3PZFA

1.75a resolution structure of serpin-2 from anopheles gambiae
Total Genus 112
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
112
sequence length
383
structure length
369
Chain Sequence
GPFQGQRQNEFDLMFVKEIFKNHNSNVVLSPFSVKILLTLIYEASDTSFGAVSNTKRELSSVIQNDNIDHTRSYYKQLLESAQQDNKDYDLNIATNFFVDDFIEVINKYQQIANTHYHAMLEKVSYSNPTQTAATINNWVSEHTNGRLREIVTPDSLEGAVITLVNVIYFKGLWTYPFPEVANNVKPFYGTRGKPTNAQYMEQNGQFYYDNSADLGAQILRLPYRGNKLAMYFILPNPDNTVNQVLDRINSASLHQALWYMEENEVNVTLPKFKFDFSEQLNEPLQQVGIREIFSQNASLPLLARGEVRVSRIFQKAGITINELGSEAYAATEIDGVQIFNANRPFIFFIEDETLGTMLFAGKIENPVF
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of native Anopheles gambiae serpin-2, a negative regulator of melanization in mosquitoes.
pubmed doi rcsb
molecule keywords Serpin 2
molecule tags Hydrolase inhibitor
source organism Anopheles gambiae
total genus 112
structure length 369
sequence length 383
ec nomenclature
pdb deposition date 2010-12-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 3pzfA01
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 3pzfA02
3Q02A 3KCGI 1MTPA 2WXXA 1JRRA 2B5TI 2QUGA 3ZHAA 4G8OA 1OPHA 1OYHL 3UT3A 1OVAA 4AFXA 4AU3B 1NQ9I 1HP7A 1B3KA 4P0OA 1OO8A 3H5CA 3EOXA 5EI0A 5CDZA 4DTEA 1LK6I 9APIA 2WXZA 1BR8I 1DB2A 2H4QA 1WZ9A 2WXZC 1DZHI 1KCTA 1M93B 3T1PA 1DZGL 1ATTA 1OC0A 3FGQA 3OZQA 5HGCA 3VVJA 3NDDA 1K9OI 2DUTA 2BEHL 4X30A 1SEKA 2VDXA 8APIA 2H4PA 4AJTA 4ZK0A 1SNGA 2VH4A 3CAAA 5INWA 4IC0A 4Y3KA 1E03I 4AJUA 2ZV6A 2B4XI 2ZNHA 3CVMA 4GA7A 1C8OA 1JJOC 2HIJL 1OVAC 5BRRI 1ATUA 4DY0A 3LW2A 2HI9A 4IF8A 3NE4A 1PSIA 7APIA 2PEFA 4ROBA 1YXAA 2WY1A 3DLWA 4BB2A 1D5SA 3CWMA 1OYHI 2H4RA 1SR5A 1ANTI 2ARRA 3B9FI 3R4LA 4YIAA 2ACHA 1LQ8A 2XN7A 4PYWA 3PZFA 1DZHL 2D26A 4AU4A 1TB6I 1XQJA 4AU3A 2OL2A 9PAIA 1A7CA 1UHGA 1EZXA 1DVMA 1JVQI 2ARQA 1QMBA 3F5NA 4KDSA 4ZK3A 4EB1L 4ROAA 1OVAB 1QMNA 4C41A 1IMVA 2XN5A 2R9YA 3DRUA 3CWLA 2B4XL 2WXWA 1QLPA 3NDAA 3DY0A 4Y40A 5IO1A 4R9IA 2ANTI 4RO9A 2GD4C 3NDFA 1AS4A 2WY0C 5CE0A 5CDXA 2CEOA 4DY7C 1LJ5A 2HIJI 1F0CA 1AZXI 2V95A 1IZ2A 1E04I 1HLEA 1E05I 4P0FA 3EVJI 2OAYA 4CAAA 3PB1I 4AU2A 1JMJA 1T1FA 1DVNA 3Q03A 2RIVA 2XN6A 4RSQA 1JMOA 1DZGI 1ATHA 2PEEA 4G8RA 3F02A 2RIWA 1BY7A 1XU8A 2XN3A 1R1LI 2WXYC 3LE2A 2BEHI 1C5GA 1JTIA 3DRMA 5C98A 1XQGA 4AQHA 2VDYA 4C49A 3F1SA 3STOA 4EB1I
chains in the Genus database with same CATH superfamily
3Q02A 3KCGI 1MTPA 2WXXA 1JRRA 2B5TI 2QUGA 3ZHAA 4G8OA 1OPHA 1OYHL 3UT3A 1OVAA 4AFXA 4AU3B 1NQ9I 1HP7A 1B3KA 4P0OA 1OO8A 3H5CA 3EOXA 5EI0A 5CDZA 4DTEA 1LK6I 9APIA 2WXZA 1BR8I 1DB2A 2H4QA 1WZ9A 2WXZC 1DZHI 1KCTA 1M93B 3T1PA 1DZGL 1ATTA 1OC0A 3FGQA 3OZQA 5HGCA 3VVJA 3NDDA 1K9OI 2DUTA 2BEHL 4X30A 1SEKA 2VDXA 8APIA 2H4PA 4AJTA 4ZK0A 1SNGA 2VH4A 3CAAA 5INWA 4IC0A 4Y3KA 1E03I 4AJUA 2ZV6A 2B4XI 2ZNHA 3CVMA 4GA7A 1C8OA 1JJOC 2HIJL 1OVAC 5BRRI 1ATUA 4DY0A 3LW2A 2HI9A 4IF8A 3NE4A 1PSIA 7APIA 2PEFA 4ROBA 1YXAA 2WY1A 3DLWA 4BB2A 1D5SA 3CWMA 1OYHI 2H4RA 1SR5A 1ANTI 2ARRA 3B9FI 3R4LA 4YIAA 2ACHA 1LQ8A 2XN7A 4PYWA 3PZFA 1DZHL 2D26A 4AU4A 1TB6I 1XQJA 4AU3A 2OL2A 9PAIA 1A7CA 1UHGA 1EZXA 1DVMA 1JVQI 2ARQA 1QMBA 3F5NA 4KDSA 4ZK3A 4EB1L 4ROAA 1OVAB 1QMNA 4C41A 1IMVA 2XN5A 2R9YA 3DRUA 3CWLA 2B4XL 2WXWA 1QLPA 3NDAA 3DY0A 4Y40A 5IO1A 4R9IA 2ANTI 4RO9A 2GD4C 3NDFA 1AS4A 2WY0C 5CE0A 5CDXA 2CEOA 4DY7C 1LJ5A 2HIJI 1F0CA 1AZXI 2V95A 1IZ2A 1E04I 1HLEA 1E05I 4P0FA 3EVJI 2OAYA 4CAAA 3PB1I 4AU2A 1JMJA 1T1FA 1DVNA 3Q03A 2RIVA 2XN6A 4RSQA 1JMOA 1DZGI 1ATHA 2PEEA 4G8RA 3F02A 2RIWA 1BY7A 1XU8A 2XN3A 1R1LI 2WXYC 3LE2A 2BEHI 1C5GA 1JTIA 3DRMA 5C98A 1XQGA 4AQHA 2VDYA 4C49A 3F1SA 3STOA 4EB1I
chains in the Genus database with same CATH topology
3Q02A 3KCGI 1MTPA 2WXXA 1JRRA 2B5TI 2QUGA 3ZHAA 4G8OA 1OPHA 1OYHL 3UT3A 1OVAA 4AFXA 4AU3B 1NQ9I 1HP7A 1B3KA 4P0OA 1OO8A 3H5CA 3EOXA 5EI0A 5CDZA 4DTEA 1LK6I 9APIA 2WXZA 1BR8I 1DB2A 2H4QA 1WZ9A 2WXZC 1DZHI 1KCTA 1M93B 3T1PA 1DZGL 1ATTA 1OC0A 3FGQA 3OZQA 5HGCA 3VVJA 3NDDA 1K9OI 2DUTA 2BEHL 4X30A 1SEKA 2VDXA 8APIA 2H4PA 4AJTA 4ZK0A 1SNGA 2VH4A 3CAAA 5INWA 4IC0A 4Y3KA 1E03I 4AJUA 2ZV6A 2B4XI 2ZNHA 3CVMA 4GA7A 1C8OA 1JJOC 2HIJL 1OVAC 5BRRI 1ATUA 4DY0A 3LW2A 2HI9A 4IF8A 3NE4A 1PSIA 7APIA 2PEFA 4ROBA 1YXAA 2WY1A 3DLWA 4BB2A 1D5SA 3CWMA 1OYHI 2H4RA 1SR5A 1ANTI 2ARRA 3B9FI 3R4LA 4YIAA 2ACHA 1LQ8A 2XN7A 4PYWA 3PZFA 1DZHL 2D26A 4AU4A 1TB6I 1XQJA 4AU3A 2OL2A 9PAIA 1A7CA 1UHGA 1EZXA 1DVMA 1JVQI 2ARQA 1QMBA 3F5NA 4KDSA 4ZK3A 4EB1L 4ROAA 1OVAB 1QMNA 4C41A 1IMVA 2XN5A 2R9YA 3DRUA 3CWLA 2B4XL 2WXWA 1QLPA 3NDAA 3DY0A 4Y40A 5IO1A 4R9IA 2ANTI 4RO9A 2GD4C 3NDFA 1AS4A 2WY0C 5CE0A 5CDXA 2CEOA 4DY7C 1LJ5A 2HIJI 1F0CA 1AZXI 2V95A 1IZ2A 1E04I 1HLEA 1E05I 4P0FA 3EVJI 2OAYA 4CAAA 3PB1I 4AU2A 1JMJA 1T1FA 1DVNA 3Q03A 2RIVA 2XN6A 4RSQA 1JMOA 1DZGI 1ATHA 2PEEA 4G8RA 3F02A 2RIWA 1BY7A 1XU8A 2XN3A 1R1LI 2WXYC 3LE2A 2BEHI 1C5GA 1JTIA 3DRMA 5C98A 1XQGA 4AQHA 2VDYA 4C49A 3F1SA 3STOA 4EB1I
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3Q02 A;  3KCG I;  1MTP A;  2WXX A;  1JRR A;  2B5T I;  2QUG A;  3ZHA A;  4G8O A;  1OPH A;  1OYH L;  3UT3 A;  1OVA A;  4AFX A;  4AU3 B;  1NQ9 I;  1HP7 A;  1B3K A;  4P0O A;  1OO8 A;  3H5C A;  3EOX A;  5EI0 A;  5CDZ A;  4DTE A;  1LK6 I;  9API A;  2WXZ A;  1BR8 I;  1DB2 A;  2H4Q A;  1WZ9 A;  2WXZ C;  1DZH I;  1KCT A;  1M93 B;  3T1P A;  1DZG L;  1ATT A;  1OC0 A;  3FGQ A;  3OZQ A;  5HGC A;  3VVJ A;  3NDD A;  1K9O I;  2DUT A;  2BEH L;  4X30 A;  1SEK A;  2VDX A;  8API A;  2H4P A;  4AJT A;  4ZK0 A;  1SNG A;  2VH4 A;  3CAA A;  5INW A;  4IC0 A;  4Y3K A;  1E03 I;  4AJU A;  2ZV6 A;  2B4X I;  2ZNH A;  3CVM A;  4GA7 A;  1C8O A;  1JJO C;  2HIJ L;  1OVA C;  5BRR I;  1ATU A;  4DY0 A;  3LW2 A;  2HI9 A;  4IF8 A;  3NE4 A;  1PSI A;  7API A;  2PEF A;  4ROB A;  1YXA A;  2WY1 A;  3DLW A;  4BB2 A;  1D5S A;  3CWM A;  1OYH I;  2H4R A;  1SR5 A;  1ANT I;  2ARR A;  3B9F I;  3R4L A;  4YIA A;  2ACH A;  1LQ8 A;  2XN7 A;  4PYW A;  3PZF A;  1DZH L;  2D26 A;  4AU4 A;  1TB6 I;  1XQJ A;  4AU3 A;  2OL2 A;  9PAI A;  1A7C A;  1UHG A;  1EZX A;  1DVM A;  1JVQ I;  2ARQ A;  1QMB A;  3F5N A;  4KDS A;  4ZK3 A;  4EB1 L;  4ROA A;  1OVA B;  1QMN A;  4C41 A;  1IMV A;  2XN5 A;  2R9Y A;  3DRU A;  3CWL A;  2B4X L;  2WXW A;  1QLP A;  3NDA A;  3DY0 A;  4Y40 A;  5IO1 A;  4R9I A;  2ANT I;  4RO9 A;  2GD4 C;  3NDF A;  1AS4 A;  2WY0 C;  5CE0 A;  5CDX A;  2CEO A;  4DY7 C;  1LJ5 A;  2HIJ I;  1F0C A;  1AZX I;  2V95 A;  1IZ2 A;  1E04 I;  1HLE A;  1E05 I;  4P0F A;  3EVJ I;  2OAY A;  4CAA A;  3PB1 I;  4AU2 A;  1JMJ A;  1T1F A;  1DVN A;  3Q03 A;  2RIV A;  2XN6 A;  4RSQ A;  1JMO A;  1DZG I;  1ATH A;  2PEE A;  4G8R A;  3F02 A;  2RIW A;  1BY7 A;  1XU8 A;  2XN3 A;  1R1L I;  2WXY C;  3LE2 A;  2BEH I;  1C5G A;  1JTI A;  3DRM A;  5C98 A;  1XQG A;  4AQH A;  2VDY A;  4C49 A;  3F1S A;  3STO A;  4EB1 I; 
#chains in the Genus database with same CATH topology
 3Q02 A;  3KCG I;  1MTP A;  2WXX A;  1JRR A;  2B5T I;  2QUG A;  3ZHA A;  4G8O A;  1OPH A;  1OYH L;  3UT3 A;  1OVA A;  4AFX A;  4AU3 B;  1NQ9 I;  1HP7 A;  1B3K A;  4P0O A;  1OO8 A;  3H5C A;  3EOX A;  5EI0 A;  5CDZ A;  4DTE A;  1LK6 I;  9API A;  2WXZ A;  1BR8 I;  1DB2 A;  2H4Q A;  1WZ9 A;  2WXZ C;  1DZH I;  1KCT A;  1M93 B;  3T1P A;  1DZG L;  1ATT A;  1OC0 A;  3FGQ A;  3OZQ A;  5HGC A;  3VVJ A;  3NDD A;  1K9O I;  2DUT A;  2BEH L;  4X30 A;  1SEK A;  2VDX A;  8API A;  2H4P A;  4AJT A;  4ZK0 A;  1SNG A;  2VH4 A;  3CAA A;  5INW A;  4IC0 A;  4Y3K A;  1E03 I;  4AJU A;  2ZV6 A;  2B4X I;  2ZNH A;  3CVM A;  4GA7 A;  1C8O A;  1JJO C;  2HIJ L;  1OVA C;  5BRR I;  1ATU A;  4DY0 A;  3LW2 A;  2HI9 A;  4IF8 A;  3NE4 A;  1PSI A;  7API A;  2PEF A;  4ROB A;  1YXA A;  2WY1 A;  3DLW A;  4BB2 A;  1D5S A;  3CWM A;  1OYH I;  2H4R A;  1SR5 A;  1ANT I;  2ARR A;  3B9F I;  3R4L A;  4YIA A;  2ACH A;  1LQ8 A;  2XN7 A;  4PYW A;  3PZF A;  1DZH L;  2D26 A;  4AU4 A;  1TB6 I;  1XQJ A;  4AU3 A;  2OL2 A;  9PAI A;  1A7C A;  1UHG A;  1EZX A;  1DVM A;  1JVQ I;  2ARQ A;  1QMB A;  3F5N A;  4KDS A;  4ZK3 A;  4EB1 L;  4ROA A;  1OVA B;  1QMN A;  4C41 A;  1IMV A;  2XN5 A;  2R9Y A;  3DRU A;  3CWL A;  2B4X L;  2WXW A;  1QLP A;  3NDA A;  3DY0 A;  4Y40 A;  5IO1 A;  4R9I A;  2ANT I;  4RO9 A;  2GD4 C;  3NDF A;  1AS4 A;  2WY0 C;  5CE0 A;  5CDX A;  2CEO A;  4DY7 C;  1LJ5 A;  2HIJ I;  1F0C A;  1AZX I;  2V95 A;  1IZ2 A;  1E04 I;  1HLE A;  1E05 I;  4P0F A;  3EVJ I;  2OAY A;  4CAA A;  3PB1 I;  4AU2 A;  1JMJ A;  1T1F A;  1DVN A;  3Q03 A;  2RIV A;  2XN6 A;  4RSQ A;  1JMO A;  1DZG I;  1ATH A;  2PEE A;  4G8R A;  3F02 A;  2RIW A;  1BY7 A;  1XU8 A;  2XN3 A;  1R1L I;  2WXY C;  3LE2 A;  2BEH I;  1C5G A;  1JTI A;  3DRM A;  5C98 A;  1XQG A;  4AQH A;  2VDY A;  4C49 A;  3F1S A;  3STO A;  4EB1 I; 
#chains in the Genus database with same CATH homology
 3Q02 A;  3KCG I;  1MTP A;  2WXX A;  1JRR A;  2B5T I;  2QUG A;  3ZHA A;  4G8O A;  1OPH A;  1OYH L;  3UT3 A;  1OVA A;  4AFX A;  4AU3 B;  1NQ9 I;  1HP7 A;  1B3K A;  4P0O A;  1OO8 A;  3H5C A;  3EOX A;  5EI0 A;  5CDZ A;  4DTE A;  1LK6 I;  9API A;  2WXZ A;  1BR8 I;  1DB2 A;  2H4Q A;  1WZ9 A;  2WXZ C;  1DZH I;  1KCT A;  1M93 B;  3T1P A;  1DZG L;  1ATT A;  1OC0 A;  3FGQ A;  3OZQ A;  5HGC A;  3VVJ A;  3NDD A;  1K9O I;  2DUT A;  2BEH L;  4X30 A;  1SEK A;  2VDX A;  8API A;  2H4P A;  4AJT A;  4ZK0 A;  1SNG A;  2VH4 A;  3CAA A;  5INW A;  4IC0 A;  4Y3K A;  1E03 I;  4AJU A;  2ZV6 A;  2B4X I;  2ZNH A;  3CVM A;  4GA7 A;  1C8O A;  1JJO C;  2HIJ L;  1OVA C;  5BRR I;  1ATU A;  4DY0 A;  3LW2 A;  2HI9 A;  4IF8 A;  3NE4 A;  1PSI A;  7API A;  2PEF A;  4ROB A;  1YXA A;  2WY1 A;  3DLW A;  4BB2 A;  1D5S A;  3CWM A;  1OYH I;  2H4R A;  1SR5 A;  1ANT I;  2ARR A;  3B9F I;  3R4L A;  4YIA A;  2ACH A;  1LQ8 A;  2XN7 A;  4PYW A;  3PZF A;  1DZH L;  2D26 A;  4AU4 A;  1TB6 I;  1XQJ A;  4AU3 A;  2OL2 A;  9PAI A;  1A7C A;  1UHG A;  1EZX A;  1DVM A;  1JVQ I;  2ARQ A;  1QMB A;  3F5N A;  4KDS A;  4ZK3 A;  4EB1 L;  4ROA A;  1OVA B;  1QMN A;  4C41 A;  1IMV A;  2XN5 A;  2R9Y A;  3DRU A;  3CWL A;  2B4X L;  2WXW A;  1QLP A;  3NDA A;  3DY0 A;  4Y40 A;  5IO1 A;  4R9I A;  2ANT I;  4RO9 A;  2GD4 C;  3NDF A;  1AS4 A;  2WY0 C;  5CE0 A;  5CDX A;  2CEO A;  4DY7 C;  1LJ5 A;  2HIJ I;  1F0C A;  1AZX I;  2V95 A;  1IZ2 A;  1E04 I;  1HLE A;  1E05 I;  4P0F A;  3EVJ I;  2OAY A;  4CAA A;  3PB1 I;  4AU2 A;  1JMJ A;  1T1F A;  1DVN A;  3Q03 A;  2RIV A;  2XN6 A;  4RSQ A;  1JMO A;  1DZG I;  1ATH A;  2PEE A;  4G8R A;  3F02 A;  2RIW A;  1BY7 A;  1XU8 A;  2XN3 A;  1R1L I;  2WXY C;  3LE2 A;  2BEH I;  1C5G A;  1JTI A;  3DRM A;  5C98 A;  1XQG A;  4AQH A;  2VDY A;  4C49 A;  3F1S A;  3STO A;  4EB1 I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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