2ANTI

The 2.6 a structure of antithrombin indicates a conformational change at the heparin binding site
Total Genus 112
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
112
sequence length
432
structure length
419
Chain Sequence
HGSPVDICTAKPRDIPMNPMCIYRSPEKKATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site.
pubmed doi rcsb
molecule keywords ANTITHROMBIN
molecule tags Serpin
total genus 112
structure length 419
sequence length 432
chains with identical sequence L
ec nomenclature
pdb deposition date 1997-01-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 2antI01
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 2antI02
2R9YA 1XQJA 1OVAA 2B5TI 1OC0A 3DY0A 4ZK0A 1BR8I 3CVMA 3DRUA 3H5CA 3DRMA 4EB1L 4G8RA 2OAYA 2H4PA 2WXXA 3F02A 4X30A 3FGQA 4P0FA 1DVMA 1XU8A 2ARQA 4AU3A 3CWMA 1SEKA 1F0CA 1LQ8A 1EZXA 1OYHI 1E03I 4BB2A 1JTIA 1MTPA 1R1LI 1K9OI 4ROBA 1QMNA 3CAAA 1DZGL 4AU3B 2PEEA 3R4LA 5C98A 1ATTA 4AQHA 2V95A 1LJ5A 3EOXA 3NDDA 4AU4A 4YIAA 2XN7A 2B4XI 3VVJA 1SR5A 9PAIA 1JMJA 1NQ9I 1LK6I 2XN5A 1XQGA 2WXZA 4AJUA 4CAAA 2HIJI 1HP7A 3NDFA 1M93B 2ZV6A 2ACHA 8APIA 2WXWA 1DZHL 2QUGA 4PYWA 4KDSA 1YXAA 4DY0A 2BEHI 2CEOA 3NDAA 1ATUA 1AZXI 1IZ2A 4C49A 4DTEA 1OYHL 1HLEA 2HI9A 2PEFA 2OL2A 1B3KA 3EVJI 1QLPA 1T1FA 4Y3KA 3Q03A 1UHGA 1JVQI 4G8OA 4IF8A 1A7CA 1OVAC 2H4QA 2WXYC 2H4RA 4EB1I 2DUTA 2B4XL 3DLWA 4GA7A 4DY7C 5HGCA 1JJOC 4IC0A 2VDYA 3LW2A 3T1PA 9APIA 2D26A 3KCGI 1E04I 4P0OA 5EI0A 4R9IA 1QMBA 1DZGI 2XN3A 3PB1I 4AU2A 3B9FI 2ARRA 1E05I 3PZFA 5CDZA 1OO8A 1JRRA 3NE4A 1TB6I 2RIWA 1SNGA 5IO1A 3F1SA 5BRRI 3CWLA 1ATHA 3OZQA 2RIVA 2XN6A 4RSQA 4ROAA 1DVNA 2VDXA 2GD4C 1DZHI 2ANTI 4Y40A 4ZK3A 1JMOA 2HIJL 1IMVA 7APIA 3UT3A 5CDXA 1OVAB 1AS4A 3STOA 4AFXA 5CE0A 3Q02A 4C41A 2WY0C 2ZNHA 1D5SA 5INWA 3LE2A 2WY1A 1ANTI 2BEHL 4RO9A 1BY7A 1DB2A 1WZ9A 1C8OA 1OPHA 1PSIA 2VH4A 4AJTA 1C5GA 2WXZC 3ZHAA 1KCTA 3F5NA
chains in the Genus database with same CATH superfamily
2R9YA 1XQJA 1OVAA 2B5TI 1OC0A 3DY0A 4ZK0A 1BR8I 3CVMA 3DRUA 3H5CA 3DRMA 4EB1L 4G8RA 2OAYA 2H4PA 2WXXA 3F02A 4X30A 3FGQA 4P0FA 1DVMA 1XU8A 2ARQA 4AU3A 3CWMA 1SEKA 1F0CA 1LQ8A 1EZXA 1OYHI 1E03I 4BB2A 1JTIA 1MTPA 1R1LI 1K9OI 4ROBA 1QMNA 3CAAA 1DZGL 4AU3B 2PEEA 3R4LA 5C98A 1ATTA 4AQHA 2V95A 1LJ5A 3EOXA 3NDDA 4AU4A 4YIAA 2XN7A 2B4XI 3VVJA 1SR5A 9PAIA 1JMJA 1NQ9I 1LK6I 2XN5A 1XQGA 2WXZA 4AJUA 4CAAA 2HIJI 1HP7A 3NDFA 1M93B 2ZV6A 2ACHA 8APIA 2WXWA 1DZHL 2QUGA 4PYWA 4KDSA 1YXAA 4DY0A 2BEHI 2CEOA 3NDAA 1ATUA 1AZXI 1IZ2A 4C49A 4DTEA 1OYHL 1HLEA 2HI9A 2PEFA 2OL2A 1B3KA 3EVJI 1QLPA 1T1FA 4Y3KA 3Q03A 1UHGA 1JVQI 4G8OA 4IF8A 1A7CA 1OVAC 2H4QA 2WXYC 2H4RA 4EB1I 2DUTA 2B4XL 3DLWA 4GA7A 4DY7C 5HGCA 1JJOC 4IC0A 2VDYA 3LW2A 3T1PA 9APIA 2D26A 3KCGI 1E04I 4P0OA 5EI0A 4R9IA 1QMBA 1DZGI 2XN3A 3PB1I 4AU2A 3B9FI 2ARRA 1E05I 3PZFA 5CDZA 1OO8A 1JRRA 3NE4A 1TB6I 2RIWA 1SNGA 5IO1A 3F1SA 5BRRI 3CWLA 1ATHA 3OZQA 2RIVA 2XN6A 4RSQA 4ROAA 1DVNA 2VDXA 2GD4C 1DZHI 2ANTI 4Y40A 4ZK3A 1JMOA 2HIJL 1IMVA 7APIA 3UT3A 5CDXA 1OVAB 1AS4A 3STOA 4AFXA 5CE0A 3Q02A 4C41A 2WY0C 2ZNHA 1D5SA 5INWA 3LE2A 2WY1A 1ANTI 2BEHL 4RO9A 1BY7A 1DB2A 1WZ9A 1C8OA 1OPHA 1PSIA 2VH4A 4AJTA 1C5GA 2WXZC 3ZHAA 1KCTA 3F5NA
chains in the Genus database with same CATH topology
2R9YA 1XQJA 1OVAA 2B5TI 1OC0A 3DY0A 4ZK0A 1BR8I 3CVMA 3DRUA 3H5CA 3DRMA 4EB1L 4G8RA 2OAYA 2H4PA 2WXXA 3F02A 4X30A 3FGQA 4P0FA 1DVMA 1XU8A 2ARQA 4AU3A 3CWMA 1SEKA 1F0CA 1LQ8A 1EZXA 1OYHI 1E03I 4BB2A 1JTIA 1MTPA 1R1LI 1K9OI 4ROBA 1QMNA 3CAAA 1DZGL 4AU3B 2PEEA 3R4LA 5C98A 1ATTA 4AQHA 2V95A 1LJ5A 3EOXA 3NDDA 4AU4A 4YIAA 2XN7A 2B4XI 3VVJA 1SR5A 9PAIA 1JMJA 1NQ9I 1LK6I 2XN5A 1XQGA 2WXZA 4AJUA 4CAAA 2HIJI 1HP7A 3NDFA 1M93B 2ZV6A 2ACHA 8APIA 2WXWA 1DZHL 2QUGA 4PYWA 4KDSA 1YXAA 4DY0A 2BEHI 2CEOA 3NDAA 1ATUA 1AZXI 1IZ2A 4C49A 4DTEA 1OYHL 1HLEA 2HI9A 2PEFA 2OL2A 1B3KA 3EVJI 1QLPA 1T1FA 4Y3KA 3Q03A 1UHGA 1JVQI 4G8OA 4IF8A 1A7CA 1OVAC 2H4QA 2WXYC 2H4RA 4EB1I 2DUTA 2B4XL 3DLWA 4GA7A 4DY7C 5HGCA 1JJOC 4IC0A 2VDYA 3LW2A 3T1PA 9APIA 2D26A 3KCGI 1E04I 4P0OA 5EI0A 4R9IA 1QMBA 1DZGI 2XN3A 3PB1I 4AU2A 3B9FI 2ARRA 1E05I 3PZFA 5CDZA 1OO8A 1JRRA 3NE4A 1TB6I 2RIWA 1SNGA 5IO1A 3F1SA 5BRRI 3CWLA 1ATHA 3OZQA 2RIVA 2XN6A 4RSQA 4ROAA 1DVNA 2VDXA 2GD4C 1DZHI 2ANTI 4Y40A 4ZK3A 1JMOA 2HIJL 1IMVA 7APIA 3UT3A 5CDXA 1OVAB 1AS4A 3STOA 4AFXA 5CE0A 3Q02A 4C41A 2WY0C 2ZNHA 1D5SA 5INWA 3LE2A 2WY1A 1ANTI 2BEHL 4RO9A 1BY7A 1DB2A 1WZ9A 1C8OA 1OPHA 1PSIA 2VH4A 4AJTA 1C5GA 2WXZC 3ZHAA 1KCTA 3F5NA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2R9Y A;  1XQJ A;  1OVA A;  2B5T I;  1OC0 A;  3DY0 A;  4ZK0 A;  1BR8 I;  3CVM A;  3DRU A;  3H5C A;  3DRM A;  4EB1 L;  4G8R A;  2OAY A;  2H4P A;  2WXX A;  3F02 A;  4X30 A;  3FGQ A;  4P0F A;  1DVM A;  1XU8 A;  2ARQ A;  4AU3 A;  3CWM A;  1SEK A;  1F0C A;  1LQ8 A;  1EZX A;  1OYH I;  1E03 I;  4BB2 A;  1JTI A;  1MTP A;  1R1L I;  1K9O I;  4ROB A;  1QMN A;  3CAA A;  1DZG L;  4AU3 B;  2PEE A;  3R4L A;  5C98 A;  1ATT A;  4AQH A;  2V95 A;  1LJ5 A;  3EOX A;  3NDD A;  4AU4 A;  4YIA A;  2XN7 A;  2B4X I;  3VVJ A;  1SR5 A;  9PAI A;  1JMJ A;  1NQ9 I;  1LK6 I;  2XN5 A;  1XQG A;  2WXZ A;  4AJU A;  4CAA A;  2HIJ I;  1HP7 A;  3NDF A;  1M93 B;  2ZV6 A;  2ACH A;  8API A;  2WXW A;  1DZH L;  2QUG A;  4PYW A;  4KDS A;  1YXA A;  4DY0 A;  2BEH I;  2CEO A;  3NDA A;  1ATU A;  1AZX I;  1IZ2 A;  4C49 A;  4DTE A;  1OYH L;  1HLE A;  2HI9 A;  2PEF A;  2OL2 A;  1B3K A;  3EVJ I;  1QLP A;  1T1F A;  4Y3K A;  3Q03 A;  1UHG A;  1JVQ I;  4G8O A;  4IF8 A;  1A7C A;  1OVA C;  2H4Q A;  2WXY C;  2H4R A;  4EB1 I;  2DUT A;  2B4X L;  3DLW A;  4GA7 A;  4DY7 C;  5HGC A;  1JJO C;  4IC0 A;  2VDY A;  3LW2 A;  3T1P A;  9API A;  2D26 A;  3KCG I;  1E04 I;  4P0O A;  5EI0 A;  4R9I A;  1QMB A;  1DZG I;  2XN3 A;  3PB1 I;  4AU2 A;  3B9F I;  2ARR A;  1E05 I;  3PZF A;  5CDZ A;  1OO8 A;  1JRR A;  3NE4 A;  1TB6 I;  2RIW A;  1SNG A;  5IO1 A;  3F1S A;  5BRR I;  3CWL A;  1ATH A;  3OZQ A;  2RIV A;  2XN6 A;  4RSQ A;  4ROA A;  1DVN A;  2VDX A;  2GD4 C;  1DZH I;  2ANT I;  4Y40 A;  4ZK3 A;  1JMO A;  2HIJ L;  1IMV A;  7API A;  3UT3 A;  5CDX A;  1OVA B;  1AS4 A;  3STO A;  4AFX A;  5CE0 A;  3Q02 A;  4C41 A;  2WY0 C;  2ZNH A;  1D5S A;  5INW A;  3LE2 A;  2WY1 A;  1ANT I;  2BEH L;  4RO9 A;  1BY7 A;  1DB2 A;  1WZ9 A;  1C8O A;  1OPH A;  1PSI A;  2VH4 A;  4AJT A;  1C5G A;  2WXZ C;  3ZHA A;  1KCT A;  3F5N A; 
#chains in the Genus database with same CATH topology
 2R9Y A;  1XQJ A;  1OVA A;  2B5T I;  1OC0 A;  3DY0 A;  4ZK0 A;  1BR8 I;  3CVM A;  3DRU A;  3H5C A;  3DRM A;  4EB1 L;  4G8R A;  2OAY A;  2H4P A;  2WXX A;  3F02 A;  4X30 A;  3FGQ A;  4P0F A;  1DVM A;  1XU8 A;  2ARQ A;  4AU3 A;  3CWM A;  1SEK A;  1F0C A;  1LQ8 A;  1EZX A;  1OYH I;  1E03 I;  4BB2 A;  1JTI A;  1MTP A;  1R1L I;  1K9O I;  4ROB A;  1QMN A;  3CAA A;  1DZG L;  4AU3 B;  2PEE A;  3R4L A;  5C98 A;  1ATT A;  4AQH A;  2V95 A;  1LJ5 A;  3EOX A;  3NDD A;  4AU4 A;  4YIA A;  2XN7 A;  2B4X I;  3VVJ A;  1SR5 A;  9PAI A;  1JMJ A;  1NQ9 I;  1LK6 I;  2XN5 A;  1XQG A;  2WXZ A;  4AJU A;  4CAA A;  2HIJ I;  1HP7 A;  3NDF A;  1M93 B;  2ZV6 A;  2ACH A;  8API A;  2WXW A;  1DZH L;  2QUG A;  4PYW A;  4KDS A;  1YXA A;  4DY0 A;  2BEH I;  2CEO A;  3NDA A;  1ATU A;  1AZX I;  1IZ2 A;  4C49 A;  4DTE A;  1OYH L;  1HLE A;  2HI9 A;  2PEF A;  2OL2 A;  1B3K A;  3EVJ I;  1QLP A;  1T1F A;  4Y3K A;  3Q03 A;  1UHG A;  1JVQ I;  4G8O A;  4IF8 A;  1A7C A;  1OVA C;  2H4Q A;  2WXY C;  2H4R A;  4EB1 I;  2DUT A;  2B4X L;  3DLW A;  4GA7 A;  4DY7 C;  5HGC A;  1JJO C;  4IC0 A;  2VDY A;  3LW2 A;  3T1P A;  9API A;  2D26 A;  3KCG I;  1E04 I;  4P0O A;  5EI0 A;  4R9I A;  1QMB A;  1DZG I;  2XN3 A;  3PB1 I;  4AU2 A;  3B9F I;  2ARR A;  1E05 I;  3PZF A;  5CDZ A;  1OO8 A;  1JRR A;  3NE4 A;  1TB6 I;  2RIW A;  1SNG A;  5IO1 A;  3F1S A;  5BRR I;  3CWL A;  1ATH A;  3OZQ A;  2RIV A;  2XN6 A;  4RSQ A;  4ROA A;  1DVN A;  2VDX A;  2GD4 C;  1DZH I;  2ANT I;  4Y40 A;  4ZK3 A;  1JMO A;  2HIJ L;  1IMV A;  7API A;  3UT3 A;  5CDX A;  1OVA B;  1AS4 A;  3STO A;  4AFX A;  5CE0 A;  3Q02 A;  4C41 A;  2WY0 C;  2ZNH A;  1D5S A;  5INW A;  3LE2 A;  2WY1 A;  1ANT I;  2BEH L;  4RO9 A;  1BY7 A;  1DB2 A;  1WZ9 A;  1C8O A;  1OPH A;  1PSI A;  2VH4 A;  4AJT A;  1C5G A;  2WXZ C;  3ZHA A;  1KCT A;  3F5N A; 
#chains in the Genus database with same CATH homology
 2R9Y A;  1XQJ A;  1OVA A;  2B5T I;  1OC0 A;  3DY0 A;  4ZK0 A;  1BR8 I;  3CVM A;  3DRU A;  3H5C A;  3DRM A;  4EB1 L;  4G8R A;  2OAY A;  2H4P A;  2WXX A;  3F02 A;  4X30 A;  3FGQ A;  4P0F A;  1DVM A;  1XU8 A;  2ARQ A;  4AU3 A;  3CWM A;  1SEK A;  1F0C A;  1LQ8 A;  1EZX A;  1OYH I;  1E03 I;  4BB2 A;  1JTI A;  1MTP A;  1R1L I;  1K9O I;  4ROB A;  1QMN A;  3CAA A;  1DZG L;  4AU3 B;  2PEE A;  3R4L A;  5C98 A;  1ATT A;  4AQH A;  2V95 A;  1LJ5 A;  3EOX A;  3NDD A;  4AU4 A;  4YIA A;  2XN7 A;  2B4X I;  3VVJ A;  1SR5 A;  9PAI A;  1JMJ A;  1NQ9 I;  1LK6 I;  2XN5 A;  1XQG A;  2WXZ A;  4AJU A;  4CAA A;  2HIJ I;  1HP7 A;  3NDF A;  1M93 B;  2ZV6 A;  2ACH A;  8API A;  2WXW A;  1DZH L;  2QUG A;  4PYW A;  4KDS A;  1YXA A;  4DY0 A;  2BEH I;  2CEO A;  3NDA A;  1ATU A;  1AZX I;  1IZ2 A;  4C49 A;  4DTE A;  1OYH L;  1HLE A;  2HI9 A;  2PEF A;  2OL2 A;  1B3K A;  3EVJ I;  1QLP A;  1T1F A;  4Y3K A;  3Q03 A;  1UHG A;  1JVQ I;  4G8O A;  4IF8 A;  1A7C A;  1OVA C;  2H4Q A;  2WXY C;  2H4R A;  4EB1 I;  2DUT A;  2B4X L;  3DLW A;  4GA7 A;  4DY7 C;  5HGC A;  1JJO C;  4IC0 A;  2VDY A;  3LW2 A;  3T1P A;  9API A;  2D26 A;  3KCG I;  1E04 I;  4P0O A;  5EI0 A;  4R9I A;  1QMB A;  1DZG I;  2XN3 A;  3PB1 I;  4AU2 A;  3B9F I;  2ARR A;  1E05 I;  3PZF A;  5CDZ A;  1OO8 A;  1JRR A;  3NE4 A;  1TB6 I;  2RIW A;  1SNG A;  5IO1 A;  3F1S A;  5BRR I;  3CWL A;  1ATH A;  3OZQ A;  2RIV A;  2XN6 A;  4RSQ A;  4ROA A;  1DVN A;  2VDX A;  2GD4 C;  1DZH I;  2ANT I;  4Y40 A;  4ZK3 A;  1JMO A;  2HIJ L;  1IMV A;  7API A;  3UT3 A;  5CDX A;  1OVA B;  1AS4 A;  3STO A;  4AFX A;  5CE0 A;  3Q02 A;  4C41 A;  2WY0 C;  2ZNH A;  1D5S A;  5INW A;  3LE2 A;  2WY1 A;  1ANT I;  2BEH L;  4RO9 A;  1BY7 A;  1DB2 A;  1WZ9 A;  1C8O A;  1OPH A;  1PSI A;  2VH4 A;  4AJT A;  1C5G A;  2WXZ C;  3ZHA A;  1KCT A;  3F5N A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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