1SR5A

Antithrombin-anhydrothrombin-heparin ternary complex structure
Total Genus 91
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
91
sequence length
427
structure length
409
Chain Sequence
VDICTAKPRDIPMNPMCIYRSPQKIPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIDDLYVSDAFHKAFLEVNEEGAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The ternary complex of antithrombin-anhydrothrombin-heparin reveals the basis of inhibitor specificity.
pubmed doi rcsb
molecule keywords Antithrombin-III
molecule tags Hydrolase/hydrolase inhibitor
total genus 91
structure length 409
sequence length 427
ec nomenclature
pdb deposition date 2004-03-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 1sr5A01
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 1sr5A02
4ROBA 3F1SA 2PEFA 2OL2A 2XN5A 3NDFA 3STOA 1DZGL 4G8RA 2PEEA 4AU4A 1DZGI 3UT3A 3EOXA 1XU8A 1JJOC 1R1LI 1BR8I 1K9OI 3CWMA 3CWLA 3NDDA 1JRRA 3Q02A 4GA7A 1DB2A 3PB1I 3CAAA 1OYHL 1XQJA 4X30A 2WXZC 2WY0C 2XN3A 2H4RA 4AQHA 1OYHI 1DVMA 2ZNHA 4YIAA 1NQ9I 2VDYA 3Q03A 2GD4C 1AZXI 4P0OA 1MTPA 2WXWA 3F02A 1AS4A 4C49A 4AU2A 3NDAA 1LK6I 2V95A 2WXZA 3DLWA 1OO8A 3EVJI 2XN6A 4DY7C 3CVMA 1SR5A 3FGQA 4AFXA 2ARRA 4G8OA 1JVQI 1KCTA 4IF8A 1JTIA 4Y3KA 4AU3B 1OC0A 3DRUA 5INWA 1LJ5A 1ATHA 1OVAC 4RO9A 2HIJL 3VVJA 3ZHAA 8APIA 9PAIA 2RIVA 4ROAA 1ANTI 2HIJI 4AJTA 3PZFA 1T1FA 3R4LA 3LE2A 2CEOA 3DY0A 2B5TI 2BEHL 2B4XI 4AU3A 2WXYC 1PSIA 2WY1A 3F5NA 1OVAA 4PYWA 4ZK0A 2WXXA 5EI0A 1LQ8A 4ZK3A 2BEHI 4EB1L 4DY0A 1JMJA 1D5SA 1TB6I 2H4PA 1EZXA 1M93B 3NE4A 1E04I 4BB2A 2ZV6A 4EB1I 2HI9A 1E05I 1OVAB 1ATUA 4KDSA 1UHGA 1QMNA 7APIA 1HLEA 2ANTI 2R9YA 2VH4A 4DTEA 4CAAA 3LW2A 2D26A 1WZ9A 3B9FI 3KCGI 5HGCA 1IMVA 4Y40A 3DRMA 2VDXA 2B4XL 1BY7A 1QLPA 2H4QA 3H5CA 1QMBA 2DUTA 5CDZA 1DVNA 5IO1A 1ATTA 2RIWA 5CDXA 1HP7A 2OAYA 1C8OA 1OPHA 1SNGA 3OZQA 4IC0A 5BRRI 3T1PA 1C5GA 1E03I 4R9IA 2ARQA 1JMOA 5C98A 1DZHL 4RSQA 2ACHA 1IZ2A 1SEKA 1A7CA 2XN7A 9APIA 1XQGA 1B3KA 1YXAA 4AJUA 4P0FA 4C41A 2QUGA 1DZHI 5CE0A 1F0CA
chains in the Genus database with same CATH superfamily
4ROBA 3F1SA 2PEFA 2OL2A 2XN5A 3NDFA 3STOA 1DZGL 4G8RA 2PEEA 4AU4A 1DZGI 3UT3A 3EOXA 1XU8A 1JJOC 1R1LI 1BR8I 1K9OI 3CWMA 3CWLA 3NDDA 1JRRA 3Q02A 4GA7A 1DB2A 3PB1I 3CAAA 1OYHL 1XQJA 4X30A 2WXZC 2WY0C 2XN3A 2H4RA 4AQHA 1OYHI 1DVMA 2ZNHA 4YIAA 1NQ9I 2VDYA 3Q03A 2GD4C 1AZXI 4P0OA 1MTPA 2WXWA 3F02A 1AS4A 4C49A 4AU2A 3NDAA 1LK6I 2V95A 2WXZA 3DLWA 1OO8A 3EVJI 2XN6A 4DY7C 3CVMA 1SR5A 3FGQA 4AFXA 2ARRA 4G8OA 1JVQI 1KCTA 4IF8A 1JTIA 4Y3KA 4AU3B 1OC0A 3DRUA 5INWA 1LJ5A 1ATHA 1OVAC 4RO9A 2HIJL 3VVJA 3ZHAA 8APIA 9PAIA 2RIVA 4ROAA 1ANTI 2HIJI 4AJTA 3PZFA 1T1FA 3R4LA 3LE2A 2CEOA 3DY0A 2B5TI 2BEHL 2B4XI 4AU3A 2WXYC 1PSIA 2WY1A 3F5NA 1OVAA 4PYWA 4ZK0A 2WXXA 5EI0A 1LQ8A 4ZK3A 2BEHI 4EB1L 4DY0A 1JMJA 1D5SA 1TB6I 2H4PA 1EZXA 1M93B 3NE4A 1E04I 4BB2A 2ZV6A 4EB1I 2HI9A 1E05I 1OVAB 1ATUA 4KDSA 1UHGA 1QMNA 7APIA 1HLEA 2ANTI 2R9YA 2VH4A 4DTEA 4CAAA 3LW2A 2D26A 1WZ9A 3B9FI 3KCGI 5HGCA 1IMVA 4Y40A 3DRMA 2VDXA 2B4XL 1BY7A 1QLPA 2H4QA 3H5CA 1QMBA 2DUTA 5CDZA 1DVNA 5IO1A 1ATTA 2RIWA 5CDXA 1HP7A 2OAYA 1C8OA 1OPHA 1SNGA 3OZQA 4IC0A 5BRRI 3T1PA 1C5GA 1E03I 4R9IA 2ARQA 1JMOA 5C98A 1DZHL 4RSQA 2ACHA 1IZ2A 1SEKA 1A7CA 2XN7A 9APIA 1XQGA 1B3KA 1YXAA 4AJUA 4P0FA 4C41A 2QUGA 1DZHI 5CE0A 1F0CA
chains in the Genus database with same CATH topology
4ROBA 3F1SA 2PEFA 2OL2A 2XN5A 3NDFA 3STOA 1DZGL 4G8RA 2PEEA 4AU4A 1DZGI 3UT3A 3EOXA 1XU8A 1JJOC 1R1LI 1BR8I 1K9OI 3CWMA 3CWLA 3NDDA 1JRRA 3Q02A 4GA7A 1DB2A 3PB1I 3CAAA 1OYHL 1XQJA 4X30A 2WXZC 2WY0C 2XN3A 2H4RA 4AQHA 1OYHI 1DVMA 2ZNHA 4YIAA 1NQ9I 2VDYA 3Q03A 2GD4C 1AZXI 4P0OA 1MTPA 2WXWA 3F02A 1AS4A 4C49A 4AU2A 3NDAA 1LK6I 2V95A 2WXZA 3DLWA 1OO8A 3EVJI 2XN6A 4DY7C 3CVMA 1SR5A 3FGQA 4AFXA 2ARRA 4G8OA 1JVQI 1KCTA 4IF8A 1JTIA 4Y3KA 4AU3B 1OC0A 3DRUA 5INWA 1LJ5A 1ATHA 1OVAC 4RO9A 2HIJL 3VVJA 3ZHAA 8APIA 9PAIA 2RIVA 4ROAA 1ANTI 2HIJI 4AJTA 3PZFA 1T1FA 3R4LA 3LE2A 2CEOA 3DY0A 2B5TI 2BEHL 2B4XI 4AU3A 2WXYC 1PSIA 2WY1A 3F5NA 1OVAA 4PYWA 4ZK0A 2WXXA 5EI0A 1LQ8A 4ZK3A 2BEHI 4EB1L 4DY0A 1JMJA 1D5SA 1TB6I 2H4PA 1EZXA 1M93B 3NE4A 1E04I 4BB2A 2ZV6A 4EB1I 2HI9A 1E05I 1OVAB 1ATUA 4KDSA 1UHGA 1QMNA 7APIA 1HLEA 2ANTI 2R9YA 2VH4A 4DTEA 4CAAA 3LW2A 2D26A 1WZ9A 3B9FI 3KCGI 5HGCA 1IMVA 4Y40A 3DRMA 2VDXA 2B4XL 1BY7A 1QLPA 2H4QA 3H5CA 1QMBA 2DUTA 5CDZA 1DVNA 5IO1A 1ATTA 2RIWA 5CDXA 1HP7A 2OAYA 1C8OA 1OPHA 1SNGA 3OZQA 4IC0A 5BRRI 3T1PA 1C5GA 1E03I 4R9IA 2ARQA 1JMOA 5C98A 1DZHL 4RSQA 2ACHA 1IZ2A 1SEKA 1A7CA 2XN7A 9APIA 1XQGA 1B3KA 1YXAA 4AJUA 4P0FA 4C41A 2QUGA 1DZHI 5CE0A 1F0CA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ROB A;  3F1S A;  2PEF A;  2OL2 A;  2XN5 A;  3NDF A;  3STO A;  1DZG L;  4G8R A;  2PEE A;  4AU4 A;  1DZG I;  3UT3 A;  3EOX A;  1XU8 A;  1JJO C;  1R1L I;  1BR8 I;  1K9O I;  3CWM A;  3CWL A;  3NDD A;  1JRR A;  3Q02 A;  4GA7 A;  1DB2 A;  3PB1 I;  3CAA A;  1OYH L;  1XQJ A;  4X30 A;  2WXZ C;  2WY0 C;  2XN3 A;  2H4R A;  4AQH A;  1OYH I;  1DVM A;  2ZNH A;  4YIA A;  1NQ9 I;  2VDY A;  3Q03 A;  2GD4 C;  1AZX I;  4P0O A;  1MTP A;  2WXW A;  3F02 A;  1AS4 A;  4C49 A;  4AU2 A;  3NDA A;  1LK6 I;  2V95 A;  2WXZ A;  3DLW A;  1OO8 A;  3EVJ I;  2XN6 A;  4DY7 C;  3CVM A;  1SR5 A;  3FGQ A;  4AFX A;  2ARR A;  4G8O A;  1JVQ I;  1KCT A;  4IF8 A;  1JTI A;  4Y3K A;  4AU3 B;  1OC0 A;  3DRU A;  5INW A;  1LJ5 A;  1ATH A;  1OVA C;  4RO9 A;  2HIJ L;  3VVJ A;  3ZHA A;  8API A;  9PAI A;  2RIV A;  4ROA A;  1ANT I;  2HIJ I;  4AJT A;  3PZF A;  1T1F A;  3R4L A;  3LE2 A;  2CEO A;  3DY0 A;  2B5T I;  2BEH L;  2B4X I;  4AU3 A;  2WXY C;  1PSI A;  2WY1 A;  3F5N A;  1OVA A;  4PYW A;  4ZK0 A;  2WXX A;  5EI0 A;  1LQ8 A;  4ZK3 A;  2BEH I;  4EB1 L;  4DY0 A;  1JMJ A;  1D5S A;  1TB6 I;  2H4P A;  1EZX A;  1M93 B;  3NE4 A;  1E04 I;  4BB2 A;  2ZV6 A;  4EB1 I;  2HI9 A;  1E05 I;  1OVA B;  1ATU A;  4KDS A;  1UHG A;  1QMN A;  7API A;  1HLE A;  2ANT I;  2R9Y A;  2VH4 A;  4DTE A;  4CAA A;  3LW2 A;  2D26 A;  1WZ9 A;  3B9F I;  3KCG I;  5HGC A;  1IMV A;  4Y40 A;  3DRM A;  2VDX A;  2B4X L;  1BY7 A;  1QLP A;  2H4Q A;  3H5C A;  1QMB A;  2DUT A;  5CDZ A;  1DVN A;  5IO1 A;  1ATT A;  2RIW A;  5CDX A;  1HP7 A;  2OAY A;  1C8O A;  1OPH A;  1SNG A;  3OZQ A;  4IC0 A;  5BRR I;  3T1P A;  1C5G A;  1E03 I;  4R9I A;  2ARQ A;  1JMO A;  5C98 A;  1DZH L;  4RSQ A;  2ACH A;  1IZ2 A;  1SEK A;  1A7C A;  2XN7 A;  9API A;  1XQG A;  1B3K A;  1YXA A;  4AJU A;  4P0F A;  4C41 A;  2QUG A;  1DZH I;  5CE0 A;  1F0C A; 
#chains in the Genus database with same CATH topology
 4ROB A;  3F1S A;  2PEF A;  2OL2 A;  2XN5 A;  3NDF A;  3STO A;  1DZG L;  4G8R A;  2PEE A;  4AU4 A;  1DZG I;  3UT3 A;  3EOX A;  1XU8 A;  1JJO C;  1R1L I;  1BR8 I;  1K9O I;  3CWM A;  3CWL A;  3NDD A;  1JRR A;  3Q02 A;  4GA7 A;  1DB2 A;  3PB1 I;  3CAA A;  1OYH L;  1XQJ A;  4X30 A;  2WXZ C;  2WY0 C;  2XN3 A;  2H4R A;  4AQH A;  1OYH I;  1DVM A;  2ZNH A;  4YIA A;  1NQ9 I;  2VDY A;  3Q03 A;  2GD4 C;  1AZX I;  4P0O A;  1MTP A;  2WXW A;  3F02 A;  1AS4 A;  4C49 A;  4AU2 A;  3NDA A;  1LK6 I;  2V95 A;  2WXZ A;  3DLW A;  1OO8 A;  3EVJ I;  2XN6 A;  4DY7 C;  3CVM A;  1SR5 A;  3FGQ A;  4AFX A;  2ARR A;  4G8O A;  1JVQ I;  1KCT A;  4IF8 A;  1JTI A;  4Y3K A;  4AU3 B;  1OC0 A;  3DRU A;  5INW A;  1LJ5 A;  1ATH A;  1OVA C;  4RO9 A;  2HIJ L;  3VVJ A;  3ZHA A;  8API A;  9PAI A;  2RIV A;  4ROA A;  1ANT I;  2HIJ I;  4AJT A;  3PZF A;  1T1F A;  3R4L A;  3LE2 A;  2CEO A;  3DY0 A;  2B5T I;  2BEH L;  2B4X I;  4AU3 A;  2WXY C;  1PSI A;  2WY1 A;  3F5N A;  1OVA A;  4PYW A;  4ZK0 A;  2WXX A;  5EI0 A;  1LQ8 A;  4ZK3 A;  2BEH I;  4EB1 L;  4DY0 A;  1JMJ A;  1D5S A;  1TB6 I;  2H4P A;  1EZX A;  1M93 B;  3NE4 A;  1E04 I;  4BB2 A;  2ZV6 A;  4EB1 I;  2HI9 A;  1E05 I;  1OVA B;  1ATU A;  4KDS A;  1UHG A;  1QMN A;  7API A;  1HLE A;  2ANT I;  2R9Y A;  2VH4 A;  4DTE A;  4CAA A;  3LW2 A;  2D26 A;  1WZ9 A;  3B9F I;  3KCG I;  5HGC A;  1IMV A;  4Y40 A;  3DRM A;  2VDX A;  2B4X L;  1BY7 A;  1QLP A;  2H4Q A;  3H5C A;  1QMB A;  2DUT A;  5CDZ A;  1DVN A;  5IO1 A;  1ATT A;  2RIW A;  5CDX A;  1HP7 A;  2OAY A;  1C8O A;  1OPH A;  1SNG A;  3OZQ A;  4IC0 A;  5BRR I;  3T1P A;  1C5G A;  1E03 I;  4R9I A;  2ARQ A;  1JMO A;  5C98 A;  1DZH L;  4RSQ A;  2ACH A;  1IZ2 A;  1SEK A;  1A7C A;  2XN7 A;  9API A;  1XQG A;  1B3K A;  1YXA A;  4AJU A;  4P0F A;  4C41 A;  2QUG A;  1DZH I;  5CE0 A;  1F0C A; 
#chains in the Genus database with same CATH homology
 4ROB A;  3F1S A;  2PEF A;  2OL2 A;  2XN5 A;  3NDF A;  3STO A;  1DZG L;  4G8R A;  2PEE A;  4AU4 A;  1DZG I;  3UT3 A;  3EOX A;  1XU8 A;  1JJO C;  1R1L I;  1BR8 I;  1K9O I;  3CWM A;  3CWL A;  3NDD A;  1JRR A;  3Q02 A;  4GA7 A;  1DB2 A;  3PB1 I;  3CAA A;  1OYH L;  1XQJ A;  4X30 A;  2WXZ C;  2WY0 C;  2XN3 A;  2H4R A;  4AQH A;  1OYH I;  1DVM A;  2ZNH A;  4YIA A;  1NQ9 I;  2VDY A;  3Q03 A;  2GD4 C;  1AZX I;  4P0O A;  1MTP A;  2WXW A;  3F02 A;  1AS4 A;  4C49 A;  4AU2 A;  3NDA A;  1LK6 I;  2V95 A;  2WXZ A;  3DLW A;  1OO8 A;  3EVJ I;  2XN6 A;  4DY7 C;  3CVM A;  1SR5 A;  3FGQ A;  4AFX A;  2ARR A;  4G8O A;  1JVQ I;  1KCT A;  4IF8 A;  1JTI A;  4Y3K A;  4AU3 B;  1OC0 A;  3DRU A;  5INW A;  1LJ5 A;  1ATH A;  1OVA C;  4RO9 A;  2HIJ L;  3VVJ A;  3ZHA A;  8API A;  9PAI A;  2RIV A;  4ROA A;  1ANT I;  2HIJ I;  4AJT A;  3PZF A;  1T1F A;  3R4L A;  3LE2 A;  2CEO A;  3DY0 A;  2B5T I;  2BEH L;  2B4X I;  4AU3 A;  2WXY C;  1PSI A;  2WY1 A;  3F5N A;  1OVA A;  4PYW A;  4ZK0 A;  2WXX A;  5EI0 A;  1LQ8 A;  4ZK3 A;  2BEH I;  4EB1 L;  4DY0 A;  1JMJ A;  1D5S A;  1TB6 I;  2H4P A;  1EZX A;  1M93 B;  3NE4 A;  1E04 I;  4BB2 A;  2ZV6 A;  4EB1 I;  2HI9 A;  1E05 I;  1OVA B;  1ATU A;  4KDS A;  1UHG A;  1QMN A;  7API A;  1HLE A;  2ANT I;  2R9Y A;  2VH4 A;  4DTE A;  4CAA A;  3LW2 A;  2D26 A;  1WZ9 A;  3B9F I;  3KCG I;  5HGC A;  1IMV A;  4Y40 A;  3DRM A;  2VDX A;  2B4X L;  1BY7 A;  1QLP A;  2H4Q A;  3H5C A;  1QMB A;  2DUT A;  5CDZ A;  1DVN A;  5IO1 A;  1ATT A;  2RIW A;  5CDX A;  1HP7 A;  2OAY A;  1C8O A;  1OPH A;  1SNG A;  3OZQ A;  4IC0 A;  5BRR I;  3T1P A;  1C5G A;  1E03 I;  4R9I A;  2ARQ A;  1JMO A;  5C98 A;  1DZH L;  4RSQ A;  2ACH A;  1IZ2 A;  1SEK A;  1A7C A;  2XN7 A;  9API A;  1XQG A;  1B3K A;  1YXA A;  4AJU A;  4P0F A;  4C41 A;  2QUG A;  1DZH I;  5CE0 A;  1F0C A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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