1E04 I;  5HGC A;  3R4L A;  1QMB A;  4G8O A;  2WXY C;  3T1P A;  1WZ9 A;  1QMN A;  1JRR A;  2VDX A;  2XN5 A;  4ZK0 A;  3F1S A;  2D26 A;  2WY0 C;  4IC0 A;  1AS4 A;  1B3K A;  1SR5 A;  1KCT A;  4AJU A;  1M93 B;  5INW A;  1DVN A;  3OZQ A;  2WXZ A;  5CDZ A;  1JTI A;  3NE4 A;  1OO8 A;  3Q03 A;  2R9Y A;  1DB2 A;  2WXX A;  5EI0 A;  2BEH L;  2H4P A;  3KCG I;  4IF8 A;  1XQG A;  4C41 A;  4AQH A;  1JVQ I;  2QUG A;  2GD4 C;  4YIA A;  1OVA C;  3H5C A;  1TB6 I;  1ATU A;  1ANT I;  1AZX I;  2DUT A;  2ARQ A;  3NDA A;  3LE2 A;  4CAA A;  1T1F A;  4X30 A;  1OYH L;  4DY7 C;  1ATT A;  4Y3K A;  3DRU A;  2BEH I;  4R9I A;  3DLW A;  3ZHA A;  1LJ5 A;  2ZV6 A;  1D5S A;  1UHG A;  9API A;  2ARR A;  3FGQ A;  2B4X I;  4RSQ A;  3B9F I;  3NDF A;  4PYW A;  1F0C A;  3VVJ A;  2PEE A;  1BR8 I;  3NDD A;  3Q02 A;  3UT3 A;  4C49 A;  1HLE A;  1OPH A;  1YXA A;  2VH4 A;  1JMJ A;  2PEF A;  4GA7 A;  4AU4 A;  4EB1 I;  3CWL A;  2B4X L;  1OYH I;  2CEO A;  5CDX A;  4G8R A;  4ROA A;  3DY0 A;  1OVA B;  4RO9 A;  2ANT I;  1QLP A;  1A7C A;  3PZF A;  5IO1 A;  4AJT A;  3F02 A;  4DY0 A;  4EB1 L;  1BY7 A;  1DZG L;  1HP7 A;  3LW2 A;  4AU3 B;  2XN6 A;  1OVA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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