4IC0A

Crystal structure of pai-1 in complex with gallate
Total Genus 113
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
113
sequence length
375
structure length
366
Chain Sequence
PSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISHLLGTGAVQQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVALALQKVKIEVNESVIVSARMAPEEIIIDRPFLFVVRHNPTGTVLFMGQVMEP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of PAI-1 in Complex with Gallate
rcsb
molecule keywords Plasminogen activator inhibitor 1
molecule tags Hydrolase inhibitor
source organism Homo sapiens
total genus 113
structure length 366
sequence length 375
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2012-12-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4ic0A02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4ic0A01
4ZK3A 4AU3A 1DZGL 8APIA 4AJUA 1WZ9A 1A7CA 2WXXA 4AFXA 1JTIA 2WXYC 1XQGA 1ATUA 2BEHL 1JMOA 5CE0A 3B9FI 2B4XI 2B5TI 3LE2A 2HIJL 2H4PA 4BB2A 2ACHA 2XN6A 4G8OA 3CWLA 2VH4A 4AJTA 4RSQA 5EI0A 4ROBA 1QLPA 1T1FA 1BY7A 3OZQA 2PEEA 2VDXA 3PB1I 2GD4C 2VDYA 3DLWA 3EOXA 4AQHA 3H5CA 4AU3B 1JRRA 3DRMA 2WXZC 2OL2A 5INWA 1SEKA 1D5SA 3UT3A 1LK6I 5CDZA 1DZHI 2ARQA 3STOA 3CWMA 4C49A 2ARRA 2WY1A 3R4LA 3Q02A 1ANTI 1OC0A 1SR5A 2WXWA 1MTPA 1OVAC 3NDAA 4KDSA 1OYHI 4EB1I 3F02A 1SNGA 2HI9A 4AU2A 3F1SA 1PSIA 1HP7A 1C5GA 1ATHA 1XU8A 2D26A 4RO9A 2V95A 2WY0C 5BRRI 1IMVA 4Y3KA 2B4XL 1NQ9I 1AZXI 4DY7C 2XN7A 1ATTA 3EVJI 2ZV6A 1KCTA 3F5NA 4C41A 1JVQI 1LJ5A 4IC0A 1YXAA 3NE4A 1C8OA 2WXZA 3PZFA 1K9OI 1F0CA 1R1LI 1E04I 1DZGI 4DY0A 3CVMA 5HGCA 2ZNHA 1OPHA 5IO1A 4YIAA 3T1PA 1EZXA 1BR8I 5C98A 2RIWA 3LW2A 2OAYA 9APIA 3NDFA 1E05I 1OVAA 2XN5A 3KCGI 2R9YA 4DTEA 2BEHI 1UHGA 2H4QA 1HLEA 1DVMA 2PEFA 4P0FA 2RIVA 3NDDA 4Y40A 3DRUA 9PAIA 3DY0A 2HIJI 4P0OA 1DZHL 3ZHAA 1IZ2A 4IF8A 1QMNA 4PYWA 7APIA 1XQJA 2CEOA 4ROAA 4G8RA 3VVJA 3CAAA 1OYHL 2DUTA 4R9IA 4EB1L 2XN3A 1QMBA 2H4RA 3Q03A 1JJOC 1LQ8A 1OO8A 1B3KA 4AU4A 4GA7A 1TB6I 1E03I 1DVNA 4ZK0A 4X30A 1M93B 3FGQA 1JMJA 1AS4A 4CAAA 1DB2A 1OVAB 5CDXA 2QUGA 2ANTI
chains in the Genus database with same CATH superfamily
4ZK3A 4AU3A 1DZGL 8APIA 4AJUA 1WZ9A 1A7CA 2WXXA 4AFXA 1JTIA 2WXYC 1XQGA 1ATUA 2BEHL 1JMOA 5CE0A 3B9FI 2B4XI 2B5TI 3LE2A 2HIJL 2H4PA 4BB2A 2ACHA 2XN6A 4G8OA 3CWLA 2VH4A 4AJTA 4RSQA 5EI0A 4ROBA 1QLPA 1T1FA 1BY7A 3OZQA 2PEEA 2VDXA 3PB1I 2GD4C 2VDYA 3DLWA 3EOXA 4AQHA 3H5CA 4AU3B 1JRRA 3DRMA 2WXZC 2OL2A 5INWA 1SEKA 1D5SA 3UT3A 1LK6I 5CDZA 1DZHI 2ARQA 3STOA 3CWMA 4C49A 2ARRA 2WY1A 3R4LA 3Q02A 1ANTI 1OC0A 1SR5A 2WXWA 1MTPA 1OVAC 3NDAA 4KDSA 1OYHI 4EB1I 3F02A 1SNGA 2HI9A 4AU2A 3F1SA 1PSIA 1HP7A 1C5GA 1ATHA 1XU8A 2D26A 4RO9A 2V95A 2WY0C 5BRRI 1IMVA 4Y3KA 2B4XL 1NQ9I 1AZXI 4DY7C 2XN7A 1ATTA 3EVJI 2ZV6A 1KCTA 3F5NA 4C41A 1JVQI 1LJ5A 4IC0A 1YXAA 3NE4A 1C8OA 2WXZA 3PZFA 1K9OI 1F0CA 1R1LI 1E04I 1DZGI 4DY0A 3CVMA 5HGCA 2ZNHA 1OPHA 5IO1A 4YIAA 3T1PA 1EZXA 1BR8I 5C98A 2RIWA 3LW2A 2OAYA 9APIA 3NDFA 1E05I 1OVAA 2XN5A 3KCGI 2R9YA 4DTEA 2BEHI 1UHGA 2H4QA 1HLEA 1DVMA 2PEFA 4P0FA 2RIVA 3NDDA 4Y40A 3DRUA 9PAIA 3DY0A 2HIJI 4P0OA 1DZHL 3ZHAA 1IZ2A 4IF8A 1QMNA 4PYWA 7APIA 1XQJA 2CEOA 4ROAA 4G8RA 3VVJA 3CAAA 1OYHL 2DUTA 4R9IA 4EB1L 2XN3A 1QMBA 2H4RA 3Q03A 1JJOC 1LQ8A 1OO8A 1B3KA 4AU4A 4GA7A 1TB6I 1E03I 1DVNA 4ZK0A 4X30A 1M93B 3FGQA 1JMJA 1AS4A 4CAAA 1DB2A 1OVAB 5CDXA 2QUGA 2ANTI
chains in the Genus database with same CATH topology
4ZK3A 4AU3A 1DZGL 8APIA 4AJUA 1WZ9A 1A7CA 2WXXA 4AFXA 1JTIA 2WXYC 1XQGA 1ATUA 2BEHL 1JMOA 5CE0A 3B9FI 2B4XI 2B5TI 3LE2A 2HIJL 2H4PA 4BB2A 2ACHA 2XN6A 4G8OA 3CWLA 2VH4A 4AJTA 4RSQA 5EI0A 4ROBA 1QLPA 1T1FA 1BY7A 3OZQA 2PEEA 2VDXA 3PB1I 2GD4C 2VDYA 3DLWA 3EOXA 4AQHA 3H5CA 4AU3B 1JRRA 3DRMA 2WXZC 2OL2A 5INWA 1SEKA 1D5SA 3UT3A 1LK6I 5CDZA 1DZHI 2ARQA 3STOA 3CWMA 4C49A 2ARRA 2WY1A 3R4LA 3Q02A 1ANTI 1OC0A 1SR5A 2WXWA 1MTPA 1OVAC 3NDAA 4KDSA 1OYHI 4EB1I 3F02A 1SNGA 2HI9A 4AU2A 3F1SA 1PSIA 1HP7A 1C5GA 1ATHA 1XU8A 2D26A 4RO9A 2V95A 2WY0C 5BRRI 1IMVA 4Y3KA 2B4XL 1NQ9I 1AZXI 4DY7C 2XN7A 1ATTA 3EVJI 2ZV6A 1KCTA 3F5NA 4C41A 1JVQI 1LJ5A 4IC0A 1YXAA 3NE4A 1C8OA 2WXZA 3PZFA 1K9OI 1F0CA 1R1LI 1E04I 1DZGI 4DY0A 3CVMA 5HGCA 2ZNHA 1OPHA 5IO1A 4YIAA 3T1PA 1EZXA 1BR8I 5C98A 2RIWA 3LW2A 2OAYA 9APIA 3NDFA 1E05I 1OVAA 2XN5A 3KCGI 2R9YA 4DTEA 2BEHI 1UHGA 2H4QA 1HLEA 1DVMA 2PEFA 4P0FA 2RIVA 3NDDA 4Y40A 3DRUA 9PAIA 3DY0A 2HIJI 4P0OA 1DZHL 3ZHAA 1IZ2A 4IF8A 1QMNA 4PYWA 7APIA 1XQJA 2CEOA 4ROAA 4G8RA 3VVJA 3CAAA 1OYHL 2DUTA 4R9IA 4EB1L 2XN3A 1QMBA 2H4RA 3Q03A 1JJOC 1LQ8A 1OO8A 1B3KA 4AU4A 4GA7A 1TB6I 1E03I 1DVNA 4ZK0A 4X30A 1M93B 3FGQA 1JMJA 1AS4A 4CAAA 1DB2A 1OVAB 5CDXA 2QUGA 2ANTI
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ZK3 A;  4AU3 A;  1DZG L;  8API A;  4AJU A;  1WZ9 A;  1A7C A;  2WXX A;  4AFX A;  1JTI A;  2WXY C;  1XQG A;  1ATU A;  2BEH L;  1JMO A;  5CE0 A;  3B9F I;  2B4X I;  2B5T I;  3LE2 A;  2HIJ L;  2H4P A;  4BB2 A;  2ACH A;  2XN6 A;  4G8O A;  3CWL A;  2VH4 A;  4AJT A;  4RSQ A;  5EI0 A;  4ROB A;  1QLP A;  1T1F A;  1BY7 A;  3OZQ A;  2PEE A;  2VDX A;  3PB1 I;  2GD4 C;  2VDY A;  3DLW A;  3EOX A;  4AQH A;  3H5C A;  4AU3 B;  1JRR A;  3DRM A;  2WXZ C;  2OL2 A;  5INW A;  1SEK A;  1D5S A;  3UT3 A;  1LK6 I;  5CDZ A;  1DZH I;  2ARQ A;  3STO A;  3CWM A;  4C49 A;  2ARR A;  2WY1 A;  3R4L A;  3Q02 A;  1ANT I;  1OC0 A;  1SR5 A;  2WXW A;  1MTP A;  1OVA C;  3NDA A;  4KDS A;  1OYH I;  4EB1 I;  3F02 A;  1SNG A;  2HI9 A;  4AU2 A;  3F1S A;  1PSI A;  1HP7 A;  1C5G A;  1ATH A;  1XU8 A;  2D26 A;  4RO9 A;  2V95 A;  2WY0 C;  5BRR I;  1IMV A;  4Y3K A;  2B4X L;  1NQ9 I;  1AZX I;  4DY7 C;  2XN7 A;  1ATT A;  3EVJ I;  2ZV6 A;  1KCT A;  3F5N A;  4C41 A;  1JVQ I;  1LJ5 A;  4IC0 A;  1YXA A;  3NE4 A;  1C8O A;  2WXZ A;  3PZF A;  1K9O I;  1F0C A;  1R1L I;  1E04 I;  1DZG I;  4DY0 A;  3CVM A;  5HGC A;  2ZNH A;  1OPH A;  5IO1 A;  4YIA A;  3T1P A;  1EZX A;  1BR8 I;  5C98 A;  2RIW A;  3LW2 A;  2OAY A;  9API A;  3NDF A;  1E05 I;  1OVA A;  2XN5 A;  3KCG I;  2R9Y A;  4DTE A;  2BEH I;  1UHG A;  2H4Q A;  1HLE A;  1DVM A;  2PEF A;  4P0F A;  2RIV A;  3NDD A;  4Y40 A;  3DRU A;  9PAI A;  3DY0 A;  2HIJ I;  4P0O A;  1DZH L;  3ZHA A;  1IZ2 A;  4IF8 A;  1QMN A;  4PYW A;  7API A;  1XQJ A;  2CEO A;  4ROA A;  4G8R A;  3VVJ A;  3CAA A;  1OYH L;  2DUT A;  4R9I A;  4EB1 L;  2XN3 A;  1QMB A;  2H4R A;  3Q03 A;  1JJO C;  1LQ8 A;  1OO8 A;  1B3K A;  4AU4 A;  4GA7 A;  1TB6 I;  1E03 I;  1DVN A;  4ZK0 A;  4X30 A;  1M93 B;  3FGQ A;  1JMJ A;  1AS4 A;  4CAA A;  1DB2 A;  1OVA B;  5CDX A;  2QUG A;  2ANT I; 
#chains in the Genus database with same CATH topology
 4ZK3 A;  4AU3 A;  1DZG L;  8API A;  4AJU A;  1WZ9 A;  1A7C A;  2WXX A;  4AFX A;  1JTI A;  2WXY C;  1XQG A;  1ATU A;  2BEH L;  1JMO A;  5CE0 A;  3B9F I;  2B4X I;  2B5T I;  3LE2 A;  2HIJ L;  2H4P A;  4BB2 A;  2ACH A;  2XN6 A;  4G8O A;  3CWL A;  2VH4 A;  4AJT A;  4RSQ A;  5EI0 A;  4ROB A;  1QLP A;  1T1F A;  1BY7 A;  3OZQ A;  2PEE A;  2VDX A;  3PB1 I;  2GD4 C;  2VDY A;  3DLW A;  3EOX A;  4AQH A;  3H5C A;  4AU3 B;  1JRR A;  3DRM A;  2WXZ C;  2OL2 A;  5INW A;  1SEK A;  1D5S A;  3UT3 A;  1LK6 I;  5CDZ A;  1DZH I;  2ARQ A;  3STO A;  3CWM A;  4C49 A;  2ARR A;  2WY1 A;  3R4L A;  3Q02 A;  1ANT I;  1OC0 A;  1SR5 A;  2WXW A;  1MTP A;  1OVA C;  3NDA A;  4KDS A;  1OYH I;  4EB1 I;  3F02 A;  1SNG A;  2HI9 A;  4AU2 A;  3F1S A;  1PSI A;  1HP7 A;  1C5G A;  1ATH A;  1XU8 A;  2D26 A;  4RO9 A;  2V95 A;  2WY0 C;  5BRR I;  1IMV A;  4Y3K A;  2B4X L;  1NQ9 I;  1AZX I;  4DY7 C;  2XN7 A;  1ATT A;  3EVJ I;  2ZV6 A;  1KCT A;  3F5N A;  4C41 A;  1JVQ I;  1LJ5 A;  4IC0 A;  1YXA A;  3NE4 A;  1C8O A;  2WXZ A;  3PZF A;  1K9O I;  1F0C A;  1R1L I;  1E04 I;  1DZG I;  4DY0 A;  3CVM A;  5HGC A;  2ZNH A;  1OPH A;  5IO1 A;  4YIA A;  3T1P A;  1EZX A;  1BR8 I;  5C98 A;  2RIW A;  3LW2 A;  2OAY A;  9API A;  3NDF A;  1E05 I;  1OVA A;  2XN5 A;  3KCG I;  2R9Y A;  4DTE A;  2BEH I;  1UHG A;  2H4Q A;  1HLE A;  1DVM A;  2PEF A;  4P0F A;  2RIV A;  3NDD A;  4Y40 A;  3DRU A;  9PAI A;  3DY0 A;  2HIJ I;  4P0O A;  1DZH L;  3ZHA A;  1IZ2 A;  4IF8 A;  1QMN A;  4PYW A;  7API A;  1XQJ A;  2CEO A;  4ROA A;  4G8R A;  3VVJ A;  3CAA A;  1OYH L;  2DUT A;  4R9I A;  4EB1 L;  2XN3 A;  1QMB A;  2H4R A;  3Q03 A;  1JJO C;  1LQ8 A;  1OO8 A;  1B3K A;  4AU4 A;  4GA7 A;  1TB6 I;  1E03 I;  1DVN A;  4ZK0 A;  4X30 A;  1M93 B;  3FGQ A;  1JMJ A;  1AS4 A;  4CAA A;  1DB2 A;  1OVA B;  5CDX A;  2QUG A;  2ANT I; 
#chains in the Genus database with same CATH homology
 4ZK3 A;  4AU3 A;  1DZG L;  8API A;  4AJU A;  1WZ9 A;  1A7C A;  2WXX A;  4AFX A;  1JTI A;  2WXY C;  1XQG A;  1ATU A;  2BEH L;  1JMO A;  5CE0 A;  3B9F I;  2B4X I;  2B5T I;  3LE2 A;  2HIJ L;  2H4P A;  4BB2 A;  2ACH A;  2XN6 A;  4G8O A;  3CWL A;  2VH4 A;  4AJT A;  4RSQ A;  5EI0 A;  4ROB A;  1QLP A;  1T1F A;  1BY7 A;  3OZQ A;  2PEE A;  2VDX A;  3PB1 I;  2GD4 C;  2VDY A;  3DLW A;  3EOX A;  4AQH A;  3H5C A;  4AU3 B;  1JRR A;  3DRM A;  2WXZ C;  2OL2 A;  5INW A;  1SEK A;  1D5S A;  3UT3 A;  1LK6 I;  5CDZ A;  1DZH I;  2ARQ A;  3STO A;  3CWM A;  4C49 A;  2ARR A;  2WY1 A;  3R4L A;  3Q02 A;  1ANT I;  1OC0 A;  1SR5 A;  2WXW A;  1MTP A;  1OVA C;  3NDA A;  4KDS A;  1OYH I;  4EB1 I;  3F02 A;  1SNG A;  2HI9 A;  4AU2 A;  3F1S A;  1PSI A;  1HP7 A;  1C5G A;  1ATH A;  1XU8 A;  2D26 A;  4RO9 A;  2V95 A;  2WY0 C;  5BRR I;  1IMV A;  4Y3K A;  2B4X L;  1NQ9 I;  1AZX I;  4DY7 C;  2XN7 A;  1ATT A;  3EVJ I;  2ZV6 A;  1KCT A;  3F5N A;  4C41 A;  1JVQ I;  1LJ5 A;  4IC0 A;  1YXA A;  3NE4 A;  1C8O A;  2WXZ A;  3PZF A;  1K9O I;  1F0C A;  1R1L I;  1E04 I;  1DZG I;  4DY0 A;  3CVM A;  5HGC A;  2ZNH A;  1OPH A;  5IO1 A;  4YIA A;  3T1P A;  1EZX A;  1BR8 I;  5C98 A;  2RIW A;  3LW2 A;  2OAY A;  9API A;  3NDF A;  1E05 I;  1OVA A;  2XN5 A;  3KCG I;  2R9Y A;  4DTE A;  2BEH I;  1UHG A;  2H4Q A;  1HLE A;  1DVM A;  2PEF A;  4P0F A;  2RIV A;  3NDD A;  4Y40 A;  3DRU A;  9PAI A;  3DY0 A;  2HIJ I;  4P0O A;  1DZH L;  3ZHA A;  1IZ2 A;  4IF8 A;  1QMN A;  4PYW A;  7API A;  1XQJ A;  2CEO A;  4ROA A;  4G8R A;  3VVJ A;  3CAA A;  1OYH L;  2DUT A;  4R9I A;  4EB1 L;  2XN3 A;  1QMB A;  2H4R A;  3Q03 A;  1JJO C;  1LQ8 A;  1OO8 A;  1B3K A;  4AU4 A;  4GA7 A;  1TB6 I;  1E03 I;  1DVN A;  4ZK0 A;  4X30 A;  1M93 B;  3FGQ A;  1JMJ A;  1AS4 A;  4CAA A;  1DB2 A;  1OVA B;  5CDX A;  2QUG A;  2ANT I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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