3NDAA

Crystal structure of serpin from tick ixodes ricinus
Total Genus 134
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
134
Knots found
sequence length
377
structure length
374
Chain Sequence
MQEEAKLTKANNRFGLRLLRALPSGPEKNVFFSPYSVSTAMGMAFAGARGQTQQELSQGLGFSDVDLTDAGVLDAYTHHTERLKSTPSNSTLDVANAAAIQRTLALLNSYESALQSSFGAELHKVDFAGEPQAAVDFVNNWVKRKTHDKIEKLFNEPLDPDTLLVLLNAIYFKGEWNTAFVKEHTEKRQFFNGGVTPVEVDTMRLEARIKYRFFDDLQVEVVELPYRGLDYTMAILLPKENTGVEGLKQNLTIDRFQNYLSDLRERKITVLLPKFKLETKYSLKAPLQSLGIKQIFESGADLSGINDGSLRVSAVEHKAVVEVNEEGTVAAATTGVVIVPYPEPVVFRVDHPFLFFIRNTRTDDIFFVGQVNKL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A tick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation.
pubmed doi rcsb
molecule keywords Serpin-2
molecule tags Hydrolase inhibitor
source organism Ixodes ricinus
total genus 134
structure length 374
sequence length 377
chains with identical sequence B
other databases KnotProt 2.0: S -31
ec nomenclature
pdb deposition date 2010-06-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 3ndaA02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 3ndaA01
1DVMA 1AS4A 3LW2A 2BEHI 3CAAA 4ZK3A 2HI9A 1OO8A 2ARRA 3NDAA 2HIJI 1M93B 1TB6I 7APIA 4DY0A 2V95A 4EB1L 1QLPA 1OVAC 2WXZA 3DRMA 1ATUA 3EOXA 4ZK0A 1OYHI 3CWMA 3PB1I 2ANTI 3FGQA 4IC0A 1OC0A 4AU3A 2PEFA 4GA7A 4RO9A 3NDFA 1PSIA 4BB2A 3B9FI 1LJ5A 1JRRA 2D26A 2DUTA 3NDDA 3KCGI 1R1LI 1KCTA 2BEHL 1DZGI 1IZ2A 1HLEA 2XN7A 3DY0A 2HIJL 1NQ9I 5C98A 2XN5A 1MTPA 3DRUA 5CDZA 2QUGA 1DVNA 2WY1A 1XU8A 1SEKA 3PZFA 3F02A 3F1SA 2WY0C 1WZ9A 1BR8I 1JMJA 1F0CA 3VVJA 4AJTA 2B5TI 2CEOA 4ROAA 2OL2A 1E03I 4R9IA 1HP7A 1QMBA 1D5SA 1SR5A 5BRRI 1OVAA 3Q02A 4C49A 2WXXA 4AU2A 1A7CA 3EVJI 8APIA 4AJUA 4AQHA 2ZNHA 2ZV6A 4Y40A 1DZGL 3STOA 9PAIA 2RIVA 4IF8A 2ARQA 5INWA 9APIA 5EI0A 4P0FA 2XN6A 5IO1A 1C8OA 2H4RA 3DLWA 1QMNA 2VH4A 1UHGA 4RSQA 2WXYC 1IMVA 2B4XI 3H5CA 1DB2A 1K9OI 5CE0A 4G8OA 2OAYA 1C5GA 2GD4C 4PYWA 1ANTI 1T1FA 5HGCA 4AU3B 1LQ8A 1JVQI 3NE4A 4G8RA 1OYHL 1BY7A 1DZHI 5CDXA 3LE2A 4DTEA 2XN3A 1EZXA 3CWLA 1JTIA 2WXWA 4Y3KA 4ROBA 4C41A 1AZXI 1OPHA 1B3KA 1LK6I 1E05I 1XQGA 2R9YA 2B4XL 2H4QA 3ZHAA 2WXZC 3CVMA 4X30A 3R4LA 1ATHA 2VDYA 4DY7C 1ATTA 4CAAA 3T1PA 1DZHL 1OVAB 1YXAA 3F5NA 4KDSA 2VDXA 4EB1I 1E04I 2RIWA 4P0OA 1XQJA 3Q03A 3OZQA 1JJOC 2ACHA 2H4PA 4YIAA 1SNGA 4AFXA 3UT3A 1JMOA 4AU4A 2PEEA
chains in the Genus database with same CATH superfamily
1DVMA 1AS4A 3LW2A 2BEHI 3CAAA 4ZK3A 2HI9A 1OO8A 2ARRA 3NDAA 2HIJI 1M93B 1TB6I 7APIA 4DY0A 2V95A 4EB1L 1QLPA 1OVAC 2WXZA 3DRMA 1ATUA 3EOXA 4ZK0A 1OYHI 3CWMA 3PB1I 2ANTI 3FGQA 4IC0A 1OC0A 4AU3A 2PEFA 4GA7A 4RO9A 3NDFA 1PSIA 4BB2A 3B9FI 1LJ5A 1JRRA 2D26A 2DUTA 3NDDA 3KCGI 1R1LI 1KCTA 2BEHL 1DZGI 1IZ2A 1HLEA 2XN7A 3DY0A 2HIJL 1NQ9I 5C98A 2XN5A 1MTPA 3DRUA 5CDZA 2QUGA 1DVNA 2WY1A 1XU8A 1SEKA 3PZFA 3F02A 3F1SA 2WY0C 1WZ9A 1BR8I 1JMJA 1F0CA 3VVJA 4AJTA 2B5TI 2CEOA 4ROAA 2OL2A 1E03I 4R9IA 1HP7A 1QMBA 1D5SA 1SR5A 5BRRI 1OVAA 3Q02A 4C49A 2WXXA 4AU2A 1A7CA 3EVJI 8APIA 4AJUA 4AQHA 2ZNHA 2ZV6A 4Y40A 1DZGL 3STOA 9PAIA 2RIVA 4IF8A 2ARQA 5INWA 9APIA 5EI0A 4P0FA 2XN6A 5IO1A 1C8OA 2H4RA 3DLWA 1QMNA 2VH4A 1UHGA 4RSQA 2WXYC 1IMVA 2B4XI 3H5CA 1DB2A 1K9OI 5CE0A 4G8OA 2OAYA 1C5GA 2GD4C 4PYWA 1ANTI 1T1FA 5HGCA 4AU3B 1LQ8A 1JVQI 3NE4A 4G8RA 1OYHL 1BY7A 1DZHI 5CDXA 3LE2A 4DTEA 2XN3A 1EZXA 3CWLA 1JTIA 2WXWA 4Y3KA 4ROBA 4C41A 1AZXI 1OPHA 1B3KA 1LK6I 1E05I 1XQGA 2R9YA 2B4XL 2H4QA 3ZHAA 2WXZC 3CVMA 4X30A 3R4LA 1ATHA 2VDYA 4DY7C 1ATTA 4CAAA 3T1PA 1DZHL 1OVAB 1YXAA 3F5NA 4KDSA 2VDXA 4EB1I 1E04I 2RIWA 4P0OA 1XQJA 3Q03A 3OZQA 1JJOC 2ACHA 2H4PA 4YIAA 1SNGA 4AFXA 3UT3A 1JMOA 4AU4A 2PEEA
chains in the Genus database with same CATH topology
1DVMA 1AS4A 3LW2A 2BEHI 3CAAA 4ZK3A 2HI9A 1OO8A 2ARRA 3NDAA 2HIJI 1M93B 1TB6I 7APIA 4DY0A 2V95A 4EB1L 1QLPA 1OVAC 2WXZA 3DRMA 1ATUA 3EOXA 4ZK0A 1OYHI 3CWMA 3PB1I 2ANTI 3FGQA 4IC0A 1OC0A 4AU3A 2PEFA 4GA7A 4RO9A 3NDFA 1PSIA 4BB2A 3B9FI 1LJ5A 1JRRA 2D26A 2DUTA 3NDDA 3KCGI 1R1LI 1KCTA 2BEHL 1DZGI 1IZ2A 1HLEA 2XN7A 3DY0A 2HIJL 1NQ9I 5C98A 2XN5A 1MTPA 3DRUA 5CDZA 2QUGA 1DVNA 2WY1A 1XU8A 1SEKA 3PZFA 3F02A 3F1SA 2WY0C 1WZ9A 1BR8I 1JMJA 1F0CA 3VVJA 4AJTA 2B5TI 2CEOA 4ROAA 2OL2A 1E03I 4R9IA 1HP7A 1QMBA 1D5SA 1SR5A 5BRRI 1OVAA 3Q02A 4C49A 2WXXA 4AU2A 1A7CA 3EVJI 8APIA 4AJUA 4AQHA 2ZNHA 2ZV6A 4Y40A 1DZGL 3STOA 9PAIA 2RIVA 4IF8A 2ARQA 5INWA 9APIA 5EI0A 4P0FA 2XN6A 5IO1A 1C8OA 2H4RA 3DLWA 1QMNA 2VH4A 1UHGA 4RSQA 2WXYC 1IMVA 2B4XI 3H5CA 1DB2A 1K9OI 5CE0A 4G8OA 2OAYA 1C5GA 2GD4C 4PYWA 1ANTI 1T1FA 5HGCA 4AU3B 1LQ8A 1JVQI 3NE4A 4G8RA 1OYHL 1BY7A 1DZHI 5CDXA 3LE2A 4DTEA 2XN3A 1EZXA 3CWLA 1JTIA 2WXWA 4Y3KA 4ROBA 4C41A 1AZXI 1OPHA 1B3KA 1LK6I 1E05I 1XQGA 2R9YA 2B4XL 2H4QA 3ZHAA 2WXZC 3CVMA 4X30A 3R4LA 1ATHA 2VDYA 4DY7C 1ATTA 4CAAA 3T1PA 1DZHL 1OVAB 1YXAA 3F5NA 4KDSA 2VDXA 4EB1I 1E04I 2RIWA 4P0OA 1XQJA 3Q03A 3OZQA 1JJOC 2ACHA 2H4PA 4YIAA 1SNGA 4AFXA 3UT3A 1JMOA 4AU4A 2PEEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DVM A;  1AS4 A;  3LW2 A;  2BEH I;  3CAA A;  4ZK3 A;  2HI9 A;  1OO8 A;  2ARR A;  3NDA A;  2HIJ I;  1M93 B;  1TB6 I;  7API A;  4DY0 A;  2V95 A;  4EB1 L;  1QLP A;  1OVA C;  2WXZ A;  3DRM A;  1ATU A;  3EOX A;  4ZK0 A;  1OYH I;  3CWM A;  3PB1 I;  2ANT I;  3FGQ A;  4IC0 A;  1OC0 A;  4AU3 A;  2PEF A;  4GA7 A;  4RO9 A;  3NDF A;  1PSI A;  4BB2 A;  3B9F I;  1LJ5 A;  1JRR A;  2D26 A;  2DUT A;  3NDD A;  3KCG I;  1R1L I;  1KCT A;  2BEH L;  1DZG I;  1IZ2 A;  1HLE A;  2XN7 A;  3DY0 A;  2HIJ L;  1NQ9 I;  5C98 A;  2XN5 A;  1MTP A;  3DRU A;  5CDZ A;  2QUG A;  1DVN A;  2WY1 A;  1XU8 A;  1SEK A;  3PZF A;  3F02 A;  3F1S A;  2WY0 C;  1WZ9 A;  1BR8 I;  1JMJ A;  1F0C A;  3VVJ A;  4AJT A;  2B5T I;  2CEO A;  4ROA A;  2OL2 A;  1E03 I;  4R9I A;  1HP7 A;  1QMB A;  1D5S A;  1SR5 A;  5BRR I;  1OVA A;  3Q02 A;  4C49 A;  2WXX A;  4AU2 A;  1A7C A;  3EVJ I;  8API A;  4AJU A;  4AQH A;  2ZNH A;  2ZV6 A;  4Y40 A;  1DZG L;  3STO A;  9PAI A;  2RIV A;  4IF8 A;  2ARQ A;  5INW A;  9API A;  5EI0 A;  4P0F A;  2XN6 A;  5IO1 A;  1C8O A;  2H4R A;  3DLW A;  1QMN A;  2VH4 A;  1UHG A;  4RSQ A;  2WXY C;  1IMV A;  2B4X I;  3H5C A;  1DB2 A;  1K9O I;  5CE0 A;  4G8O A;  2OAY A;  1C5G A;  2GD4 C;  4PYW A;  1ANT I;  1T1F A;  5HGC A;  4AU3 B;  1LQ8 A;  1JVQ I;  3NE4 A;  4G8R A;  1OYH L;  1BY7 A;  1DZH I;  5CDX A;  3LE2 A;  4DTE A;  2XN3 A;  1EZX A;  3CWL A;  1JTI A;  2WXW A;  4Y3K A;  4ROB A;  4C41 A;  1AZX I;  1OPH A;  1B3K A;  1LK6 I;  1E05 I;  1XQG A;  2R9Y A;  2B4X L;  2H4Q A;  3ZHA A;  2WXZ C;  3CVM A;  4X30 A;  3R4L A;  1ATH A;  2VDY A;  4DY7 C;  1ATT A;  4CAA A;  3T1P A;  1DZH L;  1OVA B;  1YXA A;  3F5N A;  4KDS A;  2VDX A;  4EB1 I;  1E04 I;  2RIW A;  4P0O A;  1XQJ A;  3Q03 A;  3OZQ A;  1JJO C;  2ACH A;  2H4P A;  4YIA A;  1SNG A;  4AFX A;  3UT3 A;  1JMO A;  4AU4 A;  2PEE A; 
#chains in the Genus database with same CATH topology
 1DVM A;  1AS4 A;  3LW2 A;  2BEH I;  3CAA A;  4ZK3 A;  2HI9 A;  1OO8 A;  2ARR A;  3NDA A;  2HIJ I;  1M93 B;  1TB6 I;  7API A;  4DY0 A;  2V95 A;  4EB1 L;  1QLP A;  1OVA C;  2WXZ A;  3DRM A;  1ATU A;  3EOX A;  4ZK0 A;  1OYH I;  3CWM A;  3PB1 I;  2ANT I;  3FGQ A;  4IC0 A;  1OC0 A;  4AU3 A;  2PEF A;  4GA7 A;  4RO9 A;  3NDF A;  1PSI A;  4BB2 A;  3B9F I;  1LJ5 A;  1JRR A;  2D26 A;  2DUT A;  3NDD A;  3KCG I;  1R1L I;  1KCT A;  2BEH L;  1DZG I;  1IZ2 A;  1HLE A;  2XN7 A;  3DY0 A;  2HIJ L;  1NQ9 I;  5C98 A;  2XN5 A;  1MTP A;  3DRU A;  5CDZ A;  2QUG A;  1DVN A;  2WY1 A;  1XU8 A;  1SEK A;  3PZF A;  3F02 A;  3F1S A;  2WY0 C;  1WZ9 A;  1BR8 I;  1JMJ A;  1F0C A;  3VVJ A;  4AJT A;  2B5T I;  2CEO A;  4ROA A;  2OL2 A;  1E03 I;  4R9I A;  1HP7 A;  1QMB A;  1D5S A;  1SR5 A;  5BRR I;  1OVA A;  3Q02 A;  4C49 A;  2WXX A;  4AU2 A;  1A7C A;  3EVJ I;  8API A;  4AJU A;  4AQH A;  2ZNH A;  2ZV6 A;  4Y40 A;  1DZG L;  3STO A;  9PAI A;  2RIV A;  4IF8 A;  2ARQ A;  5INW A;  9API A;  5EI0 A;  4P0F A;  2XN6 A;  5IO1 A;  1C8O A;  2H4R A;  3DLW A;  1QMN A;  2VH4 A;  1UHG A;  4RSQ A;  2WXY C;  1IMV A;  2B4X I;  3H5C A;  1DB2 A;  1K9O I;  5CE0 A;  4G8O A;  2OAY A;  1C5G A;  2GD4 C;  4PYW A;  1ANT I;  1T1F A;  5HGC A;  4AU3 B;  1LQ8 A;  1JVQ I;  3NE4 A;  4G8R A;  1OYH L;  1BY7 A;  1DZH I;  5CDX A;  3LE2 A;  4DTE A;  2XN3 A;  1EZX A;  3CWL A;  1JTI A;  2WXW A;  4Y3K A;  4ROB A;  4C41 A;  1AZX I;  1OPH A;  1B3K A;  1LK6 I;  1E05 I;  1XQG A;  2R9Y A;  2B4X L;  2H4Q A;  3ZHA A;  2WXZ C;  3CVM A;  4X30 A;  3R4L A;  1ATH A;  2VDY A;  4DY7 C;  1ATT A;  4CAA A;  3T1P A;  1DZH L;  1OVA B;  1YXA A;  3F5N A;  4KDS A;  2VDX A;  4EB1 I;  1E04 I;  2RIW A;  4P0O A;  1XQJ A;  3Q03 A;  3OZQ A;  1JJO C;  2ACH A;  2H4P A;  4YIA A;  1SNG A;  4AFX A;  3UT3 A;  1JMO A;  4AU4 A;  2PEE A; 
#chains in the Genus database with same CATH homology
 1DVM A;  1AS4 A;  3LW2 A;  2BEH I;  3CAA A;  4ZK3 A;  2HI9 A;  1OO8 A;  2ARR A;  3NDA A;  2HIJ I;  1M93 B;  1TB6 I;  7API A;  4DY0 A;  2V95 A;  4EB1 L;  1QLP A;  1OVA C;  2WXZ A;  3DRM A;  1ATU A;  3EOX A;  4ZK0 A;  1OYH I;  3CWM A;  3PB1 I;  2ANT I;  3FGQ A;  4IC0 A;  1OC0 A;  4AU3 A;  2PEF A;  4GA7 A;  4RO9 A;  3NDF A;  1PSI A;  4BB2 A;  3B9F I;  1LJ5 A;  1JRR A;  2D26 A;  2DUT A;  3NDD A;  3KCG I;  1R1L I;  1KCT A;  2BEH L;  1DZG I;  1IZ2 A;  1HLE A;  2XN7 A;  3DY0 A;  2HIJ L;  1NQ9 I;  5C98 A;  2XN5 A;  1MTP A;  3DRU A;  5CDZ A;  2QUG A;  1DVN A;  2WY1 A;  1XU8 A;  1SEK A;  3PZF A;  3F02 A;  3F1S A;  2WY0 C;  1WZ9 A;  1BR8 I;  1JMJ A;  1F0C A;  3VVJ A;  4AJT A;  2B5T I;  2CEO A;  4ROA A;  2OL2 A;  1E03 I;  4R9I A;  1HP7 A;  1QMB A;  1D5S A;  1SR5 A;  5BRR I;  1OVA A;  3Q02 A;  4C49 A;  2WXX A;  4AU2 A;  1A7C A;  3EVJ I;  8API A;  4AJU A;  4AQH A;  2ZNH A;  2ZV6 A;  4Y40 A;  1DZG L;  3STO A;  9PAI A;  2RIV A;  4IF8 A;  2ARQ A;  5INW A;  9API A;  5EI0 A;  4P0F A;  2XN6 A;  5IO1 A;  1C8O A;  2H4R A;  3DLW A;  1QMN A;  2VH4 A;  1UHG A;  4RSQ A;  2WXY C;  1IMV A;  2B4X I;  3H5C A;  1DB2 A;  1K9O I;  5CE0 A;  4G8O A;  2OAY A;  1C5G A;  2GD4 C;  4PYW A;  1ANT I;  1T1F A;  5HGC A;  4AU3 B;  1LQ8 A;  1JVQ I;  3NE4 A;  4G8R A;  1OYH L;  1BY7 A;  1DZH I;  5CDX A;  3LE2 A;  4DTE A;  2XN3 A;  1EZX A;  3CWL A;  1JTI A;  2WXW A;  4Y3K A;  4ROB A;  4C41 A;  1AZX I;  1OPH A;  1B3K A;  1LK6 I;  1E05 I;  1XQG A;  2R9Y A;  2B4X L;  2H4Q A;  3ZHA A;  2WXZ C;  3CVM A;  4X30 A;  3R4L A;  1ATH A;  2VDY A;  4DY7 C;  1ATT A;  4CAA A;  3T1P A;  1DZH L;  1OVA B;  1YXA A;  3F5N A;  4KDS A;  2VDX A;  4EB1 I;  1E04 I;  2RIW A;  4P0O A;  1XQJ A;  3Q03 A;  3OZQ A;  1JJO C;  2ACH A;  2H4P A;  4YIA A;  1SNG A;  4AFX A;  3UT3 A;  1JMO A;  4AU4 A;  2PEE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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